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Volumn 1, Issue 2000, 2000, Pages 507-537

Apolipoprotein E: Far more than a lipid transport protein

Author keywords

Alzheimer's disease; Coronary disease; Genetic polymorphism; Immunology; Infectious disease

Indexed keywords

APOLIPOPROTEIN E; ISOPROTEIN; LIPOPROTEIN;

EID: 0034575124     PISSN: 15278204     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.genom.1.1.507     Document Type: Article
Times cited : (1409)

References (117)
  • 1
    • 0023937366 scopus 로고
    • Human apolipoprotein E3 in aqueous solution. II. Properties of the amino-and carboxyl-terminal domains
    • Aggerbeck LP, Wetterau JR, Weisgraber KH, Wu C-SC, Lindgren FT. 1988. Human apolipoprotein E3 in aqueous solution. II. Properties of the amino-and carboxyl-terminal domains. J. Biol. Chem. 263:6249-58
    • (1988) J. Biol. Chem. , vol.263 , pp. 6249-6258
    • Aggerbeck, L.P.1    Wetterau, J.R.2    Weisgraber, K.H.3    Wu, C.-S.C.4    Lindgren, F.T.5
  • 2
    • 13044270401 scopus 로고    scopus 로고
    • Decreased selective uptake of high density lipoprotein cholesteryl esters in apolipoprotein E knock-out mice
    • Arai T, Rinninger F, Varban L, Fairchild-Huntress V, Liang C-P, et al. 1999. Decreased selective uptake of high density lipoprotein cholesteryl esters in apolipoprotein E knock-out mice. Proc. Natl. Acad. Sci. USA 96:12050-55
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 12050-12055
    • Arai, T.1    Rinninger, F.2    Varban, L.3    Fairchild-Huntress, V.4    Liang, C.-P.5
  • 3
    • 0028883354 scopus 로고
    • Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null mice
    • Bellosta S, Mahley RW, Sanan DA, Murata J, Newland DL, et al. 1995. Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null mice. J. Clin. Invest. 96:2170-79
    • (1995) J. Clin. Invest. , vol.96 , pp. 2170-2179
    • Bellosta, S.1    Mahley, R.W.2    Sanan, D.A.3    Murata, J.4    Newland, D.L.5
  • 4
    • 0028850374 scopus 로고
    • Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neunte outgrowth
    • Bellosta S, Nathan BP, Orth M, Dong L-M, Mahley RW, Pitas RE. 1995. Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neunte outgrowth. J. Biol. Chem. 270:27063-71
    • (1995) J. Biol. Chem. , vol.270 , pp. 27063-27071
    • Bellosta, S.1    Nathan, B.P.2    Orth, M.3    Dong, L.-M.4    Mahley, R.W.5    Pitas, R.E.6
  • 5
    • 0030045980 scopus 로고    scopus 로고
    • Prolonged postprandial responses of lipids and apolipoproteins in triglyceride-rich lipoproteins of individuals expressing an apolipoprotein ε4 allele
    • Bergeron N, Havel RJ. 1996. Prolonged postprandial responses of lipids and apolipoproteins in triglyceride-rich lipoproteins of individuals expressing an apolipoprotein ε4 allele. J. Clin. Invest. 97:65-72
    • (1996) J. Clin. Invest. , vol.97 , pp. 65-72
    • Bergeron, N.1    Havel, R.J.2
  • 6
    • 0026316538 scopus 로고
    • Role of apolipoprotein E and B gene variation in determining response of lipid, lipoprotein, and apolipoprotein levels to increased dietary cholesterol
    • Boerwinkle E, Brown SA, Rohrbach K, Gotto AM Jr, Patsch W. 1991. Role of apolipoprotein E and B gene variation in determining response of lipid, lipoprotein, and apolipoprotein levels to increased dietary cholesterol. Am. J. Hum. Genet. 49:1145-54
    • (1991) Am. J. Hum. Genet. , vol.49 , pp. 1145-1154
    • Boerwinkle, E.1    Brown, S.A.2    Rohrbach, K.3    Gotto A.M., Jr.4    Patsch, W.5
  • 7
    • 0020972414 scopus 로고
    • Lipoprotein metabolism in the macrophage: Implications for cholesterol deposition in atherosclerosis
    • Brown MS, Goldstein JL. 1983. Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis. Annu. Rev. Biochem. 52:223-61
    • (1983) Annu. Rev. Biochem. , vol.52 , pp. 223-261
    • Brown, M.S.1    Goldstein, J.L.2
  • 8
    • 0028151433 scopus 로고
    • Apolipoprotein E (apoE), a novel heparin-binding protein inhibits the development of Kaposi's sarcoma-like lesions in BALB/c nu/nu mice
    • Browning PJ, Roberts DD, Zabrenetzky V, Bryant J, Kaplan M, et al. 1994. Apolipoprotein E (apoE), a novel heparin-binding protein inhibits the development of Kaposi's sarcoma-like lesions in BALB/c nu/nu mice. J. Exp. Med. 180:1949-54
    • (1994) J. Exp. Med. , vol.180 , pp. 1949-1954
    • Browning, P.J.1    Roberts, D.D.2    Zabrenetzky, V.3    Bryant, J.4    Kaplan, M.5
  • 10
    • 0023736963 scopus 로고
    • Inhibition of lymphocyte proliferation by synthetic peptides homologous to human plasma apolipoproteins B and E
    • Cardin AD, Bowlin TL, Krstenansky JL. 1988. Inhibition of lymphocyte proliferation by synthetic peptides homologous to human plasma apolipoproteins B and E. Biochem. Biophys. Res. Commun. 154:741-45
    • (1988) Biochem. Biophys. Res. Commun. , vol.154 , pp. 741-745
    • Cardin, A.D.1    Bowlin, T.L.2    Krstenansky, J.L.3
  • 11
    • 0033551459 scopus 로고    scopus 로고
    • Preclinical memory decline in cognitively normal apolipoprotein E-ε4 homozygotes
    • Caselli RJ, Graff-Radford NR, Reiman EM, Weaver A, Osborne D, et al. 1999. Preclinical memory decline in cognitively normal apolipoprotein E-ε4 homozygotes. Neurology 53:201-7
    • (1999) Neurology , vol.53 , pp. 201-207
    • Caselli, R.J.1    Graff-Radford, N.R.2    Reiman, E.M.3    Weaver, A.4    Osborne, D.5
  • 12
    • 0030661590 scopus 로고    scopus 로고
    • Hepatic uptake of chylomicron remnants
    • Cooper AD. 1997. Hepatic uptake of chylomicron remnants. J. Lipid Res. 38:2173-92
    • (1997) J. Lipid Res. , vol.38 , pp. 2173-2192
    • Cooper, A.D.1
  • 13
    • 0027194791 scopus 로고
    • Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
    • Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, et al. 1993. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261:921-23
    • (1993) Science , vol.261 , pp. 921-923
    • Corder, E.H.1    Saunders, A.M.2    Strittmatter, W.J.3    Schmechel, D.E.4    Gaskell, P.C.5
  • 14
    • 0017264867 scopus 로고
    • Regulatory serum lipoproteins: Regulation of lymphocyte stimulation by a species of low density lipoprotein
