메뉴 건너뛰기




Volumn 34, Issue 5, 2009, Pages 807-816

mTOR function in skeletal muscle: A focal point for overnutrition and exercise

Author keywords

Insulin action; Metabolism; Nutrients; Training

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE;

EID: 73549088713     PISSN: 17155312     EISSN: None     Source Type: Journal    
DOI: 10.1139/H09-073     Document Type: Review
Times cited : (26)

References (111)
  • 1
    • 34047224186 scopus 로고    scopus 로고
    • Prior exercise increases phosphorylation of Akt substrate of 160 kDa (AS160) in rat skeletal muscle
    • doi:10.1152/ajpendo.00602.2006. PMID: 17179389
    • Arias, E.B., Kim, J., Funai, K., and Cartee, G. 2007. Prior exercise increases phosphorylation of Akt substrate of 160 kDa (AS160) in rat skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 292(4): E1191-E1200. doi:10.1152/ajpendo.00602.2006. PMID: 17179389.
    • (2007) Am. J. Physiol. Endocrinol. Metab. , vol.292 , Issue.4
    • Arias, E.B.1    Kim, J.2    Funai, K.3    Cartee, G.4
  • 2
    • 57349091231 scopus 로고    scopus 로고
    • Divergent cell signaling after shortterm intensified endurance training in human skeletal muscle
    • doi:10.1152/ajpendo.90428.2008. PMID:18827172
    • Benziane, B., Burton, T.J., Scanlan, B., Galuska, D., Canny, B.J., Chibalin, A.V., et al. 2008. Divergent cell signaling after shortterm intensified endurance training in human skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 295(6): E1427-E1438. doi:10.1152/ajpendo.90428.2008. PMID:18827172.
    • (2008) Am. J. Physiol. Endocrinol. Metab. , vol.295 , Issue.6
    • Benziane, B.1    Burton, T.J.2    Scanlan, B.3    Galuska, D.4    Canny, B.J.5    Chibalin, A.V.6
  • 3
    • 0036298262 scopus 로고    scopus 로고
    • Rapamycin partially prevents insulin resistance induced by chronic insulin treatment
    • doi:10.1016/S0006-291X(02)00333-9. PMID:12051762
    • Berg, C.E., Lavan, B.E., and Rondinone, C.M. 2002. Rapamycin partially prevents insulin resistance induced by chronic insulin treatment. Biochem. Biophys. Res. Commun. 293(3): 1021-1027. doi:10.1016/S0006-291X(02)00333-9. PMID:12051762.
    • (2002) Biochem. Biophys. Res. Commun. , vol.293 , Issue.3 , pp. 1021-1027
    • Berg, C.E.1    Lavan, B.E.2    Rondinone, C.M.3
  • 4
    • 56749096054 scopus 로고    scopus 로고
    • Translational control of localized mRNAs: restricting protein synthesis in space and time
    • doi:10.1038/nrm2548. PMID:19023284
    • Besse, F., and Ephrussi, A. 2008. Translational control of localized mRNAs: restricting protein synthesis in space and time. Nat. Rev. Mol. Cell Biol. 9(12): 971-980. doi:10.1038/nrm2548. PMID:19023284.
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , Issue.12 , pp. 971-980
    • Besse, F.1    Ephrussi, A.2
  • 5
    • 34047095297 scopus 로고    scopus 로고
    • The two TORCs and Akt
    • doi:10.1016/j.devcel.2007.03.020. PMID: 17419990
    • Bhaskar, P.T., and Hay, N. 2007. The two TORCs and Akt. Dev. Cell, 12(4): 487-502. doi:10.1016/j.devcel.2007.03.020. PMID: 17419990.
    • (2007) Dev. Cell , vol.12 , Issue.4 , pp. 487-502
    • Bhaskar, P.T.1    Hay, N.2
  • 6
    • 18044393626 scopus 로고    scopus 로고
    • Insulin signal transduction in human skeletal muscle: identifying the defects in Type II diabetes
    • Pt. 2: doi:10.1042/BST0330354. PMID:15787605
    • Bjornholm, M., and Zierath, J.R. 2005. Insulin signal transduction in human skeletal muscle: identifying the defects in Type II diabetes. Biochem. Soc. Trans. 33(Pt. 2): 354-357. doi:10.1042/BST0330354. PMID:15787605.
    • (2005) Biochem. Soc. Trans. , vol.33 , pp. 354-357
    • Bjornholm, M.1    Zierath, J.R.2
  • 7
    • 0344033820 scopus 로고    scopus 로고
    • Immediate response of mammalian target of rapamycin (mTOR)-mediated signalling following acute resistance exercise in rat skeletal muscle
    • Pt. 1. doi:10.1113/jphysiol.2003.047019. PMID:12937293
    • Bolster, D.R., Kubica, N., Crozier, S.J., Williamson, D.L., Farrell, P.A., Kimball, S.R., and Jefferson, L.S. 2003. Immediate response of mammalian target of rapamycin (mTOR)-mediated signalling following acute resistance exercise in rat skeletal muscle. J. Physiol. 553(Pt. 1): 213-220. doi:10.1113/jphysiol.2003.047019. PMID:12937293.
    • (2003) J. Physiol. , vol.553 , pp. 213-220
    • Bolster, D.R.1    Kubica, N.2    Crozier, S.J.3    Williamson, D.L.4    Farrell, P.A.5    Kimball, S.R.6    Jefferson, L.S.7
  • 8
    • 33745668478 scopus 로고    scopus 로고
    • siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle
    • doi:10.1016/j.cmet.2006.04.008. PMID: 16814735
    • Bouzakri, K., Zachrisson, A., Al-Khalili, L., Zhang, B.B., Koistinen, H.A., Krook, A., and Zierath, J.R. 2006. siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle. Cell Metab. 4(1): 89-96. doi:10.1016/j.cmet.2006.04.008. PMID: 16814735.
    • (2006) Cell Metab , vol.4 , Issue.1 , pp. 89-96
    • Bouzakri, K.1    Zachrisson, A.2    Al-Khalili, L.3    Zhang, B.B.4    Koistinen, H.A.5    Krook, A.6    Zierath, J.R.7
  • 9
    • 53449092586 scopus 로고    scopus 로고
    • A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression
    • doi:10.1152/ajpcell.00554.2007. PMID:18650261
    • Buller, C.L., Loberg, R.D., Fan, M.-H., Zhu, Q., Park, J.L., Vesely, E., et al. 2008. A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression. Am. J. Physiol. Cell Physiol. 295(3): C836-C843. doi:10.1152/ajpcell.00554.2007. PMID:18650261.
    • (2008) Am. J. Physiol. Cell Physiol. , vol.295 , Issue.3
    • Buller, C.L.1    Loberg, R.D.2    Fan M.-H. Zhu, Q.3    Park, J.L.4    Vesely, E.5
  • 10
    • 33845968034 scopus 로고    scopus 로고
    • Functional studies of Akt isoform specificity in skeletal muscle in vivo; maintained insulin sensitivity despite reduced insulin receptor substrate-1 expression
    • doi:10.1210/me.2006-0154. PMID: 17021050
    • Cleasby, M.E., Reinten, T.A., Cooney, G.J., James, D.E., and Kraegen, E.W. 2007. Functional studies of Akt isoform specificity in skeletal muscle in vivo; maintained insulin sensitivity despite reduced insulin receptor substrate-1 expression. Mol. Endocrinol. 1(1): 215-228. doi:10.1210/me.2006-0154. PMID: 17021050.
    • (2007) Mol. Endocrinol. , vol.21 , Issue.1 , pp. 215-228
    • Cleasby, M.E.1    Reinten, T.A.2    Cooney, G.J.3    James, D.E.4    Kraegen, E.W.5
  • 11
    • 0030979722 scopus 로고    scopus 로고
    • Mechanism of impaired insulin-stimulated muscle glucose metabolism in subjects with insulin-dependent diabetes mellitus
    • doi:10.1172/JCI119395. PMID:9151794
    • Cline, G.W., Magnusson, I., Rothman, D., Petersen, K., Laurent, D., and Shulman, G. 1997. Mechanism of impaired insulin-stimulated muscle glucose metabolism in subjects with insulin-dependent diabetes mellitus. J. Clin. Invest. 99(9): 2219-2224. doi:10.1172/JCI119395. PMID:9151794.
    • (1997) J. Clin. Invest. , vol.99 , Issue.9 , pp. 2219-2224
    • Cline, G.W.1    Magnusson, I.2    Rothman, D.3    Petersen, K.4    Laurent, D.5    Shulman, G.6
  • 12
    • 34548371839 scopus 로고    scopus 로고
    • The molecular bases of training adaptation
    • doi:10.2165/00007256-200737090-00001. PMID:17722947
    • Coffey, V.G., and Hawley, J.A. 2007. The molecular bases of training adaptation. Sports Med. 37(9): 737-763. doi:10.2165/00007256-200737090-00001. PMID:17722947.
    • (2007) Sports Med , vol.37 , Issue.9 , pp. 737-763
    • Coffey, V.G.1    Hawley, J.A.2
  • 13
    • 66149104031 scopus 로고    scopus 로고
    • Consecutive bouts of diverse contractile activity alter acute responses in human skeletal muscle
    • doi:10.1152/japplphysiol.91221.2008. PMID:19164772
    • Coffey, V.G., Pilegaard, H., Garnham, A.P., O'Brien, B.J., and Hawley, J.A. 2009. Consecutive bouts of diverse contractile activity alter acute responses in human skeletal muscle. J. Appl. Physiol. 106(4): 1187-1197. doi:10.1152/japplphysiol.91221.2008. PMID:19164772.
