-
1
-
-
33751267902
-
Acute myeloid leukaemia
-
Estey E, Dohner H. Acute myeloid leukaemia. Lancet 2006; 368 1894-1907.
-
(2006)
Lancet
, vol.368
, pp. 1894-1907
-
-
Estey, E.1
Dohner, H.2
-
2
-
-
13344282085
-
Clinical relevance of P-glycoprotein expression in de novo acute myeloid leukemia
-
Del Poeta G, Stasi R, Aronica G, Venditti A, Cox MC, Bruno A et al. Clinical relevance of P-glycoprotein expression in de novo acute myeloid leukemia. Blood 1996; 87: 1997-2004.
-
(1996)
Blood
, vol.87
, pp. 1997-2004
-
-
Del Poeta, G.1
Stasi, R.2
Aronica, G.3
Venditti, A.4
Cox, M.C.5
Bruno, A.6
-
3
-
-
1842457644
-
Mitoxantrone, etoposide, and cytarabine with or without valspodar in patients with relapsed or refractory acute myeloid leukemia and high-risk myelodysplastic syndrome: A phase III trial (E2995)
-
Greenberg PL, Lee SJ, Advani R, Tallman MS, Sikic BI, Letendre L et al. Mitoxantrone, etoposide, and cytarabine with or without valspodar in patients with relapsed or refractory acute myeloid leukemia and high-risk myelodysplastic syndrome: A phase III trial (E2995). J Clin Oncol 2004; 22: 1078-1086.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1078-1086
-
-
Greenberg, P.L.1
Lee, S.J.2
Advani, R.3
Tallman, M.S.4
Sikic, B.I.5
Letendre, L.6
-
4
-
-
33644510431
-
Addition of cyclosporin-A to chemotherapy in secondary (post-MDS) AML in the elderly. A multicenter randomized trial of the Leukemia Working Group of the Hellenic Society of Hematology
-
Matsouka P, Pagoni M, Zikos P, Giannakoulas N, Apostolidis I, Asprogeraka T et al. Addition of cyclosporin-A to chemotherapy in secondary (post-MDS) AML in the elderly. A multicenter randomized trial of the Leukemia Working Group of the Hellenic Society of Hematology. Ann Hematol 2006; 85: 250-256.
-
(2006)
Ann Hematol
, vol.85
, pp. 250-256
-
-
Matsouka, P.1
Pagoni, M.2
Zikos, P.3
Giannakoulas, N.4
Apostolidis, I.5
Asprogeraka, T.6
-
5
-
-
0035895056
-
Receptor- and mitochondrial-mediated apoptosis in acute leukemia: A translational view
-
Schimmer AD, Hedley DW, Penn LZ, Minden MD. Receptor- and mitochondrial-mediated apoptosis in acute leukemia: A translational view. Blood 2001; 98: 3541-3553.
-
(2001)
Blood
, vol.98
, pp. 3541-3553
-
-
Schimmer, A.D.1
Hedley, D.W.2
Penn, L.Z.3
Minden, M.D.4
-
6
-
-
0031436915
-
High bcl-2 expression in acute myeloid leukemia cells correlates with CD34 positivity and complete remission rate
-
Lauria F, Raspadori D, Rondelli D, Ventura MA, Fiacchini M, Visani G et al. High bcl-2 expression in acute myeloid leukemia cells correlates with CD34 positivity and complete remission rate. Leukemia 1997; 11: 2075-2078.
-
(1997)
Leukemia
, vol.11
, pp. 2075-2078
-
-
Lauria, F.1
Raspadori, D.2
Rondelli, D.3
Ventura, M.A.4
Fiacchini, M.5
Visani, G.6
-
7
-
-
0034644522
-
Signal transduction by the JNK group of MAP kinases
-
Davis RJ. Signal transduction by the JNK group of MAP kinases. Cell 2000; 103: 239-252.
-
(2000)
Cell
, vol.103
, pp. 239-252
-
-
Davis, R.J.1
-
8
-
-
0035735754
-
Role of mitogen-activated protein kinases in the response of tumor cells to chemotherapy
-
Fan M, Chambers TC. Role of mitogen-activated protein kinases in the response of tumor cells to chemotherapy. Drug Resist Updat 2001; 4: 253-267.
-
(2001)
Drug Resist Updat
, vol.4
, pp. 253-267
-
-
Fan, M.1
Chambers, T.C.2
-
9
-
-
0035525733
-
Cellular stress response and apoptosis in cancer therapy
-
Herr I, Debatin KM. Cellular stress response and apoptosis in cancer therapy. Blood 2001; 98: 2603-2614.
