Oncostatin M-mediated regulation of KIT-ligand-induced extracellular signal-regulated kinase signaling maintains hematopoietic repopulating activity of Lin-CD34+CD133+ cord blood cells

Stem Cells

Volumn 26, Issue 8, 2008, Pages 2164-2172

  Oostendorp, Robert A J ^a   Gilfillan, Siv ^a   Parmar, Amanda ^a   Schiemann, Matthias ^a,b   Marz, Stefanie ^a   Niemeyer, Markus ^a   Schill, Sabine ^a   Hammerschmid, Edelburga ^b   Jacobs, Volker R ^a   Peschel, Christian ^a   Götze, Katharina S ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

CD34; ERK; KIT ligand; NOD SCID; Oncostatin M; Stem cell

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CD133 ANTIGEN; CD33 ANTIGEN; CD38 ANTIGEN; CD71 ANTIGEN; GLYCOPROTEIN GP 130; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN PROTEIN; ONCOSTATIN M; PROTEIN P90; S6 KINASE; STEM CELL FACTOR;

ANIMAL CELL; ARTICLE; BLOOD CELL; CD34 SELECTION; CELL ACTIVITY; CELL CULTURE; CELL DIVISION; CELL PROLIFERATION; CELL STIMULATION; CELL SUBPOPULATION; CELL SURVIVAL; COLONY FORMING CELL; DOWN REGULATION; ENZYME ACTIVATION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; MURINAE; NEWBORN; NONHUMAN; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; UMBILICAL CORD BLOOD;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD34; CULTURE MEDIA, SERUM-FREE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FETAL BLOOD; GLYCOPROTEINS; HEMATOPOIETIC STEM CELLS; HUMANS; MICE; MICE, INBRED NOD; MICE, SCID; ONCOSTATIN M; PEPTIDES; SIGNAL TRANSDUCTION; STEM CELL FACTOR; STEM CELLS;

MURINAE;

EID: 55049110732     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.2007-1049     Document Type: Article

References (52)