    • Curtiss LK, Edgington TS. 1976. Regulatory serum lipoproteins: regulation of lymphocyte stimulation by a species of low density lipoprotein. J. Immunol. 116:1452-58
    • (1976) J. Immunol. , vol.116 , pp. 1452-1458
    • Curtiss, L.K.1    Edgington, T.S.2
  • 15
    • 0021135912 scopus 로고
    • Modulation of human lymphocyte responses by low density lipoproteins (LDL): Enhancement but not immunosuppression is mediated by LDL receptors
    • Cuthbert JA, Lipsky PE. 1984. Modulation of human lymphocyte responses by low density lipoproteins (LDL): enhancement but not immunosuppression is mediated by LDL receptors. Proc. Natl. Acad. Sci. USA 81:4539-43
    • (1984) Proc. Natl. Acad. Sci. USA , vol.81 , pp. 4539-4543
    • Cuthbert, J.A.1    Lipsky, P.E.2
  • 16
    • 0021249765 scopus 로고
    • Immunoregulation by low density lipoproteins in man. Inhibition of mitogen-induced T lymphocyte proliferation by interference with transferrin metabolism
    • Cuthbert JA, Lipsky PE. 1984. Immunoregulation by low density lipoproteins in man. Inhibition of mitogen-induced T lymphocyte proliferation by interference with transferrin metabolism. J. Clin. Invest. 73:992-1003
    • (1984) J. Clin. Invest. , vol.73 , pp. 992-1003
    • Cuthbert, J.A.1    Lipsky, P.E.2
  • 17
    • 0026514988 scopus 로고
    • Modulation of plasma triglyceride levels by apoE phenotype: A meta-analysis
    • Dallongeville J, Lussier-Cacan S, Davignon J. 1992. Modulation of plasma triglyceride levels by apoE phenotype: a meta-analysis. J. Lipid Res. 33:447-54
    • (1992) J. Lipid Res. , vol.33 , pp. 447-454
    • Dallongeville, J.1    Lussier-Cacan, S.2    Davignon, J.3
  • 19
    • 0023860891 scopus 로고
    • Apolipoprotein E polymorphism and atherosclerosis
    • Davignon J, Gregg RE, Sing CF. 1988. Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis 8:1-21
    • (1988) Arteriosclerosis , vol.8 , pp. 1-21
    • Davignon, J.1    Gregg, R.E.2    Sing, C.F.3
  • 20
    • 0032941090 scopus 로고    scopus 로고
    • Apolipoprotein E knock-out mice are highly susceptible to endotoxemia and Klebsiella pneumoniae infection
    • de Bont N, Netea MG, Demacker PNM, Verschueren I, Kullberg BJ, et al. 1999. Apolipoprotein E knock-out mice are highly susceptible to endotoxemia and Klebsiella pneumoniae infection. J. Lipid Res. 40:680-85
    • (1999) J. Lipid Res. , vol.40 , pp. 680-685
    • De Bont, N.1    Netea, M.G.2    Demacker, P.N.M.3    Verschueren, I.4    Kullberg, B.J.5
  • 21
    • 0032512634 scopus 로고    scopus 로고
    • A minimally lipidated form of cell-derived apolipoprotein E exhibits isoform-specific stimulation of neunte outgrowth in the absence of exogenous lipids or lipoproteins
    • DeMattos RB, Curtiss LK, Williams DL. 1998. A minimally lipidated form of cell-derived apolipoprotein E exhibits isoform-specific stimulation of neunte outgrowth in the absence of exogenous lipids or lipoproteins. J. Biol. Chem. 273:4206-12
    • (1998) J. Biol. Chem. , vol.273 , pp. 4206-4212
    • DeMattos, R.B.1    Curtiss, L.K.2    Williams, D.L.3
  • 22
    • 0029784503 scopus 로고    scopus 로고
    • Novel mechanism for defective receptor binding of apolipoprotein E2 in type III hyperlipoproteinemia
    • Dong L-M, Parkin S, Trakhanov SD, Rupp B, Simmons T, et al. 1996. Novel mechanism for defective receptor binding of apolipoprotein E2 in type III hyperlipoproteinemia. Nat. Struct. Biol. 3:718-22
    • (1996) Nat. Struct. Biol. , vol.3 , pp. 718-722
    • Dong, L.-M.1    Parkin, S.2    Trakhanov, S.D.3    Rupp, B.4    Simmons, T.5
  • 23
    • 0029766916 scopus 로고    scopus 로고
    • Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins
    • Dong L-M, Weisgraber KH. 1996. Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins. J. Biol. Chem. 271:19053-57
    • (1996) J. Biol. Chem. , vol.271 , pp. 19053-19057
    • Dong, L.-M.1    Weisgraber, K.H.2
  • 24
    • 0028092997 scopus 로고
    • Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms
    • Dong L-M, Wilson C, Wardell MR, Simmons T, Mahley RW, et al. 1994. Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms. J. Biol. Chem. 269:22358-65
    • (1994) J. Biol. Chem. , vol.269 , pp. 22358-22365
    • Dong, L.-M.1    Wilson, C.2    Wardell, M.R.3    Simmons, T.4    Mahley, R.W.5
  • 25
    • 0025837970 scopus 로고
    • Only multimers of a synthetic peptide of human apolipoprotein E are biologically active
    • Dyer CA, Smith RS, Curtiss LK. 1991. Only multimers of a synthetic peptide of human apolipoprotein E are biologically active. J. Biol. Chem. 266:15009-15
    • (1991) J. Biol. Chem. , vol.266 , pp. 15009-15015
    • Dyer, C.A.1    Smith, R.S.2    Curtiss, L.K.3
  • 27
    • 0028105142 scopus 로고
    • Susceptibility to diet-induced atherosclerosis in transgenic mice expressing a dysfunctional human apolipoprotein E(Arg 112,Cys142)
    • Fazio S, Sanan DA, Lee Y-L, Ji Z-S, Mahley RW, Rall SC Jr. 1994. Susceptibility to diet-induced atherosclerosis in transgenic mice expressing a dysfunctional human apolipoprotein E(Arg 112,Cys142). Arterioscler. Thromb. Vasc. Biol. 14:1873-79
    • (1994) Arterioscler. Thromb. Vasc. Biol. , vol.14 , pp. 1873-1879
    • Fazio, S.1    Sanan, D.A.2    Lee, Y.-L.3    Ji, Z.-S.4    Mahley, R.W.5    Rall S.C., Jr.6
  • 28
    • 0032785877 scopus 로고    scopus 로고
    • The evolution of Alzheimer disease, the reproductive schedule, and apoE isoforms
    • Finch CE, Sapolsky RM. 1999. The evolution of Alzheimer disease, the reproductive schedule, and apoE isoforms. Neurobiol. Aging 20:407-28
    • (1999) Neurobiol. Aging , vol.20 , pp. 407-428
    • Finch, C.E.1    Sapolsky, R.M.2
  • 29
    • 0014217585 scopus 로고
    • Fat transport in lipoproteins - An integrated approach to mechanisms and disorders
    • Fredrickson DS, Levy RI, Lees RS. 1967. Fat transport in lipoproteins - an integrated approach to mechanisms and disorders. N. Engl. J. Med. 276:34-44, 94-103, 148-56, 215-25, 273-81
    • (1967) N. Engl. J. Med. , vol.276 , pp. 34-44
    • Fredrickson, D.S.1    Levy, R.I.2    Lees, R.S.3
  • 30
    • 0029934387 scopus 로고    scopus 로고
    • Are men carrying the apolipoprotein ε4 or ε2 allele less fertile than ε3ε3 genotypes?
