IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 26, 2008, Pages 9041-9046

  Serada, Satoshi ^a   Fujimoto, Minoru ^a   Mihara, Masahiko ^b   Koike, Nobuo ^b   Ohsugi, Yoshiyuki ^b   Nomura, Shintaro ^c   Yoshida, Hiroto ^b   Nishikawa, Teppei ^c   Terabe, Fumitaka ^c   Ohkawara, Tomoharu ^c   Takahashi, Tsuyoshi ^c   Ripley, Barry ^d   Kimura, Akihiro ^d   Kishimoto, Tadamitsu ^d   Naka, Tetsuji ^a  

^a NATIONAL INSTITUTE OF BIOMEDICAL INNOVATION   (Japan)

^b CHUGAI PHARMACEUTICAL CO LTD   (Japan)

^c OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d OSAKA UNIVERSITY   (Japan)

Author keywords

Autoimmunity; Multiple sclerosis; T cells

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; IMMUNOGLOBULIN G; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 6 ANTIBODY; MYELIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; TUMOR NECROSIS FACTOR ALPHA; ANTIGEN; EPITOPE; MONOCLONAL ANTIBODY; MYELIN ASSOCIATED GLYCOPROTEIN; OLIGODENDROCYTE MYELIN GLYCOPROTEIN; OLIGODENDROCYTE-MYELIN GLYCOPROTEIN; PEPTIDE;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL MATURATION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; HELPER CELL; IMMUNOSUPPRESSIVE TREATMENT; IN VIVO STUDY; INGUINAL LYMPH NODE; LYMPHOCYTIC INFILTRATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TH1 CELL; TH17 CELL; ANIMAL; C57BL MOUSE; CELL MOTION; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; LYMPHOID TISSUE; MYELIN SHEATH; PATHOLOGY;

MURINAE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS; CELL MOVEMENT; CENTRAL NERVOUS SYSTEM; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; EPITOPES; INTERLEUKIN-6; LYMPHOCYTE ACTIVATION; LYMPHOID TISSUE; MICE; MICE, INBRED C57BL; MYELIN SHEATH; MYELIN-ASSOCIATED GLYCOPROTEIN; PEPTIDES; T-LYMPHOCYTES, HELPER-INDUCER; TH1 CELLS;

EID: 48249148236     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0802218105     Document Type: Article

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