메뉴 건너뛰기




Volumn 21, Issue 1, 2007, Pages 215-228

Functional studies of Akt isoform specificity in skeletal muscle in vivo; maintained insulin sensitivity despite reduced insulin receptor substrate-1 expression

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; INSULIN RECEPTOR SUBSTRATE 1; PROTEIN AKT 1; PROTEIN KINASE B; PROTEIN KINASE B BETA; S6 KINASE; UNCLASSIFIED DRUG;

EID: 33845968034     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2006-0154     Document Type: Article
Times cited : (88)

References (46)
  • 1
    • 0031782480 scopus 로고    scopus 로고
    • Constitutive activation of protein kinase B α by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells
    • Hajduch E, Alessi DR, Hemmings BA, Hundal HS 1998 Constitutive activation of protein kinase B α by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells. Diabetes 47:1006-1013
    • (1998) Diabetes , vol.47 , pp. 1006-1013
    • Hajduch, E.1    Alessi, D.R.2    Hemmings, B.A.3    Hundal, H.S.4
  • 4
    • 12144271277 scopus 로고    scopus 로고
    • Increased Phosphorylation of Akt Substrate of 160 kDa (AS160) in rat skeletal muscle in response to insulin or contractile activity
    • Bruss MD, Arias EB, Lienhard GE, Cartee GD 2005 Increased Phosphorylation of Akt Substrate of 160 kDa (AS160) in rat skeletal muscle in response to insulin or contractile activity. Diabetes 54:41-50
    • (2005) Diabetes , vol.54 , pp. 41-50
    • Bruss, M.D.1    Arias, E.B.2    Lienhard, G.E.3    Cartee, G.D.4
  • 8
    • 0035914388 scopus 로고    scopus 로고
    • Akt1/PKBα is required for normal growth but dispensable for maintenance of glucose homeostasis in mice
    • Cho H, Thorvaldsen JL, Chu Q, Feng F, Birnbaum MJ 2001 Akt1/PKBα is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J Biol Chem 276:38349-38352
    • (2001) J Biol Chem , vol.276 , pp. 38349-38352
    • Cho, H.1    Thorvaldsen, J.L.2    Chu, Q.3    Feng, F.4    Birnbaum, M.J.5
  • 11
    • 0035432971 scopus 로고    scopus 로고
    • Defective insulin-induced GLUT4 translocation in skeletal muscle of high fat-fed rats is associated with alterations in both Akt/protein kinase B and atypical protein kinase C (ζ/λ) activities
    • Tremblay F, Lavigne C, Jacques H, Marette A 2001 Defective insulin-induced GLUT4 translocation in skeletal muscle of high fat-fed rats is associated with alterations in both Akt/protein kinase B and atypical protein kinase C (ζ/λ) activities. Diabetes 50:1901-1910
    • (2001) Diabetes , vol.50 , pp. 1901-1910
    • Tremblay, F.1    Lavigne, C.2    Jacques, H.3    Marette, A.4
  • 13
    • 0034085886 scopus 로고    scopus 로고
    • Divergent regulation of Akt1 and Akt2 isoforms in insulin target tissues of obese Zucker rats
    • Kim YB, Peroni OD, Franke TF, Kahn BB 2000 Divergent regulation of Akt1 and Akt2 isoforms in insulin target tissues of obese Zucker rats. Diabetes 49:847-856
    • (2000) Diabetes , vol.49 , pp. 847-856
    • Kim, Y.B.1    Peroni, O.D.2    Franke, T.F.3    Kahn, B.B.4
  • 14
    • 0037381535 scopus 로고    scopus 로고
    • Defective signaling through Akt-2 and -3 but not Akt-1 in insulin-resistant human skeletal muscle: Potential role in insulin resistance
    • Brozinick JT, Jr., Roberts BR, Dohm GL 2003 Defective signaling through Akt-2 and -3 but not Akt-1 in insulin-resistant human skeletal muscle: potential role in insulin resistance. Diabetes 52:935-941
    • (2003) Diabetes , vol.52 , pp. 935-941
    • Brozinick Jr., J.T.1    Roberts, B.R.2    Dohm, G.L.3
  • 16
    • 17444404892 scopus 로고    scopus 로고
    • 14-3-3 proteins regulate glycogen synthase 3β phosphorylation and inhibit cardiomyocyte hypertrophy