-
(2001)
Blood
, vol.98
, pp. 2603-2614
-
-
Herr, I.1
Debatin, K.M.2
-
10
-
-
18444396889
-
Role for c-jun N-terminal kinase in treatment-refractory acute myeloid leukemia (AML): Signaling to multidrug-efflux and hyperproliferation
-
Cripe LD, Gelfanov VM, Smith EA, Spigel DR, Phillips CA, Gabig TG et al. Role for c-jun N-terminal kinase in treatment-refractory acute myeloid leukemia (AML): Signaling to multidrug-efflux and hyperproliferation. Leukemia 2002; 16: 799-812.
-
(2002)
Leukemia
, vol.16
, pp. 799-812
-
-
Cripe, L.D.1
Gelfanov, V.M.2
Smith, E.A.3
Spigel, D.R.4
Phillips, C.A.5
Gabig, T.G.6
-
11
-
-
34249995742
-
ERK1/2 phosphorylation is an independent predictor of complete remission in newly diagnosed adult acute lymphoblastic leukemia
-
Gregorj C, Ricciardi MR, Petrucci MT, Scerpa MC, De Cave F, Fazi P et al. ERK1/2 phosphorylation is an independent predictor of complete remission in newly diagnosed adult acute lymphoblastic leukemia. Blood 2007; 109: 5473-5476.
-
(2007)
Blood
, vol.109
, pp. 5473-5476
-
-
Gregorj, C.1
Ricciardi, M.R.2
Petrucci, M.T.3
Scerpa, M.C.4
De Cave, F.5
Fazi, P.6
-
12
-
-
37849015991
-
Deeper insights into hematological disorders via single-cell phospho-signaling analysis
-
Nolan G. Deeper insights into hematological disorders via single-cell phospho-signaling analysis. Hematology (Am Soc Hematol Educ Program) 2006; 509: 123-127.
-
(2006)
Hematology (Am Soc Hematol Educ Program)
, vol.509
, pp. 123-127
-
-
Nolan, G.1
-
13
-
-
0032704158
-
Implication of radical oxygen species in ceramide generation, c-Jun N-terminal kinase activation and apoptosis induced by daunorubicin
-
Mansat-deMas V, Bezombes C, Quillet-Mary A, Bettaieb A, D'Orgeix AD, Laurent G et al. Implication of radical oxygen species in ceramide generation, c-Jun N-terminal kinase activation and apoptosis induced by daunorubicin. Mol Pharmacol 1999; 56: 867-874.
-
(1999)
Mol Pharmacol
, vol.56
, pp. 867-874
-
-
Mansat-deMas, V.1
Bezombes, C.2
Quillet-Mary, A.3
Bettaieb, A.4
D'Orgeix, A.D.5
Laurent, G.6
-
14
-
-
0035883083
-
Signaling pathways activated by daunorubicin
-
Laurent G, Jaffrezou JP. Signaling pathways activated by daunorubicin. Blood 2001; 98: 913-924.
-
(2001)
Blood
, vol.98
, pp. 913-924
-
-
Laurent, G.1
Jaffrezou, J.P.2
-
15
-
-
8644269825
-
Long-term activation of SAPK/JNK, p38 kinase and fas-L expression by cisplatin is attenuated in human carcinoma cells that acquired drug resistance
-
Brozovic A, Fritz G, Christmann M, Zisowsky J, Jaehde U, Osmak M et al. Long-term activation of SAPK/JNK, p38 kinase and fas-L expression by cisplatin is attenuated in human carcinoma cells that acquired drug resistance. Int J Cancer 2004; 112: 974-985.
-
(2004)
Int J Cancer
, vol.112
, pp. 974-985
-
-
Brozovic, A.1
Fritz, G.2
Christmann, M.3
Zisowsky, J.4
Jaehde, U.5
Osmak, M.6
-
16
-
-
33745851561
-
Essential role of c-Jun-NH2-terminal kinase on synergy induction of apoptosis by TRAIL plus ADM in ADM resistant MCF-7/ADM cells
-
Li F, Meng L, Xing H, Zhou J, Wang S, Huang L et al. Essential role of c-Jun-NH2-terminal kinase on synergy induction of apoptosis by TRAIL plus ADM in ADM resistant MCF-7/ADM cells. Apoptosis 2006; 11: 1239-1246.
