메뉴 건너뛰기




Volumn 4, Issue 1, 2009, Pages

Experimental models for the study of neurodegeneration in amyotrophic lateral sclerosis

Author keywords

[No Author keywords available]

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; GLUTAMIC ACID; TAR DNA BINDING PROTEIN; VESICULAR GLUTAMATE TRANSPORTER 1;

EID: 68949121232     PISSN: None     EISSN: 17501326     Source Type: Journal    
DOI: 10.1186/1750-1326-4-31     Document Type: Article
Times cited : (44)

References (176)
  • 1
    • 0022443737 scopus 로고
    • Familial adult motor neuron disease: amyotrophic lateral sclerosis
    • Familial adult motor neuron disease: amyotrophic lateral sclerosis. DW Mulder LT Kurland KP Offord CM Beard, Neurology 1986 36 511 517
    • (1986) Neurology , vol.36 , pp. 511-517
    • Mulder, D.W.1    Kurland, L.T.2    Offord, K.P.3    Beard, C.M.4
  • 2
    • 35248823549 scopus 로고    scopus 로고
    • Cognitive impairment in amyotrophic lateral sclerosis
    • DOI 10.1016/S1474-4422(07)70265-X, PII S147444220770265X
    • Cognitive impairment in amyotrophic lateral sclerosis. J Phukan NP Pender O Hardiman, Lancet Neurol 2007 6 994 1003 (Pubitemid 47562321)
    • (2007) Lancet Neurology , vol.6 , Issue.11 , pp. 994-1003
    • Phukan, J.1    Pender, N.P.2    Hardiman, O.3
  • 3
    • 0027055105 scopus 로고
    • Adult onset motor neuron disease: Worldwide mortality, incidence and distribution since 1950
    • Adult onset motor neuron disease: worldwide mortality, incidence and distribution since 1950. AM Chancellor CP Warlow, J Neurol Neurosurg Psychiatry 1992 55 1106 1115
    • (1992) J Neurol Neurosurg Psychiatry , vol.55 , pp. 1106-1115
    • Chancellor, A.M.1    Warlow, C.P.2
  • 4
    • 0035936804 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis. unfolding the toxicity of the misfolded
    • Amyotrophic lateral sclerosis. unfolding the toxicity of the misfolded. JP Julien, Cell 2001 104 581 591
    • (2001) Cell , vol.104 , pp. 581-591
    • Julien, J.P.1
  • 6
    • 33749056809 scopus 로고    scopus 로고
    • ALS: A disease of motor neurons and their nonneuronal neighbors
    • ALS: a disease of motor neurons and their nonneuronal neighbors. S Boillee C Vande Velde DW Cleveland, Neuron 2006 52 39 59
    • (2006) Neuron , vol.52 , pp. 39-59
    • Boillee, S.1    Velde, C.V.2    Cleveland, D.W.3
  • 7
    • 3943102116 scopus 로고    scopus 로고
    • Unraveling the mechanisms involved in motor neuron degeneration in ALS
    • Unraveling the mechanisms involved in motor neuron degeneration in ALS. LI Bruijn TM Miller DW Cleveland, Annu Rev Neurosci 2004 27 723 749
    • (2004) Annu Rev Neurosci , vol.27 , pp. 723-749
    • Bruijn, L.I.1    Miller, T.M.2    Cleveland, D.W.3
  • 8
    • 0035516124 scopus 로고    scopus 로고
    • From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS
    • From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS. DW Cleveland JD Rothstein, Nat Rev Neurosci 2001 2 806 819
    • (2001) Nat Rev Neurosci , vol.2 , pp. 806-819
    • Cleveland, D.W.1    Rothstein, J.D.2
  • 9
    • 0035978743 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis
    • Amyotrophic lateral sclerosis. LP Rowland NA Shneider, N Engl J Med 2001 344 1688 1700
    • (2001) N Engl J Med , vol.344 , pp. 1688-1700
    • Rowland, L.P.1    Shneider, N.A.2
  • 10
    • 23144448320 scopus 로고    scopus 로고
    • Molecular and cellular pathways of neurodegeneration in motor neurone disease
    • Molecular and cellular pathways of neurodegeneration in motor neurone disease. PJ Shaw, J Neurol Neurosurg Psychiatry 2005 76 1046 1057
    • (2005) J Neurol Neurosurg Psychiatry , vol.76 , pp. 1046-1057
    • Shaw, P.J.1
  • 11
    • 23844538993 scopus 로고    scopus 로고
    • The pathobiology of amyotrophic lateral sclerosis: A proteinopathy?
    • The pathobiology of amyotrophic lateral sclerosis: a proteinopathy? MJ Strong S Kesavapany HC Pant, J Neuropathol Exp Neurol 2005 64 649 664
    • (2005) J Neuropathol Exp Neurol , vol.64 , pp. 649-664
    • Strong, M.J.1    Kesavapany, S.2    Pant, H.C.3
  • 12
    • 0036257090 scopus 로고    scopus 로고
    • A study of riluzole in the treatment of advanced stage or elderly patients with amyotrophic lateral sclerosis
    • A study of riluzole in the treatment of advanced stage or elderly patients with amyotrophic lateral sclerosis. G Bensimon L Lacomblez JC Delumeau R Bejuit P Truffinet V Meininger, J Neurol 2002 249 609 615
    • (2002) J Neurol , vol.249 , pp. 609-615
    • Bensimon, G.1    Lacomblez, L.2    Delumeau, J.C.3    Bejuit, R.4    Truffinet, P.5    Meininger, V.6
  • 13
    • 0028097839 scopus 로고
    • A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group
    • A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group. G Bensimon L Lacomblez V Meininger, N Engl J Med 1994 330 585 591
    • (1994) N Engl J Med , vol.330 , pp. 585-591
    • Bensimon, G.1    Lacomblez, L.2    Meininger, V.3
  • 14
    • 0029753270 scopus 로고    scopus 로고
    • The pharmacology and mechanism of action of riluzole
    • The pharmacology and mechanism of action of riluzole. A Doble, Neurology 1996 47 S233 241
    • (1996) Neurology , vol.47 , pp. 233-241
    • Doble, A.1
  • 16
    • 0029977337 scopus 로고    scopus 로고
    • Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis/Riluzole Study Group II
    • Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis/Riluzole Study Group II. L Lacomblez G Bensimon PN Leigh P Guillet V Meininger, Lancet 1996 347 1425 1431
    • (1996) Lancet , vol.347 , pp. 1425-1431
    • Lacomblez, L.1    Bensimon, G.2    Leigh, P.N.3    Guillet, P.4    Meininger, V.5
  • 17
    • 0029991177 scopus 로고    scopus 로고
    • Pathogenic mechanisms in familial amyotrophic lateral sclerosis due to mutation of Cu, Zn superoxide dismutase
    • Pathogenic mechanisms in familial amyotrophic lateral sclerosis due to mutation of Cu, Zn superoxide dismutase. ME Gurney FB Cutting P Zhai PK Andrus ED Hall, Pathol Biol (Paris) 1996 44 51 56
