Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis

Arthritis Research and Therapy

Volumn 10, Issue 1, 2008, Pages

  Milici, Anthony J ^a   Kudlacz, Elizabeth M ^b   Audoly, Laurent ^c   Zwillich, Samuel ^b   Changelian, Paul ^d  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b PFIZER INC   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

^d NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [N [1 (2 CYANO 1 OXOETHYL) 4 METHYL 3 PIPERIDINYL] N METHYLAMINO]PYRROLO[2,3 D]PYRIMIDINE; INTERLEUKIN 6; JANUS KINASE 3; TUMOR NECROSIS FACTOR ANTIBODY; COLLAGEN; CP 690,550; CP-690,550; ENZYME INHIBITOR; IMMUNOLOGICAL ADJUVANT; PYRIMIDINE DERIVATIVE; PYRROLE DERIVATIVE;

ADJUVANT ARTHRITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHONDROPROTECTION; CONTROLLED STUDY; DBA 1 MOUSE; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MEGADOSE; DRUG TARGETING; ENZYME INHIBITION; LEWIS RAT; LOW DRUG DOSE; MALE; MOUSE; NONHUMAN; PAW EDEMA; PROTEIN BLOOD LEVEL; RAT; RHEUMATOID ARTHRITIS; SCORING SYSTEM; ANIMAL; ARTHRITIS; ARTICULAR CARTILAGE; BLOOD; DBA MOUSE; DRUG ANTAGONISM; ENZYMOLOGY; IMMUNOLOGY; PATHOLOGY;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; CARTILAGE, ARTICULAR; COLLAGEN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; INTERLEUKIN-6; JANUS KINASE 3; MALE; MICE; MICE, INBRED DBA; PYRIMIDINES; PYRROLES; RATS; RATS, INBRED LEW;

EID: 39749164515     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar2365     Document Type: Article

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