3-Nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme

Journal of Biological Chemistry

Volumn 281, Issue 9, 2006, Pages 5965-5972

  Huang, Li Shar ^a   Sun, Gang ^b,c   Cobessi, David ^a,d   Wang, Andy C ^a   Shen, John T ^a   Tung, Eric Y ^a   Anderson, Vernon E ^b   Berry, Edward A ^a  

^a LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; COMPLEXATION; DEHYDROGENATION; ENZYMES; OXIDATION; SUBSTRATES;

MITOCHONDRIAL RESPIRATORY COMPLEX II; SUCCINATE DEHYDROGENASE; SUICIDE INHIBITOR; TANDEM MASS SPECTROSCOPIC ANALYSIS;

CARBOXYLIC ACIDS;

3 NITROPROPIONIC ACID; ARGININE; FUMARIC ACID; SUCCINATE DEHYDROGENASE (UBIQUINONE); 3-NITROPROPIONIC ACID; CARBOXIN; CONVULSANT AGENT; NITRO DERIVATIVE; PROPIONIC ACID DERIVATIVE; SUCCINATE DEHYDROGENASE; SUCCINIC ACID;

ARTICLE; DECARBOXYLATION; DEHYDROGENATION; MITOCHONDRIAL RESPIRATION; OXIDATION; PRIORITY JOURNAL; PROTEIN STRUCTURE; SHEWANELLA; TANDEM MASS SPECTROMETRY; ANIMAL; BINDING SITE; CELL RESPIRATION; CHEMICAL STRUCTURE; CHEMISTRY; CHICKEN; DRUG ANTAGONISM; METABOLISM; MITOCHONDRION; OXIDATION REDUCTION REACTION; PHYSIOLOGY; PROTEIN CONFORMATION; SWINE; X RAY CRYSTALLOGRAPHY;

SHEWANELLA;

ANIMALS; ARGININE; BINDING SITES; CARBOXIN; CELL RESPIRATION; CHICKENS; CONVULSANTS; CRYSTALLOGRAPHY, X-RAY; ELECTRON TRANSPORT COMPLEX II; MITOCHONDRIA; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NITRO COMPOUNDS; OXIDATION-REDUCTION; PROPIONIC ACIDS; PROTEIN CONFORMATION; SUCCINATE DEHYDROGENASE; SUCCINIC ACID; SWINE;

EID: 33646846683     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M511270200     Document Type: Article

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