MAPK signaling pathways in the regulation of hematopoiesis

Journal of Leukocyte Biology

Volumn 86, Issue 2, 2009, Pages 237-250

  Geest, Christian R ^a   Coffer, Paul J ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

CD34+; ERK; JNK; p38; Signal transduction; Transcription

Indexed keywords

2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRACYCLINE; ANTINEOPLASTIC AGENT; CYTOKINE; DASATINIB; DAUNORUBICIN; GROWTH FACTOR; IMATINIB; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE;

ACUTE MYELOBLASTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CELL DIFFERENTIATION; CELL EXPANSION; CELL GROWTH; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; DRUG INHIBITION; ENZYME ACTIVITY; ERYTHROID CELL; ERYTHROPOIESIS; HEMATOLOGIC MALIGNANCY; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; LEUKEMIA CELL; MYELOPOIESIS; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; METABOLISM; PHYSIOLOGY;

MAMMALIA;

ANIMALS; CELL DIFFERENTIATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; MYELOPOIESIS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; SIGNAL TRANSDUCTION;

EID: 69449088578     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0209097     Document Type: Review

References (191)

1. Chang, L., Karin, M. (2001) Mammalian MAP kinase signaling cascades. Nature 410, 37-40. (Pubitemid 32225829)
2. Dong, C., Davis, R. J., Flavell, R. A. (2002) MAP kinases in the immune response. Annu. Rev. Immunol. 20, 55-72.
3. Wada, T., Penninger, J. M. (2004) Mitogen-activated protein kinases in apoptosis regulation. Oncogene 23, 2838-2849. (Pubitemid 38638846)
4. Schaeffer, H. J., Weber, M. J. (1999) Mitogen-activated protein kinases: specific messages from ubiquitous messengers. Mol. Cell. Biol. 19, 2435-2444.
5. Davis, R. J. (2000) Signal transduction by the JNK group of MAP kinases. Cell 103, 239-252.
6. Kyriakis, J. M., Avruch, J. (2001) Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol. Rev. 81, 807-869.
7. Zarubin, T., Han, J. (2005) Activation and signaling of the p38 MAP kinase pathway. Cell Res. 15, 11-18. (Pubitemid 41653958)
8. Pearson, G., Robinson, F., Beers Gibson, T., Xu, B. E., Karandikar, M., Berman, K., Cobb, M. H. (2001) Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr. Rev. 22, 153-183. (Pubitemid 32458157)
9. Cobb, M. H., Goldsmith, E. J. (1995) How MAP kinases are regulated. J. Biol. Chem. 270, 14843-14846.
10. Biondi, R. M., Nebreda, A. R. (2003) Signaling specificity of Ser/Thr protein kinases through docking-site-mediated interactions. Biochem. J. 372, 1-13. (Pubitemid 36609602)
11. Tanoue, T., Nishida, E. (2002) Docking interactions in the mitogen-activated protein kinase cascades. Pharmacol. Ther. 93, 193-202. (Pubitemid 34615560)
12. Tanoue, T., Nishida, E. (2003) Molecular recognitions in the MAP kinase cascades. Cell. Signal. 15, 455-462. (Pubitemid 36287667)
13. Kolch, W. (2005) Coordinating ERK/MAPK signaling through scaffolds and inhibitors. Nat. Rev. Mol. Cell Biol. 6, 827-837.
14. Vomastek, T., Schaeffer, H., Tarcsafalvi, A., Smolkin, M. E., Bissonette, E. A., Weber, M. J. (2004) Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists. Proc. Natl. Acad. Sci. USA 101, 6981-6986. (Pubitemid 38596429)
15. Ishibe, S., Joly, D., Zhu, X., Cantley, L. G. (2003) Phosphorylation- dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis. Mol. Cell 12, 1275-1285. (Pubitemid 37487934)
16. Schaeffer, H. J., Catling, A. D., Eblen, S. T., Collier, L. S., Krauss, A., Weber, M. J. (1998) MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade. Science 281, 1668-1671. (Pubitemid 28435581)
17. Karandikar, M., Xu, S., Cobb, M. H. (2000) MEKK1 binds raf-1 and the ERK2 cascade components. J. Biol. Chem. 275, 40120-40127. (Pubitemid 32064638)
18. Xu, S., Cobb, M. H. (1997) MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases. J. Biol. Chem. 272, 32056-32060. (Pubitemid 28011874)
19. DeFea, K. A., Zalevsky, J., Thoma, M. S., Déry, O., Mullins, R. D., Bunnett, N. W. (2000) β-Arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2. J. Cell Biol. 148, 1267-1281. (Pubitemid 30688135)
20. Luttrell, L. M., Roudabush, F. L., Choy, E. W., Miller, W. E., Field, M. E., Pierce, K. L., Lefkowitz, R. J. (2001) Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds. Proc. Natl. Acad. Sci. USA 98, 2449-2454. (Pubitemid 32209502)
21. McDonald, P. H., Chow, C. W., Miller, W. E., Laporte, S. A., Field, M. E., Lin, F. T., Davis, R. J., Lefkowitz, R. J. (2000) β-Arrestin 2: a receptor- regulated MAPK scaffold for the activation of JNK3. Science 290, 1574-1577.
22. Dickens, M., Rogers, J. S., Cavanagh, J., Raitano, A., Xia, Z., Halpern, J. R., Greenberg, M. E., Sawyers, C. L., Davis, R. J. (1997) A cytoplasmic inhibitor of the JNK signal transduction pathway. Science 277, 693-696. (Pubitemid 27373916)
23. Yasuda, J., Whitmarsh, A. J., Cavanagh, J., Sharma, M., Davis, R. J. (1999) The JIP group of mitogen-activated protein kinase scaffold proteins. Mol. Cell. Biol. 19, 7245-7254. (Pubitemid 29441904)
24. Verhey, K. J., Meyer, D., Deehan, R., Blenis, J., Schnapp, B. J., Rapoport, T. A., Margolis, B. (2001) Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules. J. Cell Biol. 152, 959-970. (Pubitemid 34286072)
25. Buchsbaum, R. J., Connolly, B. A., Feig, L. A. (2002) Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen- activated protein kinase cascade. Mol. Cell. Biol. 22, 4073-4085.
