Docking interactions in the mitogen-activated protein kinase cascades

Pharmacology and Therapeutics

Volumn 93, Issue 2-3, 2002, Pages 193-202

  Tanoue, Takuji ^a   Nishida, Eisuke ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Docking interaction; MAP kinase; Phosphorylation; Specificity

Indexed keywords

ENZYME ACTIVATOR; ENZYME INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; MUTANT PROTEIN; PHOSPHATASE; MEMBRANE PROTEIN; SRPR PROTEIN, HUMAN;

CATALYSIS; CELL DIFFERENTIATION; CELL FUNCTION; CELL PROLIFERATION; CONFERENCE PAPER; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME ASSAY; ENZYME SPECIFICITY; ENZYME SUBSTRATE; MOLECULAR INTERACTION; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STRESS; ANIMAL; CLASSIFICATION; HUMAN; METABOLISM; MOLECULAR BIOLOGY; PHOSPHORYLATION; PHYSIOLOGY; REVIEW;

ANIMAL; HUMAN; MAP KINASE SIGNALING SYSTEM; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR BIOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMALS; HUMANS;

EID: 0035990913     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0163-7258(02)00188-2     Document Type: Conference Paper

References (54)

1. Molecular basis for the substrate specificity of protein kinase B; Comparison with MAPKAP kinase-1 and p70 S6 kinase
2. The mitogen-activated protein kinase activator
3. A PDK1 docking site is required for the phosphorylation of PKCζ and PRK2 by PDK1
4. A conserved motif at the amino termini of MEKs might mediate high-affinity interaction with the cognate MAPKs
5. The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB
6. A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways
7. Catalytic activation of the phosphatase MKP-3 by ERK2 mitogen-activated protein kinase
8. Dual specificity phosphatases: A gene family for control of MAP kinase function
9. The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation
10. Definition of a consensus sequence for peptide substrate recognition by p44mpk, the meiosis-activated myelin basic protein kinase
11. Interaction of MAP kinase with MAP kinase kinase: Its possible role in the control of nucleocytoplasmic transport of MAP kinase
12. MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates
13. A MAP kinase docking site is required for phosphorylation and activation of p90RSK/MAPKAPK-1
14. Identification of substrate recognition determinants for human ERK1 and ERK2 protein kinases
15. Protein modification: Docking sites for kinases
16. Signaling - 2000 and beyond
17. Signal transduction by the c-Jun N-terminal kinase (JNK) - From inflammation to development
18. Multiple docking sites on substrate proteins from a modular system that mediates recognition by ERK MAP kinase
19. C-Jun recruit JNK to phosphorylate dimerization partners via specific docking interactions
20. Protein phosphatases and the regulation of mitogen-activated protein kinase signalling
21. Protein kinase cascades activated by stress and inflammation
22. Genetic analysis of rolled, which encodes a Drosophila mitogen-activated protein kinase
23. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
24. Regulation of protein kinase cascades by protein phosphatase 2A
25. A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3
26. MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase
27. The mitogen-activated protein kinase phosphatase-3 N-terminal noncatalytic region is responsible for tight substrate binding and enzymatic specificity
28. The MAP kinase cascade is essential for diverse signal transduction pathways
29. Protein modules and signalling networks
30. Protein-protein interactions define specificity in signal transduction
31. How do protein kinases recognize their substrates?
32. PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif
33. Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA
34. Mitogen-activated protein kinase pathways
35. Mitogen-activated protein kinases: Specific messages from ubiquitous messengers
36. Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo
37. Creation of a stress-activated p90 ribosomal S6 kinase. The carboxyl-tail of the MAPK-activated protein kinases dictates the signal transduction pathway in which they function
38. Recent progress in characterization of protein kinase cascades for phosphorylation of ribosomal protein S6
39. Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5
40. A conserved docking motif in MAP kinases common to substrates, activators and regulators
41. Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions
42. A novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38α and β MAPKs
43. Regulation of transcription by MAP kinase cascades
44. The structure of mitogen-activated protein kinase p38 at 2.1-A resolution
45. Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2
46. Crystal structure of p38 mitogen-activated protein kinase
47. JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension
48. Crystal structure of JNK3: A kinase implicated in neuronal apoptosis
49. Hydrophobic as well as charged residues in both MEK1 and ERK2 are important for their proper docking
50. Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1
51. Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors
52. Atomic structure of the MAP kinase ERK2 at 2.3 A resolution
53. Multiple regions of MAP kinase phosphatase 3 are involved in its recognition and activation by ERK2
54. Interaction of mitogen-activated protein kinases with the kinase interaction motif of the tyrosine phosphatase PTP-SL provides substrate specificity and retains ERK2 in the cytoplasm