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Volumn 30, Issue 10, 2009, Pages 1535-1544

Linking vascular disorders and Alzheimer's disease: Potential involvement of BACE1

Author keywords

Alzheimers disease; BACE1; Beta amyloid peptide; Cardiovascular; Cerebrovascular; Hypoperfusion

Indexed keywords

AMYLOID BETA PROTEIN; BETA SECRETASE; BETA SITE APP CLEAVING ENZYME 1; UNCLASSIFIED DRUG;

EID: 69249212436     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2007.12.012     Document Type: Review
Times cited : (37)

References (120)
  • 1
    • 0042858264 scopus 로고    scopus 로고
    • Antagonistic effects of beta-site amyloid precursor protein-cleaving enzymes 1 and 2 on beta-amyloid peptide production in cells
    • Basi G., Frigon N., Barbour R., Doan T., Gordon G., McConlogue L., Sinha S., and Zeller M. Antagonistic effects of beta-site amyloid precursor protein-cleaving enzymes 1 and 2 on beta-amyloid peptide production in cells. J. Biol. Chem. 278 (2003) 31512-31520
    • (2003) J. Biol. Chem. , vol.278 , pp. 31512-31520
    • Basi, G.1    Frigon, N.2    Barbour, R.3    Doan, T.4    Gordon, G.5    McConlogue, L.6    Sinha, S.7    Zeller, M.8
  • 4
    • 1842728419 scopus 로고    scopus 로고
    • Experimental traumatic brain injury in rats stimulates the expression, production and activity of Alzheimer's disease beta-secretase (BACE-1)
    • Blasko I., Beer R., Bigl M., Apelt J., Franz G., Rudzki D., Ransmayr G., Kampfl A., and Schliebs R. Experimental traumatic brain injury in rats stimulates the expression, production and activity of Alzheimer's disease beta-secretase (BACE-1). J. Neural Transm. 111 (2004) 523-536
    • (2004) J. Neural Transm. , vol.111 , pp. 523-536
    • Blasko, I.1    Beer, R.2    Bigl, M.3    Apelt, J.4    Franz, G.5    Rudzki, D.6    Ransmayr, G.7    Kampfl, A.8    Schliebs, R.9
  • 5
    • 34248178463 scopus 로고    scopus 로고
    • Differential regulation of BACE1 promoter activity by nuclear factor-kappaB in neurons and glia upon exposure to beta-amyloid peptides
    • Bourne K.Z., Ferrari D.C., Lange-Dohna C., Rossner S., Wood T.G., and Perez-Polo J.R. Differential regulation of BACE1 promoter activity by nuclear factor-kappaB in neurons and glia upon exposure to beta-amyloid peptides. J. Neurosci. Res. 85 (2007) 1194-1204
    • (2007) J. Neurosci. Res. , vol.85 , pp. 1194-1204
    • Bourne, K.Z.1    Ferrari, D.C.2    Lange-Dohna, C.3    Rossner, S.4    Wood, T.G.5    Perez-Polo, J.R.6
  • 6
    • 14444272986 scopus 로고    scopus 로고
    • Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor
    • Buxbaum J.D., Liu K.N., Luo Y., Slack J.L., Stocking K.L., Peschon J.J., Johnson R.S., Castner B.J., Cerretti D.P., and Black R.A. Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor. J. Biol. Chem. 273 (1998) 27765-27767
    • (1998) J. Biol. Chem. , vol.273 , pp. 27765-27767
    • Buxbaum, J.D.1    Liu, K.N.2    Luo, Y.3    Slack, J.L.4    Stocking, K.L.5    Peschon, J.J.6    Johnson, R.S.7    Castner, B.J.8    Cerretti, D.P.9    Black, R.A.10
  • 7
    • 0030296713 scopus 로고    scopus 로고
    • Evidence for physiological down-regulation of brain oxidative phosphorylation in Alzheimer's disease
    • Chandrasekaran, Hatanpaa, Brady D.R., and Rapoport S.I. Evidence for physiological down-regulation of brain oxidative phosphorylation in Alzheimer's disease. Exp. Neurol. 142 (1996) 80-88
