Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice

Hepatology

Volumn 34, Issue 1, 2001, Pages 101-108

  Uesugi, T ^a   Froh, M ^a   Arteel, G E ^a   Bradford, B U ^a   Thurman, R G ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ENDOTOXIN; MESSENGER RNA; MUTANT PROTEIN; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL ACTIVATION; CONTROLLED STUDY; FEMALE; HEPATITIS; KUPFFER CELL; LIPID DIET; LIVER INJURY; LIVER NECROSIS; LIVER WEIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEATOSIS; URINARY EXCRETION; URINE LEVEL;

EID: 0034950477     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.2001.25350     Document Type: Article

References (36)

1. Gramnegative endotoxin: An extraordinary lipid with profound effects on eukaryotic signal transduction
2. Pathogenesis and potential strategies for prevention and treatment of septic shock: An update
3. Role of Kupffer cells and the spleen in modulation of endotoxin-induced liver injury after partial hepatectomy
4. 2
5. Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin
6. Antibiotics prevent liver injury in rats following long-term exposure to ethanol
7. Lactobacillus feeding reduces endotoxemia and severity of experimental alcoholic liver disease
8. Genetic control of leucocyte responses to endotoxin
9. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
10. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product
11. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction
12. Kupffer cell activation by lipopolysaccharide in rats: Role for lipopolysaccharide binding protein and toll-like receptor 4
13. Long-term cannulation model for blood sampling and intragastric infusion in the rat
14. Essential role of tumor necrosis factor α in alcohol-induced liver injury
15. Effects of ethanol ingestion and dietary fat levels on mitochondrial lipids in male and female rats
16. Fish oil, alcohol, and liver pathology: Role of cytochrome P4502E1
17. Episodic excretion of ethanol during chronic intragastric ethanol infusion in the male rat: Continuous vs. cyclic ethanol and nutrient infusions
18. Female rats exhibit greater susceptibility to early alcohol-induced injury than males
19. Chromogenic endotoxin assay in plasma. Selection of plasma pretreatment and production of standard curves
20. Clottable protein in Limulus: Its localization and kinetics of its coagulation by endotoxin
21. Beef fat prevents alcoholic liver disease in the rat
22. Cyclical pattern of blood alcohol levels during continuous intragastric ethanol infusion in rats
23. ICAM-1 is involved in the mechanism of early alcohol-induced liver injury: Studies with knockout mice
24. The leaky gut of alcoholism: Possible route of entry for toxic compounds
25. Jejunal microflora in patients with chronic alcohol abuse
26. Early alcoholic liver injury: Formation of protein adducts with acetaldehyde and lipid peroxidation products, and expression of CYP2E1 and CYP3A
27. CYP2E1 is not involved in early alcohol-induced liver injury
28. NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease
29. Reduced early alcohol-induced liver injury in CD14 deficient mice
30. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
31. Transfection of CD14 into 70Z/3 cells dramatically enhances the sensitivity to complexes of lipopolysaccharide (LPS) and LPS binding protein
32. Studies on autoimmunity for initiation of beta-cell destruction. VII. Evidence for antigenic changes on beta-cells leading to autoimmune destruction of beta-cells in BB rats
33. Development of a new, simple rat model of early alcohol-induced liver injury based on sensitization of Kupffer cells
34. E5531, a pure endotoxin antagonist of high potency
35. A lipid A analog, E5531, blocks the endotoxin response in human volunteers with experimental endotoxemia