Liposomal vaccines with conformation-specific amyloid peptide antigens define immune response and efficacy in APP transgenic mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 23, 2007, Pages 9810-9815

  Muhs, Andreas ^a   Hickman, David T ^a   Pihlgren, Maria ^a   Chuard, Nathalie ^a   Giriens, Valérie ^a   Meerschman, Carine ^a   Van Der Auwera, Ingrid ^b   Van Leuven, Fred ^c   Sugawara, Masae ^d   Weingertner, Marie Catherine ^d   Bechinger, Burkhard ^d   Greferath, Ruth ^a   Kolonko, Nadine ^a   Nagel Steger, Luitgard ^e   Riesner, Detlev ^e   Brady, Roscoe O ^f   Pfeifer, Andrea ^a   Nicolau, Claude ^a,g  

^a EPFL   (Switzerland)

^b reMYND NV   (Belgium)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d UNIVERSITÉ LOUIS PASTEUR   (France)

^e HEINRICH HEINE UNIVERSITY   (Germany)

^f NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^g TUFTS UNIVERSITY   (United States)

Author keywords

amyloid; Alzheimer's disease; Vaccine

Indexed keywords

ACI 01; ACI 24; AMYLOID BETA PROTEIN[1-15]; AMYLOID PRECURSOR PROTEIN; EPITOPE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G2B; IMMUNOGLOBULIN M; LIPOSOME; MACROGOL; PEGYLATED AMYLOID BETA PROTEIN[1-16]; TETRAPALMITOYLATED AMYLOID BETA PROTEIN[1-15]; UNCLASSIFIED DRUG; VACCINE;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ARTICLE; BETA SHEET; CIRCULAR DICHROISM; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG DESIGN; DRUG EFFICACY; DRUG SAFETY; FEMALE; IMMUNE RESPONSE; IMMUNOGENICITY; IMMUNOLOGICAL MEMORY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN CONFORMATION; TH2 CELL; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; ALZHEIMER VACCINES; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANALYSIS OF VARIANCE; ANIMALS; ANTIGENS; BRAIN; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; LIPOSOMES; MICE; MICE, TRANSGENIC; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; RECOGNITION (PSYCHOLOGY);

MUS; MUS MUSCULUS;

EID: 34547473731     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0703137104     Document Type: Article

References (46)

