Poly(2-alkylacrylic acid) polymers deliver molecules to the cytosol by pH-sensitive disruption of endosomal vesicles

Biochemical Journal

Volumn 372, Issue 1, 2003, Pages 65-75

  Jones, Rachel A ^a   Cheung, Charles Y ^b   Black, Fiona E ^b   Zia, Jasmine K ^b   Stayton, Patrick S ^b   Hoffman, Allan S ^b   Wilson, Mark R ^a  

^a UNIVERSITY OF WOLLONGONG   (Australia)

^b University of Washington   (United States)

Author keywords

Endocytosis; Endosomal disruption; Gene delivery; Haemolysis; pH sensitive polymers

Indexed keywords

CELL MEMBRANES; HYDROPHILICITY; ORGANIC ACIDS; ORGANIC POLYMERS; PH EFFECTS;

ENDOSOMAL VESICLES;

BIOCHEMISTRY;

ACRYLIC ACID COPOLYMER; DNA; LIPOSOME; POLY(2 ETHYLACRYLIC ACID); POLY(2 METHYLACRYLIC ACID); POLY(2 PROPYLACRYLIC ACID); UNCLASSIFIED DRUG;

ACIDIFICATION; ANIMAL CELL; ARTICLE; CELL CULTURE; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYTOSOL; DRUG DELIVERY SYSTEM; DRUG DESIGN; EMBRYO; ENDOCYTOSIS; ENDOSOME; GENE TARGETING; GENETIC TRANSFECTION; HEMOLYSIS; HUMAN; HUMAN CELL; HYDROPHILICITY; LYSOSOME; MEMBRANE DAMAGE; MEMBRANE PERMEABILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

BIOLOGICAL ASSAY; BIOLOGICAL TRANSPORT, ACTIVE; CATHEPSIN B; CELL LINE; CYTOSOL; ENDOSOMES; FLUORESCEINS; GENES, REPORTER; HEMOLYSIS; HUMANS; HYDROGEN-ION CONCENTRATION; PHENETHYLAMINES; PHTHALIC ANHYDRIDES; POLYMERS; POLYMETHACRYLIC ACIDS; TRANSFECTION;

ANIMALIA;

EID: 0037954557     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20021945     Document Type: Article

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