1. Moore KA, Lemischka IR. Stem cells and their niches. Science 2006;311:1880-1885.
2. Oostendorp RAJ, Robin C, Steinhoff C et al. Long-term maintenance of hematopoietic stem cells does not require contact with embryo-derived stromal cells in cocultures. STEM CELLS 2005;23:842-851.
3. Toksoz D, Zsebo KM, Smith KA et al. Support of human hematopoiesis in long-term bone marrow cultures by murine stromal cells selectively expressing the membrane-bound and secreted forms of the human homolog of the steel gene product, stem cell factor. Proc Natl Acad Sci USA 1992;89:7350-7354.
4. Zsebo KM, Williams DA, Geissler EN et al. Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor. Cell 1990;63:213-224.
5. Huang E, Nocka K, Beier DR et al. The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus. Cell 1990;63:225-233.
6. Okada S, Nakauchi H, Nagayoshi K et al. Enrichment and characterization of murine hematopoietic stem cells that express c-kit molecule. Blood 1991;78:1706-1712.
7. Broxmeyer HE, Hangoc G, Cooper S et al. Growth characteristics and expansion of human umbilical cord blood and estimation of its potential for transplantation in adults. Proc Natl Acad Sci USA 1992;89:4109-4113.
8. Sui X, Tsuji K, Tanaka R et al. Gp130 and c-Kit signalings synergize for ex vivo expansion of human primitive hemopoietic progenitor cells. Proc Natl Acad Sci USA 1995;92:2859-2863.
9. Keller JR, Gooya JM, Ruscetti FW. Direct synergistic effects of leukemia inhibitory factor on hematopoietic progenitor cell growth: comparison with other hematopoietins that use the gp130 receptor subunit. Blood 1996;88:863-869.
10. Reddy GP, McAuliffe CI, Pang L et al. Cytokine receptor repertoire and cytokine responsiveness of Ho(dull)/Rh(dull) stem cells with differing potentials for G1/S phase progression. Exp Hematol 2002;30:792-800.
11. Yoshida K, Taga T, Saito M et al. Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders. Proc Natl Acad Sci USA 1996;93:407-411.
12. Audet J, Miller CL, Rose-John S et al. Distinct role of gp130 activation in promoting self-renewal divisions by mitogenically stimulated murine hematopoietic stem cells. Proc Natl Acad Sci USA 2001;98:1757-1762.
13. Tajima S, Tsuji K, Ebihara Y et al. Analysis of interleukin 6 receptor and gp130 expressions and proliferative capability of human CD34+ cells. J Exp Med 1996;184:1357-1364.
14. Tamura T, Udagawa N, Takahashi N et al. Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6. Proc Natl Acad Sci USA 1993;90:11924-11928.
15. Fischer M, Goldschmitt J, Peschel C et al. A bioactive designer cytokine for human hematopoietic progenitor cell expansion. Nat Biotechnol 1997;15:142-145.
16. Conneally E, Cashman J, Petzer A et al. Expansion in vitro of transplantable human cord blood stem cells demonstrated using a quantitative assay of their lympho-myeloid repopulating activity in nonobese diabetic-scid/scid mice. Proc Natl Acad Sci USA 1997;94:9836-9841.
17. Oostendorp RAJ, Audet J, Eaves CJ. High-resolution tracking of cell division suggests similar cell cycle kinetics of hematopoietic stem cells stimulated in vitro and in vivo. Blood 2000;95:855-862.
18. Ueda T, Tsuji K, Yoshino H et al. Expansion of human NOD/SCID- repopulating cells by stem cell factor, Flk2/Flt3 ligand, thrombopoietin, IL-6, And Soluble IL-6 Receptor. J Clin Invest 2000;105:1013-1021.
19. Götze KS, Keller U, Rose-John S et al. Gp130-stimulating designer cytokine Hyper-interleukin-6 synergizes with murine stroma for long-term survival of primitive human hematopoietic progenitor cells. Exp Hematol 2001;29:822-832.
20. Hermanns HM, Radtke S, Schaper F et al. Non-redundant signal transduction of interleukin-6-type cytokines. The adapter protein Shc is specifically recruited to rhe oncostatin M receptor. J Biol Chem 2000;275:40742-40748.
21. Broxmeyer HE, Bruns HA, Zhang S et al. Th1 cells regulate hematopoietic progenitor cell homeostasis by production of oncostatin M. Immunity 2002;16:815-825.
22. Tanaka M, Hirabayashi Y, Sekiguchi T et al. Targeted disruption of oncostatin M receptor results in altered hematopoiesis. Blood 2003;102:3154-3162.
23. Minehata K, Takeuchi M, Hirabayashi Y et al. Oncostatin M maintains the hematopoietic microenvironment and retains hematopoietic progenitors in the bone marrow. Int J Hematol 2006;84:319-327.
24. Mukouyama Y, Hara T, Xu M et al. In vitro expansion of murine multipotential hematopoietic progenitors from the embryonic aorta-gonad- mesonephros region. Immunity 1998;8:105-114.
25. Kamiya A, Kinoshita T, Ito Y et al. Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer. EMBO J 1999;18:2127-2136.
26. Schwaller J, Parganas E, Wang D et al. Stat5 is essential for the myeloand lymphoproliferative disease induced by TEL/JAK2. Mol Cell 2000;6:693-704.