    • Gerdes LU, Gerdes C, Hansen PS, Klausen IC, Færgeman O. 1996. Are men carrying the apolipoprotein ε4 or ε2 allele less fertile than ε3ε3 genotypes? Hum. Genet. 98:239-42
    • (1996) Hum. Genet. , vol.98 , pp. 239-242
    • Gerdes, L.U.1    Gerdes, C.2    Hansen, P.S.3    Klausen, I.C.4    Færgeman, O.5
  • 34
    • 0028799668 scopus 로고
    • Arginine residues at codons 112 and 158 in the apolipoprotein E gene correspond to the ancestral state in humans
    • Hanlon CS, Rubinsztein DC. 1995. Arginine residues at codons 112 and 158 in the apolipoprotein E gene correspond to the ancestral state in humans. Atherosclerosis 112:85-90
    • (1995) Atherosclerosis , vol.112 , pp. 85-90
    • Hanlon, C.S.1    Rubinsztein, D.C.2
  • 36
    • 0027532494 scopus 로고
    • The LDL-receptor-related protein - Portrait of a multifunctional receptor
    • Herz J. 1993. The LDL-receptor-related protein - portrait of a multifunctional receptor. Curr. Opin. Lipidol. 4:107-13
    • (1993) Curr. Opin. Lipidol. , vol.4 , pp. 107-113
    • Herz, J.1
  • 37
    • 0027987988 scopus 로고
    • Functions of the LDL receptor gene family
    • Herz J, Willnow TE. 1994. Functions of the LDL receptor gene family. Ann. NY Acad. Sci. 737:14-19
    • (1994) Ann. NY Acad. Sci. , vol.737 , pp. 14-19
    • Herz, J.1    Willnow, T.E.2
  • 38
    • 0033213319 scopus 로고    scopus 로고
    • Direct binding of reelin to VLDL receptor and apoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation
    • Hiesberger T, Trommsdorff M, Howell BW, Goffinet A, Mumby MC, et al. 1999. Direct binding of reelin to VLDL receptor and apoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation. Neuron 24:481-89
    • (1999) Neuron , vol.24 , pp. 481-489
    • Hiesberger, T.1    Trommsdorff, M.2    Howell, B.W.3    Goffinet, A.4    Mumby, M.C.5
  • 39
    • 0028822219 scopus 로고
    • Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neunte outgrowth in a central nervous system-derived neuronal cell line
    • Holtzman DM, Pitas RE, Kilbridge J, Nathan B, Mahley RW, et al. 1995. Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neunte outgrowth in a central nervous system-derived neuronal cell line. Proc. Natl. Acad. Sci. USA 92:9480-84
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 9480-9484
    • Holtzman, D.M.1    Pitas, R.E.2    Kilbridge, J.3    Nathan, B.4    Mahley, R.W.5
  • 40
    • 0033238035 scopus 로고    scopus 로고
    • Overexpression of apolipoprotein E3 in transgenic rabbits causes combined hyperlipidemia by stimulating hepatic very low density lipoprotein (VLDL) production and impairing VLDL lipolysis
    • Huang Y, Ji Z-S, Brecht WJ, Rall SC Jr, Taylor JM, Mahley RW. 1999. Overexpression of apolipoprotein E3 in transgenic rabbits causes combined hyperlipidemia by stimulating hepatic very low density lipoprotein (VLDL) production and impairing VLDL lipolysis. Arterioscler. Thromb. Vasc. Biol. 19:2952-59
    • (1999) Arterioscler. Thromb. Vasc. Biol. , vol.19 , pp. 2952-2959
    • Huang, Y.1    Ji, Z.-S.2    Brecht, W.J.3    Rall S.C., Jr.4    Taylor, J.M.5    Mahley, R.W.6
  • 41
    • 0032504182 scopus 로고    scopus 로고
    • Apolipoprotein E2 reduces the low density lipoprotein level in transgenic mice by impairing lipoprotein lipase-mediated lipolysis of triglyceride-rich lipoproteins
    • Huang Y, Liu XQ, Rall SC Jr, Mahley RW. 1998. Apolipoprotein E2 reduces the low density lipoprotein level in transgenic mice by impairing lipoprotein lipase-mediated lipolysis of triglyceride-rich lipoproteins. J. Biol. Chem. 273:17483-90
    • (1998) J. Biol. Chem. , vol.273 , pp. 17483-17490
    • Huang, Y.1    Liu, X.Q.2    Rall S.C., Jr.3    Mahley, R.W.4
  • 42
    • 15644366977 scopus 로고    scopus 로고
    • Overexpression and accumulation of apolipoprotein E as a cause of hypertriglyceridemia
    • Huang Y, Liu XQ, Rall SC Jr, Taylor JM, von Eckardstein A, et al. 1998. Overexpression and accumulation of apolipoprotein E as a cause of hypertriglyceridemia. J. Biol. Chem. 273:26388-93
    • (1998) J. Biol. Chem. , vol.273 , pp. 26388-26393
    • Huang, Y.1    Liu, X.Q.2    Rall S.C., Jr.3    Taylor, J.M.4    Von Eckardstein, A.5
  • 43
    • 0031471229 scopus 로고    scopus 로고
    • Genetic factors precipitating type III hyperlipoproteinemia in hypolipidemic transgenic mice expressing human apolipoprotein E2
    • Huang Y, Rall SC Jr, Mahley RW. 1997. Genetic factors precipitating type III hyperlipoproteinemia in hypolipidemic transgenic mice expressing human apolipoprotein E2. Arterioscler. Thromb. Vasc. Biol. 17:2817-24
    • (1997) Arterioscler. Thromb. Vasc. Biol. , vol.17 , pp. 2817-2824
    • Huang, Y.1    Rall S.C., Jr.2    Mahley, R.W.3
  • 44
    • 0030987456 scopus 로고    scopus 로고
    • Apolipoprotein E2 transgenic rabbits: Modulation of the type III hyperlipoproteinemic phenotype by estrogen and occurrence of spontaneous atherosclerosis
    • Huang Y, Schwendner SW, Rall SC Jr, Sanan DA, Mahley RW. 1997. Apolipoprotein E2 transgenic rabbits: modulation of the type III hyperlipoproteinemic phenotype by estrogen and occurrence of spontaneous atherosclerosis. J. Biol. Chem. 272:22685-94
    • (1997) J. Biol. Chem. , vol.272 , pp. 22685-22694
    • Huang, Y.1    Schwendner, S.W.2    Rall S.C., Jr.3    Sanan, D.A.4    Mahley, R.W.5
