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Volumn 97, Issue 6, 2001, Pages 1823-1834

Cell-cycle-dependent activation of mitogen-activated protein kinase kinase (MEK-1/2) in myeloid leukemia cell lines and induction of growth inhibition and apoptosis by inhibitors of RAS signaling

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE METHYL ESTER; ONCOPROTEIN; TRANSCRIPTION FACTOR;

EID: 0035869396     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V97.6.1823     Document Type: Article
Times cited : (122)

References (88)
  • 1
    • 0024376173 scopus 로고
    • RAS oncogenes in human cancer: A review
    • (1989) Cancer Res , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 7
    • 0030992130 scopus 로고    scopus 로고
    • Protein prenylation, et cetera: Signal transduction in two dimensions
    • (1997) Science , vol.275 , pp. 1750-1751
    • Gelb, M.H.1
  • 28
    • 0028959163 scopus 로고
    • Constitutively activating mutations of c-Kit receptor tyrosine kinase confer factor-independent growth and tumorigenicity of factor-dependent hematopoietic cell lines
    • (1995) Blood , vol.85 , pp. 790-798
    • Kitayama, H.1    Kanakura, Y.2    Furitsu, T.3
  • 31
    • 0027494860 scopus 로고
    • Mitogenic signaling and substrate specificity of the Flk2/Flt3 receptor tyrosine kinase in fibroblasts and interleukin 3-dependent hematopoietic cells
    • (1993) Mol Cell Biol , vol.13 , pp. 6572-6585
    • Dosil, M.1    Wang, S.2    Lemischka, I.R.3
  • 33
    • 17144463437 scopus 로고    scopus 로고
    • A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFRβ oncoprotein
    • (1997) EMBO J , vol.16 , pp. 69-82
    • Jousset, C.1    Carron, C.2    Boureux, A.3
  • 36
    • 0033603435 scopus 로고    scopus 로고
    • Signaling pathways activated by oncogenic forms of Abl tyrosine kinase
    • (1999) J Biol Chem , vol.274 , pp. 18141-18144
    • Zou, X.1    Calame, K.2
  • 37
    • 0034704917 scopus 로고    scopus 로고
    • The leukaemic oncoproteins BCR-Abl and Tel-Abl (ETV6/Abl) have altered substrate preferences and activate similar intracellular signaling pathways
    • (2000) Oncogene , vol.19 , pp. 1684-1690
    • Voss, J.1    Posern, G.2    Hannemann, J.R.3
  • 40
    • 9044251606 scopus 로고    scopus 로고
    • Loss of NF-1 results in activation of the Ras signaling pathway and leads to aberrant growth in hematopoietic cells
    • (1996) Nat Genet , vol.12 , pp. 144-148
    • Bollag, G.1    Clapp, D.W.2    Shih, S.3
  • 42
    • 0030609121 scopus 로고    scopus 로고
    • CA1A2X-competitive inhibitors of farnesyltransferase as anti-cancer agents
    • (1997) TIBS , vol.18 , pp. 437-444
    • Omer, C.A.1    Kohl, N.E.2
  • 50
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of proteins utilizing the principle of protein-dye binding
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 52
    • 0031055415 scopus 로고    scopus 로고
    • Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras
    • (1997) Oncogene , vol.14 , pp. 623-625
    • De Rooij, J.1    Bos, J.L.2
  • 53
    • 0024998851 scopus 로고
    • Ras mutations are rare events in Philadelphia chromosome-negative/bcr gene rearrangement-negative chronic myelogenous leukemia, but are prevalent in chronic myelomonocytic leukemia
    • (1990) Blood , vol.76 , pp. 1214-1219
    • Hirsch-Ginsberg, C.1    LeMaistre, A.C.2    Kantarjian, H.3
  • 58
    • 0032936416 scopus 로고    scopus 로고
    • Lack of constitutive activation of MAP kinase pathway in human acute myeloid leukemia cells with N-Ras mutation
    • (1999) Leukemia , vol.13 , pp. 585-589
    • Iida, M.1    Towatari, M.2    Nakao, A.3
  • 59
    • 0033151533 scopus 로고    scopus 로고
    • Constitutive activation of extracellular signal-regulated kinase in human acute leukemias: Combined role of activation of MEK, hyperexpression of extracellular signal-regulated kinase, and downregulation of a phosphatase, PAC1
    • (1999) Blood , vol.93 , pp. 3893-3899
    • Kim, S.C.1    Hahn, J.S.2    Min, Y.H.3    Yoo, N.C.4    Ko, Y.W.5    Lee, W.J.6
  • 63
    • 0030972494 scopus 로고    scopus 로고
    • Interaction of MAP kinase with MAP kinase kinase: Its possible role in the control of nucleocytoplasmatic transport of MAP kinase
    • (1997) EMBO J , vol.16 , pp. 1901-1908
    • Fukuda, M.1    Gotoh, Y.2    Nishida, E.3
  • 68
    • 0033215340 scopus 로고    scopus 로고
    • Two co-existing mechanisms for nuclear import of MAP kinase: Passive diffusion of a monomer and active transport of a dimer
    • (1999) EMBO J , vol.19 , pp. 5347-5358
    • Adachi, M.1    Fukuda, M.2    Nishida, E.3
  • 75
    • 0032555891 scopus 로고    scopus 로고
    • Activation of the MKK/ERK pathway during somatic cell mitosis: Direct interactions of active ERK with kinetochores and regulation of the mitotic 3T3/2 phosphoantigen
    • (1998) J Cell Biol , vol.142 , pp. 1533-1545
    • Shapiro, P.S.1    Vaisberg, E.2    Hunt, A.J.3
  • 80
    • 0032546264 scopus 로고    scopus 로고
    • Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts
    • (1998) Oncogene , vol.16 , pp. 1467-1473
    • Sun, J.1    Qian, Y.2    Hamilton, A.D.3    Sebti, S.M.4
  • 81
    • 0033959438 scopus 로고    scopus 로고
    • Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
    • (2000) Carcinogenesis , vol.21 , pp. 113-116
    • Lantry, L.E.1    Zhang, Z.2    Yao, R.3
  • 86
    • 0031842342 scopus 로고    scopus 로고
    • Involvement of caspase family proteases in FPT inhibitor III-induced apoptosis in human ovarian cancer cells
    • (1998) Int J Oncol , vol.12 , pp. 1339-1342
    • Hung, W.C.1    Chuang, L.Y.2
  • 87
    • 0031974135 scopus 로고    scopus 로고
    • The farnesyltransferase inhibitor, FPT inhibitor III upregulates Bax and Bcl-xs expression and induces apoptosis in human ovarian cancer cells
    • (1998) Int J Oncol , vol.12 , pp. 137-140
    • Hung, W.C.1    Chuang, L.Y.2
  • 88
    • 0034655220 scopus 로고    scopus 로고
    • U0126 reverses Ki-ras-mediated transformation by blocking both mitogen-activated protein kinase and p70 S6 kinase pathways
    • (2000) Cancer Res , vol.60 , pp. 2104-2107
    • Fukazawa, H.1    Uehara, Y.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.