Vascular endothelial growth factor prevents paralysis and motoneuron death in a rat model of excitotoxic spinal cord neurodegeneration

Journal of Neuropathology and Experimental Neurology

Volumn 66, Issue 10, 2007, Pages 913-922

  Tovar Y Romo, Luis B ^a   Zepeda, Angélica ^a   Tapia, Ricardo ^a  

^a INSTITUTO DE FISIOLOGÍA CELULAR   (Mexico)

Author keywords

Amyotrophic lateral sclerosis; Excitotoxicity; Motoneuron degeneration; Spinal cord; Vascular endothelial growth factor

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; RECOMBINANT VASCULOTROPIN 164; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DELIVERY SYSTEM; EXCITOTOXICITY; HINDLIMB; HISTOLOGY; IMMUNOHISTOCHEMISTRY; LOCOMOTION; MALE; MOTONEURON; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; OSMOTIC MINIPUMP; PARALYSIS; PRIORITY JOURNAL; RAT; SPINAL CORD;

ANIMALS; CELL DEATH; CHOLINE O-ACETYLTRANSFERASE; HINDLIMB; IMMUNOHISTOCHEMISTRY; MALE; MOTOR NEURONS; NERVE DEGENERATION; PARALYSIS; PSYCHOMOTOR PERFORMANCE; RATS; RATS, WISTAR; RECEPTORS, AMPA; SPINAL CORD DISEASES; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 34948909599     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/nen.0b013e3181567c16     Document Type: Article

References (37)

