메뉴 건너뛰기




Volumn 130, Issue 9, 2007, Pages 2310-2319

Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy

Author keywords

Cerebral blood flow; Hypercapnia; Laser speckle flowmetry; Spreading depression; Whisker stimulation

Indexed keywords

AMYLOID BETA PROTEIN; CHLORALOSE; ISOFLURANE;

EID: 34548225478     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awm156     Document Type: Article
Times cited : (156)

References (59)
  • 1
    • 0009566277 scopus 로고    scopus 로고
    • Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS)
    • Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). Lancet 2001; 357: 169-75.
    • (2001) Lancet , vol.357 , pp. 169-175
  • 2
    • 3042852753 scopus 로고    scopus 로고
    • Laser speckle flowmetry for the study of cerebrovascular physiology in normal and ischemic mouse cortex
    • Ayata C, Dunn AK, Gursoy OY, Huang Z, Boas DA, Moskowitz MA. Laser speckle flowmetry for the study of cerebrovascular physiology in normal and ischemic mouse cortex. J Cereb Blood Flow Metab 2004a; 24: 744-55.
    • (2004) J Cereb Blood Flow Metab , vol.24 , pp. 744-755
    • Ayata, C.1    Dunn, A.K.2    Gursoy, O.Y.3    Huang, Z.4    Boas, D.A.5    Moskowitz, M.A.6
  • 4
    • 0141457931 scopus 로고    scopus 로고
    • Age-dependent cerebrovascular abnormalities and blood flow disturbances in APP23 mice modeling Alzheimer's disease
    • Beckmann N, Schuler A, Mueggler T, Meyer EP, Wiederhold KH, Staufenbiel M, et al. Age-dependent cerebrovascular abnormalities and blood flow disturbances in APP23 mice modeling Alzheimer's disease. J Neurosci 2003; 23: 8453-9.
    • (2003) J Neurosci , vol.23 , pp. 8453-8459
    • Beckmann, N.1    Schuler, A.2    Mueggler, T.3    Meyer, E.P.4    Wiederhold, K.H.5    Staufenbiel, M.6
  • 5
    • 0034020399 scopus 로고    scopus 로고
    • Mechanisms of cerebrovascular amyloid deposition. Lessons from mouse models
    • Burgermeister P, Calhoun ME, Winkler DT, Jucker M. Mechanisms of cerebrovascular amyloid deposition. Lessons from mouse models. Ann N Y Acad Sci 2000; 903: 307-16.
    • (2000) Ann N Y Acad Sci , vol.903 , pp. 307-316
    • Burgermeister, P.1    Calhoun, M.E.2    Winkler, D.T.3    Jucker, M.4
  • 6
    • 13044265226 scopus 로고    scopus 로고
    • Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid
    • Calhoun ME, Burgermeister P, Phinney AL, Stalder M, Tolnay M, Wiederhold KH, et al. Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid. Proc Natl Acad Sci U S A 1999; 96: 14088-93.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 14088-14093
    • Calhoun, M.E.1    Burgermeister, P.2    Phinney, A.L.3    Stalder, M.4    Tolnay, M.5    Wiederhold, K.H.6
  • 7
    • 0035099136 scopus 로고    scopus 로고
    • Structural and functional disruption of vascular smooth muscle cells in a transgenic mouse model of amyloid angiopathy
    • Christie R, Yamada M, Moskowitz M, Hyman B. Structural and functional disruption of vascular smooth muscle cells in a transgenic mouse model of amyloid angiopathy. Am J Pathol 2001; 158: 1065-71.
    • (2001) Am J Pathol , vol.158 , pp. 1065-1071
    • Christie, R.1    Yamada, M.2    Moskowitz, M.3    Hyman, B.4
  • 8
    • 0032032969 scopus 로고    scopus 로고
    • Characteristics of the in vitro vasoactivity of beta-amyloid peptides
    • Crawford F, Suo Z, Fang C, Mullan M. Characteristics of the in vitro vasoactivity of beta-amyloid peptides. Exp Neurol 1998; 150: 159-68.
