Non-viral gene delivery systems

Current Opinion in Biotechnology

Volumn 13, Issue 2, 2002, Pages 128-131

  Davis, Mark E ^a  

^a California Institute of Technology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIPID; NUCLEIC ACID; POLYMER; RECOMBINANT DNA;

DRUG FORMULATION; DRUG MANUFACTURE; DRUG STABILITY; GENE TARGETING; IN VIVO STUDY; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; REVIEW;

EID: 0036535679     PISSN: 09581669     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0958-1669(02)00294-X     Document Type: Review

References (34)

1. Cationic polymer-based gene delivery systems
2. Polymer chemical structure is a key determinant of physicochemical and colloidal properties of polymer-DNA complexes for gene delivery
3. Effects of structure of β-cyclodextrin-containing polymers on gene delivery
4. Observation of DNA-polymer condensate formation in real time at a molecular level
5. Strategies for maintaining the particle size of peptide DNA condensates following freeze-drying
6. Formulations of highly soluble poly(ethylene glycol)-peptide DNA condensates
7. Development of a non-viral gene delivery vehicle for systemic application
8. Poly-L-lysine-graft-PEG comb-type polycation copolymers for gene delivery
9. Stabilization of lipid/DNA complexes during the freezing step of the lyophilization process: The particle isolation hypothesis
10. Physical stabilization of DNA-based therapeutics
11. Chitosan-DNA nanoparticles as gene carriers: Synthesis characterization and transfection efficiency
12. Potential of low molecular mass chitosan as a DNA delivery system: Biocompatibility, body distribution and ability to complex and protect DNA
13. A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethylenimine: Effect of molecular weight on transfection efficiency and cytotoxicity
14. Biodistribution, metabolism, and in vivo gene expression of low molecular weight glycopeptide polyethylene glycol peptide DNA co-condensates
15. Tumor targeting with surface-shielded ligand-polycation DNA complexes
16. Steric stabilization of poly-L-lysine/DNA complexes by the covalent attachment of semitelechelic poly [N-(2-hydroxypropyl)methacrylamide]
17. Decreased binding to proteins and cells of polymeric gene delivery vectors surface modified with a multivalent hydrophilic polymer and retargeting through attachment of transferrin
18. Caged DNA does not aggregate in high ionic strength solutions
19. Efficient gene transfer using reversible cross-linked low molecular weight polyethylenimine
20. Different strategies for formation of PEGylated EGF-conjugated PEI/DNA complexes for targeted gene delivery
21. Nuclear-associated plasmid, but not cell-associated plasmid is correlated with transgene expression in cultured mammalian cells
22. Application of membrane-active peptides for non-viral gene delivery
23. A pH-sensitive polymer that enhances cationic lipid-mediated gene transfer
24. Efficient gene transfer by histidylated polylysine/pDNA complexes
25. Polymer-based gene delivery with low cytotoxicity by a unique balance of side-chain termini
26. Vector unpacking as a potential barrier for receptor-mediated polyplex gene delivery
27. Size-dependent DNA mobility in cytoplasm and nucleus
28. Critical assessment of the nuclear import of plasmid during cationic lipid-mediated gene transfer
29. Cell cycle dependence of gene transfer by lipoplex, polyplex and recombinant adenovirus
30. Different behavior of branched and linear polyethylenimine for gene delivery in vitro and in vivo
31. Overcoming the nuclear barrier: Cell cycle independent nonviral gene transfer with linear polyethylenimine or electroporation
32. A versatile system for receptor-mediated gene delivery permits increased entry of DNA to target cells, enhanced delivery to the nucleus and elevated rates of transgene expression
33. Nuclear translocation of lactosylated poly-L-lysine/cDNA complex in cystic fibrosis airway epithelial cells