26. Robidoux, J., Cao, W., Quan, H., Daniel, K. W., Moukdar, F., Bai, X., Floering, L. M., Collins, S. (2005) Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38α MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes. Mol. Cell. Biol. 25, 5466-5479. (Pubitemid 40853582)
27. Kelkar, N., Gupta, S., Dickens, M., Davis, R. J. (2000) Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3. Mol. Cell. Biol. 20, 1030-1043. (Pubitemid 30044240)
28. Matsuguchi, T., Masuda, A., Sugimoto, K., Nagai, Y., Yoshikai, Y. (2003) JNK-interacting protein 3 associates with Toll-like receptor 4 and is involved in LPS-mediated JNK activation. EMBO J. 22, 4455-4464. (Pubitemid 37087199)
29. Kelkar, N., Standen, C. L., Davis, R. J. (2005) Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways. Mol. Cell. Biol. 25, 2733-2743. (Pubitemid 40381636)
30. Uhlik, M. T., Abell, A. N., Johnson, N. L., Sun, W., Cuevas, B. D., Lobel-Rice, K. E., Horne, E. A., Dell'Acqua, M. L., Johnson, G. L. (2003) Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock. Nat. Cell Biol. 5, 1104-1110. (Pubitemid 37509118)
31. Raman, M., Chen, W., Cobb, M. H. (2007) Differential regulation and properties of MAPKs. Oncogene 26, 3100-3112.
32. Whitmarsh, A. J., Cavanagh, J., Tournier, C., Yasuda, J., Davis, R. J. (1998) A mammalian scaffold complex that selectively mediates MAP kinase activation. Science 281, 1671-1674. (Pubitemid 28435582)
33. Therrien, M., Michaud, N. R., Rubin, G. M., Morrison, D. K. (1996) KSR modulates signal propagation within the MAPK cascade. Genes Dev. 10, 2684-2695. (Pubitemid 26384489)
34. Morrison, D. K., Davis, R. J. (2003) Regulation of MAP kinase signaling modules by scaffold proteins in mammals. Annu. Rev. Cell Dev. Biol. 19, 91-118. (Pubitemid 37487344)
35. Schoorlemmer, J., Goldfarb, M. (2002) Fibroblast growth factor homologous factors and the islet brain-2 scaffold protein regulate activation of a stress-activated protein kinase. J. Biol. Chem. 277, 49111-49119. (Pubitemid 36014339)
36. Owens, D. M., Keyse, S. M. (2007) Differential regulation of MAP kinase signaling by dual-specificity protein phosphatases. Oncogene 26, 3203-3213. (Pubitemid 46763015)
37. Boulton, T. G., Cobb, M. H. (1991) Identification of multiple extracellular signal-regulated kinases (erks) with antipeptide antibodies. Cell Regul. 2, 357-371.
38. Lewis, T. S., Shapiro, P. S., Ahn, N. G. (1998) Signal transduction through MAP kinase cascades. Adv. Cancer Res. 74, 49-139. (Pubitemid 28193546)
39. Chen, Z., Gibson, T. B., Robinson, F., Silvestro, L., Pearson, G., Xu, B., Wright, A., Vanderbilt, C., Cobb, M. H. (2001) MAP kinases. Chem. Rev. 101, 2449-2476.
40. Yoon, S., Seger, R. (2006) The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions. Growth Factors 24, 21-44. (Pubitemid 43108774)
41. Turjanski, A. G., Vaqué, J. P., Gutkind, J. S. (2007) MAP kinases and the control of nuclear events. Oncogene 26, 3240-3253.
42. Yang, D. D., Conze, D., Whitmarsh, A. J., Barrett, T., Davis, R. J., Rincón, M., Flavell, R. A. (1998) Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2. Immunity 9, 575-585. (Pubitemid 28499208)
43. Tanaka, T., Kurokawa, M., Ueki, K., Tanaka, K., Imai, Y., Mitani, K., Okazaki, K., Sagata, N., Yazaki, Y., Shibata, Y., Kadowaki, T., Hirai, H. (1996) The extracellular signal-regulated kinase pathway phosphorylates AML1, an acute myeloid leukemia gene product, and potentially regulates its transactivation ability. Mol. Cell. Biol. 16, 3967-3979. (Pubitemid 26199916)
44. Nie, L., Xu, M., Vladimirova, A., Sun, X. (2003) Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities. EMBO J. 22, 5780-5792. (Pubitemid 37408817)
45. Murphy, L. O., Smith, S., Chen, R., Fingar, D. C., Blenis, J. (2002) Molecular interpretation of ERK signal duration by immediate early gene products. Nat. Cell Biol. 4, 556-564. (Pubitemid 34905594)
46. Alvarez, E., Northwood, I. C., Gonzalez, F. A., Latour, D. A., Seth, A., Abate, C., Curran, T., Davis, R. J. (1991) Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase. J. Biol. Chem. 266, 15277-15285. (Pubitemid 21907645)
47. Young, M. R., Nair, R., Bucheimer, N., Tulsian, P., Brown, N., Chapp, C., Hsu, T., Colburn, N. H. (2002) Transactivation of Fra-1 and consequent activation of AP-1 occur extracellular signal-regulated kinase dependently. Mol. Cell. Biol. 22, 587-598. (Pubitemid 34027503)
48. Chung, J., Uchida, E., Grammer, T. C., Blenis, J. (1997) STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation. Mol. Cell. Biol. 17, 6508-6516. (Pubitemid 27451197)
49. Winkler, D. G., Park, I., Kim, T., Payne, N. S., Walsh, C. T., Strominger, J. L., Shin, J. (1993) Phosphorylation of Ser-42 and Ser-59 in the N-terminal region of the tyrosine kinase p56lck. Proc. Natl. Acad. Sci. USA 90, 5176-5180. (Pubitemid 23183000)
50. Sturgill, T. W., Ray, L. B., Erikson, E., Maller, J. L. (1988) Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II. Nature 334, 715-718. (Pubitemid 18197572)
51. Deak, M., Clifton, A. D., Lucocq, L. M., Alessi, D. R. (1998) Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. EMBO J. 17, 4426-4441. (Pubitemid 28362632)
52. Fukunaga, R., Hunter, T. (1997) MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. EMBO J. 16, 1921-1933. (Pubitemid 27170953)
53. Ku, H., Meier, K. E. (2000) Phosphorylation of paxillin via the ERK mitogen- activated protein kinase cascade in EL4 thymoma cells. J. Biol. Chem. 275, 11333-11340. (Pubitemid 30212783)
54. Glading, A., Bodnar, R. J., Reynolds, I. J., Shiraha, H., Satish, L., Potter, D. A., Blair, H. C., Wells, A. (2004) Epidermal growth factor activates m-calpain (calpain II), at least in part, by extracellular signal-regulated kinase-mediated phosphorylation. Mol. Cell. Biol. 24, 2499-2512. (Pubitemid 38326004)
55. Northwood, I. C., Gonzalez, F. A., Wartmann, M., Raden, D. L., Davis, R. J. (1991) Isolation and characterization of two growth factor-stimulated protein kinases that phosphorylate the epidermal growth factor receptor at threonine 669. J. Biol. Chem. 266, 15266-15276. (Pubitemid 21907644)
56. Scheid, M. P., Schubert, K. M., Duronio, V. (1999) Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase. J. Biol. Chem. 274, 31108-31113. (Pubitemid 129576867)
57. Das, D., Pintucci, G., Stern, A. (2000) MAPK-dependent expression of p21(WAF) and p27(kip1) in PMA-induced differentiation of HL60 cells. FEBS Lett. 472, 50-52. (Pubitemid 30224584)
58. Kawada, M., Yamagoe, S., Murakami, Y., Suzuki, K., Mizuno, S., Uehara, Y. (1997) Induction of p27Kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathway. Oncogene 15, 629-637. (Pubitemid 27389926)
59. Garnovskaya, M. N., Mukhin, Y. V., Vlasova, T. M., Grewal, J. S., Ullian, M. E., Tholanikunnel, B. G., Raymond, J. R. (2004) Mitogen-induced rapid phosphorylation of serine 795 of the retinoblastoma gene product in vascular smooth muscle cells involves ERK activation. J. Biol. Chem. 279, 24899-24905.
