Uptake and transport of PEG-graft-trimethyl-chitosan copolymer-insulin nanocomplexes by epithelial cells

Pharmaceutical Research

Volumn 22, Issue 12, 2005, Pages 2058-2068

  Mao, Shirui ^a,b   Germershaus, Oliver ^a   Fischer, Dagmar ^a   Linn, Thomas ^c   Schnepf, Robert ^d   Kissel, Thomas ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^c JUSTUS LIEBIG UNIVERSITY   (Germany)

^d Complex Biosystems ^*  (Germany)

Author keywords

Caco 2 cells; Insulin nanocomplexes; PEGylation; Trimethyl chitosan; Uptake

Indexed keywords

2,4 DINITROPHENOL; CHITOSAN DERIVATIVE; COPOLYMER; CYTOCHALASIN D; INSULIN DERIVATIVE; ISOTHIOCYANIC ACID DERIVATIVE; MACROGOL; NANOPARTICLE; SODIUM AZIDE; TETRAMETHYLRHODAMINE ISOTHIOCYANATE; TRIMETHYLCHITOSAN; UNCLASSIFIED DRUG;

ADSORPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ACTIVITY; CELL STRAIN CACO 2; CELLULAR DISTRIBUTION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DENSITY; DIABETES MELLITUS; DRUG EFFECT; DRUG LABELING; DRUG MECHANISM; DRUG RELEASE; DRUG STRUCTURE; DRUG TRANSPORT; DRUG UPTAKE; ENDOCYTOSIS; EPITHELIUM CELL; FLUORESCENCE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOLECULAR WEIGHT; NONHUMAN; NOSE MUCOSA; PARTICLE SIZE; PH; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; TEMPERATURE; TIME; VISCOSITY;

ALGORITHMS; ANIMALS; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CHEMISTRY, PHYSICAL; CHITOSAN; EPITHELIAL CELLS; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; LIGHT; MALE; MICROSCOPY, CONFOCAL; MOLECULAR WEIGHT; NANOSTRUCTURES; PARTICLE SIZE; POLYETHYLENE GLYCOLS; PREDICTIVE VALUE OF TESTS; RATS; SCATTERING, RADIATION; TETRAZOLIUM SALTS; THIAZOLES; TIGHT JUNCTIONS;

EID: 29244468833     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-005-8175-y     Document Type: Article

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