27. Götze KS, Schiemann M, Marz S et al. CD133-enriched CD34(-) (CD33/CD38/CD71)(-) cord blood cells acquire CD34 prior to cell division and hematopoietic activity is exclusively associated with CD34 expression. Exp Hematol 2007;35:1408-1414.
28. Kusadasi N, Oostendorp RAJ, Koevoet WJ et al. Stromal cells from murine embryonic aorta-gonad-mesonephros region, liver and gut mesentery expand human umbilical cord blood-derived CAFC(week6) in extended long-term cultures. Leukemia 2002;16:1782-1790.
29. Holyoake TL, Nicolini FE, Eaves CJ. Functional differences between transplantable human hematopoietic stem cells from fetal liver, cord blood, and adult marrow. Exp Hematol 1999;27:1418-1427.
30. Majka M, Ratajczak J, Villaire G et al. Thrombopoietin, but not cytokines binding to gp130 protein-coupled receptors, activates MAPKp42/44, AKT, And Stat Proteins In Normal Human CD34+ cells, megakaryocytes, and Platelets. Exp Hematol 2002;30:751-760.
31. Yang JY, Zong CS, Xia W et al. ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation. Nat Cell Biol 2008;10:138-148.
32. Li CL, Johnson GR. Stem cell factor enhances the survival but not the self-renewal of murine long-term repopulating cells. Blood 1994;84:408-414.
33. Ploemacher RE, van Soest PL, Boudewijn A. Autocrine transforming growth factor beta 1 blocks colony formation and progenitor cell generation by hemopoietic stem cells stimulated with steel factor. STEM CELLS 1993;11:336-347.
34. Lennartsson J, Jelacic T, Linnekin D et al. Normal and oncogenic forms of the receptor tyrosine kinase Kit. STEM CELLS 2005;23:16-43.
35. Lennartsson J, Shivakrupa R, Linnekin D. Synergistic growth of stem cell factor and granulocyte macrophage colony-stimulating factor involves kinase-dependent and -independent contributions from c-kit. J Biol Chem 2004;43:44544-44553.
36. Arcasoy MO, Jiang X. Co-operative signalling mechanisms required for erythroid precursor expansion in response to erythropoietin and stem cell factor. Brit J Haematol 2005;130:121-129.
37. Bodine DM, Orlic D, Birkett NC et al. Stem cell factor increases colony-forming unit spleen number in vitro in synergy with interleukin-6, and in vivo in Sl/Sld mice as a single factor. Blood 1992;79:913-919.
38. Neben S, Donaldson D, Sieff C et al. Synergistic effects of interleukin-11 with other growth factors on the expansion of murine hematopoietic progenitors and maintenance of stem cells in liquid culture. Exp Hematol 1994;22:353-359.
39. Jenkins BJ, Roberts AW, Greenhill CJ et al. Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis. Blood 2007;109:2380-2388.
40. Ernst M, Jenkins BJ. Acquiring signalling specificity from the cytokine receptor gp130. Trends Genet 2004;20:23-32.
41. Peters M, Schirmacher P, Goldschmitt J et al. Extramedullary expansion of hematopoietic progenitor cells in interleukin (IL)-6-sIL-6R double transgenic mice. J Exp Med 1997;185:755-766.
42. Malik N, Haugen HS, Modrell B et al. Developmental abnormalities in mice transgenic for bovine oncostatin M. Mol Cell Biol 1995;15:2349-2358.
43. Halfter H, Friedrich M, Resch A et al. Oncostatin M induces growth arrest by inhibition of Skp2, Cks1, And Cyclin A Expression and Induced p21 expression. Cancer Res 2006;66:6530-6539.
44. Haynesworth SE, Baber MA, Caplan AI. Cytokine expression by human marrow-derived mesenchymal progenitor cells in vitro: effects of dexamethasone and IL-1 alpha. J Cell Physiol 1996;166:585-592.
45. Murphy LO, Blenis J. MAPK signal specificity: the right place at the right time. Trends Biochem Sci 2006;31:268-275.
46. Marshall CJ. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 1995;80:179-185.
47. Bonati A, Lunghi P, Gammaitoni L et al. MEK-ERK pathway is expressed but not activated in high proliferating, self-renewing cord blood hematopoietic progenitors. Hematol J 2002;3:105-113.
48. Miranda MB, Xu H, Torchia JA et al. Cytokine-induced myeloid differentiation is dependent on activation of the MEK/ERK pathway. Leuk Res 2005;29:1293-1306.
49. Miyamoto K, Araki KY, Naka K et al. Foxo3a is essential for maintenance of the hematopoietic stem cell pool. Cell Stem Cell 2007;1:101-112.
50. Kang S, Dong S, Gu TL et al. FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway. Cancer Cell 2007;12:201-214.
51. Rosenbauer F, Tenen D G. Transcription factors in myeloid development: balancing differentiation with transformation. Nat Rev Immunol 2007;7:105-117.
52. Dao MA, Nolta JA. Cytokine and integrin stimulation synergize to promote higher levels of GATA-2, c-myb, and CD34 protein in primary human hematopoietic progenitors from bone marrow. Blood 2007;109:2373-2379.