    • Liao W, Wang S, Han C, Zhang Y 2005 14-3-3 proteins regulate glycogen synthase 3β phosphorylation and inhibit cardiomyocyte hypertrophy. FEBS J 272:1845-1854
    • (2005) FEBS J , vol.272 , pp. 1845-1854
    • Liao, W.1    Wang, S.2    Han, C.3    Zhang, Y.4
  • 17
    • 24144479967 scopus 로고    scopus 로고
    • Acute bidirectional manipulation of muscle glucose uptake by in vivo electrotransfer of constructs targeting glucose transporter genes
    • Cleasby ME, Davey JR, Reinten TA, Graham MW, James DE, Kraegen EW, Cooney GJ 2005 Acute bidirectional manipulation of muscle glucose uptake by in vivo electrotransfer of constructs targeting glucose transporter genes. Diabetes 54:2702-2711
    • (2005) Diabetes , vol.54 , pp. 2702-2711
    • Cleasby, M.E.1    Davey, J.R.2    Reinten, T.A.3    Graham, M.W.4    James, D.E.5    Kraegen, E.W.6    Cooney, G.J.7
  • 18
    • 1542616960 scopus 로고    scopus 로고
    • Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation
    • Carlson CJ, White MF, Rondinone CM 2004 Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation. Biochem Biophys Res Commun 316:533-539
    • (2004) Biochem Biophys Res Commun , vol.316 , pp. 533-539
    • Carlson, C.J.1    White, M.F.2    Rondinone, C.M.3
  • 20
    • 0035836770 scopus 로고    scopus 로고
    • A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1
    • Ozes ON, Akca H, Mayo LD, Gustin JA, Maehama T, Dixon JE, Donner DB 2001 A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1. Proc Natl Acad Sci USA 98:4640-4645
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 4640-4645
    • Ozes, O.N.1    Akca, H.2    Mayo, L.D.3    Gustin, J.A.4    Maehama, T.5    Dixon, J.E.6    Donner, D.B.7
  • 22
    • 0035851205 scopus 로고    scopus 로고
    • Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells
    • Tremblay F, Marette A 2001 Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells. J Biol Chem 276:38052-38060
    • (2001) J Biol Chem , vol.276 , pp. 38052-38060
    • Tremblay, F.1    Marette, A.2
  • 24
    • 0029810181 scopus 로고    scopus 로고
    • Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation
    • Kohn AD, Takeuchi F, Roth RA 1996 Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation. J Biol Chem 271:21920-21926
    • (1996) J Biol Chem , vol.271 , pp. 21920-21926
    • Kohn, A.D.1    Takeuchi, F.2    Roth, R.A.3
  • 25
    • 0021678625 scopus 로고
    • Muscle fiber type composition of the rat hindlimb
    • Armstrong RB, Phelps RO 1984 Muscle fiber type composition of the rat hindlimb. Am J Anat 171:259-272
    • (1984) Am J Anat , vol.171 , pp. 259-272
    • Armstrong, R.B.1    Phelps, R.O.2
  • 26
    • 15744362289 scopus 로고    scopus 로고
    • Constitutive activation of GSK3 down regulates glycogen synthase abundance and glycogen deposition in rat skeletal muscle cells
    • Macaulay K, Blair AS, Hajduch E, Terashima T, Baba O, Sutherland C, Hundal HS 2005 Constitutive activation of GSK3 down regulates glycogen synthase abundance and glycogen deposition in rat skeletal muscle cells. J Biol Chem 280:9509-9518
    • (2005) J Biol Chem , vol.280 , pp. 9509-9518
    • Macaulay, K.1    Blair, A.S.2    Hajduch, E.3    Terashima, T.4    Baba, O.5    Sutherland, C.6    Hundal, H.S.7
  • 28
    • 0038521284 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells
    • Pirola L, Bonnafous S, Johnston AM, Chaussade C, Portis F, Van Obberghen E 2003 Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells. J Biol Chem 278:15641-15651
    • (2003) J Biol Chem , vol.278 , pp. 15641-15651
    • Pirola, L.1    Bonnafous, S.2    Johnston, A.M.3    Chaussade, C.4    Portis, F.5    Van Obberghen, E.6
  • 29
    • 0034463918 scopus 로고    scopus 로고
