Grb2 regulates Stat3 activation negatively in epidermal growth factor signalling

Biochemical Journal

Volumn 376, Issue 2, 2003, Pages 457-464

  Zhang, Tong ^a,b   Ma, Jing ^a   Cao, Xinmin ^a,c  

^a INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Epidermal growth factor; Grb2 (growth factor receptor binding protein 2); Receptor binding; SH2 domain (Src homology 2 domain); Stat3

Indexed keywords

DIMERIZATION; PROTEINS; RNA; SIGNALING;

EPIDERMAL GROWTH FACTOR (EGF);

BIOCHEMISTRY;

BINDING PROTEIN; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GROWTH FACTOR RECEPTOR BINDING PROTEIN 2; INTERLEUKIN 6 RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN SH2; RAS PROTEIN; RNA; STAT3 PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHOSPHORYLATION; BINDING SITE; CONTROLLED STUDY; DIMERIZATION; DOWN REGULATION; ENZYME ACTIVATION; GENE ACTIVATION; GENE FUNCTION; GENE MUTATION; GENE REPRESSION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAIN; TRANSCRIPTION INITIATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BINDING, COMPETITIVE; CELL LINE; DNA-BINDING PROTEINS; EPIDERMAL GROWTH FACTOR; GRB2 ADAPTOR PROTEIN; HUMANS; INTERLEUKIN-6; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN-TYROSINE-PHOSPHATASE; PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TYROSINE;

EID: 0348147580     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20030668     Document Type: Article

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