Chitosan-coated PLGA nanoparticles for DNA/RNA delivery: effect of the formulation parameters on complexation and transfection of antisense oligonucleotides

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 3, Issue 3, 2007, Pages 173-183

  Nafee, Noha ^a,b   Taetz, Sebastian ^a   Schneider, Marc ^a   Schaefer, Ulrich F ^a   Lehr, Claus Michael ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b Alexandria University Faculty of Pharmacy   (Egypt)

Author keywords

Antisense oligonucleotides; Chitosan; Gene delivery; PLGA nanoparticles; Telomerase inhibitors

Indexed keywords

ANTISENSE OLIGONUCLEOTIDES; CHITOSAN; GENE DELIVERY; PLGA NANOPARTICLES; TELOMERASE INHIBITORS;

COMPLEXATION; DNA; ENZYME INHIBITION; OLIGONUCLEOTIDES; RNA; SURFACE CHARGE;

NANOPARTICLES;

2' O METHYL RNA; ANTISENSE OLIGONUCLEOTIDE; CHITOSAN; NANOPARTICLE; POLYGLACTIN; UNCLASSIFIED DRUG;

ARTICLE; BIODEGRADABILITY; COMPLEX FORMATION; CONTROLLED STUDY; DRUG BINDING; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG FORMULATION; GENE TARGETING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PARTICLE SIZE; SURFACE CHARGE;

CELL LINE, TUMOR; CHITOSAN; COATED MATERIALS, BIOCOMPATIBLE; CRYSTALLIZATION; DNA; DRUG CARRIERS; DRUG COMPOUNDING; HUMANS; LACTIC ACID; LUNG NEOPLASMS; MATERIALS TESTING; NANOPARTICLES; PARTICLE SIZE; POLYGLYCOLIC ACID; POLYMERS; RNA, ANTISENSE; TRANSFECTION;

EID: 34548244065     PISSN: 15499634     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nano.2007.03.006     Document Type: Article

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