Oral vaccination with a viral vector containing Aβ cDNA attenuates age-related Aβ accumulation and memory deficits without causing inflammation in a mouse Alzheimer model

FASEB Journal

Volumn 21, Issue 9, 2007, Pages 2135-2148

  Mouri, Akihiro ^a   Noda, Yukihiro ^a,b   Hara, Hideo ^a,c   Mizoguchi, Hiroyuki ^a   Tabira, Takeshi ^c   Nabeshima, Toshitaka ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b MEIJO UNIVERSITY   (Japan)

^c NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

Author keywords

A peptide; Cognitive dysfunction

Indexed keywords

AMYLOID BETA PROTEIN; ANTIBODY; CD19 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; COMPLEMENTARY DNA; EOSIN; HEMATOXYLIN; OLIGOMER; PARVOVIRUS VECTOR;

ALZHEIMER DISEASE; AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENUATION; BRAIN REGION; COGNITIVE DEFECT; CONTROLLED STUDY; EMBRYO; FEMALE; HISTOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMMUNOTHERAPY; LEARNING TEST; MAZE TEST; MICROGLIA; MOUSE; NERVE CELL DEGENERATION; NONHUMAN; PRIORITY JOURNAL; RECOGNITION; SYNAPSE; THERAPY EFFECT; TRANSGENIC MOUSE; VACCINATION; VIRAL GENE DELIVERY SYSTEM;

ADMINISTRATION, ORAL; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; ASSOCIATION LEARNING; AVOIDANCE LEARNING; BRAIN; BRAIN CHEMISTRY; DEPENDOVIRUS; DISEASE MODELS, ANIMAL; DNA, COMPLEMENTARY; DRUG EVALUATION, PRECLINICAL; EXPLORATORY BEHAVIOR; FEAR; FEMALE; FREEZING REACTION, CATALEPTIC; GENETIC VECTORS; IMMUNOTHERAPY, ACTIVE; MAZE LEARNING; MICE; MICE, TRANSGENIC; MICROGLIA; MOTOR ACTIVITY; MUTATION, MISSENSE; PEPTIDE FRAGMENTS; POINT MUTATION; RECOGNITION (PSYCHOLOGY); SENILE PLAQUES; SOLUBILITY; SYNAPSES; VACCINATION; VACCINES, DNA;

MUS; MUS MUSCULUS;

EID: 34347399599     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.06-7685com     Document Type: Article

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