    • (2009) J. Appl. Physiol. , vol.106 , Issue.4 , pp. 1187-1197
    • Coffey, V.G.1    Pilegaard, H.2    Garnham, A.P.3    O'Brien, B.J.4    Hawley, J.A.5
  • 15
    • 0142024829 scopus 로고    scopus 로고
    • Sugars, insulin sensitivity, and the postprandial state
    • PMID:14522751
    • Daly, M. 2003. Sugars, insulin sensitivity, and the postprandial state. Am. J. Clin. Nutr. 78(4): 865S-872S. PMID:14522751.
    • (2003) Am. J. Clin. Nutr. , vol.78 , Issue.4
    • Daly, M.1
  • 16
    • 0035798097 scopus 로고    scopus 로고
    • Mammalian TOR: a homeostatic ATP sensor
    • doi:10.1126/science.1063518. PMID:11691993
    • Dennis, P.B., Jaeschke, A., Saitoh, M., Fowler, B., Kozma, S.C., and Thomas, G. 2001. Mammalian TOR: a homeostatic ATP sensor. Science, 294(5544): 1102-1105. doi:10.1126/science.1063518. PMID:11691993.
    • (2001) Science , vol.294 , Issue.5544 , pp. 1102-1105
    • Dennis, P.B.1    Jaeschke, A.2    Saitoh, M.3    Fowler, B.4    Kozma, S.C.5    Thomas, G.6
  • 17
    • 0032954778 scopus 로고    scopus 로고
    • Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity
    • doi:10.1172/JCI5001. PMID:9916137
    • Dresner, A., Laurent, D., Marcucci, M., Griffin, M.E., Dufour, S., Cline, G.W., et al. 1999. Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. J. Clin. Invest. 103(2): 253-259. doi:10.1172/JCI5001. PMID:9916137.
    • (1999) J. Clin. Invest. , vol.103 , Issue.2 , pp. 253-259
    • Dresner, A.1    Laurent, D.2    Marcucci, M.3    Griffin, M.E.4    Dufour, S.5    Cline, G.W.6
  • 18
    • 33749351995 scopus 로고    scopus 로고
    • Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle
    • doi:10.1113/jphysiol.2006.113175. PMID:16873412
    • Dreyer, H.C., Fujita, S., Cadenas, J.G., Chinkes, D.L., Volpi, E., and Rasmussen, B.B. 2006. Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle. J. Physiol. 576(2): 613-624. doi:10.1113/jphysiol.2006.113175. PMID:16873412.
    • (2006) J. Physiol. , vol.576 , Issue.2 , pp. 613-624
    • Dreyer, H.C.1    Fujita, S.2    Cadenas, J.G.3    Chinkes, D.L.4    Volpi, E.5    Rasmussen, B.B.6
  • 19
    • 57349197971 scopus 로고    scopus 로고
    • Resistance exercise increases human skeletal muscle AS160/TBC1D4 phosphorylation in association with enhanced leg glucose uptake during postexercise recovery
    • doi:10.1152/japplphysiol.90562.2008. PMID:18845784
    • Dreyer, H.C., Drummond, M.J., Glynn, E.L., Fujita, S., Chinkes, D.L., Volpi, E., and Rasmussen, B.B. 2008a. Resistance exercise increases human skeletal muscle AS160/TBC1D4 phosphorylation in association with enhanced leg glucose uptake during postexercise recovery. J. Appl. Physiol. 105(6): 1967-1974. doi:10.1152/japplphysiol.90562.2008. PMID:18845784.
    • (2008) J. Appl. Physiol. , vol.105 , Issue.6 , pp. 1967-1974
    • Dreyer, H.C.1    Drummond, M.J.2    Glynn, E.L.3    Fujita, S.4    Chinkes, D.L.5    Volpi, E.6    Rasmussen, B.B.7
  • 20
    • 38949126221 scopus 로고    scopus 로고
    • Leucine-enriched essential amino acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein synthesis in human muscle
    • doi:10.1152/ajpendo.00582.2007. PMID:18056791
    • Dreyer, H.C., Drummond, M.J., Pennings, B., Fujita, S., Glynn, E.L., Chinkes, D.L., et al. 2008b. Leucine-enriched essential amino acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein synthesis in human muscle. Am. J. Physiol. Endocrinol. Metab. 294(2): E392-E400. doi:10.1152/ajpendo.00582.2007. PMID:18056791.
    • (2008) Am. J. Physiol. Endocrinol. Metab. , vol.294 , Issue.2
    • Dreyer, H.C.1    Drummond, M.J.2    Pennings, B.3    Fujita, S.4    Glynn, E.L.5    Chinkes, D.L.6
  • 21
    • 45149131733 scopus 로고    scopus 로고
    • Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with aging
    • doi:10.1152/japplphysiol.00021.2008. PMID:18323467
    • Drummond, M.J., Dreyer, H.C., Pennings, B., Fry, C.S., Dhanani, S., Dillon, E.L., et al. 2008. Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with aging. J. Appl. Physiol. 104(5): 1452-1461. doi:10.1152/japplphysiol.00021.2008. PMID:18323467.
    • (2008) J. Appl. Physiol. , vol.104 , Issue.5 , pp. 1452-1461
    • Drummond, M.J.1    Dreyer, H.C.2    Pennings, B.3    Fry, C.S.4    Dhanani, S.5    Dillon, E.L.6
  • 22
    • 0035976615 scopus 로고    scopus 로고
    • Phosphatidic acid-mediated mitogenic activation of mTOR signaling
    • doi:10.1126/science.1066015. PMID:11729323
    • Fang, Y., Vilella-Bach, M., Bachmann, R., Flanigan, A., and Chen, J. 2001. Phosphatidic acid-mediated mitogenic activation of mTOR signaling. Science, 294(5548): 1942-1945. doi:10.1126/science.1066015. PMID:11729323.
    • (2001) Science , vol.294 , Issue.5548 , pp. 1942-1945
    • Fang, Y.1    Vilella-Bach, M.2    Bachmann, R.3    Flanigan, A.4    Chen, J.5
  • 23
    • 0014669160 scopus 로고
    • Plasma amino acid levels and insulin secretion in obesity
    • PMID:5809519
    • Felig, P., Marliss, E., and Cahill, G.F., Jr. 1969. Plasma amino acid levels and insulin secretion in obesity. N. Engl. J. Med. 281(15): 811-816. PMID:5809519.
    • (1969) N. Engl. J. Med. , vol.281 , Issue.15 , pp. 811-816
    • Felig, P.1    Marliss, E.2    Cahill G.F., Jr.3
  • 24
    • 0031887111 scopus 로고    scopus 로고
    • Amino acids stimulate phosphorylation of p70S6k and organization of rat adipocytes into multicellular clusters
    • PMID:9458729
    • Fox, H.L., Kimball, S.R., Jefferson, L.S., and Lynch, C.J. 1998a. Amino acids stimulate phosphorylation of p70S6k and organization of rat adipocytes into multicellular clusters. Am. J. Physiol. Cell Physiol. 274(1): C206-C213. PMID:9458729.
    • (1998) Am. J. Physiol. Cell Physiol. , vol.274 , Issue.1
    • Fox, H.L.1    Kimball, S.R.2    Jefferson, L.S.3    Lynch, C.J.4
  • 25
    • 0031730304 scopus 로고    scopus 로고
    • Amino acid effects on translational repressor 4EBP1 are mediated primarily by L-leucine in isolated adipocytes
    • PMID:9814971
    • Fox, H.L., Pham, P.T., Kimball, S.R., Jefferson, L.S., and Lynch, C.J. 1998b. Amino acid effects on translational repressor 4EBP1 are mediated primarily by L-leucine in isolated adipocytes. Am. J. Physiol. Cell Physiol. 275(5): C1232-C1238. PMID:9814971.
    • (1998) Am. J. Physiol. Cell Physiol. , vol.275 , Issue.5
    • Fox, H.L.1    Pham, P.T.2    Kimball, S.R.3    Jefferson, L.S.4    Lynch, C.J.5
  • 26
    • 33748471980 scopus 로고    scopus 로고
    • mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s
    • doi:10.1016/j.cub.2006.08.001. PMID:16919458
    • Frias, M.A., Thoreen, C.C., Jaffe, J.D., Schroder, W., Sculley, T., Carr, S.A., and Sabatini, D.M. 2006. mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s. Curr. Biol. 16(18): 1865-1870. doi:10.1016/j.cub.2006.08.001. PMID:16919458.
    • (2006) Curr. Biol. , vol.16 , Issue.18 , pp. 1865-1870
    • Frias, M.A.1    Thoreen, C.C.2    Jaffe, J.D.3    Schroder, W.4    Sculley, T.5    Carr, S.A.6    Sabatini, D.M.7
  • 27
    • 34547570876 scopus 로고    scopus 로고
    • Effects of endurance exercise training on insulin signaling in human skeletal muscle: interactions at the level of phosphatidylinositol 3-kinase, Akt, and AS160
    • doi:10.2337/db06-1698. PMID:17513702
    • Frosig, C., Rose, A.J., Treebak, J.T., Kiens, B., Richter, E.A., and Wojtaszewski, J.F. 2007. Effects of endurance exercise training on insulin signaling in human skeletal muscle: interactions at the level of phosphatidylinositol 3-kinase, Akt, and AS160. Diabetes, 56(8): 2093-2102. doi:10.2337/db06-1698. PMID:17513702.