-
(2006)
Apoptosis
, vol.11
, pp. 1239-1246
-
-
Li, F.1
Meng, L.2
Xing, H.3
Zhou, J.4
Wang, S.5
Huang, L.6
-
17
-
-
0034630482
-
Downregulation of JNK/SAPK activity is associated with the cross-resistance to P-glycoprotein-unrelated drugs in multidrug-resistant FM3A/M cells overexpressing P-glycoprotein
-
Kang CD, Ahn BK, Jeong CS, Kim KW, Lee HJ, Yoo SD et al. Downregulation of JNK/SAPK activity is associated with the cross-resistance to P-glycoprotein-unrelated drugs in multidrug-resistant FM3A/M cells overexpressing P-glycoprotein. Exp Cell Res 2000; 256: 300-307.
-
(2000)
Exp Cell Res
, vol.256
, pp. 300-307
-
-
Kang, C.D.1
Ahn, B.K.2
Jeong, C.S.3
Kim, K.W.4
Lee, H.J.5
Yoo, S.D.6
-
18
-
-
24044530419
-
Reversing chemoresistance in cisplatin-resistant human ovarian cancer cells: A role of c-Jun NH2-terminal kinase 1
-
Li F, Meng L, Zhou J, Xing H, Wang S, Xu G et al. Reversing chemoresistance in cisplatin-resistant human ovarian cancer cells: A role of c-Jun NH2-terminal kinase 1. Biochem Biophys Res Commun 2005; 335: 1070-1077.
-
(2005)
Biochem Biophys Res Commun
, vol.335
, pp. 1070-1077
-
-
Li, F.1
Meng, L.2
Zhou, J.3
Xing, H.4
Wang, S.5
Xu, G.6
-
19
-
-
0029611262
-
Development of human leukemia U-937 cell sublines resistant to doxorubicin: Induction of differentiation and altered sensitivities to topoisomerase-directed drugs
-
Pantazis P, Dejesus A, Early J, Rodriguez R, Chatterjee D, Han Z et al. Development of human leukemia U-937 cell sublines resistant to doxorubicin: Induction of differentiation and altered sensitivities to topoisomerase-directed drugs. Anticancer Res 1995; 15 (5B): 1873-1881.
-
(1873)
Anticancer Res 1995
, vol.15
, Issue.5 B
-
-
Pantazis, P.1
Dejesus, A.2
Early, J.3
Rodriguez, R.4
Chatterjee, D.5
Han, Z.6
-
20
-
-
0020532855
-
Plasma pharmacokinetics of adriamycin and adriamycinol: Implications for the design of in vivo experiments and treatment protocols
-
Greene RF, Collins JM, Jenkins JF, Speyer JL, Myers CE. Plasma pharmacokinetics of adriamycin and adriamycinol: Implications for the design of in vivo experiments and treatment protocols. Cancer Res 1983; 43: 3417-3421.
-
(1983)
Cancer Res
, vol.43
, pp. 3417-3421
-
-
Greene, R.F.1
Collins, J.M.2
Jenkins, J.F.3
Speyer, J.L.4
Myers, C.E.5
-
21
-
-
0037189499
-
The bone-specific transcriptional regulator Cbfa1 is a target of mechanical signals in osteoblastic cells
-
Ziros PG, Gil AP, Georgakopoulos T, Habeos I, Kletsas D, Basdra EK et al. The bone-specific transcriptional regulator Cbfa1 is a target of mechanical signals in osteoblastic cells. J Biol Chem 2002; 277 23934-23941.
-
(2002)
J Biol Chem
, vol.277
, pp. 23934-23941
-
-
Ziros, P.G.1
Gil, A.P.2
Georgakopoulos, T.3
Habeos, I.4
Kletsas, D.5
Basdra, E.K.6
-
22
-
-
0028906671
-
Predictive value for treatment outcome in acute myeloid leukemia of cellular daunorubicin accumulation and P-glycoprotein expression simultaneously determined by flow cytometry
-
Guerci A, Merlin JL, Missoum N, Feldmann L, Marchal S, Witz F et al Predictive value for treatment outcome in acute myeloid leukemia of cellular daunorubicin accumulation and P-glycoprotein expression simultaneously determined by flow cytometry. Blood 1995; 85: 2147-2153.
-
(1995)
Blood
, vol.85
, pp. 2147-2153
-
-
Guerci, A.1
Merlin, J.L.2
Missoum, N.3
Feldmann, L.4
Marchal, S.5
Witz, F.6
-
23
-
-
0028141496
-
Transformation of mammalian cells by constitutively active MAP kinase kinase
-
Mansour SJ, Matten WT, Hermann AS, Candia JM, Rong S, Fukasawa K et al. Transformation of mammalian cells by constitutively active MAP kinase kinase. Science (New York, NY) 1994; 265: 966-970.