  • 45
    • 0028346571 scopus 로고
    • A plasma lipoprotein containing only apolipoprotein E and with y mobility on electrophoresis releases cholesterol from cells
    • Huang Y, von Eckardstein A, Wu S, Maeda N, Assmann G. 1994. A plasma lipoprotein containing only apolipoprotein E and with y mobility on electrophoresis releases cholesterol from cells. Proc. Natl. Acad. Sci. USA 91:1834-38
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 1834-1838
    • Huang, Y.1    Von Eckardstein, A.2    Wu, S.3    Maeda, N.4    Assmann, G.5
  • 46
    • 0019052564 scopus 로고
    • + accumulation in mitogen-activated lymphocytes: Role of membrane-bound plasma lipoproteins
    • + accumulation in mitogen-activated lymphocytes: role of membrane-bound plasma lipoproteins. Proc. Natl. Acad. Sci. USA 77:4764-68
    • (1980) Proc. Natl. Acad. Sci. USA , vol.77 , pp. 4764-4768
    • Hui, D.Y.1    Harmony, J.A.K.2
  • 47
    • 0019275306 scopus 로고
    • Immunoregulatory plasma lipoproteins. Role of apoprotein E and apoprotein B
    • Hui DY, Harmony JAK, Innerarity TL, Mahley RW. 1980. Immunoregulatory plasma lipoproteins. Role of apoprotein E and apoprotein B. J. Biol. Chem. 255:11775-81
    • (1980) J. Biol. Chem. , vol.255 , pp. 11775-11781
    • Hui, D.Y.1    Harmony, J.A.K.2    Innerarity, T.L.3    Mahley, R.W.4
  • 49
    • 0021211156 scopus 로고
    • Normalization of receptor binding of apolipoprotein E2. Evidence for modulation of the binding site conformation
    • Innerarity TL, Weisgraber KH, Arnold KS, Rall SC Jr, Mahley RW. 1984. Normalization of receptor binding of apolipoprotein E2. Evidence for modulation of the binding site conformation. J. Biol. Chem. 259:7261-67
    • (1984) J. Biol. Chem. , vol.259 , pp. 7261-7267
    • Innerarity, T.L.1    Weisgraber, K.H.2    Arnold, K.S.3    Rall S.C., Jr.4    Mahley, R.W.5
  • 52
    • 0032577695 scopus 로고    scopus 로고
    • Differential cellular accumulation/retention of apolipoprotein E mediated by cell surface heparan sulfate proteoglycans. Apolipoproteins E3 and E2 greater than E4
    • Ji Z-S, Pitas RE, Mahley RW. 1998. Differential cellular accumulation/retention of apolipoprotein E mediated by cell surface heparan sulfate proteoglycans. Apolipoproteins E3 and E2 greater than E4. J. Biol. Chem. 273:13452-60
    • (1998) J. Biol. Chem. , vol.273 , pp. 13452-13460
    • Ji, Z.-S.1    Pitas, R.E.2    Mahley, R.W.3
  • 53
    • 0029816096 scopus 로고    scopus 로고
    • Both lipolysis and hepatic uptake of VLDL are impaired in transgenic mice coexpressing human apolipoprotein E*3Leiden and human apolipoprotein Cl
    • Jong MC, Dahlmans VEH, van Gorp PJJ, Breuer ML, Mol MJTM, et al. 1996. Both lipolysis and hepatic uptake of VLDL are impaired in transgenic mice coexpressing human apolipoprotein E*3Leiden and human apolipoprotein Cl. Arterioscler. Thromb. Vasc. Biol. 16:934-40
    • (1996) Arterioscler. Thromb. Vasc. Biol. , vol.16 , pp. 934-940
    • Jong, M.C.1    Dahlmans, V.E.H.2    Van Gorp, P.J.J.3    Breuer, M.L.4    Mjtm, M.5
  • 54
    • 0028135706 scopus 로고
    • Apolipoprotein E inhibition of proliferation of mitogen-activated T lymphocytes: Production of interleukin 2 with reduced biological activity
    • Kelly ME, Clay MA, Mistry MJ, Hsieh-Li H-M, Harmony JAK. 1994. Apolipoprotein E inhibition of proliferation of mitogen-activated T lymphocytes: production of interleukin 2 with reduced biological activity. Cell. Immunol. 159:124-39
    • (1994) Cell. Immunol. , vol.159 , pp. 124-139
    • Kelly, M.E.1    Clay, M.A.2    Mistry, M.J.3    Hsieh-Li, H.-M.4    Harmony, J.A.K.5
  • 55
    • 0029128232 scopus 로고
    • LDL receptor-related protein, a multifunctional apoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation
    • Kounnas MZ, Moir RD, Rebeck GW, Bush AI, Argraves WS, et al. 1995. LDL receptor-related protein, a multifunctional apoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation. Cell 82:331-40
    • (1995) Cell , vol.82 , pp. 331-340
    • Kounnas, M.Z.1    Moir, R.D.2    Rebeck, G.W.3    Bush, A.I.4    Argraves, W.S.5
  • 57
    • 0030748833 scopus 로고    scopus 로고
    • Association of human, rat, and rabbit apolipoprotein E with β-amyloid
    • LaDu MJ, Lukens JR, Reardon CA, Getz GS. 1997. Association of human, rat, and rabbit apolipoprotein E with β-amyloid. J. Neurosci. Res. 49:9-18
    • (1997) J. Neurosci. Res. , vol.49 , pp. 9-18
    • LaDu, M.J.1    Lukens, J.R.2    Reardon, C.A.3    Getz, G.S.4
  • 58
    • 0028173205 scopus 로고
    • 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments
    • 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments. Nature 372:92-94
    • (1994) Nature , vol.372 , pp. 92-94
    • Ma, J.1    Yee, A.2    Brewer H.B., Jr.3    Das, S.4    Potter, H.5
  • 59
    • 0024299370 scopus 로고
    • Apolipoprotein E: Cholesterol transport protein with expanding role in cell biology
    • Mahley RW. 1988. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 240:622-30
    • (1988) Science , vol.240 , pp. 622-630
    • Mahley, R.W.1
  • 60
    • 0002311452 scopus 로고    scopus 로고
    • Apolipoprotein E: Structure and function in lipid metabolism and neurobiology
    • ed. RN Rosenberg, SB Prusiner, S Di-Mauro, RL Barchi, Boston: Butterworth-Heinemann. 2nd ed.