    • (2007) Diabetes , vol.56 , Issue.8 , pp. 2093-2102
    • Frosig, C.1    Rose, A.J.2    Treebak, J.T.3    Kiens, B.4    Richter, E.A.5    Wojtaszewski, J.F.6
  • 28
    • 34249678700 scopus 로고    scopus 로고
    • Aerobic exercise overcomes the age-related insulin resistance of muscle protein metabolism by improving endothelial function and Akt/mammalian target of rapamycin signaling
    • doi:10.2337/db06-1566. PMID:17351147
    • Fujita, S., Rasmussen, B.B., Cadenas, J.G., Drummond, M.J., Glynn, E.L., Sattler, F.R., and Volpi, E. 2007. Aerobic exercise overcomes the age-related insulin resistance of muscle protein metabolism by improving endothelial function and Akt/mammalian target of rapamycin signaling. Diabetes, 56(6): 1615-1622. doi:10.2337/db06-1566. PMID:17351147.
    • (2007) Diabetes , vol.56 , Issue.6 , pp. 1615-1622
    • Fujita, S.1    Rasmussen, B.B.2    Cadenas, J.G.3    Drummond, M.J.4    Glynn, E.L.5    Sattler, F.R.6    Volpi, E.7
  • 29
    • 0038433304 scopus 로고    scopus 로고
    • Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
    • doi:10.1016/S1097-2765(03)00220-X. PMID:12820960
    • Garami, A., Zwartkruis, F.J., Nobukuni, T., Joaquin, M., Roccio, M., Stocker, H., et al. 2003. Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol. Cell, 11(6): 1457-1466. doi:10.1016/S1097-2765(03)00220-X. PMID:12820960.
    • (2003) Mol. Cell , vol.11 , Issue.6 , pp. 1457-1466
    • Garami, A.1    Zwartkruis, F.J.2    Nobukuni, T.3    Joaquin, M.4    Roccio, M.5    Stocker, H.6
  • 30
    • 0035904293 scopus 로고    scopus 로고
    • Rapamycin's resurrection: a new way to target the cancer cell cycle
    • PMID:11604470
    • Garber, K. 2001. Rapamycin's resurrection: a new way to target the cancer cell cycle. J. Natl. Cancer Inst. 93(20): 1517-1519. PMID:11604470.
    • (2001) J. Natl. Cancer Inst. , vol.93 , Issue.20 , pp. 1517-1519
    • Garber, K.1
  • 31
    • 39749190584 scopus 로고    scopus 로고
    • A chronic increase in physical activity inhibits fed-state mTOR/S6K1 signaling and reduces IRS-1 serine phosphorylation in rat skeletal muscle
    • doi:10.1139/H07-149. PMID:18347658
    • Glynn, E.L., Lujan, H.L., Kramer, V.J., Drummond, M.J., DiCarlo, S.E., and Rasmussen, B.B. 2008. A chronic increase in physical activity inhibits fed-state mTOR/S6K1 signaling and reduces IRS-1 serine phosphorylation in rat skeletal muscle. Appl. Physiol. Nutr. Metab. 33(1): 93-101. doi:10.1139/H07-149. PMID:18347658.
    • (2008) Appl. Physiol. Nutr. Metab. , vol.33 , Issue.1 , pp. 93-101
    • Glynn, E.L.1    Lujan, H.L.2    Kramer, V.J.3    Drummond, M.J.4    DiCarlo, S.E.5    Rasmussen, B.B.6
  • 32
    • 68149096799 scopus 로고    scopus 로고
    • The pharmacology of mTOR inhibition
    • PMID:19383975
    • Guertin, D.A., and Sabatini, D.M. 2009. The pharmacology of mTOR inhibition. Sci. Signal. 2(67): pe24. PMID:19383975.
    • (2009) Sci. Signal. , Issue.67
    • Guertin, D.A.1    Sabatini, D.M.2
  • 33
    • 34247120977 scopus 로고    scopus 로고
    • Nutrient sensing in the mTOR/S6K1 signalling pathway
    • Pt. 2, doi:10.1042/BST0350236. PMID:17371247
    • Gulati, P., and Thomas, G. 2007. Nutrient sensing in the mTOR/S6K1 signalling pathway. Biochem. Soc. Trans. 35(Pt. 2): 236-238. doi:10.1042/BST0350236. PMID:17371247.
    • (2007) Biochem. Soc. Trans. , vol.5 , pp. 236-238
    • Gulati, P.1    Thomas, G.2
  • 34
    • 42649112409 scopus 로고    scopus 로고
    • Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34
    • doi:10.1016/j.cmet.2008.03.002. PMID:18460336
    • Gulati, P., Gaspers, L.D., Dann, S.G., Joaquin, M., Nobukuni, T., Natt, F., et al. 2008. Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34. Cell Metab. 7(5): 456-465. doi:10.1016/j.cmet.2008.03.002. PMID:18460336.
    • (2008) Cell Metab , vol.7 , Issue.5 , pp. 456-465
    • Gulati, P.1    Gaspers, L.D.2    Dann, S.G.3    Joaquin, M.4    Nobukuni, T.5    Natt, F.6
  • 35
    • 0242637318 scopus 로고    scopus 로고
    • mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF
    • doi:10.1128/MCB.23.23.8862-8877.2003. PMID:14612424
    • Hannan, K.M., Brandenburger, Y., Jenkins, A., Sharkey, K., Cavanaugh, A., Rothblum, L., et al. 2003. mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF. Mol. Cell. Biol. 23(23): 8862-8877. doi:10.1128/MCB.23.23.8862-8877.2003. PMID:14612424.
    • (2003) Mol. Cell. Biol. , vol.23 , Issue.23 , pp. 8862-8877
    • Hannan, K.M.1    Brandenburger, Y.2    Jenkins, A.3    Sharkey, K.4    Cavanaugh, A.5    Rothblum, L.6
  • 36
    • 0032486268 scopus 로고    scopus 로고
    • Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism
    • doi:10.1074/jbc.273.23.14484. PMID:9603962
    • Hara, K., Yonezawa, K., Weng, Q.-P., Kozlowski, M.T., Belham, C., and Avruch, J. 1998. Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. J. Biol. Chem. 273(23): 14484-14494. doi:10.1074/jbc.273.23.14484. PMID:9603962.
    • (1998) J. Biol. Chem. , vol.273 , Issue.23 , pp. 14484-14494
    • Hara, K.1    Yonezawa, K.2    Weng Q.-P. Kozlowski, M.T.3    Belham, C.4    Avruch, J.5
  • 37
    • 0037178781 scopus 로고    scopus 로고
    • Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
    • doi:10.1016/S0092-8674(02)00833-4. PMID:12150926
    • Hara, K., Maruki, Y., Long, X., Yoshino, K., Oshiro, N., Hidayat, S., et al. 2002. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell, 110(2): 177-189. doi:10.1016/S0092-8674(02)00833-4. PMID:12150926.
    • (2002) Cell , vol.110 , Issue.2 , pp. 177-189
    • Hara, K.1    Maruki, Y.2    Long, X.3    Yoshino, K.4    Oshiro, N.5    Hidayat, S.6
  • 38
    • 37249066135 scopus 로고    scopus 로고
    • Exercise training-induced improvements in insulin action
    • PMID:18171435
    • Hawley, J.A., and Lessard, S.J. 2008. Exercise training-induced improvements in insulin action. Acta Physiol. (Oxf.), 192(1): 127-135. PMID:18171435.
    • (2008) Acta Physiol. (Oxf.) , vol.192 , Issue.1 , pp. 127-135
    • Hawley, J.A.1    Lessard, S.J.2
  • 39
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • doi:10.1101/gad.1212704. PMID:15314020
    • Hay, N., and Sonenberg, N. 2004. Upstream and downstream of mTOR. Genes Dev. 18(16): 1926-1945. doi:10.1101/gad.1212704. PMID:15314020.
    • (2004) Genes Dev , vol.18 , Issue.16 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 40
    • 0025776523 scopus 로고
    • Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
    • doi:10.1126/science.1715094. PMID:1715094
    • Heitman, J., Movva, N.R., and Hall, M.N. 1991. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science, 253(5022): 905-909. doi:10.1126/science.1715094. PMID:1715094.
    • (1991) Science , vol.253 , Issue.5022 , pp. 905-909
    • Heitman, J.1    Movva, N.R.2    Hall, M.N.3
  • 41
    • 0842310044 scopus 로고    scopus 로고
    • Strength training increases insulin-mediated glucose uptake, GLUT4 content, and insulin signaling in skeletal muscle in patients with type 2 diabetes
    • doi:10.2337/diabetes.53.2.294. PMID:14747278
    • Holten, M.K., Zacho, M., Gaster, M., Juel, C., Wojtaszewski, J.F., and Dela, F. 2004. Strength training increases insulin-mediated glucose uptake, GLUT4 content, and insulin signaling in skeletal muscle in patients with type 2 diabetes. Diabetes, 53(2): 294-305. doi:10.2337/diabetes.53.2.294. PMID:14747278.
