Energy inhibition elevates β-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice: Possible early events in Alzheimer's disease pathogenesis

Journal of Neuroscience

Volumn 25, Issue 47, 2005, Pages 10874-10883

  Velliquette, Rodney A ^a   O'Connor, Tracy ^a   Vassar, Robert ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

amyloid peptide; secretase; Alzheimer's disease pathogenesis; APP transgenic mice; BACE1; Energy metabolism

Indexed keywords

AMYLOID; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; DEOXYGLUCOSE; INSULIN; KAINIC ACID; PROPIONIC ACID;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD FLOW VELOCITY; BRAIN BLOOD FLOW; CONTROLLED STUDY; ENERGY METABOLISM; ENERGY YIELD; ENZYME ACTIVITY; GLUCOSE BRAIN LEVEL; GLUCOSE METABOLISM; MEMBRANE BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; TRANSGENIC MOUSE; WILD TYPE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BRAIN; ENDOPEPTIDASES; ENERGY METABOLISM; HUMANS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PEPTIDE FRAGMENTS; TIME FACTORS;

EID: 28044458281     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2350-05.2005     Document Type: Article

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