CD4+ CD25+ T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid arthritis

Clinical and Experimental Immunology

Volumn 140, Issue 2, 2005, Pages 360-367

  Möttönen, Milja ^a,b   Heikkinen, J ^a,b   Mustonen, L ^b   Isomaki P ^b,d   Luukkainen, R ^c   Lassila, O ^a,b  

^a UNIVERSITY OF TURKU   (Finland)

^b TURKU UNIVERSITY   (Finland)

^c Regional Hospital   (Finland)

^d TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

Author keywords

Human; Regulatory T cells; Rheumatoid arthritis

Indexed keywords

CD134 ANTIGEN; CD4 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INTERLEUKIN 2 RECEPTOR ALPHA; TRANSCRIPTION FACTOR FOXP3;

ADULT; AGED; ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ARTICLE; AUTOIMMUNITY; BLOOD; CLINICAL ARTICLE; CONTROLLED STUDY; EFFECTOR CELL; FEMALE; GENE; GITR GENE; HUMAN; HUMAN CELL; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE COUNT; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MALE; PHENOTYPE; PRIORITY JOURNAL; REGULATORY MECHANISM; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID; SYNOVIUM; T LYMPHOCYTE SUBPOPULATION;

ADULT; AGED; AGED, 80 AND OVER; ARTHRITIS, RHEUMATOID; CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CELLS, CULTURED; DNA-BINDING PROTEINS; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; IMMUNE TOLERANCE; IMMUNOPHENOTYPING; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; RECEPTORS, INTERLEUKIN-2; SYNOVIAL FLUID; T-LYMPHOCYTE SUBSETS;

EID: 17644384896     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2005.02754.x     Document Type: Article

References (44)

1. Bach FJ. Regulatory T cells under scrutiny. Nat Rev Immunol 2003; 3:189-98.
2. + regulatory T cells that express Toll-like receptors. J Exp Med 2003; 197:397-401.
3. von Boehmer H. Dynamics of suppressor T cells: in vivo veritas. J Exp Med 2003; 198:845-9.
4. high regulatory T cells in human peripheral blood. J Immunol 2001; 167:1245-53.
5. + thymocytes and peripheral T cells have immune suppressive activity in vitro. Eur J Immunol 2001; 31:1247-54.
6. + T cells with regulatory properties isolated from peripheral blood. J Exp Med 2001; 193:1285-94.
7. + T cells with regulatory properties from human blood. J Exp Med 2001; 193:1303-10.
8. Ng WF, Duggan PJ, Ponchel F et al. Human CD4(+) CD25(+) cells, a naturally occurring population of regulatory T cells. Blood 2001; 98:2736-44.
9. + regulatory T cells induced by an agonist self-peptide. Nat Immunol 2001; 2:301-6.
10. + regulatory T cells. Nat Immunol 2003; 4:330-6.
11. + T regulatory cells. Nat Immunol 2003; 4:337-42.
12. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299:1057-61.
13. Bennett CL, Christie J, Ramsdell F et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet 2001; 27:20-1.
14. + T cells. J Clin Invest 2003; 112:1437-43.
15. Roncarolo M-G, Levings MK, Traversari C. Differentiation of T-regulatory cells by immature dendritic cells. J Exp Med 2001; 193:F5-9.
16. + regulatory T cells: thymus or periphery. J Clin Invest 2003; 112:1310-12.
17. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med 1998; 188:287-96.
18. + T helper cells. J Exp Med 2002; 196:255-60.
19. + regulatory, contact-dependent T cells induce interleukin-10-producing, contact-independent type 1-like regulatory T cells. J Exp Med 2002; 196:247-53.
20. + regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells. Eur J Immunol 2000; 30:1538-43.
21. Bystry RS, Aluvihare V, Welch KA, Kallikourdis M, Betz AG. B cells and professional APCs recruit regulatory T cells via CCL4. Nat Immunol 2001; 2:1126-32.
22. Fallarino F, Grohmann U, Hwang KW et al. Modulation of tryptophan catabolism by regulatory T cells. Nat Immunol 2003; 4:1206-12.
23. + T cells restrain the maturation and antigen-presenting function of dendritic cells. J Immunol 2004; 172:4676-80.
24. + T suppressor cell clones produce transforming growth factor β, but not interleukin-10, and are distinct from type 1 T regulatory cells. J Exp Med 2002; 196:1335-46.
25. McHugh RS, Whitters MJ, Piccirillo CA et al. CD4(+) CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 2002; 16:311-23.
26. Firestein GS. Evolving concepts of rheumatoid arthritis. Nature 2003; 423:356-61.
27. Cush JJ, Lipsky PE. Phenotypic analysis of synovial tissue and peripheral blood lymphocytes isolated from patients with rheumatoid arthritis. Arthritis Rheum 1988; 31:1230-8.
28. + memory T cells in rheumatoid arthritis synovium. Arthritis Res 2000; 2:415-23.
29. Cope AP. Studies of T-cell activation in chronic inflammation. Arthritis Res 2002; 4:S197-211.
30. Arnett FC, Edworthy SM, Bloch DA et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31:315-24.
31. Kreuzer KA, Lass U, Landt O et al. Highly sensitive and specific fluorescence reverse transcription-PCR assay for the pseudogene-free detection of beta-actin transcripts as quantitative reference. Clin Chem 1999; 45:297-300.
32. + T cells from the target organ Of patients with rheumatoid arthritis. Eur J Immunol 2003; 33:215-23.
33. + regulatory T cells in rheumatoid arthritis: differences in the presence, phenotype, and function between peripheral blood and synovial fluid. Arthritis Rheum 2004; 50:2775-85.
34. + regulatory cells are enriched in inflamed joints of patients with chronic rheumatic disease. Arthritis Res Ther 2004; 6:R335-46.
35. + regulatory T cells that control intestinal inflammation. J Exp Med 2000; 192:295-302.
36. + regulatory T cells through GITR breaks immunological tolerance. Nat Immunol 2002; 3:135-42.
37. + cell depletion hastens the onset of severe disease in collagen-induced arthritis. Arthritis Rheum 2003; 48:1452-60.
38. + T cells. Arthritis Rheum 2002; 46:1671-82.
39. Ehrestein MR, Evans JG, Singh A et al. Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFα therapy. J Exp Med 2004; 200:277-85.
40. + regulatory T cells in patients with multiple sclerosis. J Exp Med 2004; 199:971-9.
41. Tak PP, Smeets TJM, Daha MR et al. Analysis of the synovial cell infiltrate in early rheumatoid synovial tissue in relation to local disease activity. Arthritis Rheum 1997; 40:217-25.
42. Tak PP, van der Lubbe PA, Cauli A et al. Reduction of synovial inflammation after anti-CD4 monoclonal antibody treatment in early rheumatoid arthritis. Arthritis Rheum 1995; 38:1457-65.
43. Grohmann U, Orabona C, Fallarino F et al. CTLA-4-Ig regulates tryptophan catabolism in vivo. Nat Immunol 2002; 3:1097-101.
44. Mellor AL, Baban B, Chandler P et al. Induced indoleamine 2,3 dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion. J Immunol 2003; 177:1652-5.