Importance of MEK-1/2 signaling in monocytic and granulocytic differentiation of myeloid cell lines

Leukemia

Volumn 16, Issue 4, 2002, Pages 683-692

  Miranda, M B ^a   McGuire, T F ^a   Johnson, D E ^a  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

Apoptosis; Differentiation; ERK MAP kinases; MEK 1; MEK 2; U0126

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ALCOHOL; ANTIMITOTIC AGENT; BETA ACTIN; CD11B ANTIGEN; CELL SURFACE MARKER; DIMETHYL SULFOXIDE; DNA; ENZYME ANTIBODY; ENZYME INHIBITOR; ESTERASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; NITROBLUE TETRAZOLIUM; PHORBOL 12 ACETATE 13 MYRISTATE; POLYCLONAL ANTIBODY; PROTEIN P21; PROTEIN P44; RETINOIC ACID; SERINE; THREONINE; TYROSINE; UNCLASSIFIED DRUG;

ANTIBODY SPECIFICITY; APOPTOSIS; BONE MARROW CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; GRANULOCYTE; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MONOCYTE; NITROBLUE TETRAZOLIUM TEST; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; STAINING;

EID: 0036240711     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2402400     Document Type: Review

References (58)

1. Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2
2. Raf-1 activates MAP kinase-kinase
3. Activation of mitogen-activated protein kinase kinase by v-raf in NIH3T3 cells and in vitro
4. A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf
5. Molecular structure of a protein-tyrosine/threonine kinase activating p42 mitogen-activated protein (MAP) kinase: MAP kinase kinase
6. How MAP kinases are regulated
7. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal regulated kinase activation
8. Mitogen-activated protein kinase kinase inhibition does not block the stimulation of glucose utilization by insulin
9. Transcriptional regulation by extracellular signals: Mechanisms and specificity
10. STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation
11. Signal transduction within the nucleus by mitogen-activated protein kinase
12. The regulation of AP-1 activity by mitogen-activated protein kinases
13. Gain-of-function mutations in MAP kinase kinase promotes cell transformation
14. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH3T3 cells
15. A conditionally active form of MEK-1 abrogates cytokine dependency in human and mouse hematopoietic cells
16. Effects of inducible MEK-1 activation on the cytokine dependency of lymphoid cells
17. The role of MAP kinase in interleukin-3 stimulation of proliferation
18. Downstream signaling events regulated by phosphatidylinositol 3-kinase activity
19. Phosphoinositide 3-kinases: A conserved family of signal transducers
20. Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/Akt: Involvement of MEK upstream of Bad phosphorylation
21. Serine phosphorylation of death agonist Bad in response to survival factor results in binding to 14-3-3 not Bcl-xL
22. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
23. Akt phosphorylation of BAD couples survival signals to cell-intrinsic death machinery
24. The roles of signaling by the p42/p44 mitogen-activated protein (MAP) kinase pathway; a potential route to radio- and chemo-sensitization of tumor cells resulting in the induction of apoptosis and loss of clonogenicity
25. Differential abilities of activated Raf oncoproteins to abrogate cytokine dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells
26. PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity
27. Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells
28. The MAP kinase pathway controls differentiation from double-negative to double-positive thymocytes
29. Requirement of ERK activation for visual cortical plasticity
30. Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor
31. Prolonged activation of the mitogen-activated protein kinase pathway is required for macrophage-like differentiation of a human myeloid leukemic cell line
32. Sustained activation of the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway is required for megakaryocytic differentiation of K562 cells
33. A role for the MEK/MAPK pathway in PMA-induced cell cycle arrest: Modulation of megakaryocytic differentiation of K562 cells
34. Identification of a novel inhibitor of mitogen-activated protein kinase kinase
35. Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds
36. Human promyelocytic leukemia cells in culture differentiate into macrophage-like cells when treated with phorbol diester
37. Induction of differentiation of the human promyelocytic cell line (HL-60) by retinoic acid
38. HL-60 cells induced to differentiate towards neutrophils subsequently die via apoptosis
39. Regulation and function of Bcl-2 during differentiation-induced cell death in HL-60 promyelocytic cells
40. Retinoic acid induced mitogen-activated protein (MAP)/extracellular signal regulated kinase (ERK) kinase-dependent MAP kinase activation needed to elicit HL-60 cell differentiation and growth arrest
41. Retinoic acid selectively activates the ERK2 but not JNK/SAPK or p38 MAP kinases when inducing myeloid differentiation
42. Activation of Raf-1 and mitogen-activated protein kinases during monocytic differentiation of human myeloid leukemia cells
43. Induction of morphological and functional differentiation of human promyelocytic leukemic cells (HL-60) by compounds which induce differentiation of murine leukemic cells
44. Cytochemical identification of monocytes and granulocytes
45. Regulation of p21(WAF1) expression during normal myeloid differentiation
46. MAPK-dependent expression of p21WaF1 and p27Kip1 in PMA-induced differentiation of HL-60 cells
47. The expression of Bcl-X is downregulated during differentiation of human hematopoietic progenitor cells along the granulocytic lineage but not the monocytic/macrophage lineage
48. L
49. Constitutively active ERK2/MAP kinase is sufficient for neurite outgrowth and cell transformation when targeted to the nucleus
50. The JNK/SAPK activator mixed lineage kinase 3 (MLK3) transforms NIH3T3 cells in a MEK dependent fashion
51. Cell cycle targets of Ras/Raf signaling
52. Mitogen-activated protein kinase/extracellular signal-regulated protein kinase activation by oncogenes, serum and 12-O-tetradecanoylphorbol-13-acetate requires Raf and is necessary for transformation
53. Biology of the protein kinase C family
54. Protein kinase C beta gene expression is associated with susceptibility of human promyelocytic leukemia cells to phorbol ester-induced differentiation
55. Protein kinase C-beta is required for macrophage differentiation of human HL-60 leukemia cells
56. RK-MAP kinase cascades in HL-60 cells is PKC dependent but not essential for differentiation to the macrophage-like phenotype
57. PMA-induced phenotypic changes in K562 cells: MAPK-dependent and -independent events
58. Role of ERK activation in growth and erythroid differentiation of K562 cells