-
(1994)
Science (New York, NY)
, vol.265
, pp. 966-970
-
-
Mansour, S.J.1
Matten, W.T.2
Hermann, A.S.3
Candia, J.M.4
Rong, S.5
Fukasawa, K.6
-
24
-
-
0037443754
-
MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models
-
Mahon FX, Belloc F, Lagarde V, Chollet C, Moreau-Gaudry F, Reiffers J et al. MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models. Blood 2003; 101: 2368-2373.
-
(2003)
Blood
, vol.101
, pp. 2368-2373
-
-
Mahon, F.X.1
Belloc, F.2
Lagarde, V.3
Chollet, C.4
Moreau-Gaudry, F.5
Reiffers, J.6
-
25
-
-
0031864247
-
-
Legr,and O, Simonin G, Perrot JY, Zittoun R, Marie JP. Pgp and MRP activities using calcein-AM are prognostic factors in adult acute myeloid leukemia patients. Blood 1998; 91: 4480-4488.
-
Legr,and O, Simonin G, Perrot JY, Zittoun R, Marie JP. Pgp and MRP activities using calcein-AM are prognostic factors in adult acute myeloid leukemia patients. Blood 1998; 91: 4480-4488.
-
-
-
-
26
-
-
0034607702
-
Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway
-
Tournier C, Hess P, Yang DD, Xu J, Turner TK, Nimnual A et al. Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science 2000; 288: 870-874.
-
(2000)
Science
, vol.288
, pp. 870-874
-
-
Tournier, C.1
Hess, P.2
Yang, D.D.3
Xu, J.4
Turner, T.K.5
Nimnual, A.6
-
27
-
-
31544463321
-
Reversal of P-glycoprotein-mediated multidrug resistance in cancer cells by the c-Jun NH2-terminal kinase
-
Zhou J, Liu M, Aneja R, Chandra R, Lage H, Joshi HC. Reversal of P-glycoprotein-mediated multidrug resistance in cancer cells by the c-Jun NH2-terminal kinase. Cancer Res 2006; 66: 445-452.
-
(2006)
Cancer Res
, vol.66
, pp. 445-452
-
-
Zhou, J.1
Liu, M.2
Aneja, R.3
Chandra, R.4
Lage, H.5
Joshi, H.C.6
-
28
-
-
34147215968
-
-
Hatle KM, Neveu W, Dienz O, Rymarchyk S, Barrantes R, Hale S et al Methylation-controlled J protein promotes c-Jun degradation to prevent ABCB1 transporter expression. Mol Cell Biol 2007; 27 2952-2966.
-
Hatle KM, Neveu W, Dienz O, Rymarchyk S, Barrantes R, Hale S et al Methylation-controlled J protein promotes c-Jun degradation to prevent ABCB1 transporter expression. Mol Cell Biol 2007; 27 2952-2966.
-
-
-
-
29
-
-
30144443664
-
The tyrphostin adaphostin interacts synergistically with proteasome inhibitors to induce apoptosis in human leukemia cells through a reactive oxygen species (ROS)-dependent mechanism
-
Dasmahapatra G, Rahmani M, Dent P, Grant S. The tyrphostin adaphostin interacts synergistically with proteasome inhibitors to induce apoptosis in human leukemia cells through a reactive oxygen species (ROS)-dependent mechanism. Blood 2006; 107: 232-240.
-
(2006)
Blood
, vol.107
, pp. 232-240
-
-
Dasmahapatra, G.1
Rahmani, M.2
Dent, P.3
Grant, S.4
-
30
-
-
13544274109
-
Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/ JNK
-
Dai Y, Rahmani M, Pei XY, Khanna P, Han SI, Mitchell C et al. Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/ JNK. Blood 2005; 105: 1706-1716.
-
(2005)
Blood
, vol.105
, pp. 1706-1716
-
-
Dai, Y.1
Rahmani, M.2
Pei, X.Y.3
Khanna, P.4
Han, S.I.5
Mitchell, C.6
-
31
-
-
30344433284
-
Synergistic antileukemic interactions between 2-medroxyestradiol (2-ME) and histone deacetylase inhibitors involve Akt down-regulation and oxidative stress
-
Gao N, Rahmani M, Shi X, Dent P, Grant S. Synergistic antileukemic interactions between 2-medroxyestradiol (2-ME) and histone deacetylase inhibitors involve Akt down-regulation and oxidative stress. Blood 2006; 107: 241-249.