    • (1996) Exp. Neurol. , vol.142 , pp. 80-88
    • Chandrasekaran1    Hatanpaa2    Brady, D.R.3    Rapoport, S.I.4
  • 8
    • 0035099136 scopus 로고    scopus 로고
    • Structural and functional disruption of vascular smooth muscle cells in a transgenic mouse model of amyloid angiopathy
    • Christie R., Yamada M., Moskowitz M., and Hyman B. Structural and functional disruption of vascular smooth muscle cells in a transgenic mouse model of amyloid angiopathy. Am. J. Pathol. 158 (2001) 1065-1071
    • (2001) Am. J. Pathol. , vol.158 , pp. 1065-1071
    • Christie, R.1    Yamada, M.2    Moskowitz, M.3    Hyman, B.4
  • 9
    • 38349107593 scopus 로고    scopus 로고
    • The Alzheimer's disease β-secretase enzyme, BACE1
    • Cole S.L., and Vassar R. The Alzheimer's disease β-secretase enzyme, BACE1. Mol. Neuro. 2 (2007) 22
    • (2007) Mol. Neuro. , vol.2 , pp. 22
    • Cole, S.L.1    Vassar, R.2
  • 12
    • 0032032969 scopus 로고    scopus 로고
    • Characteristics of the in vitro vasoactivity of beta-amyloid peptides
    • Crawford F., Suo Z., Fang C., and Mullan M. Characteristics of the in vitro vasoactivity of beta-amyloid peptides. Exp. Neurol. 150 (1998) 159-168
    • (1998) Exp. Neurol. , vol.150 , pp. 159-168
    • Crawford, F.1    Suo, Z.2    Fang, C.3    Mullan, M.4
  • 13
    • 0032997546 scopus 로고    scopus 로고
    • Critical threshold cerebral hypoperfusion causes Alzheimer's disease?
    • de la Torre J.C. Critical threshold cerebral hypoperfusion causes Alzheimer's disease?. Acta Neuropathol. (Berl.) 98 (1999) 1-8
    • (1999) Acta Neuropathol. (Berl.) , vol.98 , pp. 1-8
    • de la Torre, J.C.1
  • 14
    • 33748951370 scopus 로고    scopus 로고
    • How do heart disease and stroke become risk factors for Alzheimer's disease?
    • de la Torre J.C. How do heart disease and stroke become risk factors for Alzheimer's disease?. Neurol. Res. 28 (2006) 637-644
    • (2006) Neurol. Res. , vol.28 , pp. 637-644
    • de la Torre, J.C.1
  • 19
    • 0036718272 scopus 로고    scopus 로고
    • Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease
    • Fukumoto H., Cheung B.S., Hyman B.T., and Irizarry M.C. Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease. Arch. Neurol. 59 (2002) 1381-1389
    • (2002) Arch. Neurol. , vol.59 , pp. 1381-1389
    • Fukumoto, H.1    Cheung, B.S.2    Hyman, B.T.3    Irizarry, M.C.4
  • 21
    • 33846101613 scopus 로고    scopus 로고
    • Filling the gaps in the abeta cascade hypothesis of Alzheimer's disease
    • Golde T.E., Dickson D., and Hutton M. Filling the gaps in the abeta cascade hypothesis of Alzheimer's disease. Curr. Alzheimer Res. 3 (2006) 421-430
    • (2006) Curr. Alzheimer Res. , vol.3 , pp. 421-430
    • Golde, T.E.1    Dickson, D.2    Hutton, M.3
  • 23
    • 33749177143 scopus 로고    scopus 로고
    • A hundred years of Alzheimer's disease research
    • Hardy J. A hundred years of Alzheimer's disease research. Neuron 52 (2006) 3-13
    • (2006) Neuron , vol.52 , pp. 3-13
    • Hardy, J.1
  • 24
    • 0029149234 scopus 로고
    • Epidemiology of vascular dementia
    • Hebert R., and Brayne C. Epidemiology of vascular dementia. Neuroepidemiology 14 (1995) 240-257
    • (1995) Neuroepidemiology , vol.14 , pp. 240-257
    • Hebert, R.1    Brayne, C.2
  • 25
    • 8144230876 scopus 로고    scopus 로고
    • Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members