    • Mahley RW. 1997. Apolipoprotein E: structure and function in lipid metabolism and neurobiology. In The Molecular and Genetic Basis of Neurological Disease, ed. RN Rosenberg, SB Prusiner, S Di-Mauro, RL Barchi, pp. 1037-49. Boston: Butterworth-Heinemann. 2nd ed.
    • (1997) The Molecular and Genetic Basis of Neurological Disease , pp. 1037-1049
    • Mahley, R.W.1
  • 61
    • 0032839621 scopus 로고    scopus 로고
    • Apolipoprotein E: From atherosclerosis to Alzheimer's disease and beyond
    • Mahley RW, Huang Y. 1999. Apolipoprotein E: from atherosclerosis to Alzheimer's disease and beyond. Curr. Opin. Lipidol. 10:207-17
    • (1999) Curr. Opin. Lipidol. , vol.10 , pp. 207-217
    • Mahley, R.W.1    Huang, Y.2
  • 62
    • 0032743737 scopus 로고    scopus 로고
    • Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia): Questions, quandaries, and paradoxes
    • Mahley RW, Huang Y, Rall SC Jr. 1999. Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia): questions, quandaries, and paradoxes. J. Lipid Res. 40:1933-49
    • (1999) J. Lipid Res. , vol.40 , pp. 1933-1949
    • Mahley, R.W.1    Huang, Y.2    Rall S.C., Jr.3
  • 63
    • 0020537615 scopus 로고
    • Lipoprotein receptors and cholesterol homeostasis
    • Mahley RW, Innerarity TL. 1983. Lipoprotein receptors and cholesterol homeostasis. Biochim. Biophys. Acta 737:197-222
    • (1983) Biochim. Biophys. Acta , vol.737 , pp. 197-222
    • Mahley, R.W.1    Innerarity, T.L.2
  • 64
    • 0032895028 scopus 로고    scopus 로고
    • Remnant lipoprotein metabolism: Key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E
    • Mahley RW, Ji Z-S. 1999. Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E. J. Lipid Res. 40:1-16
    • (1999) J. Lipid Res. , vol.40 , pp. 1-16
    • Mahley, R.W.1    Ji, Z.-S.2
  • 65
    • 0028949496 scopus 로고
    • Apolipoprotein E: Impact of cytoskeletal stability in neurons and the relationship to Alzheimer's disease
    • Mahley RW, Nathan BP, Bellosta S, Pitas RE. 1995. Apolipoprotein E: impact of cytoskeletal stability in neurons and the relationship to Alzheimer's disease. Curr. Opin. Lipidol. 6:86-91
    • (1995) Curr. Opin. Lipidol. , vol.6 , pp. 86-91
    • Mahley, R.W.1    Nathan, B.P.2    Bellosta, S.3    Pitas, R.E.4
  • 66
    • 0001575895 scopus 로고
    • Type III hyperlipoproteinemia (dysbetalipoproteinemia): The role of apolipoprotein E in normal and abnormal lipoprotein metabolism
    • ed. CR Scriver, AL Beaudet, WS Sly, D Valle, New York: McGraw-Hill. 7th ed.
    • Mahley RW, Rall SC Jr. 1995. Type III hyperlipoproteinemia (dysbetalipoproteinemia): the role of apolipoprotein E in normal and abnormal lipoprotein metabolism. In The Metabolic and Molecular Bases of Inherited Disease, ed. CR Scriver, AL Beaudet, WS Sly, D Valle, pp. 1953-80. New York: McGraw-Hill. 7th ed.
    • (1995) The Metabolic and Molecular Bases of Inherited Disease , pp. 1953-1980
    • Mahley, R.W.1    Rall S.C., Jr.2
  • 67
    • 0002235065 scopus 로고    scopus 로고
    • Disorders of lipid metabolism
    • ed. JD Wilson, DW Foster, HM Kronenberg, PR Larsen, Philadelphia: Saunders. 9th ed.
    • Mahley RW, Weisgraber KH, Farese RV Jr. 1998. Disorders of lipid metabolism. In Williams Textbook of Endocrinology, ed. JD Wilson, DW Foster, HM Kronenberg, PR Larsen, pp. 1099-153. Philadelphia: Saunders. 9th ed.