60. Pulverer, B. J., Kyriakis, J. M., Avruch, J., Nikolakaki, E., Woodgett, J. R. (1991) Phosphorylation of c-jun mediated by MAP kinases. Nature 353, 670-674. (Pubitemid 21912588)
61. Gupta, S., Campbell, D., Dérijard, B., Davis, R. J. (1995) Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science 267, 389-393.
62. Whitmarsh, A. J., Shore, P., Sharrocks, A. D., Davis, R. J. (1995) Integration of MAP kinase signal transduction pathways at the serum response element. Science 269, 403-407.
63. Cai, Y., Lechner, M. S., Nihalani, D., Prindle, M. J., Holzman, L. B., Dressler, G. R. (2002) Phosphorylation of Pax2 by the c-Jun N-terminal kinase and enhanced Pax2-dependent transcription activation. J. Biol. Chem. 277, 1217-1222. (Pubitemid 34968871)
64. Buschmann, T., Potapova, O., Bar-Shira, A., Ivanov, V. N., Fuchs, S. Y., Henderson, S., Fried, V. A., Minamoto, T., Alarcon-Vargas, D., Pincus, M. R., Gaarde, W. A., Holbrook, N. J., Shiloh, Y., Ronai, Z. (2001) Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress. Mol. Cell. Biol. 21, 2743-2754. (Pubitemid 32244919)
65. Alarcon-Vargas, D., Ronai, Z. (2004) c-Jun-NH2 kinase (JNK) contributes to the regulation of c-Myc protein stability. J. Biol. Chem. 279, 5008-5016. (Pubitemid 38199097)
66. Zhang, T., Ma, J., Cao, X. (2003) Grb2 regulates Stat3 activation negatively in epidermal growth factor signaling. Biochem. J. 376, 457-464. (Pubitemid 38010531)
67. Essers, M. A. G., Weijzen, S., de Vries-Smits, A. M. M., Saarloos, I., de Ruiter, N. D., Bos, J. L., Burgering, B. M. T. (2004) FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK. EMBO J. 23, 4802-4812. (Pubitemid 40069710)
68. Chow, C. W., Rincón, M., Cavanagh, J., Dickens, M., Davis, R. J. (1997) Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway. Science 278, 1638-1641. (Pubitemid 27516286)
69. Chang, L., Jones, Y., Ellisman, M. H., Goldstein, L. S. B., Karin, M. (2003) JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins. Dev. Cell 4, 521-533. (Pubitemid 36437559)
70. Kim, B. J., Ryu, S., Song, B. (2006) JNK- and p38 kinase-mediated phosphorylation of Bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells. J. Biol. Chem. 281, 21256-21265. (Pubitemid 44115465)
71. Putcha, G. V., Le, S., Frank, S., Besirli, C. G., Clark, K., Chu, B., Alix, S., Youle, R. J., LaMarche, A., Maroney, A. C., Johnson Jr., E. M. (2003) JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis. Neuron 38, 899-914.
72. Jiang, Y., Chen, C., Li, Z., Guo, W., Gegner, J. A., Lin, S., Han, J. (1996) Characterization of the structure and function of a new mitogen-activated protein kinase (p38β). J. Biol. Chem. 271, 17920-17926. (Pubitemid 26250772)
73. Visconti, R., Gadina, M., Chiariello, M., Chen, E. H., Stancato, L. F., Gutkind, J. S., O'Shea, J. J. (2000) Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity. Blood 96, 1844-1852. (Pubitemid 30662111)
74. Yang, S. H., Whitmarsh, A. J., Davis, R. J., Sharrocks, A. D. (1998) Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1. EMBO J. 17, 1740-1749. (Pubitemid 28119127)
75. Tanos, T., Marinissen, M. J., Leskow, F. C., Hochbaum, D., Martinetto, H., Gutkind, J. S., Coso, O. A. (2005) Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV light. J. Biol. Chem. 280, 18842-18852. (Pubitemid 41379586)