    • Herms J., Anliker B., Heber S., Ring S., Fuhrmann M., Kretzschmar H., Sisodia S., and Muller U. Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members. EMBO J. 23 (2004) 4106-4115
    • (2004) EMBO J. , vol.23 , pp. 4106-4115
    • Herms, J.1    Anliker, B.2    Heber, S.3    Ring, S.4    Fuhrmann, M.5    Kretzschmar, H.6    Sisodia, S.7    Muller, U.8
  • 26
    • 0036260892 scopus 로고    scopus 로고
    • Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease
    • Holsinger R.M., McLean C.A., Beyreuther K., Masters C.L., and Evin G. Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease. Ann. Neurol. 51 (2002) 783-786
    • (2002) Ann. Neurol. , vol.51 , pp. 783-786
    • Holsinger, R.M.1    McLean, C.A.2    Beyreuther, K.3    Masters, C.L.4    Evin, G.5
  • 28
  • 29
    • 0033605676 scopus 로고    scopus 로고
    • Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide. Implications for oxygen sensing and signalling
    • Huang L.E., Willmore W.G., Gu J., Goldberg M.A., and Bunn H.F. Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide. Implications for oxygen sensing and signalling. J. Biol. Chem. 274 (1999) 9038-9044
    • (1999) J. Biol. Chem. , vol.274 , pp. 9038-9044
    • Huang, L.E.1    Willmore, W.G.2    Gu, J.3    Goldberg, M.A.4    Bunn, H.F.5
  • 30
    • 33646846683 scopus 로고    scopus 로고
    • 3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidative by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme
    • Huang L.S., Sun G., Cobessi D., Wang A.C., Shen J.T., Tung E.Y., Anderson V.E., and Berry E.A. 3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidative by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme. J. Biol. Chem. 281 (2006) 5965-5972
    • (2006) J. Biol. Chem. , vol.281 , pp. 5965-5972
    • Huang, L.S.1    Sun, G.2    Cobessi, D.3    Wang, A.C.4    Shen, J.T.5    Tung, E.Y.6    Anderson, V.E.7    Berry, E.A.8
  • 31
    • 0034122869 scopus 로고    scopus 로고
    • Role of the low-density lipoprotein receptor-related protein in beta-amyloid metabolism and Alzheimer disease
    • Hyman B.T., Strickland D., and Rebeck G.W. Role of the low-density lipoprotein receptor-related protein in beta-amyloid metabolism and Alzheimer disease. Arch. Neurol. 57 (2000) 646-650
    • (2000) Arch. Neurol. , vol.57 , pp. 646-650
    • Hyman, B.T.1    Strickland, D.2    Rebeck, G.W.3
  • 32
    • 0242576265 scopus 로고    scopus 로고
    • Atherosclerosis and neurodegeneration: unexpected conspirators in Alzheimer's dementia
    • Iadecola C. Atherosclerosis and neurodegeneration: unexpected conspirators in Alzheimer's dementia. Arterioscler. Thromb. Vasc. Biol. 23 (2003) 1951-1953
    • (2003) Arterioscler. Thromb. Vasc. Biol. , vol.23 , pp. 1951-1953
    • Iadecola, C.1
  • 33
    • 2342614850 scopus 로고    scopus 로고
    • Neurovascular regulation in the normal brain and in Alzheimer's disease
    • Iadecola C. Neurovascular regulation in the normal brain and in Alzheimer's disease. Nat. Rev. Neurosci. 5 (2004) 347-360
    • (2004) Nat. Rev. Neurosci. , vol.5 , pp. 347-360
    • Iadecola, C.1
  • 35
    • 0033202045 scopus 로고    scopus 로고
    • Overlap between pathology of Alzheimer disease and vascular dementia
    • Kalaria R.N., and Ballard C. Overlap between pathology of Alzheimer disease and vascular dementia. Alzheimer Dis. Assoc. Disord. 13 Suppl. 3 (1999) S115-S123