    • (2004) Diabetes , vol.53 , Issue.2 , pp. 294-305
    • Holten, M.K.1    Zacho, M.2    Gaster, M.3    Juel, C.4    Wojtaszewski, J.F.5    Dela, F.6
  • 42
    • 33746622168 scopus 로고    scopus 로고
    • Regulation of mTOR by mechanically induced signaling events in skeletal muscle
    • PMID:16855395
    • Hornberger, T.A., Sukhija, K.B., and Chien, S. 2006a. Regulation of mTOR by mechanically induced signaling events in skeletal muscle. Cell Cycle, 5(13): 1391-1396. PMID:16855395.
    • (2006) Cell Cycle , vol.5 , Issue.13 , pp. 1391-1396
    • Hornberger, T.A.1    Sukhija, K.B.2    Chien, S.3
  • 43
    • 33645241260 scopus 로고    scopus 로고
    • The role of phospholipase D and phosphatidic acid in the mechanical activation of mTOR signaling in skeletal muscle
    • doi:10.1073/pnas.0600678103. PMID:16537399
    • Hornberger, T.A., Chu, W.K., Mak, Y.W., Hsiung, J.W., Huang, S.A., and Chien, S. 2006b. The role of phospholipase D and phosphatidic acid in the mechanical activation of mTOR signaling in skeletal muscle. Proc. Natl. Acad. Sci. U.S.A. 103(12): 4741-4746. doi:10.1073/pnas.0600678103. PMID:16537399.
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , Issue.12 , pp. 4741-4746
    • Hornberger, T.A.1    Chu, W.K.2    Mak, Y.W.3    Hsiung, J.W.4    Huang, S.A.5    Chien, S.6
  • 44
    • 34548693675 scopus 로고    scopus 로고
    • mTOR is the rapamycin-sensitive kinase that confers mechanically-induced phosphorylation of the hydrophobic motif site Thr(389) in p70(S6k)
    • doi:10.1016/j.febslet.2007.08.045. PMID:17825298
    • Hornberger, T.A., Sukhija, K.B., Wang, X.R., and Chien, S. 2007. mTOR is the rapamycin-sensitive kinase that confers mechanically-induced phosphorylation of the hydrophobic motif site Thr(389) in p70(S6k). FEBS Lett. 581(24): 4562-4566. doi:10. 1016/j.febslet.2007.08.045. PMID:17825298.
    • (2007) FEBS Lett , vol.581 , Issue.24 , pp. 4562-4566
    • Hornberger, T.A.1    Sukhija, K.B.2    Wang, X.R.3    Chien, S.4
  • 45
    • 0347993713 scopus 로고    scopus 로고
    • Effect of the volume and intensity of exercise training on insulin sensitivity
    • doi:10.1152/japplphysiol.00707.2003. PMID:12972442
    • Houmard, J.A., Tanner, C.J., Slentz, C.A., Duscha, B.D., McCartney, J.S., and Kraus, W.E. 2004. Effect of the volume and intensity of exercise training on insulin sensitivity. J. Appl. Physiol. 96(1): 101-106. doi:10.1152/japplphysiol.00707.2003. PMID:12972442.
    • (2004) J. Appl. Physiol. , vol.96 , Issue.1 , pp. 101-106
    • Houmard, J.A.1    Tanner, C.J.2    Slentz, C.A.3    Duscha, B.D.4    McCartney, J.S.5    Kraus, W.E.6
  • 46
    • 38949103750 scopus 로고    scopus 로고
    • The effect of exercise and insulin on AS160 phosphorylation and 14-3-3 binding capacity in human skeletal muscle
    • doi:10.1152/ajpendo.00542.2007. PMID:18042670
    • Howlett, K.F., Mathews, A., Garnham, A., and Sakamoto, K. 2008. The effect of exercise and insulin on AS160 phosphorylation and 14-3-3 binding capacity in human skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 294(2): E401-E407. doi:10.1152/ajpendo.00542.2007. PMID:18042670.
    • (2008) Am. J. Physiol. Endocrinol. Metab. , vol.294 , Issue.2
    • Howlett, K.F.1    Mathews, A.2    Garnham, A.3    Sakamoto, K.4
  • 47
    • 28844434558 scopus 로고    scopus 로고
    • mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes
    • doi:10.1074/jbc.M508361200. PMID:16221682
    • Hresko, R.C., and Mueckler, M. 2005. mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes. J. Biol. Chem. 280(49): 40406-40416. doi:10.1074/jbc.M508361200. PMID:16221682.
    • (2005) J. Biol. Chem. , vol.280 , Issue.49 , pp. 40406-40416
    • Hresko, R.C.1    Mueckler, M.2
  • 48
    • 65649152957 scopus 로고    scopus 로고
    • Amino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient signaling
    • doi:10.1152/ajpendo.91002.2008. PMID:19158318
    • Hundal, H.S., and Taylor, P.M. 2009. Amino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient signaling. Am. J. Physiol. Endocrinol. Metab. 296(4): E603-E613. doi:10.1152/ajpendo.91002.2008. PMID:19158318.
    • (2009) Am. J. Physiol. Endocrinol. Metab. , vol.296 , Issue.4
    • Hundal, H.S.1    Taylor, P.M.2
  • 49
    • 0031902198 scopus 로고    scopus 로고
    • Resistance training improves insulin sensitivity in NIDDM subjects without altering maximal oxygen uptake
    • doi:10.2337/diacare.21.8.1353. PMID:9702447
    • Ishii, T., Yamakita, T., Sato, T., Tanaka, S., and Fujii, S. 1998. Resistance training improves insulin sensitivity in NIDDM subjects without altering maximal oxygen uptake. Diabetes Care, 21(8): 1353-1355. doi:10.2337/diacare.21.8.1353. PMID:9702447.
    • (1998) Diabetes Care , vol.21 , Issue.8 , pp. 1353-1355
    • Ishii, T.1    Yamakita, T.2    Sato, T.3    Tanaka, S.4    Fujii, S.5
  • 50
    • 7944235758 scopus 로고    scopus 로고
    • Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
    • doi:10.1038/ncb1183. PMID:15467718.
    • Jacinto, E., Loewith, R., Schmidt, A., Lin, S., Ruegg, M.A., Hall, A., and Hall, M.N. 2004. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat. Cell Biol. 6(11): 1122-1128. doi:10.1038/ncb1183. PMID:15467718.
    • (2004) Nat. Cell Biol. , vol.6 , Issue.11 , pp. 1122-1128
    • Jacinto, E.1    Loewith, R.2    Schmidt, A.3    Lin, S.4    Ruegg, M.A.5    Hall, A.6    Hall, M.N.7
  • 51
    • 33749076673 scopus 로고    scopus 로고
    • SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
    • doi:10.1016/j.cell.2006.08.033. PMID:16962653
    • Jacinto, E., Facchinetti, V., Liu, D., Soto, N., Wei, S., Jung, S.Y., et al. 2006. SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell, 127(1): 125-137. doi:10.1016/j.cell.2006.08.033. PMID:16962653.
    • (2006) Cell , vol.127 , Issue.1 , pp. 125-137
    • Jacinto, E.1    Facchinetti, V.2    Liu, D.3    Soto, N.4    Wei, S.5    Jung, S.Y.6
  • 52
    • 37549028779 scopus 로고    scopus 로고
    • Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function
    • doi:10.1080/08977190701779101. PMID:18092230
    • Jastrzebski, K., Hannan, K.M., Tchoubrieva, E.B., Hannan, R.D., and Pearson, R.B. 2007. Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function. Growth Factors, 25(4): 209-226. doi:10.1080/08977190701779101. PMID:18092230.
    • (2007) Growth Factors, , vol.25 , Issue.4 , pp. 209-226
    • Jastrzebski, K.1    Hannan, K.M.2    Tchoubrieva, E.B.3    Hannan, R.D.4    Pearson, R.B.5
  • 53
    • 0033849777 scopus 로고    scopus 로고
    • Obesity and insulin resistance
    • doi:10.1172/JCI10842. PMID:10953022
    • Kahn, B.B., and Flier, J.S. 2000. Obesity and insulin resistance. J. Clin. Invest. 106(4): 473-481. doi:10.1172/JCI10842. PMID:10953022.
    • (2000) J. Clin. Invest. , vol.106 , Issue.4 , pp. 473-481
    • Kahn, B.B.1    Flier, J.S.2
  • 54
    • 14244256097 scopus 로고    scopus 로고
    • Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance
    • doi:10.1210/en.2004-0921. PMID:15604215
    • Khamzina, L., Veilleux, A., Bergeron, S., and Marette, A. 2005. Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance. Endocrinology, 146(3): 1473-1481. doi:10.1210/en.2004-0921. PMID:15604215.
    • (2005) Endocrinology , vol.146 , Issue.3 , pp. 1473-1481
    • Khamzina, L.1    Veilleux, A.2    Bergeron, S.3    Marette, A.4
  • 55
    • 0034085886 scopus 로고    scopus 로고
    • Divergent regulation of Akt1 and Akt2 isoforms in insulin target tissues of obese Zucker rats
    • doi:10.2337/diabetes.49.5.847. PMID:10905496
    • Kim, Y.B., Peroni, O.D., Franke, T.F., and Kahn, B.B. 2000. Divergent regulation of Akt1 and Akt2 isoforms in insulin target tissues of obese Zucker rats. Diabetes, 49(5): 847-856. doi:10.2337/diabetes.49.5.847. PMID:10905496.
