Enhanced expression of type I interferon and toll-like receptor-3 in primary biliary cirrhosis

Laboratory Investigation

Volumn 85, Issue 7, 2005, Pages 908-920

  Takii, Yasushi ^a,c   Nakamura, Minoru ^a,b   Ito, Masahiro ^a,b   Yokoyama, Terufumi ^a   Komori, Atsumasa ^a,b   Shimizu Yoshida, Yuki ^a   Nakao, Rumiko ^a   Kusumoto, Koichiro ^a,b   Nagaoka, Shinya ^a,b   Yano, Koji ^a,b   Abiru, Seigo ^a,b   Ueki, Toshihito ^a,b   Matsumoto, Takehiro ^a,b   Daikoku, Manabu ^a,b   Taniguchi, Ken ^a,b   Fujioka, Hikaru ^a,b   Migita, Kiyoshi ^a,b   Yatsuhashi, Hiroshi ^a,b   Nakashima, Masahiro ^b   Harada, Mine ^c   Ishibashi, Hiromi ^a,b   more..

^a NATIONAL HOSPITAL ORGANIZATION NAGASAKI MEDICAL CENTER   (Japan)

^b NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

Author keywords

Cytokines; Interferon ; Interferon ; Laser capture microdissection; Liver; Toll like receptors

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; GAMMA INTERFERON; INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12P40; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; AUTOIMMUNE HEPATITIS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HEPATITIS C; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LASER CAPTURE MICRODISSECTION; LIVER BIOPSY; LIVER PARENCHYMA; MALE; PORTAL VEIN; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AGED; ALKALINE PHOSPHATASE; BILIARY TRACT; BIOPSY, NEEDLE; FEMALE; HEPATITIS C, CHRONIC; HEPATITIS, AUTOIMMUNE; HEPATOCYTES; HUMANS; IMMUNOENZYME TECHNIQUES; INTERFERON TYPE I; KUPFFER CELLS; LASERS; LIVER CIRRHOSIS, BILIARY; MACROPHAGES; MALE; MEMBRANE GLYCOPROTEINS; MICRODISSECTION; MIDDLE AGED; PORTAL SYSTEM; RECEPTORS, CELL SURFACE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 3; TOLL-LIKE RECEPTORS; UP-REGULATION;

EID: 22544446433     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: 10.1038/labinvest.3700285     Document Type: Article

References (53)