    • (1998) Williams Textbook of Endocrinology , pp. 1099-1153
    • Mahley, R.W.1    Weisgraber, K.H.2    Farese R.V., Jr.3
  • 68
    • 0023759190 scopus 로고
    • Expression of apolipoprotein E by cultured vascular smooth muscle cells is controlled by growth state
    • Majack RA, Castle CK, Goodman LV, Weisgraber KH, Mahley RW, et al. 1988. Expression of apolipoprotein E by cultured vascular smooth muscle cells is controlled by growth state. J. Cell Biol. 107:1207-13
    • (1988) J. Cell Biol. , vol.107 , pp. 1207-1213
    • Majack, R.A.1    Castle, C.K.2    Goodman, L.V.3    Weisgraber, K.H.4    Mahley, R.W.5
  • 69
    • 0026670705 scopus 로고
    • Apolipoprotein A-1 interacts with the N-terminal fusogenic domains of SIV (simian immunodeficiency virus) GP32 and HTV (human immunodeficiency virus) GP41 : Implications in viral entry
    • Martin I, Dubois M-C, Saermark T, Ruysschaert J-M. 1992. Apolipoprotein A-1 interacts with the N-terminal fusogenic domains of SIV (simian immunodeficiency virus) GP32 and HTV (human immunodeficiency virus) GP41 : implications in viral entry. Biochem. Biophys. Res. Commun. 186:95-101
    • (1992) Biochem. Biophys. Res. Commun. , vol.186 , pp. 95-101
    • Martin, I.1    Dubois, M.-C.2    Saermark, T.3    Ruysschaert, J.-M.4
  • 70
    • 0020618569 scopus 로고
    • Apolipoprotein E polymorphism and coronary artery disease
    • Menzel H-J, Kladetzky R-G, Assmann G. 1983. Apolipoprotein E polymorphism and coronary artery disease. Arteriosclerosis 3:310-15
    • (1983) Arteriosclerosis , vol.3 , pp. 310-315
    • Menzel, H.-J.1    Kladetzky, R.-G.2    Assmann, G.3
  • 71
    • 0029765553 scopus 로고    scopus 로고
    • Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and β-amyloid peptides
    • Miyata M, Smith JD. 1996. Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and β-amyloid peptides. Nat. Genet. 14:55-61
    • (1996) Nat. Genet. , vol.14 , pp. 55-61
    • Miyata, M.1    Smith, J.D.2
  • 72
    • 0027958084 scopus 로고
    • ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree
    • Nakashima Y, Plump AS, Raines EW, Breslow JL, Ross R. 1994. ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler. Thromb. 14:133-40
    • (1994) Arterioscler. Thromb. , vol.14 , pp. 133-140
    • Nakashima, Y.1    Plump, A.S.2    Raines, E.W.3    Breslow, J.L.4    Ross, R.5
  • 74
    • 0029157112 scopus 로고
    • The inhibitory effect of apolipoprotein E4 on neunte outgrowth is associated with microtubule depolymerization
    • Nathan BP, Chang K-C, Bellosta S, Brisch E, Ge N, et al. 1995. The inhibitory effect of apolipoprotein E4 on neunte outgrowth is associated with microtubule depolymerization. J. Biol Chem. 270:19791-99
    • (1995) J. Biol Chem. , vol.270 , pp. 19791-19799
    • Nathan, B.P.1    Chang, K.-C.2    Bellosta, S.3    Brisch, E.4    Ge, N.5
  • 75
    • 0029869015 scopus 로고    scopus 로고
    • Low-density lipoprotein receptor-deficient mice are protected against lethal endotoxemia and severe gram-negative infections
    • Netea MG, Demacker PNM, Kullberg BJ, Boerman OC, Verschueren I, et al. 1996. Low-density lipoprotein receptor-deficient mice are protected against lethal endotoxemia and severe gram-negative infections. J. Clin. Invest. 97:1366-72
    • (1996) J. Clin. Invest. , vol.97 , pp. 1366-1372
    • Netea, M.G.1    Demacker, P.N.M.2    Kullberg, B.J.3    Boerman, O.C.4    Verschueren, I.5
  • 77
    • 0025186067 scopus 로고
    • Apolipoprotein A-I and its amphipathic helix peptide analogues inhibit human immunodeficiency virus-induced syncytium formation
    • Owens RJ, Anantharamaiah GM, Kahlon JB, Srinivas RV, Compans RW, Segrest JP. 1990. Apolipoprotein A-I and its amphipathic helix peptide analogues inhibit human immunodeficiency virus-induced syncytium formation. J. Clin. Invest. 86:1142-50
    • (1990) J. Clin. Invest. , vol.86 , pp. 1142-1150
    • Owens, R.J.1    Anantharamaiah, G.M.2    Kahlon, J.B.3    Srinivas, R.V.4    Compans, R.W.5    Segrest, J.P.6
  • 78
    • 0032168460 scopus 로고    scopus 로고
    • Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: Increased susceptibility of females
    • Raber J, Wong D, Buttini M, Orth M, Bellosta S, et al. 1998. Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females. Proc. Natl. Acad. Sci. USA 95:10914-19
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 10914-10919
    • Raber, J.1    Wong, D.2    Buttini, M.3    Orth, M.4    Bellosta, S.5
  • 79
    • 0026718601 scopus 로고
    • The role of apolipoprotein E genetic variants in lipoprotein disorders
    • Rall SC Jr, Mahley RW. 1992. The role of apolipoprotein E genetic variants in lipoprotein disorders. J. Intern. Med. 231:653-59
    • (1992) J. Intern. Med. , vol.231 , pp. 653-659
    • Rall S.C., Jr.1    Mahley, R.W.2
  • 80
    • 0020490536 scopus 로고
    • Human apolipoprotein E. The complete amino acid sequence
    • Rall SC Jr, Weisgraber KH, Mahley RW. 1982. Human apolipoprotein E. The complete amino acid sequence. J. Biol. Chem. 257:4171-78
    • (1982) J. Biol. Chem. , vol.257 , pp. 4171-4178
    • Rall S.C., Jr.1    Weisgraber, K.H.2    Mahley, R.W.3
  • 81
    • 0027976942 scopus 로고
    • Atherosclerosis in mice lacking apo E. Evaluation of lesional development and progression
    • Reddick RL, Zhang SH, Maeda N. 1994. Atherosclerosis in mice lacking apo E. Evaluation of lesional development and progression. Arterioscler. Thromb. 14:141-47
    • (1994) Arterioscler. Thromb. , vol.14 , pp. 141-147
    • Reddick, R.L.1    Zhang, S.H.2    Maeda, N.3
  • 82
    • 15844414655 scopus 로고    scopus 로고
    • Apolipoprotein E effectively inhibits lipoprotein lipase-mediated lipolysis of chylomicron-like triglyceride-rich lipid emulsions in vitro and in vivo
    • Rensen PCN, van Berkel TJC. 1996. Apolipoprotein E effectively inhibits lipoprotein lipase-mediated lipolysis of chylomicron-like triglyceride-rich lipid emulsions in vitro and in vivo. J. Biol. Chem. 271:14791-99