    • (2000) Diabetes , vol.49 , Issue.5 , pp. 847-856
    • Kim, Y.B.1    Peroni, O.D.2    Franke, T.F.3    Kahn, B.B.4
  • 56
    • 0037178786 scopus 로고    scopus 로고
    • mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
    • doi:10.1016/S00928674(02)00808-5. PMID:12150925
    • Kim, D.-H., Sarbassov, D.D., Ali, S.M., King, J.E., Latek, R.R., Erdjument-Bromage, H., et al. 2002. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell, 110(2): 163-175. doi:10.1016/S00928674(02)00808-5. PMID:12150925.
    • (2002) Cell , vol.110 , Issue.2 , pp. 163-175
    • Kim D.-H. Sarbassov, D.D.1    Ali, S.M.2    King, J.E.3    Latek, R.R.4    Erdjument-Bromage, H.5
  • 57
    • 34548081433 scopus 로고    scopus 로고
    • Protein ingestion further augments S6K1 phosphorylation in skeletal muscle following resistance type exercise in males
    • PMID:17634259
    • Koopman, R., Pennings, B., Zorenc, A.H.G., and van Loon, L.J.C. 2007. Protein ingestion further augments S6K1 phosphorylation in skeletal muscle following resistance type exercise in males. J. Nutr. 137(8): 1880-1886. PMID:17634259.
    • (2007) J. Nutr. , vol.137 , Issue.8 , pp. 1880-1886
    • Koopman, R.1    Pennings, B.2    Zorenc, A.H.G.3    van Loon, L.J.C.4
  • 58
    • 33750922694 scopus 로고    scopus 로고
    • Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in mice
    • doi:10.1007/s00125-006-0439-5. PMID:17006666
    • Korsheninnikova, E., van der Zon, G.C., Voshol, P.J., Janssen, G.M., Havekes, L.M., Grefhorst, A., et al. 2006. Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in mice. Diabetologia, 49(12): 3049-3057. doi:10.1007/s00125-006-0439-5. PMID:17006666.
    • (2006) Diabetologia , vol.49 , Issue.12 , pp. 3049-3057
    • Korsheninnikova, E.1    van der Zon, G.C.2    Voshol, P.J.3    Janssen, G.M.4    Havekes, L.M.5    Grefhorst, A.6
  • 59
    • 33845998942 scopus 로고    scopus 로고
    • AS160 regulates insulin-and contraction-stimulated glucose uptake in mouse skeletal muscle
    • doi:10.1074/jbc.M605461200. PMID:16935857
    • Kramer, H.F., Witczak, C., Taylor, E., Fujii, N., Hirshman, M., and Goodyear, L. 2006. AS160 regulates insulin-and contraction-stimulated glucose uptake in mouse skeletal muscle. J. Biol. Chem. 281(42): 31478-31485. doi:10.1074/jbc.M605461200. PMID:16935857.
    • (2006) J. Biol. Chem. , vol.281 , Issue.42 , pp. 31478-31485
    • Kramer, H.F.1    Witczak, C.2    Taylor, E.3    Fujii, N.4    Hirshman, M.5    Goodyear, L.6
  • 60
    • 1842534924 scopus 로고    scopus 로고
    • Nutrient-induced insulin resistance in human skeletal muscle
    • doi:10.2174/0929867043455620. PMID:15078172
    • Krebs, M., and Roden, M. 2004. Nutrient-induced insulin resistance in human skeletal muscle. Curr. Med. Chem. 11(7): 901-908. doi:10.2174/0929867043455620. PMID:15078172.
    • (2004) Curr. Med. Chem. , vol.11 , Issue.7 , pp. 901-908
    • Krebs, M.1    Roden, M.2
  • 61
    • 0036313574 scopus 로고    scopus 로고
    • Mechanism of amino acid-induced skeletal muscle insulin resistance in humans
    • doi:10.2337/diabetes.51.3.599. PMID:11872656
    • Krebs, M., Krssak, M., Bernroider, E., Anderwald, C., Brehm, A., Meyerspeer, M., et al. 2002. Mechanism of amino acid-induced skeletal muscle insulin resistance in humans. Diabetes, 51(3): 599-605. doi:10.2337/diabetes.51.3.599. PMID:11872656.
    • (2002) Diabetes , vol.51 , Issue.3 , pp. 599-605
    • Krebs, M.1    Krssak, M.2    Bernroider, E.3    Anderwald, C.4    Brehm, A.5    Meyerspeer, M.6
  • 62
    • 34249679233 scopus 로고    scopus 로고
    • The mammalian target of rapamycin pathway regulates nutrient-sensitive glucose uptake in man
    • doi:10.2337/db06-1016. PMID:17329620
    • Krebs, M., Brunmair, B., Brehm, A., Artwohl, M., Szendroedi, J., Nowotny, P., et al. 2007. The mammalian target of rapamycin pathway regulates nutrient-sensitive glucose uptake in man. Diabetes, 56(6): 1600-1607. doi:10.2337/db06-1016. PMID:17329620.
    • (2007) Diabetes , vol.56 , Issue.6 , pp. 1600-1607
    • Krebs, M.1    Brunmair, B.2    Brehm, A.3    Artwohl, M.4    Szendroedi, J.5    Nowotny, P.6
  • 63
    • 37549000623 scopus 로고    scopus 로고
    • Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances basal glycogen synthase activity
    • doi:10.1128/MCB.01405-07. PMID:17967879
    • Kumar, A., Harris, T.E., Keller, S.R., Choi, K.M., Magnuson, M.A., and Lawrence, J.C., Jr. 2008. Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances basal glycogen synthase activity. Mol. Cell. Biol. 28(1): 61-70. doi:10.1128/MCB.01405-07. PMID:17967879.
    • (2008) Mol. Cell. Biol. , vol.28 , Issue.1 , pp. 61-70
    • Kumar, A.1    Harris, T.E.2    Keller, S.R.3    Choi, K.M.4    Magnuson, M.A.5    Lawrence J.C., Jr.6
  • 64
    • 33748452108 scopus 로고    scopus 로고
    • Elevated plasma free fatty acids decrease basal protein synthesis, but not the anabolic effect of leucine, in skeletal muscle
    • doi:10.1152/ajpendo.00065.2006. PMID:16684854
    • Lang, C.H. 2006. Elevated plasma free fatty acids decrease basal protein synthesis, but not the anabolic effect of leucine, in skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 291(3): E666-E674. doi:10.1152/ajpendo.00065.2006. PMID:16684854.
    • (2006) Am. J. Physiol. Endocrinol. Metab. , vol.291 , Issue.3
    • Lang, C.H.1
  • 65
    • 33750400410 scopus 로고    scopus 로고
    • Akt signalling through GSK-3, mTOR and Foxo1 is involved in human skeletal muscle hypertrophy and atrophy
    • doi:10.1113/jphysiol.2006.116715. PMID:16916907
    • Leger, B., Cartoni, R., Praz, M., Lamon, S., Deriaz, O., Crettenand, A., et al. 2006. Akt signalling through GSK-3, mTOR and Foxo1 is involved in human skeletal muscle hypertrophy and atrophy. J. Physiol. 576(3): 923-933. doi:10.1113/jphysiol.2006.116715. PMID:16916907.
    • (2006) J. Physiol. , vol.576 , Issue.3 , pp. 923-933
    • Leger, B.1    Cartoni, R.2    Praz, M.3    Lamon, S.4    Deriaz, O.5    Crettenand, A.6
  • 66
    • 34347390598 scopus 로고    scopus 로고
    • Tissue-specific effects of rosiglitazone and exercise in the treatment of lipid-induced insulin resistance
    • doi:10.2337/db06-1065. PMID:17440174
    • Lessard, S.J., Rivas, D.A., Chen, Z.-P., Bonen, A., Febbraio, M.A., Reeder, D.W., et al. 2007. Tissue-specific effects of rosiglitazone and exercise in the treatment of lipid-induced insulin resistance. Diabetes, 56(7): 1856-1864. doi:10.2337/db06-1065. PMID:17440174.
    • (2007) Diabetes , vol.56 , Issue.7 , pp. 1856-1864
    • Lessard, S.J.1    Rivas, D.A.2    Chen Z.-P. Bonen, A.3    Febbraio, M.A.4    Reeder, D.W.5
  • 67
    • 58149287669 scopus 로고    scopus 로고
    • mVps34 is activated following high-resistance contractions
    • Pt. 1: doi:10.1113/jphysiol.2008.159830. PMID:19015198
    • MacKenzie, M.G., Hamilton, D., Murray, J., Taylor, P., and Baar, K. 2009. mVps34 is activated following high-resistance contractions. J. Physiol. 87(Pt. 1): 253-260. doi:10.1113/jphysiol.2008.159830. PMID:19015198.
    • (2009) J. Physiol. , vol.87 , pp. 253-260
    • MacKenzie, M.G.1    Hamilton, D.2    Murray, J.3    Taylor, P.4    Baar, K.5
  • 68
    • 0036385637 scopus 로고    scopus 로고
    • Coordinate regulation of translation by the PI 3-kinase and mTOR pathways
    • doi:10.1016/S0065-230X(02)86001-8. PMID:12374276
    • Martin, K.A., and Blenis, J. 2002. Coordinate regulation of translation by the PI 3-kinase and mTOR pathways. Adv. Cancer Res. 86: 1-39. doi:10.1016/S0065-230X(02)86001-8. PMID:12374276.