    • (1999) Alzheimer Dis. Assoc. Disord. , vol.13 , Issue.SUPPL. 3
    • Kalaria, R.N.1    Ballard, C.2
  • 41
    • 4344681535 scopus 로고    scopus 로고
    • Expression of the Alzheimer protease BACE1 is suppressed via its 5′-untranslated region
    • Lammich S., Schobel S., Zimmer A.K., Lichtenthaler S.F., and Haass C. Expression of the Alzheimer protease BACE1 is suppressed via its 5′-untranslated region. EMBO Rep. 5 (2004) 620-625
    • (2004) EMBO Rep. , vol.5 , pp. 620-625
    • Lammich, S.1    Schobel, S.2    Zimmer, A.K.3    Lichtenthaler, S.F.4    Haass, C.5
  • 43
    • 0029116848 scopus 로고
    • Facilitation of lin-12 -mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene
    • Levitan D., and Greenwald I. Facilitation of lin-12 -mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature 377 (1995) 351-354
    • (1995) Nature , vol.377 , pp. 351-354
    • Levitan, D.1    Greenwald, I.2
  • 45
    • 1642345964 scopus 로고    scopus 로고
    • Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1
    • Li Q., and Sudhof T.C. Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1. J. Biol. Chem. 279 (2004) 10542-10550
    • (2004) J. Biol. Chem. , vol.279 , pp. 10542-10550
    • Li, Q.1    Sudhof, T.C.2
  • 48
    • 0036135916 scopus 로고    scopus 로고
    • Expression of neuregulin and ErbB3 and ErbB4 after a traumatic lesion in the ventral funiculus of the spinal cord and in the intact primary olfactory system
    • Lindholm T., Cullheim S., Deckner M., Carlstedt T., and Risling M. Expression of neuregulin and ErbB3 and ErbB4 after a traumatic lesion in the ventral funiculus of the spinal cord and in the intact primary olfactory system. Exp. Brain Res. 142 (2002) 81-90
    • (2002) Exp. Brain Res. , vol.142 , pp. 81-90
    • Lindholm, T.1    Cullheim, S.2    Deckner, M.3    Carlstedt, T.4    Risling, M.5
  • 49
    • 20044377433 scopus 로고    scopus 로고
    • Volume cerebral blood flow reduction in pre-clinical stage of Alzheimer disease: evidence from an ultrasonographic study
    • Maalikjy Akkawi N., Borroni B., Agosti C., Magoni M., Broli M., Pezzini A., and Padovani A. Volume cerebral blood flow reduction in pre-clinical stage of Alzheimer disease: evidence from an ultrasonographic study. J. Neurol. 252 (2005) 559-563
    • (2005) J. Neurol. , vol.252 , pp. 559-563
    • Maalikjy Akkawi, N.1    Borroni, B.2    Agosti, C.3    Magoni, M.4    Broli, M.5    Pezzini, A.6    Padovani, A.7
  • 50
    • 33947512416 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in atherosclerosis
    • Madamanchi N.R., and Runge M.S. Mitochondrial dysfunction in atherosclerosis. Circ. Res. 100 (2007) 460-473
    • (2007) Circ. Res. , vol.100 , pp. 460-473
    • Madamanchi, N.R.1    Runge, M.S.2
  • 51
    • 0034575124 scopus 로고    scopus 로고
    • Apolipoprotein E: far more than a lipid transport protein
    • Mahley R.W., and Hall S.C. Apolipoprotein E: far more than a lipid transport protein. Annu. Rev. Genomics Hum. Genet 01 (2000) 507-537
    • (2000) Annu. Rev. Genomics Hum. Genet , vol.1 , pp. 507-537
    • Mahley, R.W.1    Hall, S.C.2
  • 52
    • 0033793248 scopus 로고    scopus 로고
    • Coordinated expression of β-amyloid precursor protein and the putative β-secretase BACE and α-secretase ADAM10 in mouse and human brain
    • Marcinkiewicz M., and Seidah N.G. Coordinated expression of β-amyloid precursor protein and the putative β-secretase BACE and α-secretase ADAM10 in mouse and human brain. J. Neurochem. 75 (2000) 2133-2143