1. Lohr HF, Schlaak JF, Gerken G, et al. Phenotypical analysis and cytokine release of liver-infiltrating and peripheral blood T lymphocytes from patients with chronic hepatitis of different etiology. Liver 1994; 14:161-166.
2. Martinez OM, Villanueva JC, Gershwin ME, et al. Cytokine patterns and cytotoxic mediators in primary biliary cirrhosis. Hepatology 1995;21:113-119.
3. Tsai SL, Lai MY, Chen DS. Analysis of rearranged T cell receptor (TCR) V beta transcripts in livers of primary biliary cirrhosis: preferential V beta usage suggests antigen-driven selection. Clin Exp Immunol 1996;103: 99-104.
4. Shindo M, Mullin GE, Braun-Elwert L, et al. Cytokine mRNA expression in the liver of patients with primary biliary cirrhosis (PBC) and chronic hepatitis B (CHB). Clin Exp Immunol 1996;105:254-259.
5. Harada K, Van de Water J, Leung PS, et al. In situ nucleic acid hybridization of cytokines in primary biliary cirrhosis: predominance of the Th1 subset. Hepatology 1997;25:791-796.
6. Nagano T, Yamamoto K, Matsumoto S, et al. Cytokine profile in the liver of primary biliary cirrhosis. J Clin Immunol 1999;19:422-427.
7. Shackel NA, McGuinness PH, Abbott CA, et al. Identification of novel molecules and pathogenic pathways in primary biliary cirrhosis: cDNA array analysis of intrahepatic differential gene expression. Gut 2001;49:565-576.
8. Shimoda S, Nakamura M, Ishibashi H, et al. HLA DRB4 0101-restricted immunodominant T cell autoepitope of pyruvate dehydrogenase complex in primary biliary cirrhosis: evidence of molecular mimicry in human autoimmune diseases. J Exp Med 1995;181:1835-1845.
9. Shimoda S, Nakamura M, Shigematsu H, et al. Mimicry peptides of human PDC-E2 163-176 peptide, the immunodominant T-cell epitope of primary biliary cirrhosis. Hepatology 2000;31:1212-1216.
10. Burroughs AK, Rosenstein IJ, Epstein O, et al. Bacteriuria and primary biliary cirrhosis. Gut 1984;25: 133-137.
11. Butler P, Valle F, Hamilton-Miller JM, et al. M2 mitochondrial antibodies and urinary rough mutant bacteria in patients with primary biliary cirrhosis and in patients with recurrent bacteriuria. J Hepatol 1993; 17:408-414.
12. Harada K, Tsuneyama K, Sudo Y, et al. Molecular identification of bacterial 16S ribosomal RNA gene in liver tissue of primary biliary cirrhosis: is Propionibacterium acnes involved in granuloma formation? Hepatology 2001;33:530-536.
13. Xu L, Sakalian M, Shen Z, et al. Cloning the human betaretrovirus proviral genome from patients with primary biliary cirrhosis. Hepatology 2004;39:151-156.
14. Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol 2004;4:499-511.
15. Beutler B, Rietschel ET. Innate immune sensing and its roots: the story of endotoxin. Nat Rev Immunol 2003;3:169-176.
16. Cella M, Jarrossay D, Facchetti F, et al. Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I Interferon. Nat Med 1999;5:919-923.
17. Kadowaki N, Antonenko S, Lau JY, et al. Natural interferon alpha/beta-producing cells link innate and adaptive immunity. J Exp Med 2000;192:219-226.
18. Luft T, Pang KC, Thomas E, et al. Type I IFNs enhance the terminal differentiation of dendritic cells. J Immunol 1998;161:1947-1953.
19. Lovgren T, Eloranta ML, Bave U, et al. Induction of interferon-alpha production in plasmacytoid dendritic cells by immune complexes containing nucleic acid released by necrotic or late apoptotic cells and lupus IgG. Arthritis Rheum 2004;50:1861-1872.
20. Jego G, Palucka AK, Blanck JP, et al. Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6. Immunity 2003;19:225-234.
21. Tough DF, Borrow P, Sprent J. Induction of bystander T cell proliferation by viruses and type I interferon in vivo. Science 1996;272:1947-1950.
22. Farkas L, Beiske K, Lund-Johansen F, et al. Plasmacytoid dendritic cells (natural interferon-alpha/beta-producing cells) accumulate in cutaneous lupus erythematosus lesions. Am J Pathol 2001;159:237-243.
23. Ronnblom L, Aim GV. A pivotal role for the natural interferon alpha-producing cells (plasmacytoid dendritic cells) in the pathogenesis of lupus. J Exp Med 2001;194:F59-F63.
24. Ronnblom L, Eloranta ML, Alm GV. Role of natural interferon-alpha producing cells (plasmacytoid dendritic cells) in autoimmunity. Autoimmunity 2003;36: 463-472.
25. Neuberger J. Primary biliary cirrhosis. Lancet 1997; 350:875-879.