76. Wang, X. Z., Ron, D. (1996) Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP kinase. Science 272, 1347-1349.
77. Engelman, J. A., Lisanti, M. P., Scherer, P. E. (1998) Specific inhibitors of p38 mitogen-activated protein kinase block 3T3-L1 adipogenesis. J. Biol. Chem. 273, 32111-32120. (Pubitemid 29177155)
78. Rouse, J., Cohen, P., Trigon, S., Morange, M., Alonso-Llamazares, A., Zamanillo, D., Hunt, T., Nebreda, A. R. (1994) A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell 78, 1027-1037. (Pubitemid 24292330)
79. Lavoie, J. N., L'Allemain, G., Brunet, A., Müller, R., Pouysségur, J. (1996) Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway. J. Biol. Chem. 271, 20608-20616. (Pubitemid 26281839)
80. Freshney, N. W., Rawlinson, L., Guesdon, F., Jones, E., Cowley, S., Hsuan, J., Saklatvala, J. (1994) Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27. Cell 78, 1039-1049. (Pubitemid 24292331)
81. Sanchez-Prieto, R., Rojas, J. M., Taya, Y., Gutkind, J. S. (2000) A role for the p38 mitogen-acitvated protein kinase pathway in the transcriptional activation of p53 on genotoxic stress by chemotherapeutic agents. Cancer Res. 60, 2464-2472. (Pubitemid 30262438)
82. McCubrey, J. A., Steelman, L. S., Chappell, W. H., Abrams, S. L., Wong, E. W. T., Chang, F., Lehmann, B., Terrian, D. M., Milella, M., Tafuri, A., Stivala, F., Libra, M., Basecke, J., Evangelisti, C., Martelli, A. M., Franklin, R. A. (2007) Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. Biochim. Biophys. Acta 1773, 1263-1284. (Pubitemid 47125967)
83. Chambard, J. C., Lefloch, R., Pouysségur, J., Lenormand, P. (2007) ERK implication in cell cycle regulation. Biochim. Biophys. Acta 1773, 1299-1310. (Pubitemid 47125974)
84. Pagès, G., Guérin, S., Grall, D., Bonino, F., Smith, A., Anjuere, F., Auberger, P., Pouysségur, J. (1999) Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice. Science 286, 1374-1377. (Pubitemid 129516242)
85. Saba-El-Leil, M. K., Vella, F. D. J., Vernay, B., Voisin, L., Chen, L., Labrecque, N., Ang, S., Meloche, S. (2003) An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development. EMBO Rep. 4, 964-968. (Pubitemid 37407464)
86. Yao, Y., Li, W., Wu, J., Germann, U. A., Su, M. S. S., Kuida, K., Boucher, D. M. (2003) Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation. Proc. Natl. Acad. Sci. USA 100, 12759-12764. (Pubitemid 37339972)
87. Sabapathy, K., Kallunki, T., David, J. P., Graef, I., Karin, M., Wagner, E. F. (2001) c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation. J. Exp. Med. 193, 317-328. (Pubitemid 32524515)
88. Dong, C., Yang, D. D., Wysk, M., Whitmarsh, A. J., Davis, R. J., Flavell, R. A. (1998) Defective T cell differentiation in the absence of Jnk1. Science 282, 2092-2095. (Pubitemid 29001267)
89. Kuan, C. Y., Yang, D. D., Samanta Roy, D. R., Davis, R. J., Rakic, P., Flavell, R. A. (1999) The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron 22, 667-676. (Pubitemid 29203491)
90. Yang, D. D., Kuan, C. Y., Whitmarsh, A. J., Rincón, M., Zheng, T. S., Davis, R. J., Rakic, P., Flavell, R. A. (1997) Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature 389, 865-870. (Pubitemid 27462982)
91. Mudgett, J. S., Ding, J., Guh-Siesel, L., Chartrain, N. A., Yang, L., Gopal, S., Shen, M. M. (2000) Essential role for p38α mitogen-activated protein kinase in placental angiogenesis. Proc. Natl. Acad. Sci. USA 97, 10454-10459. (Pubitemid 30707287)
92. Tamura, K., Sudo, T., Senftleben, U., Dadak, A. M., Johnson, R., Karin, M. (2000) Requirement for p38α in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell 102, 221-231.
93. Beardmore, V. A., Hinton, H. J., Eftychi, C., Apostolaki, M., Armaka, M., Darragh, J., McIlrath, J., Carr, J. M., Armit, L. J., Clacher, C., Malone, L., Kollias, G., Arthur, J. S. (2005) Generation and characterization of p38α (MAPK11) gene-targeted mice. Mol. Cell. Biol. 25, 10454-10464. (Pubitemid 41681967)
94. Sabio, G., Arthur, J. S. C., Kuma, Y., Peggie, M., Carr, J., Murray-Tait, V., Centeno, F., Goedert, M., Morrice, N. A., Cuenda, A. (2005) p38γ regulates the localization of SAP97 in the cytoskeleton by modulating its interaction with GKAP. EMBO J. 24, 1134-1145. (Pubitemid 40516597)
95. Krens, S. F. G., Spaink, H. P., Snaar-Jagalska, B. E. (2006) Functions of the MAPK family in vertebrate-development. FEBS Lett. 580, 4984-4990.
96. Hatano, N., Mori, Y., Oh-hora, M., Kosugi, A., Fujikawa, T., Nakai, N., Niwa, H., Miyazaki, J., Hamaoka, T., Ogata, M. (2003) Essential role for ERK2 mitogen-activated protein kinase in placental development. Genes Cells 8, 847-856. (Pubitemid 37428014)
97. Racke, F. K., Lewandowska, K., Goueli, S., Goldfarb, A. N. (1997) Sustained activation of the extracellular signal-regulated kinase/mitogen- activated protein kinase pathway is required for megakaryocytic differentiation of K562 cells. J. Biol. Chem. 272, 23366-23370. (Pubitemid 27392477)
98. Matsuzaki, T., Aisaki, K. I., Yamamura, Y., Noda, M., Ikawa, Y. (2000) Induction of erythroid differentiation by inhibition of Ras/ERK pathway in a friend murine leukemia cell line. Oncogene 19, 1500-1508. (Pubitemid 30175671)
99. Miranda, M. B., Xu, H., Torchia, J. A., Johnson, D. E. (2005) Cytokine-induced myeloid differentiation is dependent on activation of the MEK/ERK pathway. Leuk. Res. 29, 1293-1306. (Pubitemid 41297642)
100. Whalen, A. M., Galasinski, S. C., Shapiro, P. S., Nahreini, T. S., Ahn, N. G. (1997) Megakaryocytic differentiation induced by constitutive activation of mitogen-activated protein kinase kinase. Mol. Cell. Biol. 17, 1947-1958. (Pubitemid 27133279)
101. Herrera, R., Hubbell, S., Decker, S., Petruzzelli, L. (1998) A role for the MEK/MAPK pathway in PMA-induced cell cycle arrest: modulation of megakaryocytic differentiation of K562 cells. Exp. Cell Res. 238, 407-414. (Pubitemid 28372828)
102. Shelly, C., Petruzzelli, L., Herrera, R. (1998) PMA-induced phenotypic changes in K562 cells: MAPK-dependent and -independent events. Leukemia 12, 1951-1961. (Pubitemid 28554468)
103. Hu, X., Moscinski, L. C., Valkov, N. I., Fisher, A. B., Hill, B. J., Zuckerman, K. S. (2000) Prolonged activation of the mitogen-activated protein kinase pathway is required for macrophage-like differentiation of a human myeloid leukemic cell line. Cell Growth Differ. 11, 191-200. (Pubitemid 30211008)
104. Miranda, M. B., McGuire, T. F., Johnson, D. E. (2002) Importance of MEK-1/-2 signaling in monocytic and granulocytic differentiation of myeloid cell lines. Leukemia 16, 683-692.