    • (2000) J. Neurochem. , vol.75 , pp. 2133-2143
    • Marcinkiewicz, M.1    Seidah, N.G.2
  • 53
    • 0034983181 scopus 로고    scopus 로고
    • Cerebral blood flow and metabolic abnormalities in Alzheimer's disease
    • Matsuda H. Cerebral blood flow and metabolic abnormalities in Alzheimer's disease. Ann. Nucl. Med. 15 (2001) 85-92
    • (2001) Ann. Nucl. Med. , vol.15 , pp. 85-92
    • Matsuda, H.1
  • 55
    • 0034603524 scopus 로고    scopus 로고
    • Risk factors for cerebral hypoperfusion, mild cognitive impairment, and dementia
    • Meyer J.S., Rauch G., Rauch R.A., and Haque A. Risk factors for cerebral hypoperfusion, mild cognitive impairment, and dementia. Neurobiol. Aging 21 (2000) 161-169
    • (2000) Neurobiol. Aging , vol.21 , pp. 161-169
    • Meyer, J.S.1    Rauch, G.2    Rauch, R.A.3    Haque, A.4
  • 57
    • 17844364259 scopus 로고    scopus 로고
    • Brain glucose metabolism in the early and specific diagnosis of Alzheimer's disease. FDG-PET studies in MCI and AD
    • Mosconi L. Brain glucose metabolism in the early and specific diagnosis of Alzheimer's disease. FDG-PET studies in MCI and AD. Eur. J. Nucl. Med. Mol. Imaging 32 (2005) 486-510
    • (2005) Eur. J. Nucl. Med. Mol. Imaging , vol.32 , pp. 486-510
    • Mosconi, L.1
  • 60
    • 33749521100 scopus 로고    scopus 로고
    • Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation
    • Oakley H., Cole S.L., Logan S., Maus E., Shao P., Craft J., Guillozet-Bongaarts A., Ohno M., Disterhoft J., Van Eldik L., Berry R., and Vassar R. Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation. J. Neurosci. 26 (2006) 10129-10140
    • (2006) J. Neurosci. , vol.26 , pp. 10129-10140
    • Oakley, H.1    Cole, S.L.2    Logan, S.3    Maus, E.4    Shao, P.5    Craft, J.6    Guillozet-Bongaarts, A.7    Ohno, M.8    Disterhoft, J.9    Van Eldik, L.10    Berry, R.11    Vassar, R.12
  • 68
    • 0342980328 scopus 로고    scopus 로고
    • In vivo PET imaging and postmortem studies suggest potentially reversible and irreversible stages of brain metabolic failure in Alzheimer's disease
    • Rapoport S.I. In vivo PET imaging and postmortem studies suggest potentially reversible and irreversible stages of brain metabolic failure in Alzheimer's disease. Eur. Arch. Psychiatry Clin. Neurosci. 249 Suppl. 3 (1999) 46-55
    • (1999) Eur. Arch. Psychiatry Clin. Neurosci. , vol.249 , Issue.SUPPL. 3 , pp. 46-55
    • Rapoport, S.I.1
  • 71
    • 1542357687 scopus 로고    scopus 로고
    • Differential utilization of upstream AUGs in the beta-secretase mRNA suggests that a shunting mechanism regulates translation
    • Rogers G.W., Edelman Jr. G.M., and Mauro V.P. Differential utilization of upstream AUGs in the beta-secretase mRNA suggests that a shunting mechanism regulates translation. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 2794-2799
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 2794-2799
    • Rogers, G.W.1    Edelman Jr., G.M.2    Mauro, V.P.3
  • 73
    • 0036327146 scopus 로고    scopus 로고
    • Vascular dementia revisited: diagnosis, pathogenesis, treatment, and prevention
    • Roman G.C. Vascular dementia revisited: diagnosis, pathogenesis, treatment, and prevention. Med. Clin. North Am. 86 (2002) 477-499
    • (2002) Med. Clin. North Am. , vol.86 , pp. 477-499
    • Roman, G.C.1