    • (1996) J. Biol. Chem. , vol.271 , pp. 14791-14799
    • Rensen, P.C.N.1    Van Berkel, T.J.C.2
  • 83
    • 0031687891 scopus 로고    scopus 로고
    • Apolipoprotein E-deficient mice have impaired innate immune responses to Listeria monocytogenes in vivo
    • Roselaar SE, Daugherty A. 1998. Apolipoprotein E-deficient mice have impaired innate immune responses to Listeria monocytogenes in vivo. J. Lipid Res. 39:1740-43
    • (1998) J. Lipid Res. , vol.39 , pp. 1740-1743
    • Roselaar, S.E.1    Daugherty, A.2
  • 84
    • 0028026587 scopus 로고
    • Apolipoprotein E associates with βamyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3
    • Sanan DA, Weisgraber KH, Russell SJ, Mahley RW, Huang D, et al. 1994. Apolipoprotein E associates with βamyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3. J. Clin. Invest. 94:860-69
    • (1994) J. Clin. Invest. , vol.94 , pp. 860-869
    • Sanan, D.A.1    Weisgraber, K.H.2    Russell, S.J.3    Mahley, R.W.4    Huang, D.5
  • 85
    • 0019391208 scopus 로고
    • Familial dysbetalipoproteinemia. Abnormal binding of mutant apoprotein E to low density lipoprotein receptors of human fibroblasts and membranes from liver and adrenal of rats, rabbits, and cows
    • Schneider WJ, Kovanen PT, Brown MS, Goldstein JL, Utermann G, et al. 1981. Familial dysbetalipoproteinemia. Abnormal binding of mutant apoprotein E to low density lipoprotein receptors of human fibroblasts and membranes from liver and adrenal of rats, rabbits, and cows. J. Clin. Invest. 68:1075-85
    • (1981) J. Clin. Invest. , vol.68 , pp. 1075-1085
    • Schneider, W.J.1    Kovanen, P.T.2    Brown, M.S.3    Goldstein, J.L.4    Utermann, G.5
  • 86
    • 0029807992 scopus 로고    scopus 로고
    • Dual interaction of the malaria circumsporozoite protein with the low density lipoprotein receptor-related protein (LRP) and heparan sulfate proteoglycans
    • Shakibaei M, Frevert U. 1996. Dual interaction of the malaria circumsporozoite protein with the low density lipoprotein receptor-related protein (LRP) and heparan sulfate proteoglycans. J. Exp. Med. 184:1699-711
    • (1996) J. Exp. Med. , vol.184 , pp. 1699-1711
    • Shakibaei, M.1    Frevert, U.2
  • 87
  • 88
    • 0021824223 scopus 로고
    • Role of the apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation
    • Sing CF, Davignon J. 1985. Role of the apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation. Am. J. Hum. Genet. 37:268-85
    • (1985) Am. J. Hum. Genet. , vol.37 , pp. 268-285
    • Sing, C.F.1    Davignon, J.2
  • 90
    • 0030614814 scopus 로고    scopus 로고
    • Apolipoprotein E ε4 and the risk of dementia with stroke. A population-based investigation
    • Slooter AJC, Tang M-X, van Duijn CM, Stern Y, Ott A, et al. 1997. Apolipoprotein E ε4 and the risk of dementia with stroke. A population-based investigation. JAMA 277:818-21
    • (1997) JAMA , vol.277 , pp. 818-821
    • Slooter, A.J.C.1    Tang, M.-X.2    Van Duijn, C.M.3    Stern, Y.4    Ott, A.5
  • 91
    • 0032969230 scopus 로고    scopus 로고
    • Memory self-appraisal in middle-aged and older adults with the apolipoprotein E-4 allele
    • Small GW, Chen ST, Komo S, Ercoli L, Bookheimer S, et al. 1999. Memory self-appraisal in middle-aged and older adults with the apolipoprotein E-4 allele. Am. J. Psychiatry 156:1035-38
    • (1999) Am. J. Psychiatry , vol.156 , pp. 1035-1038
    • Small, G.W.1    Chen, S.T.2    Komo, S.3    Ercoli, L.4    Bookheimer, S.5
  • 92
    • 0028832051 scopus 로고
    • Apolipoprotein E polymorphism predicts death from coronary heart disease in a longitudinal study of elderly Finnish men
    • Stengård JH, Zerba KE, Pekkanen J, Ehnholm C, Nissinen A, Sing CF 1995. Apolipoprotein E polymorphism predicts death from coronary heart disease in a longitudinal study of elderly Finnish men. Circulation 91:265-69
    • (1995) Circulation , vol.91 , pp. 265-269
    • Stengård, J.H.1    Zerba, K.E.2    Pekkanen, J.3    Ehnholm, C.4    Nissinen, A.5    Sing, C.F.6
  • 93
    • 0028035306 scopus 로고
    • Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: Implications for Alzheimer disease
    • Strittmatter WJ, Saunders AM, Goedert M, Weisgraber KH, Dong L-M, et al. 1994. Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease. Proc. Natl. Acad. Sci. USA 91:11183-86
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 11183-11186
    • Strittmatter, W.J.1    Saunders, A.M.2    Goedert, M.3    Weisgraber, K.H.4    Dong, L.-M.5
  • 94
    • 12044254746 scopus 로고
    • Binding of human apolipoprotein E to synthetic amyloid βpeptide: Isoform-specific effects and implications for late-onset Alzheimer disease
    • Strittmatter WJ, Weisgraber KH, Huang DY, Dong L-M, Salvesen GS, et al. 1993. Binding of human apolipoprotein E to synthetic amyloid βpeptide: isoform-specific effects and implications for late-onset Alzheimer disease. Proc. Natl. Acad. Sci. USA 90:8098-102
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 8098-8102
    • Strittmatter, W.J.1    Weisgraber, K.H.2    Huang, D.Y.3    Dong, L.-M.4    Salvesen, G.S.5
  • 95
    • 0032080231 scopus 로고    scopus 로고
    • Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: Astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins
    • Sun YL, Wu S, Bu GJ, Onifade MK, Patel SN, et al. 1998. Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins. J. Neurosci. 18:3261-72
    • (1998) J. Neurosci. , vol.18 , pp. 3261-3272
    • Sun, Y.L.1    Wu, S.2    Bu, G.J.3    Onifade, M.K.4    Patel, S.N.5
  • 96
    • 0032509346 scopus 로고    scopus 로고
    • Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein
    • Trommsdorff M, Borg J-P, Margolis B, Herz J. 1998. Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein. J. Biol. Chem. 273:33556-60
    • (1998) J. Biol. Chem. , vol.273 , pp. 33556-33560