105. Ross, S. E., Radomska, H. S., Wu, B., Zhang, P., Winnay, J. N., Bajnok, L., Wright, W. S., Schaufele, F., Tenen, D. G., MacDougald, O. A. (2004) Phosphorylation of C/EBPα inhibits granulopoiesis. Mol. Cell. Biol. 24, 675-686.
106. Hsu, C. L., Kikuchi, K., Kondo, M. (2007) Activation of mitogen-activated protein kinase kinase (MEK)/extracellular signal regulated kinase (ERK) signaling pathway is involved in myeloid lineage commitment. Blood 110, 1420-1428. (Pubitemid 47443956)
107. Hernandez-Hernandez, A., Ray, P., Litos, G., Ciro, M., Ottolenghi, S., Beug, H., Boyes, J. (2006) Acetylation and MAPK phosphorylation cooperate to regulate the degradation of active GATA-1. EMBO J. 25, 3264-3274. (Pubitemid 44141785)
108. Harigae, H. (2006) GATA transcription factors and hematological diseases. Tohoku J. Exp. Med. 210, 1-9. (Pubitemid 44377783)
109. Tang, T., Prasad, K. S., Koury, M. J., Brandt, S. J. (1999) Mitogen-activated protein kinase mediates erythropoietin-induced phosphorylation of the TAL1/SCL transcription factor in murine proerythroblasts. Biochem. J. 343, 615-620. (Pubitemid 29537373)
110. Cheng, J. T., Cobb, M. H., Baer, R. (1993) Phosphorylation of the TAL1 oncoprotein by the extracellular-signal-regulated protein kinase ERK1. Mol. Cell. Biol. 13, 801-808. (Pubitemid 23040245)
111. Burdon, T., Smith, A., Savatier, P. (2002) Signaling, cell cycle and pluripotency in embryonic stem cells. Trends Cell Biol. 12, 432-438. (Pubitemid 35239952)
112. Binétruy, B., Heasley, L., Bost, F., Caron, L., Aouadi, M. (2007) Concise review: regulation of embryonic stem cell lineage commitment by mitogen-activated protein kinases. Stem Cells 25, 1090-1095. (Pubitemid 46684867)
113. Kunath, T., Saba-El-Leil, M. K., Almousailleakh, M., Wray, J., Meloche, S., Smith, A. (2007) FGF stimulation of the Erk1/2 signaling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment. Development 134, 2895-2902. (Pubitemid 47386902)
114. Kamata, T., Kang, J., Lee, T., Wojnowski, L., Pritchard, C. A., Leavitt, A. D. (2005) A critical function for B-Raf at multiple stages of myelopoiesis. Blood 106, 833-840. (Pubitemid 41076422)
115. Mori, M., Uchida, M., Watanabe, T., Kirito, K., Hatake, K., Ozawa, K., Komatsu, N. (2003) Activation of extracellular signal-regulated kinases ERK1 and ERK2 induces Bcl-xL up-regulation via inhibition of caspase activities in erythropoietin signaling. J. Cell. Physiol. 195, 290-297. (Pubitemid 36384302)
116. Elorza, A., Hyde, B., Mikkola, H. K., Collins, S., Shirihai, O. S. (2008) UCP2 modulates cell proliferation through the MAPK/ERK pathway during erythropoiesis and has no effect on heme biosynthesis. J. Biol. Chem. 283, 30461-30470.
117. Secchiero, P., Melloni, E., Heikinheimo, M., Mannisto, S., Di Pietro, R., Iacone, A., Zauli, G. (2004) TRAIL regulates normal erythroid maturation through an ERK-dependent pathway. Blood 103, 517-522. (Pubitemid 38140081)
118. Dérijard, B., Hibi, M., Wu, I. H., Barrett, T., Su, B., Deng, T., Karin, M., Davis, R. J. (1994) JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76, 1025-1037. (Pubitemid 24106383)
119. Kallunki, T., Su, B., Tsigelny, I., Sluss, H. K., Dérijard, B., Moore, G., Davis, R., Karin, M. (1994) JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. Genes Dev. 8, 2996-3007.
120. Sluss, H. K., Barrett, T., Dérijard, B., Davis, R. J. (1994) Signal transduction by tumor necrosis factor mediated by JNK protein kinases. Mol. Cell. Biol. 14, 8376-8384. (Pubitemid 24373586)
121. Gupta, S., Barrett, T., Whitmarsh, A. J., Cavanagh, J., Sluss, H. K., Dérijard, B., Davis, R. J. (1996) Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J. 15, 2760-2770. (Pubitemid 26176253)
122. Wang, X., Destrument, A., Tournier, C. (2007) Physiological roles of MKK4 and MKK7: insights from animal models. Biochim. Biophys. Acta 1773, 1349-1357. (Pubitemid 47125970)
123. Tournier, C., Hess, P., Yang, D. D., Xu, J., Turner, T. K., Nimnual, A., Bar-Sagi, D., Jones, S. N., Flavell, R. A., Davis, R. J. (2000) Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science 288, 870-874. (Pubitemid 30257738)
124. Behrens, A., Sibilia, M., Wagner, E. F. (1999) Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation. Nat. Genet. 21, 326-329. (Pubitemid 29124945)
125. Jacobs-Helber, S. M., Ryan, J. J., Sawyer, S. T. (2000) JNK and p38 are activated by erythropoietin (EPO) but are not induced in apoptosis following EPO withdrawal in EPO-dependent HCD57 cells. Blood 96, 933-940.
126. Foltz, I. N., Schrader, J. W. (1997) Activation of the stress-activated protein kinases by multiple hematopoietic growth factors with the exception of interleukin-4. Blood 89, 3092-3096.
127. Nagata, Y., Nishida, E., Todokoro, K. (1997) Activation of JNK signaling pathway by erythropoietin, thrombopoietin, and interleukin-3. Blood 89, 2664-2669. (Pubitemid 27172550)
128. Nagata, Y., Takahashi, N., Davis, R. J., Todokoro, K. (1998) Activation of p38 MAP kinase and JNK but not ERK is required for erythropoietin-induced erythroid differentiation. Blood 92, 1859-1869. (Pubitemid 28446674)
129. Jacobs-Helber, S. M., Sawyer, S. T. (2004) Jun N-terminal kinase promotes proliferation of immature erythroid cells and erythropoietin-dependent cell lines. Blood 104, 696-703.