    • (2002) Adv. Cancer Res. , vol.86 , pp. 1-39
    • Martin, K.A.1    Blenis, J.2
  • 69
    • 34547683916 scopus 로고    scopus 로고
    • Changes in signalling pathways regulating protein synthesis in human muscle in the recovery period after endurance exercise
    • doi:10.1111/j.1748-1716.2007.01712.x. PMID:17488244
    • Mascher, H., Andersson, H., Nilsson, P.A., Ekblom, B., and Blomstrand, E. 2007. Changes in signalling pathways regulating protein synthesis in human muscle in the recovery period after endurance exercise. Acta Physiol. (Oxf.), 191(1): 67-75. doi:10.1111/j.1748-1716.2007.01712.x. PMID:17488244.
    • (2007) Acta Physiol. (Oxf.) , vol.191 , Issue.1 , pp. 67-75
    • Mascher, H.1    Andersson, H.2    Nilsson, P.A.3    Ekblom, B.4    Blomstrand, E.5
  • 70
    • 38349043742 scopus 로고    scopus 로고
    • Repeated resistance exercise training induces different changes in mRNA expression of MAFbx and MuRF-1 in human skeletal muscle
    • doi:10.1152/ajpendo.00504.2007. PMID:17971512
    • Mascher, H., Tannerstedt, J., Brink-Elfegoun, T., Ekblom, B., Gustafsson, T., and Blomstrand, E. 2008. Repeated resistance exercise training induces different changes in mRNA expression of MAFbx and MuRF-1 in human skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 294(1): E43-E51. doi:10.1152/ajpendo.00504.2007. PMID:17971512.
    • (2008) Am. J. Physiol. Endocrinol. Metab. , vol.294 , Issue.1
    • Mascher, H.1    Tannerstedt, J.2    Brink-Elfegoun, T.3    Ekblom, B.4    Gustafsson, T.5    Blomstrand, E.6
  • 71
    • 0036894449 scopus 로고    scopus 로고
    • Diet quality and major chronic disease risk in men and women: moving toward improved dietary guidance
    • PMID:12450892
    • McCullough, M.L., Feskanich, D., Stampfer, M.J., Giovannucci, E.L., Rimm, E.B., Hu, F.B., et al. 2002. Diet quality and major chronic disease risk in men and women: moving toward improved dietary guidance. Am. J. Clin. Nutr. 76(6): 1261-1271. PMID:12450892.
    • (2002) Am. J. Clin. Nutr. , vol.76 , Issue.6 , pp. 1261-1271
    • McCullough, M.L.1    Feskanich, D.2    Stampfer, M.J.3    Giovannucci, E.L.4    Rimm, E.B.5    Hu, F.B.6
  • 72
    • 34548092167 scopus 로고    scopus 로고
    • Activation of mammalian target of rapamycin complex 1 and insulin resistance induced by palmitate in hepatocytes
    • doi:10.1016/j.bbrc.2007.08.004. PMID:17698034
    • Mordier, S., and Iynedjian, P.B. 2007. Activation of mammalian target of rapamycin complex 1 and insulin resistance induced by palmitate in hepatocytes. Biochem. Biophys. Res. Commun. 362(1): 206-211. doi:10.1016/j.bbrc.2007.08.004. PMID:17698034.
    • (2007) Biochem. Biophys. Res. Commun. , vol.362 , Issue.1 , pp. 206-211
    • Mordier, S.1    Iynedjian, P.B.2
  • 73
    • 27744549321 scopus 로고    scopus 로고
    • mTOR function in skeletal muscle hypertrophy: increased ribosomal RNA via cell cycle regulators
    • doi:10.1152/ajpcell.00165.2005. PMID:16079186
    • Nader, G.A., McLoughlin, T.J., and Esser, K.A. 2005. mTOR function in skeletal muscle hypertrophy: increased ribosomal RNA via cell cycle regulators. Am. J. Physiol. Cell Physiol. 289(6): -. doi:10.1152/ajpcell.00165.2005. PMID:16079186.
    • (2005) Am. J. Physiol. Cell Physiol. , vol.289 , Issue.6
    • Nader, G.A.1    McLoughlin, T.J.2    Esser, K.A.3
  • 74
    • 26444575415 scopus 로고    scopus 로고
    • Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OHkinase
    • doi:10.1073/pnas.0506925102. PMID:16176982
    • Nobukuni, T., Joaquin, M., Roccio, M., Dann, S.G., Kim, S.Y., Gulati, P., et al. 2005. Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OHkinase. Proc. Natl. Acad. Sci. U.S.A. 102(40): 14238-14243. doi:10.1073/pnas.0506925102. PMID:16176982.
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , Issue.40 , pp. 14238-14243
    • Nobukuni, T.1    Joaquin, M.2    Roccio, M.3    Dann, S.G.4    Kim, S.Y.5    Gulati, P.6
  • 75
    • 0001437616 scopus 로고    scopus 로고
    • Bidirectional modulation of insulin action by amino acids
    • doi:10.1172/JCI1326. PMID:9525995
    • Patti, M.-E., Brambilla, E., Luzi, L., Landaker, E.J., and Kahn, R.C. 1998. Bidirectional modulation of insulin action by amino acids. J. Clin. Invest. 101(7): 1519-1529. doi:10.1172/JCI1326. PMID:9525995.
    • (1998) J. Clin. Invest. , vol.101 , Issue.7 , pp. 1519-1529
    • Patti M.-E. Brambilla, E.1    Luzi, L.2    Landaker, E.J.3    Kahn, R.C.4
  • 76
    • 50049116472 scopus 로고    scopus 로고
    • SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth
    • doi:10.1016/j.cmet.2008.07.007. PMID:18762023
    • Porstmann, T., Santos, C.R., Griffiths, B., Cully, M., Wu, M., Leevers, S., et al. 2008. SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth. Cell Metab. 8(3): 224-236. doi:10.1016/j.cmet.2008.07.007. PMID:18762023.
    • (2008) Cell Metab , vol.8 , Issue.3 , pp. 224-236
    • Porstmann, T.1    Santos, C.R.2    Griffiths, B.3    Cully, M.4    Wu, M.5    Leevers, S.6
  • 77
    • 58149141517 scopus 로고    scopus 로고
    • Protein, amino acids and the control of food intake
    • doi:10.1097/MCO.0b013e32831b9e01. PMID:19057188
    • Potier, M., Darcel, N., and Tome, D. 2009. Protein, amino acids and the control of food intake. Curr. Opin. Clin. Nutr. Metab. Care, 12(1): 54-58. doi:10.1097/MCO.0b013e32831b9e01. PMID:19057188.
    • (2009) Curr. Opin. Clin. Nutr. Metab. Care , vol.12 , Issue.1 , pp. 54-58
    • Potier, M.1    Darcel, N.2    Tome, D.3
  • 78
    • 52049106904 scopus 로고    scopus 로고
    • Cell growth control: mTOR takes on fat
    • doi:10.1016/j.molcel.2008.09.006. PMID:18922461
    • Powers, T. 2008. Cell growth control: mTOR takes on fat. Mol. Cell, 31(6): 775-776. doi:10.1016/j.molcel.2008.09.006. PMID:18922461.
    • (2008) Mol. Cell , vol.31 , Issue.6 , pp. 775-776
    • Powers, T.1
  • 79
    • 0014618879 scopus 로고
    • Amino acid balance across tissues of the forearm in postabsorptive man. Effects of insulin at two dose levels
    • doi:10.1172/JCI106193. PMID:5355340
    • Pozefsky, T., Felig, P., Tobin, J.D., Soeldner, J.S., and Cahill, G.F., Jr. 1969. Amino acid balance across tissues of the forearm in postabsorptive man. Effects of insulin at two dose levels. J. Clin. Invest. 48(12): 2273-2282. doi:10.1172/JCI106193. PMID:5355340.
    • (1969) J. Clin. Invest. , vol.48 , Issue.12 , pp. 2273-2282
    • Pozefsky, T.1    Felig, P.2    Tobin, J.D.3    Soeldner, J.S.4    Cahill G.F., Jr.5
  • 80
    • 0032578998 scopus 로고    scopus 로고
    • Phosphorylation and activation of p70s6k by PDK1
    • doi:10.1126/science.279.5351.707. PMID:9445476
    • Pullen, N., Dennis, P.B., Andjelkovic, M., Dufner, A., Kozma, S.C., Hemmings, B.A., and Thomas, G. 1998. Phosphorylation and activation of p70s6k by PDK1. Science, 279(5351): 707-710. doi:10.1126/science.279.5351.707. PMID:9445476.
    • (1998) Science , vol.279 , Issue.5351 , pp. 707-710
    • Pullen, N.1    Dennis, P.B.2    Andjelkovic, M.3    Dufner, A.4    Kozma, S.C.5    Hemmings, B.A.6    Thomas, G.7
  • 81
    • 70349323414 scopus 로고    scopus 로고
    • Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5'-aminoimidazole-4-carboxamide-1-D-ribofuranoside
    • PMID:19574345
    • Rivas, D.A., Yaspelkis, B.B., III, Hawley, J.A., and Lessard, S.J. 2009. Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5'-aminoimidazole-4-carboxamide-1-D-ribofuranoside. J. Endocrinol. 202: 441-451. PMID: 19574345.