    • (1996) Pathol Biol (Paris) , vol.44 , pp. 51-56
    • Gurney, M.E.1    Cutting, F.B.2    Zhai, P.3    Andrus, P.K.4    Hall, E.D.5
  • 18
    • 0034624001 scopus 로고    scopus 로고
    • Copper- and zinc-containing superoxide dismutase can act as a superoxide reductase and a superoxide oxidase
    • Copper- and zinc-containing superoxide dismutase can act as a superoxide reductase and a superoxide oxidase. SI Liochev I Fridovich, J Biol Chem 2000 275 38482 38485
    • (2000) J Biol Chem , vol.275 , pp. 38482-38485
    • Liochev, S.I.1    Fridovich, I.2
  • 25
    • 0029584941 scopus 로고
    • Superoxide dismutase in familial amyotrophic lateral sclerosis: Models for gain of function
    • Superoxide dismutase in familial amyotrophic lateral sclerosis: models for gain of function. RH Brown Jr, Curr Opin Neurobiol 1995 5 841 846
    • (1995) Curr Opin Neurobiol , vol.5 , pp. 841-846
    • Brown Jr., R.H.1
  • 30
    • 0034520591 scopus 로고    scopus 로고
    • Human Cu/Zn superoxide dismutase (SOD1) overexpression in mice causes mitochondrial vacuolization, axonal degeneration, and premature motoneuron death and accelerates motoneuron disease in mice expressing a familial amyotrophic lateral sclerosis mutant SOD1
    • Human Cu/Zn superoxide dismutase (SOD1) overexpression in mice causes mitochondrial vacuolization, axonal degeneration, and premature motoneuron death and accelerates motoneuron disease in mice expressing a familial amyotrophic lateral sclerosis mutant SOD1. D Jaarsma ED Haasdijk JA Grashorn R Hawkins W van Duijn HW Verspaget J London JC Holstege, Neurobiol Dis 2000 7 623 643
    • (2000) Neurobiol Dis , vol.7 , pp. 623-643
    • Jaarsma, D.1    Haasdijk, E.D.2    Grashorn, J.A.3    Hawkins, R.4    Van Duijn, W.5    Verspaget, H.W.6    London, J.7    Holstege, J.C.8
  • 34
    • 0028933344 scopus 로고
    • Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu, Zn SOD, and in mice overexpressing wild type human SOD: A model of familial amyotrophic lateral sclerosis (FALS)
    • Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu, Zn SOD, and in mice overexpressing wild type human SOD: a model of familial amyotrophic lateral sclerosis (FALS). MC Dal Canto ME Gurney, Brain Res 1995 676 25 40
    • (1995) Brain Res , vol.676 , pp. 25-40
    • Dal Canto, M.C.1    Gurney, M.E.2
  • 35
    • 0029991827 scopus 로고    scopus 로고
    • Colocalization of NOS and SOD1 in neurofilament accumulation within motor neurons of amyotrophic lateral sclerosis: An immunohistochemical study
    • Colocalization of NOS and SOD1 in neurofilament accumulation within motor neurons of amyotrophic lateral sclerosis: an immunohistochemical study. SM Chou HS Wang K Komai, J Chem Neuroanat 1996 10 249 258
    • (1996) J Chem Neuroanat , vol.10 , pp. 249-258
    • Chou, S.M.1    Wang, H.S.2    Komai, K.3
  • 37
    • 0029842923 scopus 로고    scopus 로고
    • Immunohistochemical study on superoxide dismutases in spinal cords from autopsied patients with amyotrophic lateral sclerosis
    • Immunohistochemical study on superoxide dismutases in spinal cords from autopsied patients with amyotrophic lateral sclerosis. N Shibata K Asayama A Hirano M Kobayashi, Dev Neurosci 1996 18 492 498
    • (1996) Dev Neurosci , vol.18 , pp. 492-498
    • Shibata, N.1    Asayama, K.2    Hirano, A.3    Kobayashi, M.4
  • 43
    • 38449113556 scopus 로고    scopus 로고
    • Genetics of sporadic amyotrophic lateral sclerosis
    • Genetics of sporadic amyotrophic lateral sclerosis. JC Schymick K Talbot BJ Traynor, Hum Mol Genet 2007 16 Spec No 2 R233 242
    • (2007) Hum Mol Genet , vol.16 , Issue.SPEC NO 2 , pp. 233-242
    • Schymick, J.C.1    Talbot, K.2    Traynor, B.J.3
  • 44
    • 37849043062 scopus 로고    scopus 로고
    • Genetics of familial amyotrophic lateral sclerosis
    • Genetics of familial amyotrophic lateral sclerosis. PN Valdmanis GA Rouleau, Neurology 2008 70 144 152
    • (2008) Neurology , vol.70 , pp. 144-152
    • Valdmanis, P.N.1    Rouleau, G.A.2
  • 50
    • 0025237394 scopus 로고
    • Hereditary motor system diseases (chronic juvenile amyotrophic lateral sclerosis). Conditions combining a bilateral pyramidal syndrome with limb and bulbar amyotrophy
    • Hereditary motor system diseases (chronic juvenile amyotrophic lateral sclerosis). Conditions combining a bilateral pyramidal syndrome with limb and bulbar amyotrophy. M Ben Hamida F Hentati C Ben Hamida, Brain 1990 113 Pt 2 347 363
    • (1990) Brain , vol.113 , Issue.PT 2 , pp. 347-363
    • Ben Hamida, M.1    Hentati, F.2    Ben Hamida, C.3
  • 51
    • 38449092804 scopus 로고    scopus 로고
    • Alsin and the molecular pathways of amyotrophic lateral sclerosis
    • Alsin and the molecular pathways of amyotrophic lateral sclerosis. J Chandran J Ding H Cai, Mol Neurobiol 2007 36 224 231
    • (2007) Mol Neurobiol , vol.36 , pp. 224-231
    • Chandran, J.1    Ding, J.2    Cai, H.3
  • 52
    • 49249118746 scopus 로고    scopus 로고
    • TDP-43 is a culprit in human neurodegeneration, and not just an innocent bystander
    • TDP-43 is a culprit in human neurodegeneration, and not just an innocent bystander. GT Banks A Kuta AM Isaacs EM Fisher, Mamm Genome 2008 19 299 305
    • (2008) Mamm Genome , vol.19 , pp. 299-305
    • Banks, G.T.1    Kuta, A.2    Isaacs, A.M.3    Fisher, E.M.4
  • 55
    • 0042536473 scopus 로고    scopus 로고
    • Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity
    • Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity. M Arundine M Tymianski, Cell Calcium 2003 34 325 337
    • (2003) Cell Calcium , vol.34 , pp. 325-337
    • Arundine, M.1    Tymianski, M.2
  • 56
    • 0032709462 scopus 로고    scopus 로고
    • Calcium, glutamate, and amyotrophic lateral sclerosis: More evidence but no certainties
    • Calcium, glutamate, and amyotrophic lateral sclerosis: more evidence but no certainties. PJ Shaw, Ann Neurol 1999 46 803 805
