Remarkable increase in cerebrospinal fluid 3-nitrotyrosine in patients with sporadic amyotrophic lateral sclerosis

Annals of Neurology

Volumn 46, Issue 1, 1999, Pages 129-131

  Tohgi, Hideo ^a   Abe, Takashi ^a   Yamizaki, Kinya ^a   Murata, Takahiko ^a   Ishizaki, Eri ^a   Isobe, Chiaki ^a  

^a IWATE MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; PEROXYNITRITE;

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CATALYSIS; CEREBROSPINAL FLUID ANALYSIS; CEREBROSPINAL FLUID EXAMINATION; CLINICAL ARTICLE; ENZYME ACTIVITY; FEMALE; GENE MUTATION; HUMAN; HYPOTHESIS; MALE; NITRATION; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; STATISTICAL ANALYSIS;

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; HUMANS; MALE; MIDDLE AGED; TYROSINE;

EID: 0033009113     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/1531-8249(199907)46:1<129::AID-ANA21>3.0.CO;2-Y     Document Type: Article

References (18)

1. Siddique T, Figlewicz DA, Pericak-Vance MA, et al. Linkage of a gene causing familial amyotrophic lateral sclerosis to chromosome 21 and evidence of genetic-locus heterogeneity. N Engl J Med 1991;324:1381-1384
2. Rosen DR, Siddique T, Patterson D, et al. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 1993;362:59-62
3. Jones CT, Swingler RJ, Brock DJH: Identification of a novel SOD1 mutation in an apparently sporadic amyotrophic lateral sclerosis patient and the detection of 1le 113 Thr in three others. Hum Mol Genet 1994;3:649-650
4. Aoki M, Abe K, Houi K, et al. Variance of age at onset in a Japanese family with amyotrophic lateral sclerosis associated with a novel Cu/Zn superoxide dismutase mutation. Ann Neurol 1995;37: 676-679
5. Gurney ME, Pu H, Chiu AY, et al. Motor neuron degeneration in mice that express a human Cu/Zn superoxide dismutase mutation. Science 1994;264:1772-1775
6. Wiedau-Pazos M, Goto JJ, Rabizadeh S, et al. Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis. Science 1996;271:515-518
7. Yim MB, Kang JH, Yim HS, et al. A gain-of-function of an amyotrophic lateral sclerosis-associated Cu, Zn-superoxide dismutase mutant: an enhancement of free radical formation due to a decrease in Km for hydrogen peroxide. Proc Natl Acad Sci USA 1996;93: 5709-5714
8. Ischiropoulos H, Zhu L, Chen J, et al. Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase. Arch Biochem Biophys 1992;298:431-437
9. Beckman JS, Carson M, Smith CD, Koppenol WH. ALS, SOD and peroxynitrite. Nature 1993;364:584
10. Coyle JT, Puttfarcken P. Oxidative stress, glutamate, and neurode-generative disorders. Science 1993;262:689-695
11. Beal MF, Ferrante RJ, Browne SE, et al. Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis. Ann Neurol 1997;42:644-654
12. Abe K, Pan LH, Watanabe M, et al. Upregulation of protein-tyrosine nitration in the anterior horn cells of amyotrophic lateral sclerosis. Neurol Res 1997;19:124-128
13. Ferrante RJ, Shinobu LA, Schulz JB, et al. Increased 3-nitrotyrosine and oxidative damage in mice with a human copper/zinc superoxide dismutase mutation. Ann Neurol 1997;42:326-334
14. Mulder DW. Motor neuron disease. In: Dyck PJ, Thomas PK, Lambert EH, Bunge R, eds. Peripheral neuropathy. Philadelphia: WB Saunders, 1984:1525-1536
15. Jablecki CK, Berry C, Leach J. Survival prediction in amyotrophic lateral sclerosis. Muscle Nerve 1989;12:833-841
16. Acworth IN, Bogdanov MB, McCabe DR, Beal MF. Estimation of hydroxyl free radical levels in vivo based on liquid chromatography with electrochemical detection. Methods Enzymol 1998;300:297-313
17. Tohgi H, Abe T, Yamazaki K, et al. Increase in oxidized NO products and reduction in oxidized glutathione in cerebrospinal fluid from patients with sporadic form of amyotrophic lateral sclerosis. Neurosci Lett 1999;260:204-206
18. Su JH, Deng G, Cotman CW. Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer's disease brain. Brain Res 1997;774:193-199