130. Bonnesen, B., Orskov, C., Rasmussen, S., Holst, P. J., Christensen, J. P., Eriksen, K. W., Qvortrup, K., Odum, N., Labuda, T. (2005) MEK kinase 1 activity is required for definitive erythropoiesis in the mouse fetal liver. Blood 106, 3396-3404. (Pubitemid 41609173)
131. Jacobs-Helber, S. M., Wickrema, A., Birrer, M. J., Sawyer, S. T. (1998) AP1 regulation of proliferation and initiation of apoptosis in erythropoietin- dependent erythroid cells. Mol. Cell. Biol. 18, 3699-3707. (Pubitemid 28287891)
132. Trivedi, A. K., Bararia, D., Christopeit, M., Peerzada, A. A., Singh, S. M., Kieser, A., Hiddemann, W., Behre, H. M., Behre, G. (2007) Proteomic identification of C/EBP-DBD multiprotein complex: JNK1 activates stem cell regulator C/EBPα by inhibiting its ubiquitination. Oncogene 26, 1789-1801. (Pubitemid 46426194)
133. Zhang, D. E., Zhang, P., Wang, N. D., Hetherington, C. J., Darlington, G. J., Tenen, D. G. (1997) Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein α-deficient mice. Proc. Natl. Acad. Sci. USA 94, 569-574. (Pubitemid 27053674)
134. Radomska, H. S., Huettner, C. S., Zhang, P., Cheng, T., Scadden, D. T., Tenen, D. G. (1998) CCAAT/enhancer binding protein α is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors. Mol. Cell. Biol. 18, 4301-4314. (Pubitemid 28287953)
135. Cai, D. H., Wang, D., Keefer, J., Yeamans, C., Hensley, K., Friedman, A. D. (2008) C/EBP α:AP-1 leucine zipper heterodimers bind novel DNA elements, activate the PU.1 promoter and direct monocyte lineage commitment more potently than C/EBP α homodimers or AP-1. Oncogene 27, 2772-2779. (Pubitemid 351581472)
136. Reddy, V. A., Iwama, A., Iotzova, G., Schulz, M., Elsasser, A., Vangala, R. K., Tenen, D. G., Hiddemann, W., Behre, G. (2002) Granulocyte inducer C/EBPα inactivates the myeloid master regulator PU.1: possible role in lineage commitment decisions. Blood 100, 483-490. (Pubitemid 34761110)
137. Sasaki, T., Wada, T., Kishimoto, H., Irie-Sasaki, J., Matsumoto, G., Goto, T., Yao, Z., Wakeham, A., Mak, T. W., Suzuki, A., Cho, S. K., Zuniga- Pflucker, J. C., Oliveira-dos-Santos, A. J., Katada, T., Nishina, H., Penninger, J. M. (2001) The stress kinase mitogen-activated protein kinase kinase (MKK)7 is a negative regulator of antigen receptor and growth factor receptor-induced proliferation in hematopoietic cells. J. Exp. Med. 194, 757-768. (Pubitemid 32983012)
138. Takekawa, M., Saito, H. (1998) A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAP-KKK. Cell 95, 521-530. (Pubitemid 28533308)
139. Gupta, S. K., Gupta, M., Hoffman, B., Liebermann, D. A. (2006) Hematopoietic cells from gadd45a-deficient and gadd45b-deficient mice exhibit impaired stress responses to acute stimulation with cytokines, myeloablation and inflammation. Oncogene 25, 5537-5546. (Pubitemid 44344104)
140. Arnold, R., Frey, C. R., Müller, W., Brenner, D., Krammer, P. H., Kiefer, F. (2007) Sustained JNK signaling by proteolytically processed HPK1 mediates IL-3 independent survival during monocytic differentiation. Cell Death Differ. 14, 568-575. (Pubitemid 46259964)
141. Xu, B., Bhattacharjee, A., Roy, B., Xu, H., Anthony, D., Frank, D. A., Feldman, G. M., Cathcart, M. K. (2003) Interleukin-13 induction of 15- lipoxygenase gene expression requires p38 mitogen-activated protein kinase-mediated serine 727 phosphorylation of Stat1 and Stat3. Mol. Cell. Biol. 23, 3918-3928. (Pubitemid 36597470)
142. Nebreda, A. R., Porras, A. (2000) p38 MAP kinases: beyond the stress response. Trends Biochem. Sci. 25, 257-260.
143. Ono, K., Han, J. (2000) The p38 signal transduction pathway: activation and function. Cell. Signal. 12, 1-13. (Pubitemid 30017963)
144. Adams, R. H., Porras, A., Alonso, G., Jones, M., Vintersten, K., Panelli, S., Valladares, A., Perez, L., Klein, R., Nebreda, A. R. (2000) Essential role of p38α MAP kinase in placental but not embryonic cardiovascular development. Mol. Cell 6, 109-116.
145. Kuida, K., Boucher, D. M. (2004) Functions of MAP kinases: insights from gene-targeting studies. J. Biochem. 135, 653-656. (Pubitemid 38899711)
146. Arai, H., Maki, K., Waga, K., Sasaki, K., Nakamura, Y., Imai, Y., Kurokawa, M., Hirai, H., Mitani, K. (2002) Functional regulation of TEL by p38-induced phosphorylation. Biochem. Biophys. Res. Commun. 299, 116-125. (Pubitemid 35366043)
147. Wang, L. C., Swat, W., Fujiwara, Y., Davidson, L., Visvader, J., Kuo, F., Alt, F. W., Gilliland, D. G., Golub, T. R., Orkin, S. H. (1998) The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow. Genes Dev. 12, 2392-2402. (Pubitemid 28371358)
148. Nagata, Y., Todokoro, K. (1999) Requirement of activation of JNK and p38 for environmental stress-induced erythroid differentiation and apoptosis and of inhibition of ERK for apoptosis. Blood 94, 853-863. (Pubitemid 29361815)
149. Park, J. I., Choi, H. S., Jeong, J. S., Han, J. Y., Kim, I. H. (2001) Involvement of p38 kinase in hydroxyurea-induced differentiation of K562 cells. Cell Growth Differ. 12, 481-486. (Pubitemid 32906093)
150. Somervaille, T. C. P., Linch, D. C., Khwaja, A. (2003) Different levels of p38 MAP kinase activity mediate distinct biological effects in primary human erythroid progenitors. Br. J. Haematol. 120, 876-886.