    • (1999) Ann Neurol , vol.46 , pp. 803-805
    • Shaw, P.J.1
  • 57
    • 0027946813 scopus 로고
    • The role of calcium-binding proteins in selective motoneuron vulnerability in amyotrophic lateral sclerosis
    • The role of calcium-binding proteins in selective motoneuron vulnerability in amyotrophic lateral sclerosis. ME Alexianu BK Ho AH Mohamed V La Bella RG Smith SH Appel, Ann Neurol 1994 36 846 858
    • (1994) Ann Neurol , vol.36 , pp. 846-858
    • Alexianu, M.E.1    Ho, B.K.2    Mohamed, A.H.3    La Bella, V.4    Smith, R.G.5    Appel, S.H.6
  • 58
    • 0025358573 scopus 로고
    • Calbindin D-28k and parvalbumin in the rat nervous system
    • Calbindin D-28k and parvalbumin in the rat nervous system. MR Celio, Neuroscience 1990 35 375 475
    • (1990) Neuroscience , vol.35 , pp. 375-475
    • Celio, M.R.1
  • 60
    • 0033569575 scopus 로고    scopus 로고
    • Calcium dynamics and buffering in motoneurones of the mouse spinal cord
    • Calcium dynamics and buffering in motoneurones of the mouse spinal cord. J Palecek MB Lips BU Keller, J Physiol 1999 520 Pt 2 485 502
    • (1999) J Physiol , vol.520 , Issue.PT 2 , pp. 485-502
    • Palecek, J.1    Lips, M.B.2    Keller, B.U.3
  • 62
    • 0025923461 scopus 로고
    • Ca2+ permeability of KA-AMPA - Gated glutamate receptor channels depends on subunit composition
    • Ca2+ permeability of KA-AMPA - gated glutamate receptor channels depends on subunit composition. M Hollmann M Hartley S Heinemann, Science 1991 252 851 853
    • (1991) Science , vol.252 , pp. 851-853
    • Hollmann, M.1    Hartley, M.2    Heinemann, S.3
  • 63
    • 0025784548 scopus 로고
    • Identification of a site in glutamate receptor subunits that controls calcium permeability
    • Identification of a site in glutamate receptor subunits that controls calcium permeability. RI Hume R Dingledine SF Heinemann, Science 1991 253 1028 1031
    • (1991) Science , vol.253 , pp. 1028-1031
    • Hume, R.I.1    Dingledine, R.2    Heinemann, S.F.3
  • 64
    • 0026543243 scopus 로고
    • Divalent ion permeability of AMPA receptor channels is dominated by the edited form of a single subunit
    • Divalent ion permeability of AMPA receptor channels is dominated by the edited form of a single subunit. N Burnashev H Monyer PH Seeburg B Sakmann, Neuron 1992 8 189 198
    • (1992) Neuron , vol.8 , pp. 189-198
    • Burnashev, N.1    Monyer, H.2    Seeburg, P.H.3    Sakmann, B.4
  • 65
    • 0028941168 scopus 로고
    • In vitro kainate injury to large, SMI-32(+) spinal neurons is Ca2+ dependent
    • In vitro kainate injury to large, SMI-32(+) spinal neurons is Ca2+ dependent. SG Carriedo HZ Yin R Lamberta JH Weiss, Neuroreport 1995 6 945 948
    • (1995) Neuroreport , vol.6 , pp. 945-948
    • Carriedo, S.G.1    Yin, H.Z.2    Lamberta, R.3    Weiss, J.H.4
  • 66
    • 0030015076 scopus 로고    scopus 로고
    • Motor neurons are selectively vulnerable to AMPA/kainate receptor-mediated injury in vitro
    • Motor neurons are selectively vulnerable to AMPA/kainate receptor-mediated injury in vitro. SG Carriedo HZ Yin JH Weiss, J Neurosci 1996 16 4069 4079
    • (1996) J Neurosci , vol.16 , pp. 4069-4079
    • Carriedo, S.G.1    Yin, H.Z.2    Weiss, J.H.3
  • 67
    • 0033985186 scopus 로고    scopus 로고
    • Characterization of the AMPA-activated receptors present on motoneurons
    • Characterization of the AMPA-activated receptors present on motoneurons. A Greig SD Donevan TJ Mujtaba TN Parks MS Rao, J Neurochem 2000 74 179 191
    • (2000) J Neurochem , vol.74 , pp. 179-191
    • Greig, A.1    Donevan, S.D.2    Mujtaba, T.J.3    Parks, T.N.4    Rao, M.S.5
  • 68
    • 0024454210 scopus 로고
    • Kainic acid induces early and delayed degenerative neuronal changes in rat spinal cord
    • Kainic acid induces early and delayed degenerative neuronal changes in rat spinal cord. J Hugon JM Vallat PS Spencer MJ Leboutet D Barthe, Neurosci Lett 1989 104 258 262
    • (1989) Neurosci Lett , vol.104 , pp. 258-262
    • Hugon, J.1    Vallat, J.M.2    Spencer, P.S.3    Leboutet, M.J.4    Barthe, D.5
  • 69
    • 0029113872 scopus 로고
    • Neuroprotective strategies in a model of chronic glutamate-mediated motor neuron toxicity
    • Neuroprotective strategies in a model of chronic glutamate-mediated motor neuron toxicity. JD Rothstein RW Kuncl, J Neurochem 1995 65 643 651
    • (1995) J Neurochem , vol.65 , pp. 643-651
    • Rothstein, J.D.1    Kuncl, R.W.2
  • 70
    • 0036713846 scopus 로고    scopus 로고
    • GluR2-dependent properties of AMPA receptors determine the selective vulnerability of motor neurons to excitotoxicity
    • GluR2-dependent properties of AMPA receptors determine the selective vulnerability of motor neurons to excitotoxicity. P Van Damme L Van Den Bosch E Van Houtte G Callewaert W Robberecht, J Neurophysiol 2002 88 1279 1287
    • (2002) J Neurophysiol , vol.88 , pp. 1279-1287
    • Van Damme, P.1    Van Den Bosch, L.2    Van Houtte, E.3    Callewaert, G.4    Robberecht, W.5
  • 72
    • 0030789347 scopus 로고    scopus 로고
    • Calcium-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors: A molecular determinant of selective vulnerability in amyotrophic lateral sclerosis
    • Calcium-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors: a molecular determinant of selective vulnerability in amyotrophic lateral sclerosis. TL Williams NC Day PG Ince RK Kamboj PJ Shaw, Ann Neurol 1997 42 200 207
    • (1997) Ann Neurol , vol.42 , pp. 200-207
    • Williams, T.L.1    Day, N.C.2    Ince, P.G.3    Kamboj, R.K.4    Shaw, P.J.5
  • 73
    • 2542498984 scopus 로고    scopus 로고
    • AMPA receptor activation, but not the accumulation of endogenous extracellular glutamate, induces paralysis and motor neuron death in rat spinal cord in vivo
    • AMPA receptor activation, but not the accumulation of endogenous extracellular glutamate, induces paralysis and motor neuron death in rat spinal cord in vivo. JC Corona R Tapia, J Neurochem 2004 89 988 997