    • (1998) Exp Neurol , vol.150 , pp. 159-168
    • Crawford, F.1    Suo, Z.2    Fang, C.3    Mullan, M.4
  • 9
    • 0029018863 scopus 로고
    • Cerebrovascular responses under controlled and monitored physiological conditions in the anesthetized mouse
    • Dalkara T, Irikura K, Huang Z, Panahian N, Moskowitz MA. Cerebrovascular responses under controlled and monitored physiological conditions in the anesthetized mouse. J Cereb Blood Flow Metab 1995; 15: 631-8.
    • (1995) J Cereb Blood Flow Metab , vol.15 , pp. 631-638
    • Dalkara, T.1    Irikura, K.2    Huang, Z.3    Panahian, N.4    Moskowitz, M.A.5
  • 12
    • 0029973286 scopus 로고    scopus 로고
    • Ellis RJ, Olichney JM, Thal LJ, Mirra SS, Morris JC, Beekly D, et al. Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease: the CERAD experience, Part XV. Neurology 1996; 46: 1592-6.
    • Ellis RJ, Olichney JM, Thal LJ, Mirra SS, Morris JC, Beekly D, et al. Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease: the CERAD experience, Part XV. Neurology 1996; 46: 1592-6.
  • 13
    • 0022888328 scopus 로고
    • Calcium antagonism and calcium entry blockade
    • Godfraind T, Miller R, Wibo M. Calcium antagonism and calcium entry blockade. Pharmacol Rev 1986; 38: 321-416.
    • (1986) Pharmacol Rev , vol.38 , pp. 321-416
    • Godfraind, T.1    Miller, R.2    Wibo, M.3
  • 14
    • 0034982951 scopus 로고    scopus 로고
    • Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy
    • Grabowski TJ, Cho HS, Vonsattel JP, Rebeck GW, Greenberg SM. Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy. Ann Neurol 2001; 49: 697-705.
    • (2001) Ann Neurol , vol.49 , pp. 697-705
    • Grabowski, T.J.1    Cho, H.S.2    Vonsattel, J.P.3    Rebeck, G.W.4    Greenberg, S.M.5
  • 15
    • 0036130319 scopus 로고    scopus 로고
    • Cerebral amyloid angiopathy and vessel dysfunction
    • Greenberg SM. Cerebral amyloid angiopathy and vessel dysfunction. Cerebrovasc Dis 2002; 13 (Suppl 2): 42-7.
    • (2002) Cerebrovasc Dis , vol.13 , Issue.SUPPL. 2 , pp. 42-47
    • Greenberg, S.M.1
  • 16
    • 33645523000 scopus 로고    scopus 로고
    • Small vessels, big problems
    • Greenberg SM. Small vessels, big problems. N Engl J Med 2006; 354: 1451-3.
    • (2006) N Engl J Med , vol.354 , pp. 1451-1453
    • Greenberg, S.M.1
  • 17
    • 7644219821 scopus 로고    scopus 로고
    • Amyloid angiopathy-related vascular cognitive impairment
    • Greenberg SM, Gurol ME, Rosand J, Smith EE. Amyloid angiopathy-related vascular cognitive impairment. Stroke 2004; 35: 2616-9.
    • (2004) Stroke , vol.35 , pp. 2616-2619
    • Greenberg, S.M.1    Gurol, M.E.2    Rosand, J.3    Smith, E.E.4
  • 18
  • 19
    • 0036355286 scopus 로고    scopus 로고
    • Cerebral amyloid angiopathy, white matter lesions and Alzheimer encephalopathy - a histopathological assessment
    • Haglund M, Englund E. Cerebral amyloid angiopathy, white matter lesions and Alzheimer encephalopathy - a histopathological assessment. Dement Geriatr Cogn Disord 2002; 14: 161-6.
    • (2002) Dement Geriatr Cogn Disord , vol.14 , pp. 161-166
    • Haglund, M.1    Englund, E.2
  • 20
    • 0029742199 scopus 로고    scopus 로고
    • Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice
    • Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, et al. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 1996; 274: 99-102.
