Activation pattern of signal transducers and activators of transcription (STAT) factors in inflammatory bowel diseases

American Journal of Gastroenterology

Volumn 100, Issue 1, 2005, Pages 64-72

  Mudter, Jonas ^b   Weigmann, Benno ^b   Bartsch, Brigitte ^b   Kiesslich, Ralf ^b   Strand, Dennis ^b   Galle, Peter R ^b   Lehr, Hans A ^b   Schmidt, Jan ^b   Neurath, Markus F ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD2 ANTIGEN; CD28 ANTIGEN; CD4 ANTIGEN; GAMMA INTERFERON; INTERFERON; INTERLEUKIN 6; STAT1 PROTEIN; STAT2 PROTEIN; STAT3 PROTEIN; STAT4 PROTEIN; STAT6 PROTEIN; DNA BINDING PROTEIN; STAT1 PROTEIN, HUMAN; STAT2 PROTEIN, HUMAN; STAT3 PROTEIN, HUMAN; STAT4 PROTEIN, HUMAN; STAT6 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CROHN DISEASE; ENTERITIS; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; MONONUCLEAR CELL; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; T LYMPHOCYTE; ULCERATIVE COLITIS; CASE CONTROL STUDY; CD4+ T LYMPHOCYTE; COLON; METABOLISM; PATHOLOGY;

CASE-CONTROL STUDIES; CD4-POSITIVE T-LYMPHOCYTES; COLON; DNA-BINDING PROTEINS; HUMANS; INFLAMMATORY BOWEL DISEASES; STAT1 TRANSCRIPTION FACTOR; STAT2 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; STAT4 TRANSCRIPTION FACTOR; STAT6 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS;

EID: 13744249714     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1111/j.1572-0241.2005.40615.x     Document Type: Article

References (34)

1. Shanahan F. Crohn's disease. Lancet 2002;359:62-9.
2. Atreya R, Mudter J, Finotto S, et al. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in Crohn disease and experimental colitis in vivo. Nat Med 2000;6:583-8.
3. Afkarian M, Sedy JR, Yang J, et al. T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4+ T cells. Nat Immunol 2002;3:549-57.
4. Nishikomori R, Usui T, Wu CY, et al. Activated STAT4 has an essential role in Th1 differentiation and proliferation that is independent of its role in the maintenance of IL-12R beta 2 chain expression and signaling. J Immunol 2002;169:4388-98.
5. Mudter J, Wirtz S, Galle PR, et al. A new model of chronic colitis in SCID mice induced by adoptive transfer of CD62L+ CD4+ T cells: Insights into the regulatory role of interleukin-6 on apoptosis. Pathobiology 2002;70:170-6.
6. Mudter J, Neurath MF. Mucosal T-cells: Mediators or guardians of inflammatory bowel disease? Curr Opin Gastroenterol 2003;19:343-9.
7. Monteleone G, Holloway J, Salvati VM, et al. Activated STAT4 and a functional role for IL-12 in human Peyer's patches. J Immunol 2003;170:300-7.
8. Jacobson NG, Szabo SJ, Weber-Nordt RM, et al. Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. J Exp Med 1995;181:1755-62.
9. Takeda K, Tanaka T, Shi W, et al. Essential role of Stat6 in IL-4 signalling. Nature 1996;380:627-30.
10. Neurath MF, Weigmann B, Finotto S, et al. The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease. J Exp Med 2002;195:1129-43.
11. Park C, Li S, Cha E, et al. Immune response in Stat2 knockout mice. Immunity 2000;13:795-804.
12. Tilg H, Vogelsang H, Ludwiczek O, et al. A randomised placebo controlled trial of pegylated interferon alpha in active ulcerative colitis. Gut 2003;52:1728-33.
13. Neurath MF, Pettersson S, Meyer zum Buschenfelde KH, et al. Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappa B abrogates established experimental colitis in mice. Nat Med 1996;2:998-1004.
14. Burke JR, Pattoli MA, Gregor KR, et al. BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice. J Biol Chem 2003;278:1450-6.
15. Fuss IJ, Neurath M, Boirivant M, et al. Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J Immunol 1996;157:1261-70.
16. Podolsky DK. Inflammatory bowel disease. N Engl J Med 2002;347:417-29.
17. Strober W, Fuss IJ, Blumberg RS. The immunology of mucosal models of inflammation. Annu Rev Immunol 2002;20:495-549.
18. Meraz MA, White JM, Sheehan KC, et al. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 1996;84:431-42.
19. Takeda K, Kaisho T, Yoshida N, et al. Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: Generation and characterization of T cell- specific Stat3-deficient mice. J Immunol 1998;161:4652-60.
20. Thierfelder WE, van Deursen JM, Yamamoto K, et al. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 1996;382:171-4.
21. Lankford CS, Frucht DM. A unique role for IL-23 in promoting cellular immunity. J Leukoc Biol 2003;73:49-56.
22. Kaplan MH, Schindler U, Smiley ST, et al. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 1996;4:313-9.
23. Shimoda K, van Deursen J, Sangster MY, et al. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 1996;380:630-3.
24. Schreiber S, Rosenstiel P, Hampe J, et al. Activation of signal transducer and activator of transcription (STAT) 1 in human chronic inflammatory bowel disease. Gut 2002;51:379-85.
25. Dondi E, Rogge L, Lutfalla G, et al. Down-modulation of responses to type I IFN upon T cell activation. J Immunol 2003;170:749-56.
26. Wirtz S, Finotto S, Kanzler S, et al. Cutting edge: Chronic intestinal inflammation in STAT-4 transgenic mice: Characterization of disease and adoptive transfer by TNF- plus IFN-gamma-producing CD4+ T cells that respond to bacterial antigens. J Immunol 1999;162:1884-8.
27. Simpson SJ, Shah S, Comiskey M, et al. T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon gamma expression by T cells. J Exp Med 1998;187:1225-34.
28. Lovato P, Brender C, Agnholt J, et al. Constitutive Stat3 activation in intestinal T cells from patients with Crohn's disease. J Biol Chem 2003;3:3.
29. Yamamoto M, Yoshizaki K, Kishimoto T, et al. IL-6 is required for the development of Th1 cell-mediated murine colitis. J Immunol 2000;164:4878-82.
30. Suzuki A, Hanada T, Mitsuyama K, et al. CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation. J Exp Med 2001;193:471-81.
31. Takeda K, Clausen BE, Kaisho T, et al. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 1999;10:39-49.
32. Welte T, Zhang SS, Wang T, et al. STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: A critical role of STAT3 in innate immunity. Proc Natl Acad Sci USA 2003;100:1879-84.
33. Ito H, Takazoe M, Fukuda Y, et al. A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease. Gastroenterology 2004;126:989-96.
34. Ito H. Anti-interleukin-6 therapy for Crohn's disease. Curr Pharm Des 2003;9:295-305.