    • (2004) J Neurochem , vol.89 , pp. 988-997
    • Corona, J.C.1    Tapia, R.2
  • 74
    • 34047131622 scopus 로고    scopus 로고
    • Ca2+-permeable AMPA receptors and intracellular Ca2+ determine motoneuron vulnerability in rat spinal cord in vivo
    • Ca2+-permeable AMPA receptors and intracellular Ca2+ determine motoneuron vulnerability in rat spinal cord in vivo. JC Corona R Tapia, Neuropharmacology 2007 52 1219 1228
    • (2007) Neuropharmacology , vol.52 , pp. 1219-1228
    • Corona, J.C.1    Tapia, R.2
  • 75
    • 0035001341 scopus 로고    scopus 로고
    • Glutamate uptake
    • Glutamate uptake. NC Danbolt, Prog Neurobiol 2001 65 1 105
    • (2001) Prog Neurobiol , vol.65 , pp. 1-105
    • Danbolt, N.C.1
  • 76
    • 0026597010 scopus 로고
    • Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis
    • Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis. JD Rothstein LJ Martin RW Kuncl, N Engl J Med 1992 326 1464 1468
    • (1992) N Engl J Med , vol.326 , pp. 1464-1468
    • Rothstein, J.D.1    Martin, L.J.2    Kuncl, R.W.3
  • 77
    • 0028168346 scopus 로고
    • [3H]D-aspartate binding sites in the normal human spinal cord and changes in motor neuron disease: A quantitative autoradiographic study
    • [3H]D-aspartate binding sites in the normal human spinal cord and changes in motor neuron disease: a quantitative autoradiographic study. PJ Shaw RM Chinnery PG Ince, Brain Res 1994 655 195 201
    • (1994) Brain Res , vol.655 , pp. 195-201
    • Shaw, P.J.1    Chinnery, R.M.2    Ince, P.G.3
  • 78
    • 0033938202 scopus 로고    scopus 로고
    • Excitatory amino acid transporter 1 and 2 immunoreactivity in the spinal cord in amyotrophic lateral sclerosis
    • Excitatory amino acid transporter 1 and 2 immunoreactivity in the spinal cord in amyotrophic lateral sclerosis. S Sasaki T Komori M Iwata, Acta Neuropathol 2000 100 138 144
    • (2000) Acta Neuropathol , vol.100 , pp. 138-144
    • Sasaki, S.1    Komori, T.2    Iwata, M.3
  • 79
    • 0023617392 scopus 로고
    • Abnormal glutamate metabolism in amyotrophic lateral sclerosis
    • Abnormal glutamate metabolism in amyotrophic lateral sclerosis. A Plaitakis JT Caroscio, Ann Neurol 1987 22 575 579
    • (1987) Ann Neurol , vol.22 , pp. 575-579
    • Plaitakis, A.1    Caroscio, J.T.2
  • 81
    • 0029067210 scopus 로고
    • CSF and plasma amino acid levels in motor neuron disease: Elevation of CSF glutamate in a subset of patients
    • CSF and plasma amino acid levels in motor neuron disease: elevation of CSF glutamate in a subset of patients. PJ Shaw V Forrest PG Ince JP Richardson HJ Wastell, Neurodegeneration 1995 4 209 216
    • (1995) Neurodegeneration , vol.4 , pp. 209-216
    • Shaw, P.J.1    Forrest, V.2    Ince, P.G.3    Richardson, J.P.4    Wastell, H.J.5
  • 82
    • 0037081113 scopus 로고    scopus 로고
    • Glutamate levels in cerebrospinal fluid in amyotrophic lateral sclerosis: A reappraisal using a new HPLC method with coulometric detection in a large cohort of patients
    • Glutamate levels in cerebrospinal fluid in amyotrophic lateral sclerosis: a reappraisal using a new HPLC method with coulometric detection in a large cohort of patients. O Spreux-Varoquaux G Bensimon L Lacomblez F Salachas PF Pradat N Le Forestier A Marouan M Dib V Meininger, J Neurol Sci 2002 193 73 78
    • (2002) J Neurol Sci , vol.193 , pp. 73-78
    • Spreux-Varoquaux, O.1    Bensimon, G.2    Lacomblez, L.3    Salachas, F.4    Pradat, P.F.5    Le Forestier, N.6    Marouan, A.7    Dib, M.8    Meininger, V.9
  • 83
    • 60949096316 scopus 로고    scopus 로고
    • Chronic elevation of extracellular glutamate due to transport blockade is innocuous for spinal motoneurons in vivo
    • Chronic elevation of extracellular glutamate due to transport blockade is innocuous for spinal motoneurons in vivo. LB Tovar-y-Romo LD Santa-Cruz A Zepeda R Tapia, Neurochem Int 2009 54 186 191 10.1016/j.neuint.2008.09.015 19100799
    • (2009) Neurochem Int , vol.54 , pp. 186-191
    • Tovar-Y-Romo, L.B.1    Santa-Cruz, L.D.2    Zepeda, A.3    Tapia, R.4
  • 84
    • 33745270015 scopus 로고    scopus 로고
    • Cerebral neurons of transgenic ALS mice are vulnerable to glutamate release stimulation but not to increased extracellular glutamate due to transport blockade
    • Cerebral neurons of transgenic ALS mice are vulnerable to glutamate release stimulation but not to increased extracellular glutamate due to transport blockade. LB Tovar-y-Romo R Tapia, Exp Neurol 2006 199 281 290
    • (2006) Exp Neurol , vol.199 , pp. 281-290
    • Tovar-Y-Romo, L.B.1    Tapia, R.2
  • 87
    • 0029082389 scopus 로고
    • Oxidative damage to protein in sporadic motor neuron disease spinal cord
    • Oxidative damage to protein in sporadic motor neuron disease spinal cord. PJ Shaw PG Ince G Falkous D Mantle, Ann Neurol 1995 38 691 695
    • (1995) Ann Neurol , vol.38 , pp. 691-695
    • Shaw, P.J.1    Ince, P.G.2    Falkous, G.3    Mantle, D.4
  • 88
    • 0028971936 scopus 로고
    • Induction of nitrotyrosine-like immunoreactivity in the lower motor neuron of amyotrophic lateral sclerosis
    • Induction of nitrotyrosine-like immunoreactivity in the lower motor neuron of amyotrophic lateral sclerosis. K Abe LH Pan M Watanabe T Kato Y Itoyama, Neurosci Lett 1995 199 152 154
    • (1995) Neurosci Lett , vol.199 , pp. 152-154
    • Abe, K.1    Pan, L.H.2    Watanabe, M.3    Kato, T.4    Itoyama, Y.5
  • 89
    • 0030888919 scopus 로고    scopus 로고
    • Upregulation of protein-tyrosine nitration in the anterior horn cells of amyotrophic lateral sclerosis
    • Upregulation of protein-tyrosine nitration in the anterior horn cells of amyotrophic lateral sclerosis. K Abe LH Pan M Watanabe H Konno T Kato Y Itoyama, Neurol Res 1997 19 124 128
    • (1997) Neurol Res , vol.19 , pp. 124-128
    • Abe, K.1    Pan, L.H.2    Watanabe, M.3    Konno, H.4    Kato, T.5    Itoyama, Y.6
  • 93
