Biodegradation and distribution of water-soluble chitosan in mice

Biomaterials

Volumn 20, Issue 2, 1999, Pages 175-182

  Onishi, Hiraku ^a   Machida, Yoshiharu ^a  

^a HOSHI UNIVERSITY   (Japan)

Author keywords

Biodegradability; Body distribution; Lysozyme; Randomly 50 deacetylated chitosan (Chi); Urinary excretion

Indexed keywords

BIODEGRADATION; BODY FLUIDS; ENZYMES; MOLECULAR WEIGHT; POLYSACCHARIDES;

CHITOSAN; FLUORESCEIN ISOTHIOCYANATE; URINARY EXCRETION;

BIOMATERIALS;

CHITOSAN; DRUG CARRIER; FLUORESCEIN ISOTHIOCYANATE; LYSOZYME;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; ASCITES; BIODEGRADATION; BODY DISTRIBUTION; GEL CHROMATOGRAPHY; IN VITRO STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; KIDNEY; LIVER; MALE; MOLECULAR WEIGHT; MOUSE; PLASMA; PRIORITY JOURNAL; SOLUBILITY; SPLEEN; URINARY EXCRETION; URINE;

ACETYLATION; ANIMALS; BIOCOMPATIBLE MATERIALS; BIODEGRADATION, ENVIRONMENTAL; BIOTRANSFORMATION; CARBOHYDRATE SEQUENCE; CHITIN; CHITOSAN; DRUG CARRIERS; FLUORESCEIN-5-ISOTHIOCYANATE; MICE; MOLECULAR SEQUENCE DATA; MURAMIDASE; SOLUBILITY; TISSUE DISTRIBUTION; VISCOSITY; WATER;

ANIMALIA; MURINAE;

EID: 0032916739     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0142-9612(98)00159-8     Document Type: Article

References (25)

1. Ogawa Y, Yamamoto M, Okada H, Yashiki T, Shimamoto T. A new technique to efficiently entrap leuprolide acetate into microspheres of polylactic acid or copoly(lactic/glycolic) acid. Chem Pharm Bull 1988;36:1095-103.
2. Ogawa Y, Yamamoto M, Takada S, Okada H, Shimamoto T. Controlled-release of leuprolide acetate from polylactic acid or copoly(lactic/glycolic) acid microshperes: Influence of molecular weight and copolymer ratio of polymer. Chem Pharm Bull 1988;36:1502-7.
3. Ogawa Y, Okada H, Yamamoto M, Shimamoto T. In vivo release profiles of leuprolide acetate from microspheres prepared with polylactic acids or poly(lactic/glycolic) acids and in vivo degradation of these polymers. Chem Pharm Bull 1988;36:2576-81.
4. Yokoyama M, Miyauchi M, Yamada N, Okano T, Sakurai Y, Kataoka K, Inoue S. Polymer micelles as novel drug carrier: Adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer. J Contr Rel 1990;11:269-78.
5. Yokoyama M, Miyauchi M, Yamada N, Okano T, Sakurai Y, Kataoka K, Inoue S. Characterization and anticancer activity of the micelle-forming polymeric anticancer drug adriamycin- conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer. Cancer Res 1990;50:1693-700.
6. Yokoyama M, Okano T, Sakurai Y, Ekimoto H, Shibazaki C, Kataoka K. Toxicity and antitumor activity against solid tumors of micelle-forming polymeric anticancer drug and its extremely long circulation in blood. Cancer Res 1991;51:3229-36.
7. Davies RC, Neuberger A, Wilson BM. The dependence of lysozyme activity on ph and ionic strength. Biochim Biophys Acta 1969;178:294-305.
8. Amano K, Ito E. The action of lysozyme on partially deacetylated chitin. Eur J Biochem 1978;85:97-104.
9. Pangburn SH, Trescony PV, Heller J. Lysozyme degradation of partially deacetylated chitin, its films and hydrogels. Biomaterials 1982;3:105-8.
10. Yomota C, Komuro T, Kimura T. Studies on the degradation of chitosan films by lysozyme and release of loaded chemicals. Yakugaku Zasshi 1990;110:442-8.
11. Li YP, Machida Y, Sannan T, Nagai T. Preparation of chitosan microspheres containing fluorouracil using the dry-in-oil method and its release characteristics. STP Pharma Sciences 1991;1:363-8.
12. 4-(4-carboxybutyryl)-1-β-D-arabinofuranosylcytosine and chitosan as a macromolecular prodrug of 1-β-D-arabinofuranosylcytosine. Drug Design Discovery 1993;10:343-53.
13. Onishi H, Machida Y, Nagai T. Synthesis and properties of the monoesters of 5-fluorouridine with 4-carboxybutyric acid and their conjugates with chitosan. Chem Pharm Bull 1995;43:340-3.
14. Yoshino T, Machida Y, Onishi H, Nagai T. Characteristics of drug loading, drug release and degradation of chitosan micro- spheres prepared using the dry-in-oil method. STP Pharma Sciences 1996;6:122-8.
15. Onishi H, Nagai T, Machida Y. Applications of chitin, chitosan, and their derivatives to drug carriers for microparticulated or conjugated drug delivery systems. Applications of Chitin and Chitosan. Lancaster: Technomic Publishing, 1997:205-31.
16. Nakamura F, Onishi H, Machida Y, Nagai T. Lysozyme- catalyzedcatalyzed degradation properties of the conjugates between chitosans having some deacetylation degrees and methotrexate. Yakuzaigaku 1992;52:59-67.
17. Lee KY, Ha WS, Park WH. Blood compatibility and biodegradability of partially N-acylated chitosan derivatives. Biomaterials 1995;16:1211-6.
18. Carreno-Gomez B, Duncan R. Evaluation of the properties of soluble chitosan and chitosan microspheres. Int J Pharmaceut 1997;148:231-40.
19. Klenha J, Krs V. Lysozyme in mouse and human skin. J Invest Dermatol 1967;49:396-9.
20. Harrison JF, Lunt GS, Scott P, Blainey JD. Urinary lysozyme, ribonuclease, and low-molecular-weight protein in renal disease. Lancet 1968;i:371-4.
21. Akema R. On the assay method of lysozyme activity contained in animal organ. Bull Kanagawa PH Lab 1974;4:75-7.
22. Klockars M. Distribution of lysozyme in the serum, urine and kidneys of AKR mice during the pathogenesis of lymphocytic leukemia. Acta Path Microbiol Scand Sect A 1974;82A:665-74.
23. Tarsi R, Ripa S, Simonetti N, Lazzarino G. Serum lysozyme increased by fructose-1,6-diphosphate in men, rabbits, and mice. J Leukocyte Biol 1984;35:459-65.
24. Tanaka T, Kaneo Y, Shiramoto S, Iguchi S. The disposition of serum proteins as drug carriers in mice bearing Sarcoma 180. Biol Pharm Bull 1993;16:1270-5.
25. Seymour LW, Ulbrich K, Steyger PS, Brereton M, Subr V, Strohalm J, Duncan R. Tumor tropism and anti-cancer efficacy of polymer based doxorubicin prodrugs in the treatment of subcutaneous B16F10 melanoma. Br J Cancer 1994;70:636-41.