1. Braak H, Braak E, Bohl J (1993) Eur Neurol 33:403-408.
2. Jellinger KA, Bancher C (1996) Neurology 46:1186-1187.
3. Soto C (1999) Mol Med Today 5:343-350.
4. Selkoe DJ (1993) Trends Neurosci 16:403-409.
5. Hardy J, Selkoe DJ (2002) Science 297:353-356.
6. Walsh DM, Selkoe DJ (2004) Neuron 44:181-193.
7. Bard F, Cannon C, Barbour R, Burke RL, Games D, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, et al. (2000) Nat Med 6:916-919.
8. DeMattos RB, Bales KR, Cummins DJ, Dodart JC, Paul SM, Holtzman DM (2001) Proc Natl Acad Sci USA 98:8850-8855.
9. Dodart JC, Bales KR, Gannon KS, Greene SJ, DeMattos RB, Mathis C, DeLong CA, Wu S, Wu X, Holtzman DM, et al. (2002) Nat Neurosci 5:452-457.
10. Lee EB, Leng LZ, Zhang B, Kwong L, Trojanowski JQ, Abel T, Lee VM (2006) J Biol Chem 281:4292-4299.
11. Levites Y, Das P, Price RW, Rochette MJ, Kostura LA, McGowan EM, Murphy MP, Golde TE (2006) J Clin Invest 116:193-201.
12. Maier M, Seabrook TJ, Lazo ND, Jiang L, Das P, Janus C, Lemere CA (2006) J Neurosci 26:4717-4728.
13. Seabrook TJ, Thomas K, Jiang L, Bloom J, Spooner E, Maier M, Bitan G, Lemere CA (2007) Neurobiol Aging 28:813-823.
14. Schenk D, Barbour R, Dunn W, Gordon G, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, Khan K, et al. (1999) Nature 400:173-177.
15. Weiner HL, Lemere CA, Maron R, Spooner ET, Grenfell TJ, Mori C, Issazadeh S, Hancock WW, Selkoe DJ (2000) Ann Neurol 48:567-579.
16. Qu B, Boyer PJ, Johnston SA, Hynan LS, Rosenberg RN (2006) J Neurol Sci 244:151-158.
17. Qu B, Rosenberg RN, Li L, Boyer PJ, Johnston SA (2004) Arch Neurol 61:1859-1864.
18. Morgan D, Diamond DM, Gottschall PE, Ugen KE, Dickey C, Hardy J, Duff K, Jantzen P, DiCarlo G, Wilcock D, et al. (2000) Nature 408:982-985.
19. Nicolau C, Greferath R, Balaban TS, Lazarte JE, Hopkins RJ (2002) Proc Natl Acad Sci USA 99:2332-2337.
20. Orgogozo JM, Gilman S, Dartigues JF, Laurent B, Puel M, Kirby LC, Jouanny P, Dubois B, Eisner L, Flitman, et al. (2003) Neurology 61:46-54.
21. Nicoll JA, Wilkinson D, Holmes C, Steart P, Markham H, Weller RO (2003) Nat Med 9:448-452.
22. Ferrer I, Boada RM, Sanchez Guerra ML, Rey MJ, Costa-Jussa F (2004) Brain Pathol 14:11-20.
23. Dewachter I, Van DJ, Smeijers L, Gilis M, Kuiperi C, Laenen I, Caluwaerts N, Moechars D, Checler F, Vanderstichele H, et al. (2000) J Neurosci 20:6452-6458.
24. Monsonego A, Maron R, Zota V, Selkoe DJ, Weiner HL (2001) Proc Natl Acad Sci USA 98:10273-10278.
25. Monsonego A, Zota V, Kami A, Krieger JI, Bar-Or A, Bitan G, Budson AE, Sperling R, Selkoe DJ, Weiner HL (2003) J Clin Invest 112:415-422.
26. Tosi PF, Radu D, Nicolau C (1995) Biochem Biophys Res Commun 212:494-500.
27. Allen TM, Hansen C, Martin F, Redemann C, Yau-Young A (1991) Biochim Biophys Acta 1066:29-36.
28. Furrer J, Piotto M, Bourdonneau M, Limal D, Guichard G, Elbayed K, Raya J, Briand JP, Bianco A (2001) J Am Chem Soc 123:4130-4138.
29. Bechinger B, Aisenbrey C, Bertani P (2004) Biochim Biophys Acta 1666:190-204.
30. Cruciani O, Mannina L, Sobolev AP, Segre A, Luisi P (2004) Langmuir 20:1144-1151.
31. Zirah S, Kozin SA, Mazur A, Blond A, Cheminant M, Segalas-Milazzo I, Debey P, Rebuffat S (2006) J Biol Chem 27:2151-2161.
32. Gavin AL, Barnes N, Dijstelbloem HM, Hogarth PM (1998) J Immunol 160:20-23.
33. Maier M, Seabrook TJ, Lemere CA (2005) Vaccine 23:5149-5159.
34. De Gioia L, Selvaggini C, Ghibaudi E, Diomede L, Bugiani O, Forloni G, Tagliavini F, Salmona M (1994) J Biol Chem 269:7859-7862.
35. Ono S, Lee S, Mihara H, Aoyagi H, Kato T, Yamasaki N (1990) Biochim Biophys Acta 1022:237-244.
36. Lowik DW, Linhardt JG, Adams PJ, van Hest JC (2003) Org Biomol Chem 1:1827-1829.
37. Petkova AT, Ishii Y, Balbach JJ, Antzutkin ON, Leapman RD, Delaglio F, Tycko R (2002) Proc Natl Acad Sci USA 99:16742-16747.
38. Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, Yang F, Cole G (1996) Science 274:99-102.
39. Sigurdsson EM, Knudsen E, Asuni A, Fitzer-Attas C, Sage D, Quartermain D, Goni F, Frangione B, Wisniewski T (2004) J Neurosci 24:6277-6282.
40. Weiner HL, Frenkel D (2006) Nat Rev Immunol 6:404-416.
41. Sreerama N, Woody RW (2000) Anal Biochem 287:252-260.
42. Moechars D, Lorent K, De Strooper B, Dewachter I, van Leuven F (1996) EMBO J 15:1265-1274.
43. Dewachter I, Van DJ, Smeijers L, Gilis M, Kuiperi C, Laenen I, Caluwaerts N, Moechars D, Checler F, Vanderstichele H, et al. (2000) J Neurosci 20:6452-6458.
44. Tang YP, Shimizu E, Dube GR, Rampon C, Kerchner GA, Zhuo M, Liu G, Tsien JZ (1999) Nature 401:63-69.
45. Rampon C, Tang YP, Goodhouse J, Shimizu E, Kyin M, Tsien JZ (2000) Nat Neurosci 3:238-244.
46. Moechars D, Dewachter I, Lorent K, Reverse D, Baekelandt V, Naidu A, Tesseur I, Spittaels K, Haute CV, Checler, et al. (1999) J Biol Chem 274:6483-6492.