Phase 1B, randomized, double-blind, dose-escalation trial of CPG 10101 in patients with chronic hepatitis C virus

Hepatology

Volumn 46, Issue 5, 2007, Pages 1341-1349

  McHutchison, John G ^a,i   Bacon, Bruce R ^b   Gordon, Stuart C ^c   Lawitz, Eric ^d   Shiffman, Mitchell ^e   Afdhal, Nezam H ^f   Jacobson, Ira M ^g   Muir, Andrew ^a   Al Adhami, Mohammed ^h   Morris, Mary L ^h   Lekstrom Himes, Julie A ^h   Efler, Susan M ^h   Davis, Heather L ^h  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HENRY FORD HOSPITAL   (United States)

^d Alamo Medical Research   (United States)

^e VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^g WEILL CORNELL MEDICAL CENTER   (United States)

^h PFIZER INC   (United States)

ⁱ DUKE CLINICAL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2'5' OLIGOADENYLATE SYNTHETASE; ALPHA INTERFERON; CPG 10101; GAMMA INTERFERON INDUCIBLE PROTEIN 10; PLACEBO; SYNTHETASE; UNCLASSIFIED DRUG; 2',5' OLIGOADENYLATE SYNTHETASE;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG DOSE ESCALATION; DRUG MECHANISM; DRUG SAFETY; DRUG TOLERABILITY; FATIGUE; FEMALE; FEVER; FLU LIKE SYNDROME; GASTROINTESTINAL DISEASE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; IMMUNOREACTIVITY; INJECTION SITE ERYTHEMA; INJECTION SITE PAIN; INJECTION SITE SWELLING; INJECTION SITE WARMTH; LEUKOPENIA; MAJOR CLINICAL STUDY; MALAISE; MALE; MULTICENTER STUDY; NEUTROPENIA; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL; RASH; RIGOR; SKIN INDURATION; TREATMENT OUTCOME; TREATMENT RESPONSE; ASTHENIA; CHRONIC HEPATITIS C; COHORT ANALYSIS; CONSTIPATION; DIARRHEA; DRUG EFFICACY; DRUG WITHDRAWAL; GASTROINTESTINAL SYMPTOM; HEADACHE; HEPATITIS C VIRUS GENOTYPE 1; INJECTION SITE CONTUSION; INJECTION SITE DERMATITIS; INJECTION SITE EDEMA; INJECTION SITE INDURATION; INJECTION SITE INFLAMMATION; INJECTION SITE PRURITUS; INJECTION SITE RASH; INJECTION SITE URTICARIA; LETHARGY; LOWER ABDOMINAL PAIN; NAUSEA; TREATMENT DURATION; UPPER ABDOMINAL PAIN; VOMITING;

ANTIVIRAL AGENTS; DOUBLE-BLIND METHOD; FEMALE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; INJECTIONS, SUBCUTANEOUS; MALE; MIDDLE AGED; OLIGODEOXYRIBONUCLEOTIDES; RNA, VIRAL; TOLL-LIKE RECEPTOR 9;

EID: 36348931521     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.21773     Document Type: Article

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