  • 75
    • 0036717261 scopus 로고    scopus 로고
    • Explaining the cause of the amyloid burden in Alzheimer disease
    • Rosenberg R.N. Explaining the cause of the amyloid burden in Alzheimer disease. Arch. Neurol. 59 (2002) 1367-1368
    • (2002) Arch. Neurol. , vol.59 , pp. 1367-1368
    • Rosenberg, R.N.1
  • 76
    • 33747347875 scopus 로고    scopus 로고
    • Transcriptional and translational regulation of BACE1 expression-implications for Alzheimer's disease
    • Rossner S., Sastre M., Bourne K., and Lichtenthaler S.F. Transcriptional and translational regulation of BACE1 expression-implications for Alzheimer's disease. Prog. Neurobiol. 79 (2006) 95-111
    • (2006) Prog. Neurobiol. , vol.79 , pp. 95-111
    • Rossner, S.1    Sastre, M.2    Bourne, K.3    Lichtenthaler, S.F.4
  • 79
    • 0034495353 scopus 로고    scopus 로고
    • Amyloid precursor protein β-secretase (BACE) mRNA expression in human neural cell lines following induction of neuronal differentiation and exposure to cytokines and growth factors
    • Sato J.-I., and Kuroda Y. Amyloid precursor protein β-secretase (BACE) mRNA expression in human neural cell lines following induction of neuronal differentiation and exposure to cytokines and growth factors. Neuropathology 20 (2000) 289-296
    • (2000) Neuropathology , vol.20 , pp. 289-296
    • Sato, J.-I.1    Kuroda, Y.2
  • 80
    • 0030989545 scopus 로고    scopus 로고
    • 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease
    • Sayre L.M., Zelasko D.A., Harris P.L., Perry G., Salomon R.G., and Smith M.A. 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease. J. Neurochem. 68 (1997) 2092-2097
    • (1997) J. Neurochem. , vol.68 , pp. 2092-2097
    • Sayre, L.M.1    Zelasko, D.A.2    Harris, P.L.3    Perry, G.4    Salomon, R.G.5    Smith, M.A.6
  • 82
    • 35748959415 scopus 로고    scopus 로고
    • Mixed brain pathologies account for most dementia cases in community-dwelling older persons
    • Schneider J.A., Arvanitakis Z., Bang W., and Bennett D.A. Mixed brain pathologies account for most dementia cases in community-dwelling older persons. Neurology 69 (2007) 2197-2204
    • (2007) Neurology , vol.69 , pp. 2197-2204
    • Schneider, J.A.1    Arvanitakis, Z.2    Bang, W.3    Bennett, D.A.4
  • 83
    • 34547821883 scopus 로고    scopus 로고
    • Subcortical infarcts, Alzheimer's disease pathology, and memory function in older persons
    • Schneider J.A., Boyle P.A., Arvanitakis Z., Bienias J.L., and Bennett D.A. Subcortical infarcts, Alzheimer's disease pathology, and memory function in older persons. Ann. Neurol. 62 (2007) 59-66
    • (2007) Ann. Neurol. , vol.62 , pp. 59-66
    • Schneider, J.A.1    Boyle, P.A.2    Arvanitakis, Z.3    Bienias, J.L.4    Bennett, D.A.5
  • 84
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: genes, proteins, and therapy
    • Selkoe D.J. Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 81 (2001) 741-766
    • (2001) Physiol. Rev. , vol.81 , pp. 741-766
    • Selkoe, D.J.1
  • 85
    • 2642555563 scopus 로고    scopus 로고
    • HIF1 and oxygen sensing in the brain
    • Sharp F.R., and Bernaudin M. HIF1 and oxygen sensing in the brain. Nat. Rev. Neurosci. 5 (2004) 437-448
    • (2004) Nat. Rev. Neurosci. , vol.5 , pp. 437-448
    • Sharp, F.R.1    Bernaudin, M.2
  • 91
    • 34247578755 scopus 로고    scopus 로고
    • Neurondegeneration and Alzheimer's disease: the lesson from tauopathies
