Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

Nature

Volumn 379, Issue 6566, 1996, Pages 645-648

  Meydan, Naftaly ^a,b   Grunberger, Tom ^a,b   Dadi, Harjit ^a,b   Shahar, Michal ^a,b   Arpaia, Enrico ^a,b   Lapidot, Zvi ^c   Leeder, J Steven ^a,b   Freedman, Melvin ^a,b   Cohen, Amos ^a,b   Gazit, Aviv ^d   Levitzki, Alexander ^d   Roifman, Chaim M ^a,b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^d HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; JAK 2 INHIBITOR; MEMBRANE ANTIGEN; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; B LYMPHOCYTE; CELL DEATH; CELL GROWTH; CELL SURFACE; CHEMICAL STRUCTURE; CHILDHOOD CANCER; CONTROLLED STUDY; GROWTH REGULATION; HEMATOPOIESIS; HUMAN; HUMAN CELL; LYMPHOID CELL; PHENOTYPE; PHOSPHORYLATION; PRIORITY JOURNAL; RELAPSE; STEM CELL;

ANIMALS; ANTINEOPLASTIC AGENTS; B-LYMPHOCYTES; CELL DIVISION; ENZYME INHIBITORS; HUMANS; JANUS KINASE 2; LEUKEMIA, LYMPHOCYTIC, ACUTE; MICE; MICE, SCID; NEOPLASM TRANSPLANTATION; NITRILES; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; TYRPHOSTINS;

EID: 13344295097     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/379645a0     Document Type: Article

References (30)

1. Nadler, L. M. et al. J. Immun. 131, 244-250 (1983).
2. Greaves, M. F. Science 234, 697-704 (1986).
3. Uckun, F. M. et al. New Engl. J. Med. 329, 1296-1301 (1993).
4. Williams, G. T., Smith, C. A., Spooncer, E , Dexter, T. M. & Jaylor, D R. Nature 343, 76-79 (1990).
5. Cohen, A. et al. Blood 78, 94-102 (1991).
6. Touw, J. et al. Blood 75, 2097-2101 (1990).
7. Grimaldi, J C. & Meeker, T. C. Blood 73, 2081-2085 (1989).
8. Dadi, H , Ke, S. & Roifman, C. M. Biochem. biophys. Res. Commun. 192, 459-464 (1993).
9. Burke, T. et al. J. med. Chem. 36, 425-432 (1993).
10. Cushman, M. et al. J. med. Chem. 37, 3353-3362 (1994).
11. Osherove, N. & Levitzki, A. Eur. J. Biochem. 225, 1047-1053 (1994).
12. Padeh, S., Levitzki, A., Gazit, A., Mills, G. & Roifman, C. M. J. clin Invest. 87, 1114-1118 (1991).
13. Osamu, M. et al. Blood 84, 1501-1507 (1994).
14. Sato, M. et al. J. exp. Med. 180, 2101-211 (1994).
15. Barber, D. L. & D'Andrea, A. D. Molec cell. Biol. 14, 6506-6514 (1994).
16. Tanaka, N. et al. Proc. natn. Acad. Sci. U.S.A. 91, 7271-7275 (1994).
17. Johnston, J A. et al. Nature 370, 151-153 (1994).
18. Witthuhn, B. A. et al. Nature 370, 153-157 (1994).
19. Roifman, C. M., Wang, G., Freedman, M & Pan, Z. J. Immun. 148, 1136-1142 (1992).
20. Wilks, A. F. et al. Molec. cell. Biol. 11, 2057-2065 (1991).
21. Harpur, A. G. Andres, A-C., Ziemiecki, A., Aston, R. R. & Wilkes A. F. Oncogene 7, 1347-1353 (1992).
22. Rothman, P et al. Immunity 1, 457-468 (1994).
23. Bolen, J. B., Thompson, P. A., Eiseman, E. & Horak, I. D. Adv. Cancer Res. 57, 103-149 (1991)
24. Bolen, J. B. et al. FASEB J. 6, 3403-3409 (1992).
25. Estrov, Z. & Freedman, M. H. Expl Hemat. 19, 221-225 (1991).
26. Schmid, I., Uittenbogaart, C. H. & Giorgi, J. V. Cytometry 15, 12-20 (1994).
27. Uckun, F. M. et al. Science 267, 886-891 (1995).
28. Kamel-Reid, S. et al. Science 246, 1597-1600 (1989).
29. Kamel-Reid, S. et al. Leukemia 6, 8-17 (1992).
30. Arpaia, E., Shahar, M., Dadi, H., Cohen, A. & Roifman, C. M. Cell 76, 947-958 (1994)