    • (1996) Science , vol.274 , pp. 99-102
    • Hsiao, K.1    Chapman, P.2    Nilsen, S.3    Eckman, C.4    Harigaya, Y.5    Younkin, S.6
  • 21
    • 2342614850 scopus 로고    scopus 로고
    • Neurovascular regulation in the normal brain and in Alzheimer's disease
    • Iadecola C. Neurovascular regulation in the normal brain and in Alzheimer's disease. Nat Rev Neurosci 2004; 5: 347-60.
    • (2004) Nat Rev Neurosci , vol.5 , pp. 347-360
    • Iadecola, C.1
  • 22
    • 0033363939 scopus 로고    scopus 로고
    • SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein
    • Iadecola C, Zhang F, Niwa K, Eckman C, Turner SK, Fischer E, et al. SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein. Nat Neurosci 1999; 2: 157-61.
    • (1999) Nat Neurosci , vol.2 , pp. 157-161
    • Iadecola, C.1    Zhang, F.2    Niwa, K.3    Eckman, C.4    Turner, S.K.5    Fischer, E.6
  • 23
    • 0035863055 scopus 로고    scopus 로고
    • Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease
    • Kawarabayashi T, Younkin LH, Saido TC, Shoji M, Ashe KH, Younkin SG. Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease. J Neurosci 2001; 21: 372-81.
    • (2001) J Neurosci , vol.21 , pp. 372-381
    • Kawarabayashi, T.1    Younkin, L.H.2    Saido, T.C.3    Shoji, M.4    Ashe, K.H.5    Younkin, S.G.6
  • 24
    • 0036898833 scopus 로고    scopus 로고
    • Isoflurane-induced cerebral hyperemia is partially mediated by nitric oxide and epoxyeicosatrienoic acids in mice in vivo
    • Kehl F, Shen H, Moreno C, Farber NE, Roman RJ, Kampine JP, et al. Isoflurane-induced cerebral hyperemia is partially mediated by nitric oxide and epoxyeicosatrienoic acids in mice in vivo. Anesthesiology 2002; 97: 1528-33.
    • (2002) Anesthesiology , vol.97 , pp. 1528-1533
    • Kehl, F.1    Shen, H.2    Moreno, C.3    Farber, N.E.4    Roman, R.J.5    Kampine, J.P.6
  • 25
    • 18244362302 scopus 로고    scopus 로고
    • Impaired cerebral vasoreactivity in a transgenic mouse model of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy arteriopathy
    • Lacombe P, Oligo C, Domenga V, Tournier-Lasserve E, Joutel A. Impaired cerebral vasoreactivity in a transgenic mouse model of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy arteriopathy. Stroke 2005; 36: 1053-8.
    • (2005) Stroke , vol.36 , pp. 1053-1058
    • Lacombe, P.1    Oligo, C.2    Domenga, V.3    Tournier-Lasserve, E.4    Joutel, A.5
  • 26
    • 0032421512 scopus 로고    scopus 로고
    • Local cerebral blood flow, local cerebral glucose utilization, and flow-metabolism coupling during sevoflurane versus isoflurane anesthesia in rats
    • Lenz C, Rebel A, van Ackern K, Kuschinsky W, Waschke KF. Local cerebral blood flow, local cerebral glucose utilization, and flow-metabolism coupling during sevoflurane versus isoflurane anesthesia in rats. Anesthesiology 1998; 89: 1480-8.
    • (1998) Anesthesiology , vol.89 , pp. 1480-1488
    • Lenz, C.1    Rebel, A.2    van Ackern, K.3    Kuschinsky, W.4    Waschke, K.F.5
  • 27
    • 0016442208 scopus 로고
    • The incidence of cerebral amyloid angiopathy in Alzheimer's disease
    • Mandybur TI. The incidence of cerebral amyloid angiopathy in Alzheimer's disease. Neurology 1975; 25: 120-6.
    • (1975) Neurology , vol.25 , pp. 120-126
    • Mandybur, T.I.1
  • 29
    • 0033525520 scopus 로고    scopus 로고
    • Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain
    • Moechars D, Dewachter I, Lorent K, Reverse D, Baekelandt V, Naidu A, et al. Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain. J Biol Chem 1999; 274: 6483-92.
