The CD45 tyrosine phosphatase: A positive and negative regulator of immune cell function

Seminars in Immunology

Volumn 12, Issue 4, 2000, Pages 349-359

  Alexander, Denis R ^a  

^a BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

CD45; Lymphocyte development; p56(lck); Src kinases; Tyrosine phosphatase

Indexed keywords

CD45 ANTIGEN; PROTEIN TYROSINE PHOSPHATASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL SURVIVAL; ENZYME ACTIVITY; IMMUNOCOMPETENT CELL; LYMPHOPOIESIS; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

EID: 0033794973     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1006/smim.2000.0218     Document Type: Article

References (85)

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2. Evidence that the leukocyte-common antigen is required for antigen-induced lymphocyte-T proliferation
3. Demonstration that the leukocyte common antigen CD45 is a protein tyrosine phosphatase
4. Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein-kinase in murine iymphoma T-cell lines
5. CD45-tyrosine phosphatase-activated p59fyn couples the T-cell antigen receptor to pathways of diacylglycerol production, protein-kinase-C activation and calcium influx
6. Correlation between Src family member regulation by the protein-tyrosine-phosphatase CD45 and transmembrane signaling through the T-cell receptor
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14. Positive and negative regulation of Src-family membrane kinases by CD45
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17. Normal B-lymphocyte development but impaired T-cell maturation in CD45-exon6 protein-tyrosine-phosphatase deficient mice
18. CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4(+)CD8(+) thymocytes, and in B-cell maturation
19. Greatly reduced efficiency of both positive and negative selection of thymocytes in CD45 tyrosine phosphatase-deficient mice
20. Molecular and cellular events in early thymocyte development
21. Pleiotropic changes controlled by the pre-T-cell receptor
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25. The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling
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27. Expression of the p56(lck) Y505F mutation in CD45-deficient mice rescues thymocyte development
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32. Differential requirements of CD45 for lymphocyte development and function
33. Identification of the tyrosine phosphatase PTP1C as a B-cell antigen receptor-associated protein involved in the regulation of B-cell signaling
34. CD45 regulates tyrosine phosphorylation of CD22 and its association with the protein tyrosine phosphatase SHP-1
35. Modulation of B lymphocyte antigen receptor signal transduction by a CD19/CD22 regulatory loop
36. Positive and negative roles of the tyrosine kinase Lyn in B cell function
37. CD45 protein-tyrosine phosphatase associates with the WW domain-containing protein, CD45AP, through the transmembrane region
38. LPAP, a novel 32-kDa phosphoprotein that interacts with CD45 in human-lymphocytes
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40. CD45-associated protein is not essential for the regulation of antigen receptor-mediated signal transduction
41. Biochemical and functional analysis of mice deficient in expression of the CD45-associated phospho-protein LPAP
42. Differential requirements of CD45 protein tyrosine phosphatase for cytolytic activities and intrathymic and extrathymic development of intestinal intraepithelial lymphocytes
43. Tyrosine phosphatases in T-cell development and signalling
44. CD45 ligation induces programmed cell-death in T-lymphocyte and B-lymphocyte
45. Peripheral T-cells undergoing superantigen-induced apoptosis in-vivo express B220 and up-regulate Fas and Fas ligand
46. Expression of B220 on activated T cell blasts precedes apoptosis
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48. Regulation of integrin-mediated T cell adhesion by the transmembrane protein tyrosine phosphatase CD45
49. The CD45 tyrosine phosphatase regulates specific pools of antigen receptor-associated p59fyn and CD4-associated p56(lck) tyrosine kinases in human T-cells
50. Distinct intracellular-localization of Lck and Fyn protein-tyrosine kinases in human T-lymphocytes
51. Crystal structures of c-Src reveal features of its autoinhibitory mechanism
52. Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement
53. Proline residues in CD28 and the Src homology (SH)3 domain of Lck are required for T cell costimulation
54. Src regulated by C-terminal phosphorylation is monomeric
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56. Insights into Src kinase functions: Structural comparisons
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59. CD45 modulates phosphorylation of both autophosphorylation and negative regulatory tyrosines of Lyn in B-cells
60. CD45 negatively regulates Lyn activity by dephosphorylating both positive and negative regulatory tyrosine residues in immature B cells
61. Cutting edge: The CD45 tyrosine phosphatase is an inhibitor of Lck activity in thymocytes
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63. Tyrosine 319, a newly identified phosphorylation site of ZAP-70, plays a critical role in T cell antigen receptor signaling
64. Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck
65. The structure and ligand interactions of CD2: Implications for T-cell function
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71. Contribution of kinases and the CD45 phosphatase to the generation of tyrosine phosphorylation patterns in the T-cell receptor complex zeta chain
72. The catalytic activity of the CD45 membrane-proximal phosphatase domain is required for TCR signaling and regulation
73. + T-cell subsets
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76. Physical association of CD4 and CD45 in primary, resting CD4(+) T cells
77. Ligand-mediated negative regulation of a chimeric transmembrane receptor tyrosine phosphatase
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79. Dimerization inhibits the activity of receptor-like protein-tyrosine phosphatase-α
80. Dimerization-induced inhibition of receptor protein tyrosine phosphatase function through an inhibitory wedge
81. Characterization of recombinant CD45 cytoplasmic domain proteins - Evidence for intramolecular and intermolecular interactions
82. Prevention and reversal of renal allograft rejection by antibody against CD45RB
83. Antibody-mediated targeting of CD45 isoforms: A novel immunotherapeutic strategy
84. Development of T-leukemias in CD45 tyrosine phosphatase-deficient mutant lck mice