Chitosan-g-PEG/DNA complexes deliver gene to the rat liver via intrabiliary and intraportal infusions

Journal of Gene Medicine

Volumn 8, Issue 4, 2006, Pages 477-487

  Jiang, Xuan ^a,b   Dai, Hui ^c   Leong, Kam W ^c,d   Goh, Suat Hong ^b   Mao, Hai Quan ^c,e,f   Yang, Yi Yan ^a  

^a INSTITUTE OF BIOENGINEERING AND NANOTECHNOLOGY   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c Johns Hopkins Singapore   (Singapore)

^d Johns Hopkins University   (United States)

^e Johns Hopkins University   (United States)

^f NONE   (United States)

Author keywords

Bile duct; Chitosan; Gene delivery; Liver targeting; PEGylation; Portal vein

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BETA GALACTOSIDASE; CHITOSAN; LUCIFERASE; MACROGOL; MONOSACCHARIDE; PLASMID DNA;

AGAR GEL ELECTROPHORESIS; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILE; BILE DUCT; CELL STRAIN HEPG2; CONTROLLED STUDY; DEACETYLATION; DNA DEGRADATION; DRUG INFUSION; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIVER FUNCTION TEST; LIVER TOXICITY; MALE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NONVIRAL GENE THERAPY; PARTICLE SIZE; PORTAL VEIN; PRIORITY JOURNAL; RAT; REPORTER GENE; SAFETY; SERUM; SYRINGE;

ANIMALS; BILE; BILE DUCTS; CELL LINE; CHITOSAN; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; HUMANS; INFUSIONS, INTRAVENOUS; LIVER; NANOSTRUCTURES; POLYETHYLENE GLYCOLS; PORTAL VEIN; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

ANIMALIA;

EID: 33646268788     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.868     Document Type: Article

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