    • Sorrentino G., and Bonavita V. Neurondegeneration and Alzheimer's disease: the lesson from tauopathies. Neurol. Sci. 28 (2007) 63-71
    • (2007) Neurol. Sci. , vol.28 , pp. 63-71
    • Sorrentino, G.1    Bonavita, V.2
  • 92
    • 34250170146 scopus 로고    scopus 로고
    • Clinical significance of silent cerebral infarctions in patients with Alzheimer disease
    • Song I.U., Kim J.S., Kim Y.I., Eah K.Y., and Lee K.S. Clinical significance of silent cerebral infarctions in patients with Alzheimer disease. Cogn. Behav. Neurol. 20 (2007) 93-98
    • (2007) Cogn. Behav. Neurol. , vol.20 , pp. 93-98
    • Song, I.U.1    Kim, J.S.2    Kim, Y.I.3    Eah, K.Y.4    Lee, K.S.5
  • 95
    • 33745228920 scopus 로고    scopus 로고
    • The various aggregation states of beta-amyloid 1-42 mediate different effects on oxidative stress, neurodegeneration, and BACE-1 expression
    • Tamagno E., Bardini P., Guglielmotto M., Danni O., and Tabaton M. The various aggregation states of beta-amyloid 1-42 mediate different effects on oxidative stress, neurodegeneration, and BACE-1 expression. Free Radic. Biol. Med. 41 (2006) 202-212
    • (2006) Free Radic. Biol. Med. , vol.41 , pp. 202-212
    • Tamagno, E.1    Bardini, P.2    Guglielmotto, M.3    Danni, O.4    Tabaton, M.5
  • 99
    • 0029670094 scopus 로고    scopus 로고
    • beta-Amyloid-mediated vasoactivity and vascular endothelial damage
    • Thomas T., Thomas G., McLendon C., Sutton T., and Mullan M. beta-Amyloid-mediated vasoactivity and vascular endothelial damage. Nature 380 (1996) 168-171
    • (1996) Nature , vol.380 , pp. 168-171
    • Thomas, T.1    Thomas, G.2    McLendon, C.3    Sutton, T.4    Mullan, M.5
  • 102
    • 0037080159 scopus 로고    scopus 로고
    • Repetitive mild brain trauma accelerates Abeta deposition, lipid peroxidation, and cognitive impairment in a transgenic mouse model of Alzheimer amyloidosis
    • Uryu K., Laurer H., McIntosh T., Pratico D., Martinez D., Leight S., Lee V.M., and Trojanowski J.Q. Repetitive mild brain trauma accelerates Abeta deposition, lipid peroxidation, and cognitive impairment in a transgenic mouse model of Alzheimer amyloidosis. J. Neurosci. 22 (2002) 446-454
    • (2002) J. Neurosci. , vol.22 , pp. 446-454
    • Uryu, K.1    Laurer, H.2    McIntosh, T.3    Pratico, D.4    Martinez, D.5    Leight, S.6    Lee, V.M.7    Trojanowski, J.Q.8
  • 103
    • 4344630985 scopus 로고    scopus 로고
    • BACE1: the beta-secretase enzyme in Alzheimer's disease
    • Vassar R. BACE1: the beta-secretase enzyme in Alzheimer's disease. J. Mol. Neurosci. 23 (2004) 105-114
    • (2004) J. Mol. Neurosci. , vol.23 , pp. 105-114
    • Vassar, R.1
  • 105
    • 28044458281 scopus 로고    scopus 로고
    • Energy inhibition elevates beta-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice: possible early events in Alzheimer's disease pathogenesis
    • Velliquette R.A., O'Connor T., and Vassar R. Energy inhibition elevates beta-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice: possible early events in Alzheimer's disease pathogenesis. J. Neurosci. 25 (2005) 10874-10883
    • (2005) J. Neurosci. , vol.25 , pp. 10874-10883
    • Velliquette, R.A.1    O'Connor, T.2    Vassar, R.3
  • 108
    • 2142815707 scopus 로고    scopus 로고
    • Increased beta-secretase activity and expression in rats following transient cerebral ischemia.