    • A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1
    • Haruta T, Uno T, Kawahara J, Takano A, Egawa K, Sharma PM, Olefsky JM, Kobayashi M 2000 A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1. Mol Endocrinol 14:783-794
    • (2000) Mol Endocrinol , vol.14 , pp. 783-794
    • Haruta, T.1    Uno, T.2    Kawahara, J.3    Takano, A.4    Egawa, K.5    Sharma, P.M.6    Olefsky, J.M.7    Kobayashi, M.8
  • 30
    • 27844517354 scopus 로고    scopus 로고
    • Both saturated and n-6 polyunsaturated fat diets reduce phosphorylation of insulin receptor substrate-1 and protein kinase B in muscle during the initial stages of in vivo insulin stimulation
    • Frangioudakis G, Ye JM, Cooney GJ 2005 Both saturated and n-6 polyunsaturated fat diets reduce phosphorylation of insulin receptor substrate-1 and protein kinase B in muscle during the initial stages of in vivo insulin stimulation. Endocrinology 146:5596-5603
    • (2005) Endocrinology , vol.146 , pp. 5596-5603
    • Frangioudakis, G.1    Ye, J.M.2    Cooney, G.J.3
  • 31
    • 0031984952 scopus 로고    scopus 로고
    • Altered expression levels and impaired steps in the pathway to phosphatidylinositol 3-kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty rats
    • Anai M, Funaki M, Ogihara T, Terasaki J, Inukai K, Katagiri H, Fukushima Y, Yazaki Y, Kikuchi M, Oka Y, Asano T 1998 Altered expression levels and impaired steps in the pathway to phosphatidylinositol 3-kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty rats. Diabetes 47:13-23
    • (1998) Diabetes , vol.47 , pp. 13-23
    • Anai, M.1    Funaki, M.2    Ogihara, T.3    Terasaki, J.4    Inukai, K.5    Katagiri, H.6    Fukushima, Y.7    Yazaki, Y.8    Kikuchi, M.9    Oka, Y.10    Asano, T.11
  • 33
    • 14844302667 scopus 로고    scopus 로고
    • Resistance exercise increases muscle protein synthesis and translation of eukaryotic initiation factor 2Bε mRNA in a mammalian target of rapamycin-dependent manner
    • Kubica N, Bolster DR, Farrell PA, Kimball SR, Jefferson LS 2005 Resistance exercise increases muscle protein synthesis and translation of eukaryotic initiation factor 2Bε mRNA in a mammalian target of rapamycin-dependent manner. J Biol Chem 280:7570-7580
    • (2005) J Biol Chem , vol.280 , pp. 7570-7580
    • Kubica, N.1    Bolster, D.R.2    Farrell, P.A.3    Kimball, S.R.4    Jefferson, L.S.5
  • 34
    • 1542781732 scopus 로고    scopus 로고
    • Isoform-specific regulation of insulin-dependent glucose uptake by Akt/PKB
    • Bae SS, Han C, Mu J, Birnbaum MJ 2003 Isoform-specific regulation of insulin-dependent glucose uptake by Akt/PKB. J Biol Chem 278:49530-49536
    • (2003) J Biol Chem , vol.278 , pp. 49530-49536
    • Bae, S.S.1    Han, C.2    Mu, J.3    Birnbaum, M.J.4
  • 35
    • 0033927667 scopus 로고    scopus 로고
    • Cellular mechanisms of insulin resistance
    • Shulman GI 2000 Cellular mechanisms of insulin resistance. J Clin Invest 106:171-176
    • (2000) J Clin Invest , vol.106 , pp. 171-176
    • Shulman, G.I.1
  • 36
    • 0027183935 scopus 로고
    • Evidence from transgenic mice that glucose transport is rate-limiting for glycogen deposition and glycolysis in skeletal muscle
    • Ren JM, Marshall BA, Gulve EA, Gao J, Johnson DW, Holloszy JO, Mueckler M 1993 Evidence from transgenic mice that glucose transport is rate-limiting for glycogen deposition and glycolysis in skeletal muscle. J Biol Chem 268:16113-16115
    • (1993) J Biol Chem , vol.268 , pp. 16113-16115
    • Ren, J.M.1    Marshall, B.A.2    Gulve, E.A.3    Gao, J.4    Johnson, D.W.5    Holloszy, J.O.6    Mueckler, M.7
  • 37
    • 0035653508 scopus 로고    scopus 로고