26. Toda G, Zeniya M, Watanabe F, et al. Present status of autoimmune hepatitis in Japan-correlating the characteristics with international criteria in an area with a high rate of HCV infection. Japanese National Study Group of Autoimmune Hepatitis. J Hepatol 1997;26: 1207-1212.
27. Alvarez F, Berg PA, Bianchi FB, et al. International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis. J Hepatol 1999;31:929-938.
28. Scheuer P. Primary biliary cirrhosis. Proc R Soc Med 1967;60:1257-1260.
29. Kroemer G, Hirsch F, Gonzalez-Garcia A, et al. Differential involvement of Th1 and Th2 cytokines in autoimmune diseases. Autoimmunity 1996:24:25-33.
30. Mosmann TR, Sad S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol Today 1996; 17:138-146.
31. Berg PA, Klein R, Rocken M. Cytokines in primary biliary cirrhosis. Semin Liver Dis 1997;17:115-123.
32. Napoli J, Bishop GA, McCaughan GW. Increased intrahepatic messenger RNA expression of interleukins 2, 6, and 8 in human cirrhosis. Gastroenterology 1994;107:789-798.
33. Muller U, Steinhoff U, Reis LF, et al. Functional role of type I and type II interferons in antiviral defense. Science 1994;264:1918-1921.
34. Taniguchi T, Ogasawara K, Takaoka A, et al. IRF family of transcription factors as regulators of host defense. Annu Rev Immunol 2001;19:623-655.
35. Doyle S, Vaidya S, O'Connell R, et al. IRF3 mediates a TLR3/TLR4-specific antiviral gene program. Immunity 2002;17:251-263.
36. Doyle SE, O'Connell R, Vaidya SA, et al. Toll-like receptor 3 mediates a more potent antiviral response than Toll-like receptor 4. J Immunol 2003; 170:3565-3571.
37. Punturieri A, Alviani RS, Polak T, et al. Specific engagement of TLR4 or TLR3 does not lead to IFN-beta-mediated innate signal amplification and STAT1 phosphorylation in resident murine alveolar macrophages. J Immunol 2004;173:1033-1042.
38. Miettinen M, Sareneva T, Julkunen I, et al. IFNs activate toll-like receptor gene expression in viral infections. Genes Immun 2001;2:349-355.
39. Heinz S, Haehnel V, Karaghiosoff M, et al. Species-specific regulation of Toll-like receptor 3 genes in men and mice. J Biol Chem 2003;278:21502-21509.
40. Tanabe M, Kurita-Taniguchi M, Takeuchi K, et al. Mechanism of up-regulation of human Toll-like receptor 3 secondary to infection of measles virus-attenuated strains. Biochem Biophys Res Commun 2003; 311:39-48.
41. Sutherland CG, al-Badri AM, Howatson AG, et al. Immunolocalization of alpha interferon in liver disease. J Clin Pathol 1989;42:1065-1069.
42. Khan NU, Gibson A, Foulis AK. The distribution of immunoreactive interferon-alpha in formalin-fixed paraffin-embedded normal human foetal and infant tissues. Immunology 1990;71:230-235.
43. Khan NU, Pulford KA, Farquharson MA, et al. The distribution of immunoreactive interferon-alpha in normal human tissues. Immunology 1989;66: 201-206.
44. Nouri-Aria KT, Arnold J, Davison F, et al. Hepatic interferon-alpha gene transcripts and products in liver specimens from acute and chronic hepatitis B virus infection. Hepatology 1991;13:1029-1034.
45. Dienes HP, Hess G, Woorsdorfer M, et al. Ultrastructural localization of interferon-producing cells in the livers of patients with chronic hepatitis B. Hepatology 1991;13:321-326.
46. Fang JW, Wu PC, Lai CL, et al. Hepatic expression of interferon-alpha in chronic hepatitis B virus infection. Digest Dis Sci 1994;39:2014-2021.
47. Mihm S, Frese M, Meier V, et al. Interferon type I gene expression in chronic hepatitis C. Lab Invest 2004; 84:1148-1159.
48. Keskinen P, Nyqvist M, Sareneva T, et al. Impaired antiviral response in human hepatoma cells. Virology 1999;263:364-375.
49. Kerkmann M, Rothenfusser S, Hornung V, et al. Activation with CpG-A and CpG-B oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cells. J Immunol 2003;170:4465-4474.
50. Hemmi H, Kaisho T, Takeda K, et al. The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets. J Immunol 2003;170:3059-3064.
51. Riordan SM, Skinner N, Nagree A, et al. Peripheral blood mononuclear cell expression of toll-like receptors and relation to cytokine levels in cirrhosis. Hepatology 2003;37:1154-1164.
52. Paik YH, Schwabe RF, Bataller R, et al. Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Hepatology 2003;37:1043-1055.
53. Kariko K, Ni H, Capodici J, et al. mRNA is an endogenous ligand for Toll-like receptor 3. J Biol Chem 2004;279:12542-12550 (Epub 12004 Jan 12516).