Amino acid effects on translational repressor 4E-BP1 are mediated primarily by L-leucine in isolated adipocytes

American Journal of Physiology - Cell Physiology

Volumn 275, Issue 5 44-5, 1998, Pages

  Fox, Heather L ^a   Pham, Phuong T ^a   Kimball, Scot R ^a   Jefferson, Leonard S ^a   Lynch, Christopher J ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

(Aminooxy)acetic acid; Eukaryotic initiation factor 4E; Metabolic regulation; Multicellular clustering; Protein synthesis; Target of rapamycin; ketoisocaproic acid

Indexed keywords

2 OXOISOCAPROIC ACID; AMINO ACID; AMINOOXYACETIC ACID; AMINOTRANSFERASE; BRANCHED CHAIN AMINO ACID; INITIATION FACTOR 4E; LEUCINE; PROTEIN SERINE THREONINE KINASE; RAPAMYCIN; REPRESSOR PROTEIN;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; STEREOSPECIFICITY; TRANSLATION REGULATION;

EID: 0031730304     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.1998.275.5.c1232     Document Type: Article

References (15)

1. Aoki, T. T., M. F. Brennan, W. A. Muller, J. S. Soeldner, J. S. Alpert, S. B. Saltz, R. L. Kaufmann, M. H. Tan, and G. F. Cahill, Jr. Amino acid levels across normal forearm muscle and splanchnic bed after a protein meal. Am. J. Clin. Nutr. 29: 340-350, 1976.
2. Blommaart, E. F., J. J. Luiken, P. J. Blommaart, G. M. van Woerkom, and A. J. Meijer. Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes. J. Biol. Chem. 270: 2320-2326, 1995.
3. Blommaart, E. F., J. J. Luiken, and A. J. Meijer. Autophagic proteolysis: control and specificity. Histochem. J. 29: 365-385, 1997.
4. Brown, L. M., H. L. Fox, S. A. Hazen, K. F. LaNoue, S. R. Rannels, and C. J. Lynch. Role of the matrixin MMP-2 in multicellular organization of adipocytes cultured in basement membrane components. Am. J. Physiol. 272 (Cell. Physiol. 41): C937-C949, 1997.
5. Brunn, G. J., C. C. Hudson, A. Sekulic, J. M. Williams, H. Hosoi, P. J. Houghton, J. C. Lawrence, Jr., and R. T. Abraham. Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin. Science 277: 99-101, 1997.
6. Brunn, G. J., J. Williams, C. Sabers, G. Wiederrecht, J. C. Lawrence, Jr., and R. T. Abraham. Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002. EMBO J. 15: 5256-5267, 1996.
7. Buse, M. G., R. Atwell, and V. Mancusi. In vitro effect of branched chain amino acids on the ribosomal cycle in muscles of fasted rats. Horm. Metab. Res. 11: 289-292, 1979.
8. Buse, M. G., and S. S. Reid. Leucine. A possible regulator of protein turnover in muscle. J. Clin. Invest. 56: 1250-1261, 1975.
9. Buse, M. G., and D. A. Weigand. Studies concerning the specificity of the effect of leucine on the turnover of proteins in muscles of control and diabetic rats. Biochim. Biophys. Acta 475: 81-89, 1977.
10. Chang, T. W., and A. L. Goldberg. Leucine inhibits oxidation of glucose and pyruvate in skeletal muscles during fasting. J. Biol. Chem. 253: 3696-3701, 1978.
11. Everson, W. V., K. E. Flaim, D. M. Susco, S. R. Kimball, and L. S. Jefferson. Effect of amino acid deprivation on initiation of protein synthesis in rat hepatocytes. Am. J. Physiol. 256 (Cell. Physiol. 25): C18-C27, 1989.
12. Fadden, P., T. A. J. Haystead, and J. C. Lawrence. Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes. J. Biol. Chem. 272: 10240-10247, 1997.
13. Flaim, K. E., W. S. Liao, D. E. Peavy, J. M. Taylor, and L. S. Jefferson. The role of amino acids in the regulation of protein synthesis in perfused rat liver. II. Effects of amino acid deficiency on peptide chain initiation, polysomal aggregation, and distribution of albumin mRNA. J. Biol. Chem. 257: 2939-2946, 1982.
14. Flaim, K. E., D. E. Peayy, W. V. Everson, and L. S. Jefferson. The role of amino acids in the regulation of protein synthesis in perfused rat liver. I. Reduction in rates of synthesis resulting from amino acid deprivation and recovery during flow-through perfusion. J. Biol. Chem. 257: 2932-2938, 1982.
15. S6k and organization of rat adipocytes into multicellular clusters. Am. J. Physiol. 274 (Cell. Physiol. 43): C206-C213, 1998.