    • 13244275028 scopus 로고    scopus 로고
    • Oxidative stress and metal content in blood and cerebrospinal fluid of amyotrophic lateral sclerosis patients with and without a Cu, Zn-superoxide dismutase mutation
    • Oxidative stress and metal content in blood and cerebrospinal fluid of amyotrophic lateral sclerosis patients with and without a Cu, Zn-superoxide dismutase mutation. Y Ihara K Nobukuni H Takata T Hayabara, Neurol Res 2005 27 105 108 10.1179/016164105X18430 15829169
    • (2005) Neurol Res , vol.27 , pp. 105-108
    • Ihara, Y.1    Nobukuni, K.2    Takata, H.3    Hayabara, T.4
  • 95
    • 0030968429 scopus 로고    scopus 로고
    • Evaluation of antioxidants, protein, and lipid oxidation products in blood from sporadic amyotrophic lateral sclerosis patients
    • Evaluation of antioxidants, protein, and lipid oxidation products in blood from sporadic amyotrophic lateral sclerosis patients. PI Oteiza OD Uchitel F Carrasquedo AL Dubrovski JC Roma CG Fraga, Neurochem Res 1997 22 535 539
    • (1997) Neurochem Res , vol.22 , pp. 535-539
    • Oteiza, P.I.1    Uchitel, O.D.2    Carrasquedo, F.3    Dubrovski, A.L.4    Roma, J.C.5    Fraga, C.G.6
  • 96
    • 2442701519 scopus 로고    scopus 로고
    • Increased lipid peroxidation in sera of ALS patients: A potential biomarker of disease burden
    • Increased lipid peroxidation in sera of ALS patients: a potential biomarker of disease burden. EP Simpson YK Henry JS Henkel RG Smith SH Appel, Neurology 2004 62 1758 1765
    • (2004) Neurology , vol.62 , pp. 1758-1765
    • Simpson, E.P.1    Henry, Y.K.2    Henkel, J.S.3    Smith, R.G.4    Appel, S.H.5
  • 97
    • 0031722955 scopus 로고    scopus 로고
    • Presence of 4-hydroxynonenal in cerebrospinal fluid of patients with sporadic amyotrophic lateral sclerosis
    • Presence of 4-hydroxynonenal in cerebrospinal fluid of patients with sporadic amyotrophic lateral sclerosis. RG Smith YK Henry MP Mattson SH Appel, Ann Neurol 1998 44 696 699
    • (1998) Ann Neurol , vol.44 , pp. 696-699
    • Smith, R.G.1    Henry, Y.K.2    Mattson, M.P.3    Appel, S.H.4
  • 98
    • 0033009113 scopus 로고    scopus 로고
    • Remarkable increase in cerebrospinal fluid 3-nitrotyrosine in patients with sporadic amyotrophic lateral sclerosis
    • Remarkable increase in cerebrospinal fluid 3-nitrotyrosine in patients with sporadic amyotrophic lateral sclerosis. H Tohgi T Abe K Yamazaki T Murata E Ishizaki C Isobe, Ann Neurol 1999 46 129 131
    • (1999) Ann Neurol , vol.46 , pp. 129-131
    • Tohgi, H.1    Abe, T.2    Yamazaki, K.3    Murata, T.4    Ishizaki, E.5    Isobe, C.6
  • 99
    • 1842788079 scopus 로고    scopus 로고
    • Cerebrospinal fluid levels of free 3-nitrotyrosine are not elevated in the majority of patients with amyotrophic lateral sclerosis or Alzheimer's disease
    • Cerebrospinal fluid levels of free 3-nitrotyrosine are not elevated in the majority of patients with amyotrophic lateral sclerosis or Alzheimer's disease. H Ryberg AS Soderling P Davidsson K Blennow K Caidahl LI Persson, Neurochem Int 2004 45 57 62
    • (2004) Neurochem Int , vol.45 , pp. 57-62
    • Ryberg, H.1    Soderling, A.S.2    Davidsson, P.3    Blennow, K.4    Caidahl, K.5    Persson, L.I.6
  • 100
    • 0031784348 scopus 로고    scopus 로고
    • Protein oxidative damage in a transgenic mouse model of familial amyotrophic lateral sclerosis
    • Protein oxidative damage in a transgenic mouse model of familial amyotrophic lateral sclerosis. PK Andrus TJ Fleck ME Gurney ED Hall, J Neurochem 1998 71 2041 2048
    • (1998) J Neurochem , vol.71 , pp. 2041-2048
    • Andrus, P.K.1    Fleck, T.J.2    Gurney, M.E.3    Hall, E.D.4
  • 101
    • 18144398928 scopus 로고    scopus 로고
    • Protein nitration in a mouse model of familial amyotrophic lateral sclerosis: Possible multifunctional role in the pathogenesis
    • Protein nitration in a mouse model of familial amyotrophic lateral sclerosis: possible multifunctional role in the pathogenesis. F Casoni M Basso T Massignan E Gianazza C Cheroni M Salmona C Bendotti V Bonetto, J Biol Chem 2005 280 16295 16304
    • (2005) J Biol Chem , vol.280 , pp. 16295-16304
    • Casoni, F.1    Basso, M.2    Massignan, T.3    Gianazza, E.4    Cheroni, C.5    Salmona, M.6    Bendotti, C.7    Bonetto, V.8
  • 103
    • 0031768025 scopus 로고    scopus 로고
    • Enhanced oxygen radical production in a transgenic mouse model of familial amyotrophic lateral sclerosis
    • Enhanced oxygen radical production in a transgenic mouse model of familial amyotrophic lateral sclerosis. R Liu JS Althaus BR Ellerbrock DA Becker ME Gurney, Ann Neurol 1998 44 763 770
    • (1998) Ann Neurol , vol.44 , pp. 763-770
    • Liu, R.1    Althaus, J.S.2    Ellerbrock, B.R.3    Becker, D.A.4    Gurney, M.E.5
  • 105
    • 0034004476 scopus 로고    scopus 로고
    • AMPA exposures induce mitochondrial Ca(2+) overload and ROS generation in spinal motor neurons in vitro
    • AMPA exposures induce mitochondrial Ca(2+) overload and ROS generation in spinal motor neurons in vitro. SG Carriedo SL Sensi HZ Yin JH Weiss, J Neurosci 2000 20 240 250
    • (2000) J Neurosci , vol.20 , pp. 240-250
    • Carriedo, S.G.1    Sensi, S.L.2    Yin, H.Z.3    Weiss, J.H.4
  • 109
    • 0032427646 scopus 로고    scopus 로고
    • Novel insertion in the KSP region of the neurofilament heavy gene in amyotrophic lateral sclerosis (ALS)
    • Novel insertion in the KSP region of the neurofilament heavy gene in amyotrophic lateral sclerosis (ALS). J Tomkins P Usher JY Slade PG Ince A Curtis K Bushby PJ Shaw, Neuroreport 1998 9 3967 3970
    • (1998) Neuroreport , vol.9 , pp. 3967-3970
    • Tomkins, J.1    Usher, P.2    Slade, J.Y.3    Ince, P.G.4    Curtis, A.5    Bushby, K.6    Shaw, P.J.7
  • 110
    • 0027465098 scopus 로고
    • Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: A mouse model of amyotrophic lateral sclerosis
    • Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: a mouse model of amyotrophic lateral sclerosis. F Cote JF Collard JP Julien, Cell 1993 73 35 46