    • (1999) J Biol Chem , vol.274 , pp. 6483-6492
    • Moechars, D.1    Dewachter, I.2    Lorent, K.3    Reverse, D.4    Baekelandt, V.5    Naidu, A.6
  • 32
    • 0035203856 scopus 로고    scopus 로고
    • Dementia in hereditary cerebral hemorrhage with amyloidosis-Dutch type is associated with cerebral amyloid angiopathy but is independent of plaques and neurofibrillary tangles
    • Natte R, Maat-Schieman ML, Haan J, Bornebroek M, Roos RA, van Duinen SG. Dementia in hereditary cerebral hemorrhage with amyloidosis-Dutch type is associated with cerebral amyloid angiopathy but is independent of plaques and neurofibrillary tangles. Ann Neurol 2001; 50: 765-72.
    • (2001) Ann Neurol , vol.50 , pp. 765-772
    • Natte, R.1    Maat-Schieman, M.L.2    Haan, J.3    Bornebroek, M.4    Roos, R.A.5    van Duinen, S.G.6
  • 33
    • 0033622480 scopus 로고    scopus 로고
    • Exogenous A beta1-40 reproduces cerebrovascular alterations resulting from amyloid precursor protein overexpression in mice
    • Niwa K, Carlson GA, Iadecola C. Exogenous A beta1-40 reproduces cerebrovascular alterations resulting from amyloid precursor protein overexpression in mice. J Cereb Blood Flow Metab 2000a; 20: 1659-68.
    • (2000) J Cereb Blood Flow Metab , vol.20 , pp. 1659-1668
    • Niwa, K.1    Carlson, G.A.2    Iadecola, C.3
  • 35
    • 0036176504 scopus 로고    scopus 로고
    • Alterations in cerebral blood flow and glucose utilization in mice overexpressing the amyloid precursor protein
    • Niwa K, Kazama K, Younkin SG, Carlson GA, Iadecola C. Alterations in cerebral blood flow and glucose utilization in mice overexpressing the amyloid precursor protein. Neurobiol Dis 2002b; 9: 61-8.
    • (2002) Neurobiol Dis , vol.9 , pp. 61-68
    • Niwa, K.1    Kazama, K.2    Younkin, S.G.3    Carlson, G.A.4    Iadecola, C.5
  • 37
    • 0034662501 scopus 로고    scopus 로고
    • Abeta 1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation
    • Niwa K, Younkin L, Ebeling C, Turner SK, Westaway D, Younkin S, et al. Abeta 1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation. Proc Natl Acad Sci U S A 2000b; 97: 9735-40.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 9735-9740
    • Niwa, K.1    Younkin, L.2    Ebeling, C.3    Turner, S.K.4    Westaway, D.5    Younkin, S.6
  • 38
    • 17644431039 scopus 로고    scopus 로고
    • Isoflurane-induced cerebral hyperemia in neuronal nitric oxide synthase gene deficient mice
    • Okamoto H, Meng W, Ma J, Ayata C, Roman RJ, Bosnjak ZJ, et al. Isoflurane-induced cerebral hyperemia in neuronal nitric oxide synthase gene deficient mice. Anesthesiology 1997; 86: 875-84.
    • (1997) Anesthesiology , vol.86 , pp. 875-884
    • Okamoto, H.1    Meng, W.2    Ma, J.3    Ayata, C.4    Roman, R.J.5    Bosnjak, Z.J.6
  • 39
    • 0030723931 scopus 로고    scopus 로고
    • Types of cerebrovascular lesions associated with severe cerebral amyloid angiopathy in Alzheimer's disease
    • Olichney JM, Ellis RJ, Katzman R, Sabbagh MN, Hansen L. Types of cerebrovascular lesions associated with severe cerebral amyloid angiopathy in Alzheimer's disease. Ann N Y Acad Sci 1997; 826: 493-7.