151. Witt, O., Sand, K., Pekrun, A. (2000) Butyrate-induced erythroid differentiation of human K562 leukemia cells involves inhibition of ERK and activation of p38 MAP kinase pathways. Blood 95, 2391-2396. (Pubitemid 30167741)
152. Buck, I., Morceau, F., Cristofanon, S., Heintz, C., Chateauvieux, S., Reuter, S., Dicato, M., Diederich, M. (2008) Tumor necrosis factor α inhibits erythroid differentiation in human erythropoietin-dependent cells involving p38 MAPK pathway, GATA-1 and FOG-1 downregulation and GATA-2 upregulation. Biochem. Pharmacol. 76, 1229-1239.
153. Davies, S. P., Reddy, H., Caivano, M., Cohen, P. (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J. 351, 95-105. (Pubitemid 30781561)
154. Nagata, Y., Moriguchi, T., Nishida, E., Todokoro, K. (1997) Activation of p38 map kinase pathway by erythropoietin and interleukin-3. Blood 90, 929-934. (Pubitemid 27314124)
155. Uddin, S., Ah-Kang, J., Ulaszek, J., Mahmud, D., Wickrema, A. (2004) Differentiation stage-specific activation of p38 mitogen-activated protein kinase isoforms in primary human erythroid cells. Proc. Natl. Acad. Sci. USA 101, 147-152. (Pubitemid 38084218)
156. Katsoulidis, E., Li, Y., Yoon, P., Sassano, A., Altman, J., Kannan-Thulasiraman, P., Balasubramanian, L., Parmar, S., Varga, J., Tallman, M. S., Verma, A., Platanias, L. C. (2005) Role of the p38 mitogen-activated protein kinase pathway in cytokine-mediated hematopoietic suppression in myelodysplastic syndromes. Cancer Res. 65, 9029-9037. (Pubitemid 41377395)
157. Navas, T. A., Mohindru, M., Estes, M., Ma, J. Y., Sokol, L., Pahanish, P., Parmar, S., Haghnazari, E., Zhou, L., Collins, R., Kerr, I., Nguyen, A. N., Xu, Y., Platanias, L. C., List, A. A., Higgins, L. S., Verma, A. (2006) Inhibition of overactivated p38 MAPK can restore hematopoiesis in myelodysplastic syndrome progenitors. Blood 108, 4170-4177. (Pubitemid 44913289)
158. Verma, A., Deb, D. K., Sassano, A., Uddin, S., Varga, J., Wickrema, A., Platanias, L. C. (2002) Activation of the p38 mitogen-activated protein kinase mediates the suppressive effects of type I interferons and transforming growth factor-β on normal hematopoiesis. J. Biol. Chem. 277, 7726-7735. (Pubitemid 34968219)
159. Li, Y., Sassano, A., Majchrzak, B., Deb, D. K., Levy, D. E., Gaestel, M., Nebreda, A. R., Fish, E. N., Platanias, L. C. (2004) Role of p38α Map kinase in type I interferon signaling. J. Biol. Chem. 279, 970-979. (Pubitemid 38082618)
160. Kale, V. P. (2004) Differential activation of MAPK signaling pathways by TGF-β1 forms the molecular mechanism behind its dose-dependent bidirectional effects on hematopoiesis. Stem Cells Dev. 13, 27-38.
161. Gibson, F. M., Scopes, J., Daly, S., Ball, S., Gordon-Smith, E. C. (1995) Hemopoietic growth factor production by normal and aplastic anaemia stroma in long-term bone marrow culture. Br. J. Haematol. 91, 551-561.
162. Scicchitano, M. S., McFarland, D. C., Tierney, L. A., Boyce, R. W., Frazier, K. S., Schwartz, L. W., Thomas, H. C. (2008) Role of p38 in regulation of hematopoiesis: effect of p38 inhibition on cytokine production and transcription factor activity in human bone marrow stromal cells. Blood Cells Mol. Dis. 40, 370-380.
163. Weissman, I. L., Anderson, D. J., Gage, F. (2001) Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations. Annu. Rev. Cell Dev. Biol. 17, 387-403.
164. Ito, K., Hirao, A., Arai, F., Takubo, K., Matsuoka, S., Miyamoto, K., Ohmura, M., Naka, K., Hosokawa, K., Ikeda, Y., Suda, T. (2006) Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells. Nat. Med. 12, 446-451.
165. Jang, Y. Y., Sharkis, S. J. (2007) A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche. Blood 110, 3056-3063.
166. Oostendorp, R. A. J., Gilfillan, S., Parmar, A., Schiemann, M., Marz, S., Niemeyer, M., Schill, S., Hammerschmid, E., Jacobs, V. R., Peschel, C., Götze, K. S. (2008) Oncostatin M-mediated regulation of KIT-ligand-induced extracellular signal-regulated kinase signaling maintains hematopoietic repopulating activity of Lin-CD34+CD133+ cord blood cells. Stem Cells 26, 2164-2172.
167. Platanias, L. C. (2003) Map kinase signaling pathways and hematologic malignancies. Blood 101, 4667-4679. (Pubitemid 36857719)
168. Johnson, D. E. (2008) Src family kinases and the MEK/ERK pathway in the regulation of myeloid differentiation and myeloid leukemogenesis. Adv. Enzyme Regul. 48, 98-112.