    • (1993) Cell , vol.73 , pp. 35-46
    • Cote, F.1    Collard, J.F.2    Julien, J.P.3
  • 111
    • 0027410516 scopus 로고
    • Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease
    • Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease. Z Xu LC Cork JW Griffin DW Cleveland, Cell 1993 73 23 33
    • (1993) Cell , vol.73 , pp. 23-33
    • Xu, Z.1    Cork, L.C.2    Griffin, J.W.3    Cleveland, D.W.4
  • 112
    • 0017669602 scopus 로고
    • Mouse spinal cord in cell culture. I. Morphology and intrinsic neuronal electrophysiologic properties
    • Mouse spinal cord in cell culture. I. Morphology and intrinsic neuronal electrophysiologic properties. BR Ransom E Neale M Henkart PN Bullock PG Nelson, J Neurophysiol 1977 40 1132 1150
    • (1977) J Neurophysiol , vol.40 , pp. 1132-1150
    • Ransom, B.R.1    Neale, E.2    Henkart, M.3    Bullock, P.N.4    Nelson, P.G.5
  • 113
    • 0019794038 scopus 로고
    • Separation of cell types from embryonic chicken and 333062 rat spinal cord: Characterization of motoneuron-enriched fractions
    • 7264717
    • Separation of cell types from embryonic chicken and rat spinal cord: characterization of motoneuron-enriched fractions. RI Schnaar AE Schaffner, J Neurosci 1981 1 204 217 7264717
    • (1981) J Neurosci , vol.1 , pp. 204-217
    • Schnaar, R.I.1    Schaffner, A.E.2
  • 114
    • 0026630523 scopus 로고
    • Purification of embryonic rat motoneurons by panning on a monoclonal antibody to the low-affinity NGF receptor
    • Purification of embryonic rat motoneurons by panning on a monoclonal antibody to the low-affinity NGF receptor. W Camu CE Henderson, J Neurosci Methods 1992 44 59 70
    • (1992) J Neurosci Methods , vol.44 , pp. 59-70
    • Camu, W.1    Henderson, C.E.2
  • 115
    • 0021522805 scopus 로고
    • Motoneurons purified by cell sorting respond to two distinct activities in myotube-conditioned medium
    • Motoneurons purified by cell sorting respond to two distinct activities in myotube-conditioned medium. AL Calof LF Reichardt, Dev Biol 1984 106 194 210
    • (1984) Dev Biol , vol.106 , pp. 194-210
    • Calof, A.L.1    Reichardt, L.F.2
  • 116
    • 0037047320 scopus 로고    scopus 로고
    • Directed differentiation of embryonic stem cells into motor neurons
    • Directed differentiation of embryonic stem cells into motor neurons. H Wichterle I Lieberam JA Porter TM Jessell, Cell 2002 110 385 397
    • (2002) Cell , vol.110 , pp. 385-397
    • Wichterle, H.1    Lieberam, I.2    Porter, J.A.3    Jessell, T.M.4
  • 117
    • 0345269737 scopus 로고    scopus 로고
    • Disruption of glial glutamate transport by reactive oxygen species produced in motor neurons
    • Disruption of glial glutamate transport by reactive oxygen species produced in motor neurons. SD Rao HZ Yin JH Weiss, J Neurosci 2003 23 2627 2633
    • (2003) J Neurosci , vol.23 , pp. 2627-2633
    • Rao, S.D.1    Yin, H.Z.2    Weiss, J.H.3
  • 118
    • 34247473080 scopus 로고    scopus 로고
    • Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model
    • Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model. FP Di Giorgio MA Carrasco MC Siao T Maniatis K Eggan, Nat Neurosci 2007 10 608 614
    • (2007) Nat Neurosci , vol.10 , pp. 608-614
    • Di Giorgio, F.P.1    Carrasco, M.A.2    Siao, M.C.3    Maniatis, T.4    Eggan, K.5
  • 125
    • 38149115471 scopus 로고    scopus 로고
    • Cysteine 111 affects aggregation and cytotoxicity of mutant Cu, Zn-superoxide dismutase associated with familial amyotrophic lateral sclerosis
    • Cysteine 111 affects aggregation and cytotoxicity of mutant Cu, Zn-superoxide dismutase associated with familial amyotrophic lateral sclerosis. M Cozzolino I Amori MG Pesaresi A Ferri M Nencini MT Carri, J Biol Chem 2008 283 866 874
    • (2008) J Biol Chem , vol.283 , pp. 866-874
    • Cozzolino, M.1    Amori, I.2    Pesaresi, M.G.3    Ferri, A.4    Nencini, M.5    Carri, M.T.6
  • 126
    • 17844364182 scopus 로고    scopus 로고
    • Low levels of ALS-linked Cu/Zn superoxide dismutase increase the production of reactive oxygen species and cause mitochondrial damage and death in motor neuron-like cells
    • Low levels of ALS-linked Cu/Zn superoxide dismutase increase the production of reactive oxygen species and cause mitochondrial damage and death in motor neuron-like cells. M Rizzardini A Mangolini M Lupi P Ubezio C Bendotti L Cantoni, J Neurol Sci 2005 232 95 103
    • (2005) J Neurol Sci , vol.232 , pp. 95-103
    • Rizzardini, M.1    Mangolini, A.2    Lupi, M.3    Ubezio, P.4    Bendotti, C.5    Cantoni, L.6
  • 127
    • 0037541152 scopus 로고    scopus 로고
    • The MYC oncogene as a cancer drug target
    • The MYC oncogene as a cancer drug target. H Hermeking, Curr Cancer Drug Targets 2003 3 163 175
    • (2003) Curr Cancer Drug Targets , vol.3 , pp. 163-175
    • Hermeking, H.1
  • 128
    • 0024391672 scopus 로고
    • Ventral and dorsal horn acetylcholinesterase neurons are maintained in organotypic cultures of postnatal rat spinal cord explants
    • Ventral and dorsal horn acetylcholinesterase neurons are maintained in organotypic cultures of postnatal rat spinal cord explants. J Delfs J Friend S Ishimoto D Saroff, Brain Res 1989 488 31 42
    • (1989) Brain Res , vol.488 , pp. 31-42
    • Delfs, J.1    Friend, J.2    Ishimoto, S.3    Saroff, D.4
  • 129
    • 0027274623 scopus 로고
    • Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity
    • Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity. JD Rothstein L Jin M Dykes-Hoberg RW Kuncl, Proc Natl Acad Sci USA 1993 90 6591 6595
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 6591-6595
    • Rothstein, J.D.1    Jin, L.2    Dykes-Hoberg, M.3    Kuncl, R.W.4
  • 130
    • 0032702435 scopus 로고    scopus 로고
    • Preclinical testing of neuroprotective neurotrophic factors in a model of chronic motor neuron degeneration