    • Wen Y., Onyewuchi O., Yang S., Liu R., and Simpkins J.W. Increased beta-secretase activity and expression in rats following transient cerebral ischemia. Brain Res. 1009 (2004) 1-8
    • (2004) Brain Res. , vol.1009 , pp. 1-8
    • Wen, Y.1    Onyewuchi, O.2    Yang, S.3    Liu, R.4    Simpkins, J.W.5
  • 110
    • 33744935554 scopus 로고    scopus 로고
    • Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in Mild Cognitive Impairment and early Alzheimer's disease
    • Williams T.I., Lynn B.C., Markesbery W.R., and Lovell M.A. Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in Mild Cognitive Impairment and early Alzheimer's disease. Neurobiol. Aging 27 (2006) 1094-1099
    • (2006) Neurobiol. Aging , vol.27 , pp. 1094-1099
    • Williams, T.I.1    Lynn, B.C.2    Markesbery, W.R.3    Lovell, M.A.4
  • 111
    • 20744454142 scopus 로고    scopus 로고
    • Beta subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase
    • Wong H.K., Sakurai T., Oyama F., Kaneko K., Wada K., Miyazaki H., Kurosawa M., De Strooper B., Saftig P., and Nukina N. Beta subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase. J. Biol. Chem. 280 (2005) 23009-23017
    • (2005) J. Biol. Chem. , vol.280 , pp. 23009-23017
    • Wong, H.K.1    Sakurai, T.2    Oyama, F.3    Kaneko, K.4    Wada, K.5    Miyazaki, H.6    Kurosawa, M.7    De Strooper, B.8    Saftig, P.9    Nukina, N.10
  • 114
    • 34447510973 scopus 로고    scopus 로고
    • Mitochondrial respiratory inhibition and oxidative stress elevate beta-secretase (BACE1) proteins and activity in vivo in the rat retina
    • Xiong K., Cai H., Luo X.G., Struble R.G., Clough R.W., and Yan X.X. Mitochondrial respiratory inhibition and oxidative stress elevate beta-secretase (BACE1) proteins and activity in vivo in the rat retina. Exp. Brain Res. 181 (2007) 435-446
    • (2007) Exp. Brain Res. , vol.181 , pp. 435-446
    • Xiong, K.1    Cai, H.2    Luo, X.G.3    Struble, R.G.4    Clough, R.W.5    Yan, X.X.6
  • 115
    • 0035823610 scopus 로고    scopus 로고
    • BACE2 functions as an alternative alpha-secretase in cells
    • Yan R., Munzner J.B., Shuck M.E., and Bienkowski M.J. BACE2 functions as an alternative alpha-secretase in cells. J. Biol. Chem. 276 (2001) 34019-34027
    • (2001) J. Biol. Chem. , vol.276 , pp. 34019-34027
    • Yan, R.1    Munzner, J.B.2    Shuck, M.E.3    Bienkowski, M.J.4
  • 116
    • 33846523416 scopus 로고    scopus 로고
    • Beta-secretase expression in normal and functionally deprived rat olfactory bulbs: inverse correlation with oxidative metabolic activity
    • Yan X.X., Xiong K., Luo X.G., Struble R.G., and Clough R.W. Beta-secretase expression in normal and functionally deprived rat olfactory bulbs: inverse correlation with oxidative metabolic activity. J. Comp. Neurol. 501 (2007) 52-69
    • (2007) J. Comp. Neurol. , vol.501 , pp. 52-69
    • Yan, X.X.1    Xiong, K.2    Luo, X.G.3    Struble, R.G.4    Clough, R.W.5
  • 119
    • 34249727115 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation
    • Zhang X., Zhou K., Wang R., Cui J., Lipton S.A., Liao F.F., Xu H., and Zhang Y.W. Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation. J. Biol. Chem. 282 (2007) 10873-10880
    • (2007) J. Biol. Chem. , vol.282 , pp. 10873-10880
    • Zhang, X.1    Zhou, K.2    Wang, R.3    Cui, J.4    Lipton, S.A.5    Liao, F.F.6    Xu, H.7    Zhang, Y.W.8
  • 120
    • 34147120073 scopus 로고    scopus 로고
    • Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis
    • Zhao J., Fu Y., Yasvoina M., Shao P., Hitt B., O'Connor T., Logan S., Maus E., Citron M., Berry R., Binder L., and Vassar R. Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis. J. Neurosci. 27 (2007) 3639-3649
    • (2007) J. Neurosci. , vol.27 , pp. 3639-3649
    • Zhao, J.1    Fu, Y.2    Yasvoina, M.3    Shao, P.4    Hitt, B.5    O'Connor, T.6    Logan, S.7    Maus, E.8    Citron, M.9    Berry, R.10    Binder, L.11    Vassar, R.12


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.