    • Storgaard H, Song XM, Jensen CB, Madsbad S, Bjornholm M, Vaag A, Zierath JR 2001 Insulin signal transduction in skeletal muscle from glucose-intolerant relatives of type 2 diabetic patients. Diabetes [Erratum (2002) 51:552] 50:2770-2778
    • Storgaard H, Song XM, Jensen CB, Madsbad S, Bjornholm M, Vaag A, Zierath JR 2001 Insulin signal transduction in skeletal muscle from glucose-intolerant relatives of type 2 diabetic patients. Diabetes [Erratum (2002) 51:552] 50:2770-2778
  • 38
    • 0025809486 scopus 로고
    • New pUC-derived cloning vectors with different selectable markers and DNA replication origins
    • Vieira J, Messing J 1991 New pUC-derived cloning vectors with different selectable markers and DNA replication origins. Gene 100:189-194
    • (1991) Gene , vol.100 , pp. 189-194
    • Vieira, J.1    Messing, J.2
  • 40
    • 0025273991 scopus 로고
    • Pentobarbital reduces basal liver glucose output and its insulin suppression in rats
    • Clark PW, Jenkins AB, Kraegen EW 1990 Pentobarbital reduces basal liver glucose output and its insulin suppression in rats. Am J Physiol 258:E701-E707
    • (1990) Am J Physiol , vol.258
    • Clark, P.W.1    Jenkins, A.B.2    Kraegen, E.W.3
  • 41
    • 0022036226 scopus 로고
    • Dose-response curves for in vivo insulin sensitivity in individual tissues in rats
    • Kraegen EW, James DE, Jenkins AB, Chisholm DJ 1985 Dose-response curves for in vivo insulin sensitivity in individual tissues in rats. Am J Physiol 248:E353-E362
    • (1985) Am J Physiol , vol.248
    • Kraegen, E.W.1    James, D.E.2    Jenkins, A.B.3    Chisholm, D.J.4
  • 42
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • Bligh EG, Dyer WJ 1959 A rapid method of total lipid extraction and purification. Can J Med Sci 37:911-917
    • (1959) Can J Med Sci , vol.37 , pp. 911-917
    • Bligh, E.G.1    Dyer, W.J.2
  • 43
    • 0017159024 scopus 로고
    • A rapid method for the determination of glycogen content and radioactivity in small quantities of tissue or isolated hepatocytes
    • Chan TM, Exton JH 1976 A rapid method for the determination of glycogen content and radioactivity in small quantities of tissue or isolated hepatocytes. Anal Biochem 71:96-105
    • (1976) Anal Biochem , vol.71 , pp. 96-105
    • Chan, T.M.1    Exton, J.H.2
  • 44
    • 0038708307 scopus 로고    scopus 로고
    • PTG gene deletion causes impaired glycogen synthesis and developmental insulin resistance
    • Crosson SM, Khan A, Printen J, Pessin JE, Saltiel AR 2003 PTG gene deletion causes impaired glycogen synthesis and developmental insulin resistance. J Clin Invest 111:1423-1432
    • (2003) J Clin Invest , vol.111 , pp. 1423-1432
    • Crosson, S.M.1    Khan, A.2    Printen, J.3    Pessin, J.E.4    Saltiel, A.R.5
  • 45
    • 9444272216 scopus 로고    scopus 로고
    • Metformin prevents the development of acute lipid-induced insulin resistance in the rat through altered hepatic signaling mechanisms
    • Cleasby ME, Dzamko N, Hegarty BD, Cooney GJ, Kraegen EW, Ye JM 2004 Metformin prevents the development of acute lipid-induced insulin resistance in the rat through altered hepatic signaling mechanisms. Diabetes 53:3258-3266
    • (2004) Diabetes , vol.53 , pp. 3258-3266
    • Cleasby, M.E.1    Dzamko, N.2    Hegarty, B.D.3    Cooney, G.J.4    Kraegen, E.W.5    Ye, J.M.6
  • 46
    • 0024592462 scopus 로고
    • Molecular cloning and characterization of an insulin-regulatable glucose transporter
    • James DE, Strube M, Mueckler M 1989 Molecular cloning and characterization of an insulin-regulatable glucose transporter. Nature 338:83-87
    • (1989) Nature , vol.338 , pp. 83-87
    • James, D.E.1    Strube, M.2    Mueckler, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.