Immune responses to viral antigens versus transgene product in the elimination of recombinant adenovirus-infected hepatocytes in vivo

Gene Therapy

Volumn 3, Issue 2, 1996, Pages 137-144

  Yang, Y ^a,b   Ku, Jooss ^a,b   Su, Q ^a,b   Ertl, H C J ^b   Wilson, J M ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b WISTAR INSTITUTE   (United States)

Author keywords

CTLs; Gene therapy; Recombinant adenovirus

Indexed keywords

ANTIBODY; BETA GALACTOSIDASE; GENE PRODUCT; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; VIRUS ANTIGEN;

ADENOVIRUS; ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIGEN BINDING; ARTICLE; B LYMPHOCYTE; CELL DESTRUCTION; CELL KILLING; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FEMALE; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER; IMMUNE RESPONSE; IMMUNIZATION; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECOMBINANT GENE; TRANSGENE; VIRUS INFECTION; VIRUS RECOMBINANT;

ADENOVIRUSES, HUMAN; ADOPTIVE TRANSFER; ANIMALS; ANTIBODIES, VIRAL; ANTIGENS, VIRAL; BETA-GALACTOSIDASE; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; LIVER; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MICE, TRANSGENIC; SPLEEN; T-LYMPHOCYTES, CYTOTOXIC; TRANSGENES;

ADENOVIRIDAE; ANIMALIA; HUMAN ADENOVIRUS; MUS MUSCULUS; ROSA;

EID: 9244220682     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Stratford-Perricaudet LD et al. Evaluation of the transfer and expression in mice of an enzyme-encoding gene using a human adenovirus vector. Hum Gene Ther 1990; 1: 241-256.
2. Jaffe HA et al. Adenovirus-mediated in vivo gene transfer and expression in normal rat liver. Nat Genet 1992; 1: 372-378.
3. Herz J, Gerard R. Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice. Proc Natl Acad Sci USA 1993; 90: 2812-2816.
4. Kay MA et al. In vivo hepatic gene therapy: complete albeit transient correction of factor IX deficiency in hemophilia B dogs. Proc Natl Acad Sci USA 1994; 91: 2353-2357.
5. Smith TAG et al. Adenovirus mediated expression of therapeutic plasma levels of human factor IX in mice. Nat Genet 1993; 5: 397-402.
6. Horwitz MS. Adenoviridae and their replication. In. Fields BN et al (eds). Virology. Raven Press: New York, 1990, pp 1679-1721.
7. Graham FL, Smiley J, Russell WL, Nairn R. Characterization of a human cell line transformed by DNA from adenovirus 5. J Gen Virol 1977; 36. 59-72.
8. Rosenfeld MA et al. Adenovirus-mediated transfer of a recombinant α1-antitrypsin gene to the lung epithelium in vivo. Science 1991; 252: 431-434.
9. Ragot T et al Efficient adenovirus-mediated transfer of a human minidystrophin gene to skeletal muscle of mdx mice. Nature 1993; 361: 647-650.
10. Le Gal La Salle G et al. An adenovirus vector for gene transfer into neurons and glia in the brain. Science 1993; 259: 988-990.
11. Roessler BJ et al. Adenoviral-mediated gene transfer to rabbit synovium in viva. J Clin Invest 1993; 92: 1085-1092.
12. Bennett J et al. Adenovirus vector-mediated in vivo gene transfer into adult murine retina. Invest Opthalm Vis Sci 1994; 35: 2535-2542.
13. Yang Y, Li Q, Ertl HCJ, Wilson JM. Cellular and humoral immune responses to viral antigens created barriers to lung-directed gene therapy with recombinant adenoviruses. J Virol 1995; 69: 2004-2015.
14. Yang Y, Ertl HCJ, Wilson JM. MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with El-deleted recombinant adenoviruses. Immunity 1994; 1: 433-442.
15. Dai Y et al. Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: tolerization of factor IX and vector antigens allows for long-term expression. Proc Natl Acad Sci USA 1995; 92: 1401-1405.
16. Yang Y, Greenough K, Wilson JM. Transient immune blockade prevents formation of neutralizing antibody to recombinant adenovirus and allows repeated gene transfer to mouse liver. Gene Therapy 1996 (in press).
17. Friedrich G, Soriano P. Promoter traps in embryonic stem cell: a genetic screen to identify and mutate developmental genes in mice. Genes Devel 1991; 5: 1513-1523.
18. Yang Y et al. Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. Proc Natl Acad Sci USA 1994; 91: 4407-4411.
19. Xiang Z, Yang Y, Wilson JM, Ertl HCJ. A replication-defective human adenovirus recombinant serves as a highly efficacious vaccine carrier. Virology 1995 (submitted for publication).
20. Yang Y, Janich S, Cohn JA, Wilson JM. The common variant of cystic fibrosis transmembrane conductance regulator is recognized by hsp70 and degraded in a pre-Golgi nonlysosomal compartment. Proc Natl Acad Sci USA 1993; 90: 9480-9484.
21. Drumm ML et al. Correction of the cystic fibrosis defect in vitro by retrovirus-mediated gene transfer. Cell 1990; 62: 1227-1233.
22. Xiang Z et al. Vaccination with a plasmid vector carrying the rabies virus glycoprotein gene induces protective immunity against rabies virus. Virology 1994; 199: 132-140.