    • Trommsdorff, M.1    Borg, J.-P.2    Margolis, B.3    Herz, J.4
  • 97
    • 0001808636 scopus 로고
    • Genetic polymorphism of apolipoprotein E - Impact on plasma lipoprotein metabolism
    • ed. G Crepaldi, A Tiengo, G Baggio, Amsterdam: Elsevier Science
    • Utermann G. 1985. Genetic polymorphism of apolipoprotein E - impact on plasma lipoprotein metabolism. In Diabetes, Obesity and Hyperlipidemias - III, ed. G Crepaldi, A Tiengo, G Baggio, pp. 1-28. Amsterdam: Elsevier Science
    • (1985) Diabetes, Obesity and Hyperlipidemias , vol.3 , pp. 1-28
    • Utermann, G.1
  • 98
    • 0017773790 scopus 로고
    • Polymorphism of apolipoprotein E and occurrence of dysbetalipoproteinaemia in man
    • Utermann G, Hees M, Steimnetz A. 1977. Polymorphism of apolipoprotein E and occurrence of dysbetalipoproteinaemia in man. Nature 269:604-7
    • (1977) Nature , vol.269 , pp. 604-607
    • Utermann, G.1    Hees, M.2    Steimnetz, A.3
  • 101
    • 0019979691 scopus 로고
    • Genetic control of human apolipoprotein E polymorphism: Comparison of one-and two-dimensional techniques of isoprotein analysis
    • Utermann G, Steinmetz A, Weber W. 1982. Genetic control of human apolipoprotein E polymorphism: comparison of one-and two-dimensional techniques of isoprotein analysis. Hum. Genet. 60:344-51
    • (1982) Hum. Genet. , vol.60 , pp. 344-351
    • Utermann, G.1    Steinmetz, A.2    Weber, W.3
  • 102
    • 0032946723 scopus 로고    scopus 로고
    • In LDL receptor-deficient mice, catabolism of remnant lipoproteins requires a high level of apoE but is inhibited by excess apoE
    • van Dijk KW, van Vlijmen BJM, van't Hof HB, van der Zee A, Santamarina-Fojo S, et al. 1999. In LDL receptor-deficient mice, catabolism of remnant lipoproteins requires a high level of apoE but is inhibited by excess apoE. J. Lipid Res. 40:336-44
    • (1999) J. Lipid Res. , vol.40 , pp. 336-344
    • Van Dijk, K.W.1    Van Vlijmen, B.J.M.2    Van't Hof, H.B.3    Van Der Zee, A.4    Santamarina-Fojo, S.5
  • 104
    • 0023481281 scopus 로고
    • Dietary fat clearance in normal subjects is regulated by genetic variation of apolipoprotein E
    • Weintraub MS, Eisenberg S, Breslow JL. 1987. Dietary fat clearance in normal subjects is regulated by genetic variation of apolipoprotein E. J. Clin. Invest. 80:1571-77
    • (1987) J. Clin. Invest. , vol.80 , pp. 1571-1577
    • Weintraub, M.S.1    Eisenberg, S.2    Breslow, J.L.3
  • 105
    • 0028303072 scopus 로고
    • Apolipoprotein E: Structure-function relationships
    • Weisgraber KH. 1994. Apolipoprotein E: structure-function relationships. Adv. Protein Chem. 45:249-302
    • (1994) Adv. Protein Chem. , vol.45 , pp. 249-302
    • Weisgraber, K.H.1
  • 106
    • 0020478765 scopus 로고
    • Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to cysteine-arginine interchange at a single site
    • Weisgraber KH, Innerarity TL, Mahley RW. 1982. Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to cysteine-arginine interchange at a single site. J. Biol. Chem. 257:2518-21
    • (1982) J. Biol. Chem. , vol.257 , pp. 2518-2521
    • Weisgraber, K.H.1    Innerarity, T.L.2    Mahley, R.W.3
  • 107
    • 0029844205 scopus 로고    scopus 로고
    • Human apolipoprotein E: The Alzheimer's disease connection
    • Weisgraber KH, Mahley RW. 1996. Human apolipoprotein E: the Alzheimer's disease connection. FASEB J. 10:1485-94
    • (1996) FASEB J. , vol.10 , pp. 1485-1494
    • Weisgraber, K.H.1    Mahley, R.W.2
  • 108
    • 0028146969 scopus 로고
    • Lipoproteins, neurobiology, and Alzheimer's disease: Structure and function of apolipoprotein E
    • Weisgraber KH, Pitas RE, Mahley RW. 1994. Lipoproteins, neurobiology, and Alzheimer's disease: structure and function of apolipoprotein E. Curr. Opin. Struct. Biol. 4:507-15
    • (1994) Curr. Opin. Struct. Biol. , vol.4 , pp. 507-515
    • Weisgraber, K.H.1    Pitas, R.E.2    Mahley, R.W.3
  • 110
    • 0023900109 scopus 로고
    • Human apolipoprotein E3 in aqueous solution. I. Evidence for two structural domains
    • Wetterau JR, Aggerbeck LP, Rall SC Jr, Weisgraber KH. 1988. Human apolipoprotein E3 in aqueous solution. I. Evidence for two structural domains. J. Biol. Chem. 263:6240-48
    • (1988) J. Biol. Chem. , vol.263 , pp. 6240-6248
    • Wetterau, J.R.1    Aggerbeck, L.P.2    Rall S.C., Jr.3    Weisgraber, K.H.4
  • 112
    • 0025860481 scopus 로고
    • Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E
    • Wilson C, Wardell MR, Weisgraber KH, Mahley RW, Agard DA. 1991. Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E. Science 252:1817-22
    • (1991) Science , vol.252 , pp. 1817-1822
    • Wilson, C.1    Wardell, M.R.2    Weisgraber, K.H.3    Mahley, R.W.4    Agard, D.A.5
  • 114
    • 0024990330 scopus 로고
    • Neurotrophic and neurotoxic effects of amyloid βprotein: Reversal by tachykinin neuropeptides
    • Yankner BA, Duffy LK, Kirschner DA. 1990. Neurotrophic and neurotoxic effects of amyloid βprotein: reversal by tachykinin neuropeptides. Science 250:279-82
    • (1990) Science , vol.250 , pp. 279-282
    • Yankner, B.A.1    Duffy, L.K.2    Kirschner, D.A.3
  • 115
    • 0019433761 scopus 로고
    • Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and post-translational modification
    • Zannis VI, Breslow JL. 1981. Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and post-translational modification. Biochemistry 20:1033-41
    • (1981) Biochemistry , vol.20 , pp. 1033-1041
    • Zannis, V.I.1    Breslow, J.L.2
  • 117
    • 0019379410 scopus 로고
    • Human apolipoprotein E isoprotein subclasses are genetically determined
    • Zannis VI, Just PW, Breslow JL. 1981. Human apolipoprotein E isoprotein subclasses are genetically determined. Am. J. Hum. Genet. 33:11-24
    • (1981) Am. J. Hum. Genet. , vol.33 , pp. 11-24
    • Zannis, V.I.1    Just, P.W.2    Breslow, J.L.3


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