    • Preclinical testing of neuroprotective neurotrophic factors in a model of chronic motor neuron degeneration. AM Corse MM Bilak SR Bilak M Lehar JD Rothstein RW Kuncl, Neurobiol Dis 1999 6 335 346
    • (1999) Neurobiol Dis , vol.6 , pp. 335-346
    • Corse, A.M.1    Bilak, M.M.2    Bilak, S.R.3    Lehar, M.4    Rothstein, J.D.5    Kuncl, R.W.6
  • 131
    • 42549127816 scopus 로고    scopus 로고
    • Vascular endothelial growth factor protects spinal cord motoneurons against glutamate-induced excitotoxicity via phosphatidylinositol 3-kinase
    • Vascular endothelial growth factor protects spinal cord motoneurons against glutamate-induced excitotoxicity via phosphatidylinositol 3-kinase. L Tolosa M Mir VJ Asensio G Olmos J Llado, J Neurochem 2008
    • (2008) J Neurochem
    • Tolosa, L.1    Mir, M.2    Asensio, V.J.3    Olmos, G.4    Llado, J.5
  • 132
    • 0026594583 scopus 로고
    • Wobbler, a mutation affecting motoneuron survival and gonadal functions in the mouse, maps to proximal chromosome 11
    • Wobbler, a mutation affecting motoneuron survival and gonadal functions in the mouse, maps to proximal chromosome 11. K Kaupmann D Simon-Chazottes JL Guenet H Jockusch, Genomics 1992 13 39 43
    • (1992) Genomics , vol.13 , pp. 39-43
    • Kaupmann, K.1    Simon-Chazottes, D.2    Guenet, J.L.3    Jockusch, H.4
  • 134
    • 0020429617 scopus 로고
    • Murine motor neuron disease (the wobbler mouse): Degeneration and regeneration of the lower motor neuron
    • Murine motor neuron disease (the wobbler mouse): degeneration and regeneration of the lower motor neuron. H Mitsumoto WG Bradley, Brain 1982 105 Pt 4 811 834
    • (1982) Brain , vol.105 , Issue.PT 4 , pp. 811-834
    • Mitsumoto, H.1    Bradley, W.G.2
  • 135
    • 0028316075 scopus 로고
    • Abnormal astrocyte differentiation and defective cellular interactions in wobbler mouse spinal cord
    • Abnormal astrocyte differentiation and defective cellular interactions in wobbler mouse spinal cord. D Hantaz-Ambroise B Blondet M Murawsky F Rieger, J Neurocytol 1994 23 179 192
    • (1994) J Neurocytol , vol.23 , pp. 179-192
    • Hantaz-Ambroise, D.1    Blondet, B.2    Murawsky, M.3    Rieger, F.4
  • 136
    • 0035800232 scopus 로고    scopus 로고
    • Glutamate transporters in the spinal cord of the wobbler mouse
    • Glutamate transporters in the spinal cord of the wobbler mouse. P Bigini A Bastone T Mennini, Neuroreport 2001 12 1815 1820
    • (2001) Neuroreport , vol.12 , pp. 1815-1820
    • Bigini, P.1    Bastone, A.2    Mennini, T.3
  • 137
    • 32644434547 scopus 로고    scopus 로고
    • Riluzole, unlike the AMPA antagonist RPR119990, reduces motor impairment and partially prevents motoneuron death in the wobbler mouse, a model of neurodegenerative disease
    • Riluzole, unlike the AMPA antagonist RPR119990, reduces motor impairment and partially prevents motoneuron death in the wobbler mouse, a model of neurodegenerative disease. E Fumagalli P Bigini S Barbera M De Paola T Mennini, Exp Neurol 2006 198 114 128
    • (2006) Exp Neurol , vol.198 , pp. 114-128
    • Fumagalli, E.1    Bigini, P.2    Barbera, S.3    De Paola, M.4    Mennini, T.5
  • 138
    • 0031080386 scopus 로고    scopus 로고
    • TRPM-2 expression and tunel staining in neurodegenerative diseases: Studies in wobbler and rd mice
    • TRPM-2 expression and tunel staining in neurodegenerative diseases: studies in wobbler and rd mice. P Popper DB Farber PE Micevych K Minoofar JM Bronstein, Exp Neurol 1997 143 246 254
    • (1997) Exp Neurol , vol.143 , pp. 246-254
    • Popper, P.1    Farber, D.B.2    Micevych, P.E.3    Minoofar, K.4    Bronstein, J.M.5
  • 140
    • 0037175395 scopus 로고    scopus 로고
    • Missense mutation in the tubulin-specific chaperone e (Tbce) gene in the mouse mutant progressive motor neuronopathy, a model of human motoneuron disease
    • Missense mutation in the tubulin-specific chaperone E (Tbce) gene in the mouse mutant progressive motor neuronopathy, a model of human motoneuron disease. H Bommel G Xie W Rossoll S Wiese S Jablonka T Boehm M Sendtner, J Cell Biol 2002 159 563 569
    • (2002) J Cell Biol , vol.159 , pp. 563-569
    • Bommel, H.1    Xie, G.2    Rossoll, W.3    Wiese, S.4    Jablonka, S.5    Boehm, T.6    Sendtner, M.7
  • 143
    • 0032728304 scopus 로고    scopus 로고
    • Experimental models of amyotrophic lateral sclerosis
    • Experimental models of amyotrophic lateral sclerosis. JL Elliott, Neurobiol Dis 1999 6 310 320
    • (1999) Neurobiol Dis , vol.6 , pp. 310-320
    • Elliott, J.L.1
  • 145
    • 0031723577 scopus 로고    scopus 로고
    • Adenovirus-mediated transfer of the neurotrophin-3 gene into skeletal muscle of pmn mice: Therapeutic effects and mechanisms of action
    • Adenovirus-mediated transfer of the neurotrophin-3 gene into skeletal muscle of pmn mice: therapeutic effects and mechanisms of action. G Haase B Pettmann E Vigne L Castelnau-Ptakhine H Schmalbruch A Kahn, J Neurol Sci 1998 160 Suppl 1 S97 105
    • (1998) J Neurol Sci , vol.160 , Issue.SUPPL 1 , pp. 97-105
    • Haase, G.1    Pettmann, B.2    Vigne, E.3    Castelnau-Ptakhine, L.4    Schmalbruch, H.5    Kahn, A.6
  • 146
  • 147
    • 0024458118 scopus 로고
    • Ultrastructural, morphometric, and immunocytochemical study of anterior horn cells in mice with "wasted" mutation
    • Ultrastructural, morphometric, and immunocytochemical study of anterior horn cells in mice with "wasted" mutation. HL Lutsep M Rodriguez, J Neuropathol Exp Neurol 1989 48 519 533
    • (1989) J Neuropathol Exp Neurol , vol.48 , pp. 519-533
    • Lutsep, H.L.1    Rodriguez, M.2
  • 159
    • 0034060692 scopus 로고    scopus 로고
    • What transgenic mice tell us about neurodegenerative disease
    • What transgenic mice tell us about neurodegenerative disease. ME Gurney, Bioessays 2000 22 297 304
    • (2000) Bioessays , vol.22 , pp. 297-304
    • Gurney, M.E.1
  • 160
    • 0028888945 scopus 로고
    • Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis
    • Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis. ME Ripps GW Huntley PR Hof JH Morrison JW Gordon, Proc Natl Acad Sci USA 1995 92 689 693
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 689-693
    • Ripps, M.E.1    Huntley, G.W.2    Hof, P.R.3    Morrison, J.H.4    Gordon, J.W.5
  • 162
    • 0035575761 scopus 로고    scopus 로고
    • Rats expressing human cytosolic copper-zinc superoxide dismutase transgenes with amyotrophic lateral sclerosis: Associated mutations develop motor neuron disease
    • Rats expressing human cytosolic copper-zinc superoxide dismutase transgenes with amyotrophic lateral sclerosis: associated mutations develop motor neuron disease. M Nagai M Aoki I Miyoshi M Kato P Pasinelli N Kasai RH Brown Jr Y Itoyama, J Neurosci 2001 21 9246 9254 11717358
    • (2001) J Neurosci , vol.21 , pp. 9246-9254
    • Nagai, M.1    Aoki, M.2    Miyoshi, I.3    Kato, M.4    Pasinelli, P.5    Kasai, N.6    Jr B. H, R.7    Itoyama, Y.8
  • 163
    • 0032949602 scopus 로고    scopus 로고
    • Oxidative stress and motor neurone disease
    • Oxidative stress and motor neurone disease. MR Cookson PJ Shaw, Brain Pathol 1999 9 165 186
    • (1999) Brain Pathol , vol.9 , pp. 165-186
    • Cookson, M.R.1    Shaw, P.J.2
  • 165
    • 36749049874 scopus 로고    scopus 로고
    • Glutamate excitotoxicity and therapeutic targets for amyotrophic lateral sclerosis
    • Glutamate excitotoxicity and therapeutic targets for amyotrophic lateral sclerosis. JC Corona LB Tovar-y-Romo R Tapia, Expert Opin Ther Targets 2007 11 1415 1428
    • (2007) Expert Opin Ther Targets , vol.11 , pp. 1415-1428
    • Corona, J.C.1    Tovar-Y-Romo, L.B.2    Tapia, R.3
  • 167
    • 33646241740 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and amyotrophic lateral sclerosis
    • Mitochondrial dysfunction and amyotrophic lateral sclerosis. I Hervias MF Beal G Manfredi, Muscle Nerve 2006 33 598 608
    • (2006) Muscle Nerve , vol.33 , pp. 598-608
    • Hervias, I.1    Beal, M.F.2    Manfredi, G.3
  • 168
    • 23644437653 scopus 로고    scopus 로고
    • Impairment of axonal transport in the axon hillock and the initial segment of anterior horn neurons in transgenic mice with a G93A mutant SOD1 gene
    • Impairment of axonal transport in the axon hillock and the initial segment of anterior horn neurons in transgenic mice with a G93A mutant SOD1 gene. S Sasaki H Warita K Abe M Iwata, Acta Neuropathol 2005 110 48 56
    • (2005) Acta Neuropathol , vol.110 , pp. 48-56
    • Sasaki, S.1    Warita, H.2    Abe, K.3    Iwata, M.4
  • 169
    • 38049097948 scopus 로고    scopus 로고
    • Deletion of the BH3-only protein puma protects motoneurons from ER stress-induced apoptosis and delays motoneuron loss in ALS mice
    • Deletion of the BH3-only protein puma protects motoneurons from ER stress-induced apoptosis and delays motoneuron loss in ALS mice. D Kieran I Woods A Villunger A Strasser JH Prehn, Proc Natl Acad Sci USA 2007 104 20606 20611
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 20606-20611
    • Kieran, D.1    Woods, I.2    Villunger, A.3    Strasser, A.4    Prehn, J.H.5
  • 170
    • 33947323759 scopus 로고    scopus 로고
    • Lost in translation: Treatment trials in the SOD1 mouse and in human ALS
    • Lost in translation: treatment trials in the SOD1 mouse and in human ALS. M Benatar, Neurobiol Dis 2007 26 1 13
    • (2007) Neurobiol Dis , vol.26 , pp. 1-13
    • Benatar, M.1
  • 172
    • 46249106545 scopus 로고    scopus 로고
    • Calpain Inhibition Protects Spinal Motoneurons from the Excitotoxic Effects of AMPA in vivo
    • Calpain Inhibition Protects Spinal Motoneurons from the Excitotoxic Effects of AMPA In vivo. JC Corona R Tapia, Neurochem Res 2008
    • (2008) Neurochem Res
    • Corona, J.C.1    Tapia, R.2
  • 173
    • 0030814058 scopus 로고    scopus 로고
    • Blocking effect of 1-naphthyl acetyl spermine on Ca(2+)-permeable AMPA receptors in cultured rat hippocampal neurons
    • Blocking effect of 1-naphthyl acetyl spermine on Ca(2+)-permeable AMPA receptors in cultured rat hippocampal neurons. M Koike M Iino S Ozawa, Neurosci Res 1997 29 27 36
    • (1997) Neurosci Res , vol.29 , pp. 27-36
    • Koike, M.1    Iino, M.2    Ozawa, S.3
  • 174
    • 24744431841 scopus 로고    scopus 로고
    • Blockade of calcium-permeable AMPA receptors protects hippocampal neurons against global ischemia-induced death
    • Blockade of calcium-permeable AMPA receptors protects hippocampal neurons against global ischemia-induced death. KM Noh H Yokota T Mashiko PE Castillo RS Zukin MV Bennett, Proc Natl Acad Sci USA 2005 102 12230 12235
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 12230-12235
    • Noh, K.M.1    Yokota, H.2    Mashiko, T.3    Castillo, P.E.4    Zukin, R.S.5    Bennett, M.V.6
  • 175
    • 0037082328 scopus 로고    scopus 로고
    • Blockade of Ca2+-permeable AMPA/kainate channels decreases oxygen-glucose deprivation-induced Zn2+ accumulation and neuronal loss in hippocampal pyramidal neurons
    • Blockade of Ca2+-permeable AMPA/kainate channels decreases oxygen-glucose deprivation-induced Zn2+ accumulation and neuronal loss in hippocampal pyramidal neurons. HZ Yin SL Sensi F Ogoshi JH Weiss, J Neurosci 2002 22 1273 1279
    • (2002) J Neurosci , vol.22 , pp. 1273-1279
    • Yin, H.Z.1    Sensi, S.L.2    Ogoshi, F.3    Weiss, J.H.4
  • 176
    • 34948909599 scopus 로고    scopus 로고
    • Vascular endothelial growth factor prevents paralysis and motoneuron death in a rat model of excitotoxic spinal cord neurodegeneration
    • Vascular endothelial growth factor prevents paralysis and motoneuron death in a rat model of excitotoxic spinal cord neurodegeneration. LB Tovar-y-Romo A Zepeda R Tapia, J Neuropathol Exp Neurol 2007 66 913 922
    • (2007) J Neuropathol Exp Neurol , vol.66 , pp. 913-922
    • Tovar-Y-Romo, L.B.1    Zepeda, A.2    Tapia, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.