    • (2009) J. Endocrinol. , vol.202 , pp. 441-451
    • Rivas, D.A.1    Yaspelkis B.B.III2    Hawley, J.A.3    Lessard, S.J.4
  • 82
    • 0028000563 scopus 로고
    • Differentiating glucose toxicity from glucose desensitization: a new message from the insulin gene
    • doi:10.2337/diabetes.43.9.1085. PMID:8070607
    • Robertson, R.P., Olson, L., and Zhang, H. 1994. Differentiating glucose toxicity from glucose desensitization: a new message from the insulin gene. Diabetes, 43(9): 1085-1089. doi:10.2337/diabetes.43.9.1085. PMID:8070607.
    • (1994) Diabetes , vol.43 , Issue.9 , pp. 1085-1089
    • Robertson, R.P.1    Olson, L.2    Zhang, H.3
  • 83
    • 44049092767 scopus 로고    scopus 로고
    • Signaling mechanisms in skeletal muscle: acute responses and chronic adaptations to exercise
    • doi:10.1002/iub.21. PMID:18380005
    • Röckl, K.S.C., Witczak, C.A., and Goodyear, L.J. 2008. Signaling mechanisms in skeletal muscle: acute responses and chronic adaptations to exercise. IUBMB Life, 60(3): 145-153. doi:10.1002/iub.21. PMID:18380005.
    • (2008) IUBMB Life , vol.60 , Issue.3 , pp. 145-153
    • Röckl, K.S.C.1    Witczak, C.A.2    Goodyear, L.J.3
  • 84
    • 33747819801 scopus 로고    scopus 로고
    • mTOR and cancer: insights into a complex relationship
    • doi:10.1038/nrc1974. PMID:16915295
    • Sabatini, D.M. 2006. mTOR and cancer: insights into a complex relationship. Nat. Rev. Cancer, 6(9): 729-734. doi:10.1038/nrc1974. PMID:16915295.
    • (2006) Nat. Rev. Cancer , vol.6 , Issue.9 , pp. 729-734
    • Sabatini, D.M.1
  • 85
    • 0028239893 scopus 로고
    • RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
    • doi:10.1016/0092-8674(94)90570-3. PMID:7518356
    • Sabatini, D.M., Erdjument-Bromage, H., Lui, M., Tempst, P., and Snyder, S.H. 1994. RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell, 78(1): 35-43. doi:10.1016/0092-8674(94)90570-3. PMID:7518356.
    • (1994) Cell , vol.78 , Issue.1 , pp. 35-43
    • Sabatini, D.M.1    Erdjument-Bromage, H.2    Lui, M.3    Tempst, P.4    Snyder, S.H.5
  • 86
    • 36148932174 scopus 로고    scopus 로고
    • The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation
    • doi:10.1074/jbc.M704150200. PMID:17848569
    • Saito, T., Jones, C.C., Huang, S., Czech, M.P., and Pilch, P.F. 2007. The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation. J. Biol. Chem. 282(44): 32280-32287. doi:10.1074/jbc.M704150200. PMID:17848569.
    • (2007) J. Biol. Chem. , vol.282 , Issue.44 , pp. 32280-32287
    • Saito, T.1    Jones, C.C.2    Huang, S.3    Czech, M.P.4    Pilch, P.F.5
  • 87
    • 45849105156 scopus 로고    scopus 로고
    • The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
    • doi:10.1126/science.1157535. PMID:18497260
    • Sancak, Y., Peterson, T.R., Shaul, Y.D., Lindquist, R.A., Thoreen, C.C., Bar-Peled, L., and Sabatini, D.M. 2008. The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science, 320(5882): 1496-1501. doi:10.1126/science.1157535. PMID:18497260.
    • (2008) Science , vol.320 , Issue.5882 , pp. 1496-1501
    • Sancak, Y.1    Peterson, T.R.2    Shaul, Y.D.3    Lindquist, R.A.4    Thoreen, C.C.5    Bar-Peled, L.6    Sabatini, D.M.7
  • 88
    • 3342895823 scopus 로고    scopus 로고
    • Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor independent pathway that regulates the cytoskeleton
    • doi:10.1016/j.cub.2004.06.054. PMID:15268862
    • Sarbassov, D.D., Ali, S.M., Kim, D.-H., Guertin, D.A., Latek, R.R., Erdjument-Bromage, H., et al. 2004. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor independent pathway that regulates the cytoskeleton. Curr. Biol. 14(14): 1296-1302. doi:10.1016/j.cub.2004.06.054. PMID:15268862.
    • (2004) Curr. Biol. , vol.14 , Issue.14 , pp. 1296-1302
    • Sarbassov, D.D.1    Ali, S.M.2    Kim D.-H. Guertin, D.A.3    Latek, R.R.4    Erdjument-Bromage, H.5
  • 89
    • 27544500981 scopus 로고    scopus 로고
    • Growing roles for the mTOR pathway
    • doi:10.1016/j.ceb.2005.09.009. PMID:16226444
    • Sarbassov, D.D., Ali, S.M., and Sabatini, D.M. 2005a. Growing roles for the mTOR pathway. Curr. Opin. Cell Biol. 17(6): 596-603. doi:10.1016/j.ceb.2005.09.009. PMID:16226444.
    • (2005) Curr. Opin. Cell Biol. , vol.17 , Issue.6 , pp. 596-603
    • Sarbassov, D.D.1    Ali, S.M.2    Sabatini, D.M.3
  • 90
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • doi:10.1126/science.1106148. PMID:15718470
    • Sarbassov, D.D., Guertin, D.A., Ali, S.M., and Sabatini, D.M. 2005b. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science, 307(5712): 1098-1101. doi:10.1126/science.1106148. PMID:15718470.
    • (2005) Science , vol.307 , Issue.5712 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 91
    • 33646023695 scopus 로고    scopus 로고
    • Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
    • doi:10.1016/j.molcel.2006.03.029. PMID:16603397
    • Sarbassov, D.D., Ali, S.M., Sengupta, S., Sheen, J.H., Hsu, P.P., Bagley, A.F., et al. 2006. Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol. Cell, 22(2): 159-168. doi:10.1016/j.molcel.2006.03.029. PMID:16603397.
    • (2006) Mol. Cell , vol.22 , Issue.2 , pp. 159-168
    • Sarbassov, D.D.1    Ali, S.M.2    Sengupta, S.3    Sheen, J.H.4    Hsu, P.P.5    Bagley, A.F.6
  • 92
    • 35248820393 scopus 로고    scopus 로고
    • Rapamycinmediated inhibition of mammalian target of rapamycin in skeletal muscle cells reduces glucose utilization and increases fatty acid oxidation
    • doi:10.1016/j.metabol.2006.08.002. PMID:17142137
    • Sipula, I.J., Brown, N.F., and Perdomo, G. 2006. Rapamycinmediated inhibition of mammalian target of rapamycin in skeletal muscle cells reduces glucose utilization and increases fatty acid oxidation. Metabolism, 55(12): 1637-1644. doi:10.1016/j.metabol.2006.08.002. PMID:17142137.
    • (2006) Metabolism , vol.55 , Issue.12 , pp. 1637-1644
    • Sipula, I.J.1    Brown, N.F.2    Perdomo, G.3
  • 93
    • 21244480367 scopus 로고    scopus 로고
    • The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses
    • doi:10.1074/jbc.M414499200. PMID:15772076
    • Smith, E.M., Finn, S.G., Tee, A.R., Browne, G.J., and Proud, C.G. 2005. The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses. J. Biol. Chem. 280(19): 18717-18727. doi:10.1074/jbc.M414499200. PMID:15772076.
    • (2005) J. Biol. Chem. , vol.280 , Issue.19 , pp. 18717-18727
    • Smith, E.M.1    Finn, S.G.2    Tee, A.R.3    Browne, G.J.4    Proud, C.G.5
  • 95
    • 33244464562 scopus 로고    scopus 로고
    • Critical nodes in signalling pathways: insights into insulin action
    • PMID:16493415
    • Taniguchi, C.M., Emanuelli, B., and Kahn, C.R. 2006. Critical nodes in signalling pathways: insights into insulin action. Nature reviews 7(2): 85-96. PMID:16493415.
    • (2006) Nature reviews , vol.7 , Issue.2 , pp. 85-96
    • Taniguchi, C.M.1    Emanuelli, B.2    Kahn, C.R.3
  • 96
    • 65549145048 scopus 로고    scopus 로고
    • An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1
    • doi:10.1074/jbc.M900301200. PMID:19150980
    • Thoreen, C.C., Kang, S., Chang, J., Liu, Q., Zhang, J., Gao, Y., et al. 2009. An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J. Biol. Chem. 284(12): 8023-8032. doi:10.1074/jbc.M900301200. PMID:19150980.
    • (2009) J. Biol. Chem. , vol.284 , Issue.12 , pp. 8023-8032
    • Thoreen, C.C.1    Kang, S.2    Chang, J.3    Liu, Q.4    Zhang, J.5    Gao, Y.6
  • 97
    • 62849111751 scopus 로고    scopus 로고
    • Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin
    • doi:10.1128/MCB.00782-08. PMID:19114562
    • Toschi, A., Lee, E., Xu, L., Garcia, A., Gadir, N., and Foster, D.A. 2009. Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin. Mol. Cell. Biol. 29(6): 1411-1420. doi:10.1128/MCB.00782-08. PMID:19114562.