-
(2006)
Blood
, vol.107
, pp. 241-249
-
-
Gao, N.1
Rahmani, M.2
Shi, X.3
Dent, P.4
Grant, S.5
-
32
-
-
1942456821
-
JNK activation is a mediator of arsenic trioxide-induced apoptosis in acute promyelocytic leukemia cells
-
Davison K, Mann KK, Waxman S, Miller Jr WH. JNK activation is a mediator of arsenic trioxide-induced apoptosis in acute promyelocytic leukemia cells. Blood 2004; 103: 3496-3502.
-
(2004)
Blood
, vol.103
, pp. 3496-3502
-
-
Davison, K.1
Mann, K.K.2
Waxman, S.3
Miller Jr, W.H.4
-
33
-
-
33644755493
-
Pharmacodynamics of cytarabine alone and in combination with 7-hydroxystaurosporine (UCN-01) in AML blasts in vitro and during a clinical trial
-
Sampath D, Cortes J, Estrov Z, Du M, Shi Z, Andreeff M et al. Pharmacodynamics of cytarabine alone and in combination with 7-hydroxystaurosporine (UCN-01) in AML blasts in vitro and during a clinical trial. Blood 2006; 107: 2517-2524.
-
(2006)
Blood
, vol.107
, pp. 2517-2524
-
-
Sampath, D.1
Cortes, J.2
Estrov, Z.3
Du, M.4
Shi, Z.5
Andreeff, M.6
-
34
-
-
0035877779
-
Glutathione S-transferase P1-1(GSTP1-1) inhibits c-Jun N-terminal kinase (JNK1) signaling through interaction with the C terminus
-
Wang T, Arifoglu P, Ronai Z, Tew KD. Glutathione S-transferase P1-1(GSTP1-1) inhibits c-Jun N-terminal kinase (JNK1) signaling through interaction with the C terminus. J Biol Chem 2001; 276: 20999-21003.
-
(2001)
J Biol Chem
, vol.276
, pp. 20999-21003
-
-
Wang, T.1
Arifoglu, P.2
Ronai, Z.3
Tew, K.D.4
-
35
-
-
33748995966
-
Mitogen-Activated Protein Kinase Phosphatase-1 is required for Cisplatin Resistance
-
Wang Z, Xu J, Zhou JY, Liu Y, Wu GS. Mitogen-Activated Protein Kinase Phosphatase-1 is required for Cisplatin Resistance. Cancer Res 2006; 66: 8870-8877.
-
(2006)
Cancer Res
, vol.66
, pp. 8870-8877
-
-
Wang, Z.1
Xu, J.2
Zhou, J.Y.3
Liu, Y.4
Wu, G.S.5
-
36
-
-
26444495615
-
Death versus survival: Functional interaction between the apoptotic and stress-inducible heat shock protein pathways
-
Beere HM. Death versus survival: Functional interaction between the apoptotic and stress-inducible heat shock protein pathways. J Clin Invest 2005; 115: 2633-2639.
-
(2005)
J Clin Invest
, vol.115
, pp. 2633-2639
-
-
Beere, H.M.1
-
37
-
-
0035891320
-
Inhibition of JNK activation through NF-kappaB target genes
-
Tang G, Minemoto Y, Dibling B, Purcell NH, Li Z, Karin M, Lin A. Inhibition of JNK activation through NF-kappaB target genes. Nature 2001; 414: 313-317.
-
(2001)
Nature
, vol.414
, pp. 313-317
-
-
Tang, G.1
Minemoto, Y.2
Dibling, B.3
Purcell, N.H.4
Li, Z.5
Karin, M.6
Lin, A.7
-
38
-
-
30144433248
-
A bunch of JNK?
-
Gore S. ROS' n' roll: A bunch of JNK? Blood 2006; 107: 9-10.
-
(2006)
Blood
, vol.107
, pp. 9-10
-
-
Gore, S.1
n' roll, R.2
-
39
-
-
45149121372
-
The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism
-
Chiarini F, Del Sole M, Mongiorgi S, Gaboardi GC, Cappellini A, Mantovani I et al. The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism. Leukemia 2008; 22: 1106-1116.
-
(2008)
Leukemia
, vol.22
, pp. 1106-1116
-
-
Chiarini, F.1
Del Sole, M.2
Mongiorgi, S.3
Gaboardi, G.C.4
Cappellini, A.5
Mantovani, I.6
|