Efficiency of polyethylenimines and polyethylenimine-graft-poly (ethylene glycol) block copolymers to protect oligonucleotides against enzymatic degradation

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 57, Issue 3, 2004, Pages 427-430

  Brus, Carola ^a   Petersen, Holger ^a   Aigner, Achim ^a   Czubayko, Frank ^a   Kissel, Thomas ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Oligonucleotides; PEGylation; Polyethylenimine; RNA; Stabilization

Indexed keywords

COPOLYMER; DNA; MACROGOL; NUCLEASE; OLIGONUCLEOTIDE; POLYETHYLENEIMINE DERIVATIVE; RNA;

ARTICLE; COMPLEX FORMATION; DENSITOMETRY; DNA MODIFICATION; DRUG EFFICACY; DRUG FORMULATION; DRUG MECHANISM; DRUG STABILITY; ENZYME DEGRADATION; GEL ELECTROPHORESIS; MOLECULAR WEIGHT; PH; PROTECTION; QUANTITATIVE ANALYSIS; SERUM;

ENZYME STABILITY; OLIGONUCLEOTIDES; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE;

EID: 1842850707     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2004.02.004     Document Type: Article

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