    • (2009) Mol. Cell. Biol. , vol.29 , Issue.6 , pp. 1411-1420
    • Toschi, A.1    Lee, E.2    Xu, L.3    Garcia, A.4    Gadir, N.5    Foster, D.A.6
  • 98
    • 0035851205 scopus 로고    scopus 로고
    • Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells
    • PMID:11498541
    • Tremblay, F., and Marette, A. 2001. Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells. J. Biol. Chem. 276(41): 38052-38060. PMID:11498541.
    • (2001) J. Biol. Chem. , vol.276 , Issue.41 , pp. 38052-38060
    • Tremblay, F.1    Marette, A.2
  • 99
    • 20844451550 scopus 로고    scopus 로고
    • Modulation of insulin action by dietary proteins and amino acids: role of the mammalian target of rapamycin nutrient sensing pathway
    • PMID:15930974
    • Tremblay, F., Jacques, H., and Marette, A. 2005. Modulation of insulin action by dietary proteins and amino acids: role of the mammalian target of rapamycin nutrient sensing pathway. Curr. Opin. Clin. Nutr. Metab. Care, 8(4): 457-462. PMID:15930974.
    • (2005) Curr. Opin. Clin. Nutr. Metab. Care , vol.8 , Issue.4 , pp. 457-462
    • Tremblay, F.1    Jacques, H.2    Marette, A.3
  • 100
    • 35348832340 scopus 로고    scopus 로고
    • Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient-and obesity-induced insulin resistance
    • doi:10.1073/pnas.0706517104. PMID:17709744
    • Tremblay, F., Brule, S., Hee Um, S., Li, Y., Masuda, K., Roden, M., et al. 2007. Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient-and obesity-induced insulin resistance. Proc. Natl. Acad. Sci. U.S.A. 104(35): 14056-14061. doi:10.1073/pnas.0706517104. PMID:17709744.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , Issue.35 , pp. 14056-14061
    • Tremblay, F.1    Brule, S.2    Hee Um, S.3    Li, Y.4    Masuda, K.5    Roden, M.6
  • 101
    • 33644886769 scopus 로고    scopus 로고
    • Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTORmediated insulin receptor substrate 1 phosphorylation
    • doi:10.1128/MCB.26.1.63-76.2006. PMID:16354680
    • Tzatsos, A., and Kandror, K.V. 2006. Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTORmediated insulin receptor substrate 1 phosphorylation. Mol. Cell. Biol. 26(1): 63-76. doi:10.1128/MCB.26.1.63-76.2006. PMID:16354680.
    • (2006) Mol. Cell. Biol. , vol.26 , Issue.1 , pp. 63-76
    • Tzatsos, A.1    Kandror, K.V.2
  • 102
    • 4544220704 scopus 로고    scopus 로고
    • Absence of S6K1 protects against age-and diet-induced obesity while enhancing insulin sensitivity
    • doi:10.1038/nature02866. PMID:15306821
    • Um, S.H., Frigerio, F., Watanabe, M., Picard, F., Joaquin, M., Sticker, M., et al. 2004. Absence of S6K1 protects against age-and diet-induced obesity while enhancing insulin sensitivity. Nature, 431(7005): 200-205. doi:10.1038/nature02866. PMID:15306821.
    • (2004) Nature , vol.431 , Issue.7005 , pp. 200-205
    • Um, S.H.1    Frigerio, F.2    Watanabe, M.3    Picard, F.4    Joaquin, M.5    Sticker, M.6
  • 103
    • 33744505375 scopus 로고    scopus 로고
    • Nutrient overload insulin resistance, and ribosomal protein S6 kinase 1, S6K1
    • doi:10.1016/j.cmet.2006.05.003. PMID: 16753575
    • Um, S.H., D'Alessio, D., and Thomas, G. 2006. Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1. Cell Metab. 3(6): 393-402. doi:10.1016/j.cmet.2006.05.003. PMID:16753575.
    • (2006) Cell Metab , vol.3 , Issue.6 , pp. 393-402
    • Um, S.H.1    D'Alessio, D.2    Thomas, G.3
  • 104
    • 0037022261 scopus 로고    scopus 로고
    • Dietary patterns and risk for type 2 diabetes mellitus in U.S. men
    • PMID:11827496
    • van Dam, R.M., Rimm, E.B., Willett, W.C., Stampfer, M.J., and Hu, F.B. 2002. Dietary patterns and risk for type 2 diabetes mellitus in U.S. men. Ann. Intern. Med. 136(3): 201-209. PMID:11827496.
    • (2002) Ann. Intern. Med. , vol.136 , Issue.3 , pp. 201-209
    • van Dam, R.M.1    Rimm, E.B.2    Willett, W.C.3    Stampfer, M.J.4    Hu, F.B.5
  • 105
    • 0032528917 scopus 로고    scopus 로고
    • Amino acid availability regulates p70 S6 kinase and multiple translation factors
    • PMID:9693128
    • Wang, X., Campbell, L.E., Miller, C.M., and Proud, C.G. 1998. Amino acid availability regulates p70 S6 kinase and multiple translation factors. Biochem. J. 334(1): 261-267. PMID:9693128.
    • (1998) Biochem. J. , vol.334 , Issue.1 , pp. 261-267
    • Wang, X.1    Campbell, L.E.2    Miller, C.M.3    Proud, C.G.4
  • 106
    • 48549107440 scopus 로고    scopus 로고
    • Differential effects of resistance and endurance exercise in the fed state on signaling molecule phosphorylation and protein synthesis in human muscle
    • Pt. 15: doi:10.1113/jphysiol.2008.153916. PMID:18556367
    • Wilkinson, S.B., Phillips, S.M., Atherton, P.J., Patel, R., Yarasheski, K.E., Tarnopolsky, M.A., and Rennie, M.J. 2008. Differential effects of resistance and endurance exercise in the fed state on signaling molecule phosphorylation and protein synthesis in human muscle. J. Physiol. 586(Pt. 15): 3701-3717. doi:10.1113/jphysiol.2008.153916. PMID:18556367.
    • (2008) J. Physiol. , vol.586 , pp. 3701-3717
    • Wilkinson, S.B.1    Phillips, S.M.2    Atherton, P.J.3    Patel, R.4    Yarasheski, K.E.5    Tarnopolsky, M.A.6    Rennie, M.J.7
  • 107
    • 39049179892 scopus 로고    scopus 로고
    • Effects of acute exercise and training on insulin action and sensitivity: focus on molecular mechanisms in muscle
    • doi:10.1042/bse0420031. PMID:17144878
    • Wojtaszewski, J.F., and Richter, E.A. 2006. Effects of acute exercise and training on insulin action and sensitivity: focus on molecular mechanisms in muscle. Essays Biochem. 42: 31-46. doi:10.1042/bse0420031. PMID:17144878.
    • (2006) Essays Biochem , vol.42 , pp. 31-46
    • Wojtaszewski, J.F.1    Richter, E.A.2
  • 108
    • 34547907805 scopus 로고    scopus 로고
    • Expanding mTOR signaling
    • doi:10.1038/cr.2007.64. PMID:17680028
    • Yang, Q., and Guan, K.L. 2007. Expanding mTOR signaling. Cell Res. 17(8): 666-681. doi:10.1038/cr.2007.64. PMID:17680028.
    • (2007) Cell Res , vol.17 , Issue.8 , pp. 666-681
    • Yang, Q.1    Guan, K.L.2
  • 109
    • 33645638721 scopus 로고    scopus 로고
    • Resistance training improves insulin signaling and action in skeletal muscle
    • doi:10.1097/00003677-200601000-00009. PMID:16394814
    • Yaspelkis, B.B., 3rd. 2006. Resistance training improves insulin signaling and action in skeletal muscle. Exerc. Sport Sci. Rev. 34(1): 42-46. doi:10.1097/00003677-200601000-00009. PMID:16394814.
    • (2006) Exerc. Sport Sci. Rev. , vol.34 , Issue.1 , pp. 42-46
    • Yaspelkis B.B., 3rd.1
  • 110
    • 27344447850 scopus 로고    scopus 로고
    • Elevated glucose activates protein synthesis in cultured cardiac myocytes
    • doi:10.1016/j.metabol.2005.05.010. PMID:16253633
    • Yeshao, W., Gu, J., Peng, X., Nairn, A.C., and Nadler, J.L. 2005. Elevated glucose activates protein synthesis in cultured cardiac myocytes. Metabolism, 54(11): 1453-1460. doi:10.1016/j.metabol.2005.05.010. PMID:16253633.
    • (2005) Metabolism , vol.54 , Issue.11 , pp. 1453-1460
    • Yeshao, W.1    Gu, J.2    Peng, X.3    Nairn, A.C.4    Nadler, J.L.5
  • 111
    • 47549087332 scopus 로고    scopus 로고
    • Signal transduction: Linking nutrients to growth
    • doi:10.1038/454287a. PMID:18633406
    • Zinzalla, V., and Hall, M.N. 2008. Signal transduction: Linking nutrients to growth. Nature, 454(7202): 287-288. doi:10.1038/454287a. PMID:18633406.
    • (2008) Nature , vol.454 , Issue.7202 , pp. 287-288
    • Zinzalla, V.1    Hall, M.N.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.