    • (1997) Ann N Y Acad Sci , vol.826 , pp. 493-497
    • Olichney, J.M.1    Ellis, R.J.2    Katzman, R.3    Sabbagh, M.N.4    Hansen, L.5
  • 40
    • 0029038881 scopus 로고
    • Cerebral infarction in Alzheimer's disease is associated with severe amyloid angiopathy and hypertension
    • Olichney JM, Hansen LA, Hofstetter CR, Grundman M, Katzman R, Thal LJ. Cerebral infarction in Alzheimer's disease is associated with severe amyloid angiopathy and hypertension. Arch Neurol 1995; 52: 702-8.
    • (1995) Arch Neurol , vol.52 , pp. 702-708
    • Olichney, J.M.1    Hansen, L.A.2    Hofstetter, C.R.3    Grundman, M.4    Katzman, R.5    Thal, L.J.6
  • 41
    • 0042387969 scopus 로고    scopus 로고
    • Vasoactive effects of A beta in isolated human cerebrovessels and in a transgenic mouse model of Alzheimer's disease: Role of inflammation
    • Paris D, Humphrey J, Quadros A, Patel N, Crescentini R, Crawford F, et al. Vasoactive effects of A beta in isolated human cerebrovessels and in a transgenic mouse model of Alzheimer's disease: role of inflammation. Neurol Res 2003; 25: 642-51.
    • (2003) Neurol Res , vol.25 , pp. 642-651
    • Paris, D.1    Humphrey, J.2    Quadros, A.3    Patel, N.4    Crescentini, R.5    Crawford, F.6
  • 42
    • 1542316987 scopus 로고    scopus 로고
    • Abeta-induced vascular oxidative stress and attenuation of functional hyperemia in mouse somatosensory cortex
    • Park L, Anrather J, Forster C, Kazama K, Carlson GA, Iadecola C. Abeta-induced vascular oxidative stress and attenuation of functional hyperemia in mouse somatosensory cortex. J Cereb Blood Flow Metab 2004; 24: 334-42.
    • (2004) J Cereb Blood Flow Metab , vol.24 , pp. 334-342
    • Park, L.1    Anrather, J.2    Forster, C.3    Kazama, K.4    Carlson, G.A.5    Iadecola, C.6
  • 43
    • 14044258771 scopus 로고    scopus 로고
    • NADPH oxidase-derived reactive oxygen species mediate the cerebrovascular dysfunction induced by the amyloid beta peptide
    • Park L, Anrather J, Zhou P, Frys K, Pitstick R, Younkin S, et al. NADPH oxidase-derived reactive oxygen species mediate the cerebrovascular dysfunction induced by the amyloid beta peptide. J Neurosci 2005; 25: 1769-77.
    • (2005) J Neurosci , vol.25 , pp. 1769-1777
    • Park, L.1    Anrather, J.2    Zhou, P.3    Frys, K.4    Pitstick, R.5    Younkin, S.6
  • 44
    • 34548239148 scopus 로고    scopus 로고
    • Reactive oxygen species (ROS) derived from a nox2-containing NADPH oxidase disrupt neurovascular regulation in normal aging
    • Park L, Zhou P, Anrather J, Iadecola C. Reactive oxygen species (ROS) derived from a nox2-containing NADPH oxidase disrupt neurovascular regulation in normal aging. Society for Neuroscience Annual Meeting 2006.
    • (2006) Society for Neuroscience Annual Meeting
    • Park, L.1    Zhou, P.2    Anrather, J.3    Iadecola, C.4
  • 45
    • 0037062566 scopus 로고    scopus 로고
    • Cerebral amyloid angiopathy and cognitive function: The HAAS autopsy study
    • Pfeifer LA, White LR, Ross GW, Petrovitch H, Launer LJ. Cerebral amyloid angiopathy and cognitive function: the HAAS autopsy study. Neurology 2002; 58: 1629-34.