1. Rosen DR, Siddique T, Patterson D, et al. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 1993;362:59-62
2. Bar-Peled O, O'Brien RJ, Morrison JH, Rothstein JD. Cultured motor neurons possess calcium-permeable AMPA/kainate receptors. Neuroreport 1999;10:855-59
3. Kawahara Y, Kwak S. Excitotoxicity and ALS: What is unique about the AMPA receptors expressed on spinal motor neurons? Amyotroph Lateral Scler Other Motor Neuron Disord 2005;6:131-44
4. Van Damme P, Braeken D, Callewaert G, et al. GluR2 deficiency accelerates motor neuron degeneration in a mouse model of amyotrophic lateral sclerosis. J Neuropathol Exp Neurol 2005;64:605-12
5. Van Damme P, Van Den Bosch L, Van Houtte E, et al. GluR2-dependent properties of AMPA receptors determine the selective vulnerability of motor neurons to excitotoxicity. J Neurophysiol 2002;88:1279-87
6. 2+-permeable AMPA receptors and selective vulnerability of motor neurons. J Neurol Sci 2000;180:29-34
7. Vandenberghe W, Bindokas VP, Miller RJ, et al. Subcellular localization of calcium-permeable AMPA receptors in spinal motoneurons. Eur J Neurosci 2001;14:305-14
8. Williams TL, Day NC, Ince PG, et al. Calcium-permeable α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors: A molecular determinant of selective vulnerability in amyotrophic lateral sclerosis. Ann Neurol 1997;42:200-207
9. 2+ determine motoneuron vulnerability in rat spinal cord in vivo. Neuropharmacology 2007;52:1219-28
10. Corona JC, Tapia R. AMPA receptor activation, but not the accumulation of endogenous extracellular glutamate, induces paralysis and motor neuron death in rat spinal cord in vivo. J Neurochem 2004;89:988-97
11. Kotzbauer PT, Holtzman DM. Expectations and challenges in the therapeutic use of neurotrophic factors. Ann Neurol 2006;59:444-47
12. Gurney ME, Pu H, Chiu AY, et al. Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. Science 1994;264:1772-75
13. Wang LJ, Lu YY, Muramatsu S, et al. Neuroprotective effects of glial cell line-derived neurotrophic factor mediated by an adeno-associated virus vector in a transgenic animal model of amyotrophic lateral sclerosis. J Neurosci 2002;22:6920-28
14. Kaspar BK, Llado J, Sherkat N, et al. Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model. Science 2003;301:839-42
15. Azzouz M, Ralph GS, Storkebaum E, et al. VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model. Nature 2004;429:413-17
16. Oosthuyse B, Moons L, Storkebaum E, et al. Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Nat Genet 2001;28:131-38
17. Storkebaum E, Lambrechts D, Dewerchin M, et al. Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS. Nat Neurosci 2005;8:85-92
18. Wang Y, Mao XO, Xie L, et al. Vascular endothelial growth factor overexpression delays neurodegeneration and prolongs survival in amyotrophic lateral sclerosis mice. J Neurosci 2007;27:304-307
19. Zheng C, Nennesmo I, Fadeel B, Henter JI. Vascular endothelial growth factor prolongs survival in a transgenic mouse model of ALS. Ann Neurol 2004;56:564-67
20. Weydt P, Hong SY, Kliot M, Moller T. Assessing disease onset and progression in the SOD1 mouse model of ALS. Neuroreport 2003;14:1051-54
21. Zeltser R, Beilin B, Zaslansky R, Seltzer Z. Comparison of autotomy behavior induced in rats by various clinically-used neurectomy methods. Pain 2000;89:19-24
22. Matsumoto A, Okada Y, Nakamichi M, et al. Disease progression of human SOD1 (G93A) transgenic ALS model rats. J Neurosci Res 2006;83:119-33
23. Nagai M, Aoki M, Miyoshi I, et al. Rats expressing human cytosolic copper-zinc superoxide dismutase transgenes with amyotrophic lateral sclerosis: Associated mutations develop motor neuron disease. J Neurosci 2001;21:9246-54
24. Hartmann B, Ahmadi S, Heppenstall PA, et al. The AMPA receptor subunits GluR-A and GluR-B reciprocally modulate spinal synaptic plasticity and inflammatory pain. Neuron 2004;44:637-50
25. 2+-permeable and-impermeable AMPA receptors contribute to primary synaptic drive onto rat dorsal horn neurons. J Physiol 2006;575:133-44
26. Fairbanks CA, Schreiber KL, Brewer KL, et al. Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury. Proc Natl Acad Sci USA 2000;97:10584-89
27. Brockington A, Wharton SB, Fernando M, et al. Expression of vascular endothelial growth factor and its receptors in the central nervous system in amyotrophic lateral sclerosis. J Neuropathol Exp Neurol 2006;65:26-36
28. Li B, Xu W, Luo C, Gozal D, Liu R. VEGF-induced activation of the PI3-K/Akt pathway reduces mutant SOD1-mediated motor neuron cell death. Brain Res Mol Brain Res 2003;111:155-64
29. Newbern J, Taylor A, Robinson M, et al. Decreases in phosphoinositide-3- kinase/Akt and extracellular signal-regulated kinase 1/2 signaling activate components of spinal motoneuron death. J Neurochem 2005;94:1652-65
30. Yu F, Sugawara T, Maier CM, et al. Akt/Bad signaling and motor neuron survival after spinal cord injury. Neurobiol Dis 2005;20:491-99
31. Matsuzaki H, Tamatani M, Yamaguchi A, et al. Vascular endothelial growth factor rescues hippocampal neurons from glutamate-induced toxicity: Signal transduction cascades. FASEB J 2001;15:1218-20
32. Nicholls DG, Budd SL. Mitochondria and neuronal survival. Physiol Rev 2000:80:315-60
33. Polster BM, Fiskum G. Mitochondrial mechanisms of neural cell apoptosis. J Neurochem 2004;90:1281-89
34. Cardone MH, Roy N, Stennicke HR, et al. Regulation of cell death protease caspase-9 by phosphorylation. Science 1998;282:1318-21
35. Kilic U, Kilic E, Jarve A, et al. Human vascular endothelial growth factor protects axotomized retinal ganglion cells in vivo by activating ERK-1/2 and Akt pathways. J Neurosci 2006;26:12439-46
36. Gora-Kupilas K, Josko J. The neuroprotective function of vascular endothelial growth factor (VEGF). Folia Neuropathol 2005;43:31-39
37. Nieder C, Wiedenmann N, Andratschke N, Molls M. Current status of angiogenesis inhibitors combined with radiation therapy. Cancer Treat Rev 2006;32:348-64