169. Morgan, M. A., Dolp, O., Reuter, C. W. (2001) Cell-cycle-dependent activation of mitogen-activated protein kinase kinase (MEK-1/2) in myeloid leukemia cell lines and induction of growth inhibition and apoptosis by inhibitors of RAS signaling. Blood 97, 1823-1834. (Pubitemid 32217252)
170. Siendones, E., Barbarroja, N., Torres, L. A., Buendía, P., Velasco, F., Dorado, G., Torres, A., López-Pedrera, C. (2007) Inhibition of Flt3-activating mutations does not prevent constitutive activation of ERK/Akt/STAT pathways in some AML cells: a possible cause for the limited effectiveness of monotherapy with small-molecule inhibitors. Hematol. Oncol. 25, 30-37. (Pubitemid 46474312)
171. Towatari, M., Iida, H., Tanimoto, M., Iwata, H., Hamaguchi, M., Saito, H. (1997) Constitutive activation of mitogen-activated protein kinase pathway in acute leukemia cells. Leukemia 11, 479-484. (Pubitemid 27173933)
172. Milella, M., Kornblau, S. M., Estrov, Z., Carter, B. Z., Lapillonne, H., Harris, D., Konopleva, M., Zhao, S., Estey, E., Andreeff, M. (2001) Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia. J. Clin. Invest. 108, 851-859. (Pubitemid 32880294)
173. Hoyle, P. E., Moye, P. W., Steelman, L. S., Blalock, W. L., Franklin, R. A., Pearce, M., Cherwinski, H., Bosch, E., McMahon, M., McCubrey, J. A. (2000) Differential abilities of the Raf family of protein kinases to abrogate cytokine dependency and prevent apoptosis in murine hematopoietic cells by a MEK1-dependent mechanism. Leukemia 14, 642-656. (Pubitemid 30195455)
174. Lunghi, P., Tabilio, A., Dall'Aglio, P. P., Ridolo, E., Carlo-Stella, C., Pelicci, P. G., Bonati, A. (2003) Downmodulation of ERK activity inhibits the proliferation and induces the apoptosis of primary acute myelogenous leukemia blasts. Leukemia 17, 1783-1793. (Pubitemid 37185254)
175. Milella, M., Konopleva, M., Precupanu, C. M., Tabe, Y., Ricciardi, M. R., Gregorj, C., Collins, S. J., Carter, B. Z., D'Angelo, C., Petrucci, M. T., Foà, R., Cognetti, F., Tafuri, A., Andreeff, M. (2007) MEK blockade converts AML differentiating response to retinoids into extensive apoptosis. Blood 109, 2121-2129. (Pubitemid 46348214)
176. Kerr, A. H. J., James, J. A., Smith, M. A., Willson, C., Court, E. L., Smith, J. G. (2003) An investigation of the MEK/ERK inhibitor U0126 in acute myeloid leukemia. Ann. N. Y. Acad. Sci. 1010, 86-89. (Pubitemid 38264955)
177. James, J. A., Smith, M. A., Court, E. L., Yip, C., Ching, Y., Willson, C., Smith, J. G. (2003) An investigation of the effects of the MEK inhibitor U0126 on apoptosis in acute leukemia. Hematol. J. 4, 427-432. (Pubitemid 38088788)
178. Radomska, H. S., Bassères, D. S., Zheng, R., Zhang, P., Dayaram, T., Yamamoto, Y., Sternberg, D. W., Lokker, N., Giese, N. A., Bohlander, S. K., Schnittger, S., Delmotte, M. H., Davis, R. J., Small, D., Hiddemann, W., Gilliland, D. G., Tenen, D. G. (2006) Block of C/EBP α function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations. J. Exp. Med. 203, 371-381. (Pubitemid 43290846)
179. Yu, C., Krystal, G., Varticovksi, L., McKinstry, R., Rahmani, M., Dent, P., Grant, S. (2002) Pharmacologic mitogen-activated protein/extracellular signal-regulated kinase kinase/mitogen-activated protein kinase inhibitors interact synergistically with STI571 to induce apoptosis in Bcr/Abl-expressing human leukemia cells. Cancer Res. 62, 188-199. (Pubitemid 34074004)
180. Nguyen, T. K., Rahmani, M., Harada, H., Dent, P., Grant, S. (2007) MEK1/2 inhibitors sensitize Bcr/Abl+ human leukemia cells to the dual Abl/Src inhibitor BMS-354/825. Blood 109, 4006-4015. (Pubitemid 46641754)
181. Boucher, M. J., Morisset, J., Vachon, P. H., Reed, J. C., Lainé, J., Rivard, N. (2000) MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-X(L), and Mcl-1 and promotes survival of human pancreatic cancer cells. J. Cell. Biochem. 79, 355-369. (Pubitemid 30797131)
182. Willis, S. N., Chen, L., Dewson, G., Wei, A., Naik, E., Fletcher, J. I., Adams, J. M., Huang, D. C. S. (2005) Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Genes Dev. 19, 1294-1305. (Pubitemid 41003019)
183. Harada, H., Quearry, B., Ruiz-Vela, A., Korsmeyer, S. J. (2004) Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity. Proc. Natl. Acad. Sci. USA 101, 15313-15317. (Pubitemid 39441538)
184. Bulavin, D. V., Phillips, C., Nannenga, B., Timofeev, O., Donehower, L. A., Anderson, C. W., Appella, E., Fornace, A. J. J. (2004) Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway. Nat. Genet. 36, 343-350. (Pubitemid 38437256)
185. Manke, I. A., Nguyen, A., Lim, D., Stewart, M. Q., Elia, A. E. H., Yaffe, M. B. (2005) MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation. Mol. Cell 17, 37-48. (Pubitemid 40075363)
186. Shahjahan, M., Dunphy, C. H., Ewton, A., Zu, Y., Monzon, F. A., Rice, L., Chang, C. (2008) p38 Mitogen-activated protein kinase has different degrees of activation in myeloproliferative disorders and myelodysplastic syndromes. Am. J. Clin. Pathol. 130, 635-641.
187. Raitano, A. B., Halpern, J. R., Hambuch, T. M., Sawyers, C. L. (1995) The Bcr-Abl leukemia oncogene activates Jun kinase and requires Jun for transformation. Proc. Natl. Acad. Sci. USA 92, 11746-11750.
188. Elsässer, A., Franzen, M., Kohlmann, A., Weisser, M., Schnittger, S., Schoch, C., Reddy, V. A., Burel, S., Zhang, D., Ueffing, M., Tenen, D. G., Hiddemann, W., Behre, G. (2003) The fusion protein AML1-ETO in acute myeloid leukemia with translocation t(8;21) induces c-jun protein expression via the proximal AP-1 site of the c-jun promoter in an indirect, JNK-dependent manner. Oncogene 22, 5646-5657. (Pubitemid 37102701)
189. Hartman, A. D., Wilson-Weekes, A., Suvannasankha, A., Burgess, G. S., Phillips, C. A., Hincher, K. J., Cripe, L. D., Boswell, H. S. (2006) Constitutive c-jun N-terminal kinase activity in acute myeloid leukemia derives from Flt3 and affects survival and proliferation. Exp. Hematol. 34, 1360-1376. (Pubitemid 44374837)
190. Cripe, L. D., Gelfanov, V. M., Smith, E. A., Spigel, D. R., Phillips, C. A., Gabig, T. G., Jung, S., Fyffe, J., Hartman, A. D., Kneebone, P., Mercola, D., Burgess, G. S., Boswell, H. S. (2002) Role for c-jun N-terminal kinase in treatment-refractory acute myeloid leukemia (AML): signaling to multidrug-efflux and hyperproliferation. Leukemia 16, 799-812. (Pubitemid 34537551)
191. Lagadinou, E. D., Ziros, P. G., Tsopra, O. A., Dimas, K., Kokkinou, D., Thanopoulou, E., Karakantza, M., Pantazis, P., Spyridonidis, A., Zoumbos, N. C. (2008) c-Jun N-terminal kinase activation failure is a new mechanism of anthracycline resistance in acute myeloid leukemia. Leukemia 22, 1899-1908.