    • (2002) Neurology , vol.58 , pp. 1629-1634
    • Pfeifer, L.A.1    White, L.R.2    Ross, G.W.3    Petrovitch, H.4    Launer, L.J.5
  • 47
    • 0017711143 scopus 로고
    • Comparative effects of chloralose anesthesia and Sernylan analgesia on cerebral blood flow, CO2 responsiveness, and brain metabolism in the baboon
    • Sandor P, Nyary I, Reivich M, Kovach AG. Comparative effects of chloralose anesthesia and Sernylan analgesia on cerebral blood flow, CO2 responsiveness, and brain metabolism in the baboon. Stroke 1977; 8: 432-6.
    • (1977) Stroke , vol.8 , pp. 432-436
    • Sandor, P.1    Nyary, I.2    Reivich, M.3    Kovach, A.G.4
  • 48
    • 0026570193 scopus 로고
    • Pial arteriolar constriction following cortical spreading depression is mediated by prostanoids
    • Shibata M, Leffler CW, Busija DW. Pial arteriolar constriction following cortical spreading depression is mediated by prostanoids. Brain Res 1992; 572: 190-7.
    • (1992) Brain Res , vol.572 , pp. 190-197
    • Shibata, M.1    Leffler, C.W.2    Busija, D.W.3
  • 52
    • 0021073896 scopus 로고
    • Local effect of anaesthesia on cerebral blood flow in the rat
    • Szabo L, Kovach AG, Babosa M. Local effect of anaesthesia on cerebral blood flow in the rat. Acta Physiol Hung 1983; 62: 113-21.
    • (1983) Acta Physiol Hung , vol.62 , pp. 113-121
    • Szabo, L.1    Kovach, A.G.2    Babosa, M.3
  • 53
    • 0029670094 scopus 로고    scopus 로고
    • beta-Amyloid-mediated vasoactivity and vascular endothelial damage
    • Thomas T, Thomas G, McLendon C, Sutton T, Mullan M. beta-Amyloid-mediated vasoactivity and vascular endothelial damage. Nature 1996; 380: 168-71.
    • (1996) Nature , vol.380 , pp. 168-171
    • Thomas, T.1    Thomas, G.2    McLendon, C.3    Sutton, T.4    Mullan, M.5
  • 54
    • 0033809909 scopus 로고    scopus 로고
    • Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the london mutant of human APP in neurons
    • Van Dorpe J, Smeijers L, Dewachter I, Nuyens D, Spittaels K, Van Den Haute C, et al. Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the london mutant of human APP in neurons. Am J Pathol 2000; 157: 1283-98.
    • (2000) Am J Pathol , vol.157 , pp. 1283-1298
    • Van Dorpe, J.1    Smeijers, L.2    Dewachter, I.3    Nuyens, D.4    Spittaels, K.5    Van Den Haute, C.6
  • 55
    • 0023254674 scopus 로고
    • Cerebral amyloid angiopathy. A critical review
    • Vinters HV. Cerebral amyloid angiopathy. A critical review. Stroke 1987; 18: 311-24.
    • (1987) Stroke , vol.18 , pp. 311-324
    • Vinters, H.V.1
  • 57
    • 24344484333 scopus 로고    scopus 로고
    • Ion changes in spreading ischaemia induce rat middle cerebral artery constriction in the absence of
    • Windmuller O, Lindauer U, Foddis M, Einhaupl KM, Dirnagl U, Heinemann U, et al. Ion changes in spreading ischaemia induce rat middle cerebral artery constriction in the absence of NO. Brain 2005; 128: 2042-51.
    • (2005) Brain , vol.128 , pp. 2042-2051
    • Windmuller, O.1    Lindauer, U.2    Foddis, M.3    Einhaupl, K.M.4    Dirnagl, U.5    Heinemann, U.6
  • 59
    • 0030848729 scopus 로고    scopus 로고
    • Increased susceptibility to ischemic brain damage in transgenic mice overexpressing the amyloid precursor protein
    • Zhang F, Eckman C, Younkin S, Hsiao KK, Iadecola C. Increased susceptibility to ischemic brain damage in transgenic mice overexpressing the amyloid precursor protein. J Neurosci 1997; 17: 7655-61.
    • (1997) J Neurosci , vol.17 , pp. 7655-7661
    • Zhang, F.1    Eckman, C.2    Younkin, S.3    Hsiao, K.K.4    Iadecola, C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.