Selective binding and oligomerization of the murine granulocyte colony-stimulating factor receptor by a low molecular weight, nonpeptidyl ligand

Journal of Biological Chemistry

Volumn 278, Issue 11, 2003, Pages 9426-9434

  Doyle, Michael L ^a,c   Tian, Shin Shay ^b,d   Miller, Stephen G ^b   Kessler, Linda ^b   Baker, Audrey E ^a   Brigham Burke, Michael R ^a   Dillon, Susan B ^a,e   Duffy, Kevin J ^a   Keenan, Richard M ^a   Lehr, Ruth ^a   Rosen, Jon ^b   Schneeweis, Lumelle A ^a   Trill, John ^a   Young, Peter R ^a,f   Luengo, Juan I ^a   Lamb, Peter ^b,g  

^a GLAXOSMITHKLINE   (United States)

^b LIGAND PHARMACEUTICALS INC   (United States)

^c BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

^d Deltagen Research Laboratories   (United States)

^e CENTOCOR INC   (United States)

^f SUGEN INC   (United States)

^g EXELIXIS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; CALORIMETRY; OLIGOMERS; TITRATION;

OLIGOMERIZATION;

CELLS;

CYTOKINE RECEPTOR; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE COLONY STIMULATING FACTOR RECEPTOR; LIGAND; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; SB 247464; SB 250017; UNCLASSIFIED DRUG; ZINC; BENZIMIDAZOLE DERIVATIVE; CYTOKINE; EDETIC ACID; GUANIDINE DERIVATIVE; HYBRID PROTEIN; ION; PEPTIDE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG MECHANISM; DRUG PROTEIN BINDING; GRANULOCYTE; HUMAN; MICROCALORIMETRY; MOLECULAR WEIGHT; MOUSE; NEUTROPENIA; NEUTROPHIL; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; TITRIMETRY; ULTRACENTRIFUGATION; ANIMAL; BONE MARROW CELL; CALORIMETRY; CELL LINE; CHEMICAL MODEL; CHEMISTRY; CIRCULAR DICHROISM; DIMERIZATION; DOSE RESPONSE; GENETIC TRANSFECTION; METABOLISM; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION;

ANIMALIA; MURINAE;

ANIMALS; BENZIMIDAZOLES; BONE MARROW CELLS; CALORIMETRY; CELL LINE; CIRCULAR DICHROISM; CYTOKINES; DIMERIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; EDETIC ACID; GUANIDINES; IONS; LIGANDS; MICE; MODELS, CHEMICAL; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, GRANULOCYTE COLONY-STIMULATING FACTOR; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; TRANSFECTION; ULTRACENTRIFUGATION; ZINC;

EID: 0037646490     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M209220200     Document Type: Article

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