Bone cells-biomaterials interactions

Frontiers in Bioscience

Volumn 14, Issue 3, 2009, Pages 1023-1067

  Marquis, Marie Eve ^a   Lord, Etienne ^a   Bergeron, Eric ^a   Drevelle, Olivier ^a   Park, Hyunjin ^a   Cabana, Francois ^b   Senta, Helena ^a   Faucheux, Nathalie ^a  

^a UNIVERSITÉ DE SHERBROOKE   (Canada)

^b CENTRE HOSPITALIER UNIVERSITAIRE DE SHERBROOKE   (Canada)

Author keywords

BMP; Bone substitute; Extracellular matrix; Integrin; Osteoblast; Osteoclast; Osteoconduction; Osteoinduction; Peptide; Signal transduction

Indexed keywords

BIOMATERIAL;

ANIMAL; BONE; CELL ADHESION; CYTOLOGY; HUMAN; REVIEW;

ANIMALS; BIOCOMPATIBLE MATERIALS; BONE AND BONES; CELL ADHESION; HUMANS;

EID: 63849307685     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/3293     Document Type: Article

References (424)

1. Cohen, M. M. Jr: The new bone biology: pathologic, molecular, and clinical correlates. Am J Med Genet 140A, 2646-2706 (2006). (Pubitemid 44865095)
2. Hench, L. L., J. R. Jones and P. Sepulveda: Bioactive materials for tissue engineering scaffolds. In: Future strategies for tissue and organ replacement. Eds: Polak, J. M., L. L. Hench and P. Kemp, Imperial College Press, London (United Kingdom), 3-24 (2002).
3. World Health Organization: The burden of musculoskeletal conditions at the start of the new millennium. WHO Technical Report Series 919, World Health Organization, Geneva (Switzerland), 228 pp. (2003).
4. Li, R. H. and J. M. Wozney: Delivering on the promise of bone morphogenetic proteins. Trends Biotechnol 19, 255-265 (2001). (Pubitemid 32537763)
5. Seeherman, H., J. Wozney and R. Li: Bone morphogenetic protein delivery systems. Spine 27, S16-S23 (2002).
6. Ludwig, S. C., J. M. Kowalski and S. D. Boden: Osteoinductive bone graft substitutes. Eur Spine J 9, S119- S125 (2000).
7. Geiger, M., R. H. Li and W. Friess: Collagen sponges for bone regeneration with rhBMP-2. Adv Drug Deliv Rev 55, 1613-1629 (2003). (Pubitemid 37420006)
8. Saito, N., N. Murakami, J. Takahashi, H. Horiuchi, H. Ota, H. Kato, T. Okada, K. Nozaki and K. Takaoka: Synthetic biodegradable polymers as drug delivery systems for bone morphogenetic proteins. Adv Drug Deliv Rev 57, 1037-1048 (2005). (Pubitemid 40692290)
9. Giannoudis, P. V., H. Dinopoulos and E. Tsiridis: Bone substitutes: An update. Injury 36S, S20-S27 (2005).
10. Bauer, T. W. and S. T. Smith: Bioactive materials in orthopaedic surgery: Overview and regulatory considerations. Clin Orthop Relat Res 395, 11-22 (2002). (Pubitemid 34136653)
11. Lu, H. H., S. F. El-Amin, K. D. Scott and C. T. Laurencin: Three-dimensional, bioactive, biodegradable, polymer-bioactive glass composite scaffolds with improved mechanical properties support collagen synthesis and mineralization of human osteoblast-like cells in vitro. J Biomed Mater Res 64A, 465-474 (2003). (Pubitemid 37522486)
12. Yang, X. B., D. Webb, J. Blaker, A. R. Boccaccini, V. Maquet, C. Cooper and R. O. C. Oreffo: Evaluation of human bone marrow stromal cell growth on biodegradable polymer/Bioglass composites. Biochem Biophys Res Commun 342, 1098-1107 (2006).
13. Hench, L. L. and J. M. Polak: Third-generation biomedical materials. Science 295, 1014-1017 (2002).
14. Aparicio, C., F. J. Gil, J. A. Planell and E. Engel: Human-osteoblast proliferation and differentiation on gritblasted and bioactive titanium for dental applications. J Mater Sci: Mater Med 13, 1105-1111 (2002). (Pubitemid 36169447)
15. Spoerke, E. D. and S. I. Stupp: Colonization of organoapatite-titanium mesh by preosteoblastic cells. J Biomed Mater Res 67A, 960-969 (2003). (Pubitemid 37521571)
16. de Oliveira, P. T. and A. Nanci: Nanotexturing of titanium-based surfaces upregulates expression of bone sialoprotein and osteopontin by cultured osteogenic cells. Biomaterials 25, 403-413 (2004). (Pubitemid 37329691)
17. Gough, J. E., J. R. Jones and L. L. Hench: Nodule formation and mineralisation of human primary osteoblasts cultured on a porous bioactive glass scaffold. Biomaterials 25, 2039-2046 (2004). (Pubitemid 38102404)
18. Junqueira, L. C., J. Carneiro and R. O. Kelley: Histologie, Piccin Nuova Libraria, Padova (Italy), 485 pp. (2001).
19. Locke, M.: Structure of long bones in mammals. J Morphol 262, 546-565 (2004). (Pubitemid 39520773)
20. Toppets, V., V. Pastoret, V. de Behr, N. Antoine, C. Dessy and A. Gabriel: Morphologie, croissance et remaniement du tissu osseux. Ann Med Vet 148, 1-13 (2004). (Pubitemid 44418953)
21. Bruder, S. P. and A. I. Caplan: Bone regeneration through cellular engineering. In: Principles in Tissue Engineering (2nd edition). Eds: Lanza, R., R. Langer and J. Vacanti, Academic Press, San Diego, CA, 683-696 (2000).
22. Nakashima, K., X. Zhou, G. Kunkel, Z. Zhang, J. M. Deng, R. R. Behringer and B. de Crombrugghe: The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 108, 17-29 (2002). (Pubitemid 34137009)
23. Stains, J. P. and R. Civitelli: Cell-to-cell interactions in bone. Biochem Biophys Res Commun 328, 721-727 (2005). (Pubitemid 40208309)
24. Ferrari, S. L., K. Traianedes, M. Thorne, M. H. Lafage-Proust, P. Genever, M. G. Cecchini, V. Behar, A. Bisello, M. Chorev, M. Rosenblatt and L. J. Suva: A role for Ncadherin in the development of the differentiated osteoblastic phenotype. J Bone Miner Res 15, 198-208 (2000). (Pubitemid 30095706)
25. Mackie, E. J.: Osteoblasts: novel roles in orchestration of skeletal architecture. Int J Biochem Cell Biol 35, 1301- 1305 (2003). (Pubitemid 36703168)
26. Marie, P.: Differenciation, fonction et controle de l'osteoblaste. Med Sci (Paris) 17, 1252-1259. Copyright EDK (2001).
27. Franz-Odendaal, T. A., B. K. Hall and P. E. Witten: Buried alive: how osteoblasts become osteocytes. Dev Dyn 235, 176-190 (2006). (Pubitemid 46939715)
28. Tanaka-Kamioka, K., H. Kamioka, H. Ris and S.-S. Lim: Osteocyte shape is dependent on actin filaments and osteocyte processes are unique actin-rich projections. J Bone Miner Res 13, 1555-1568 (1998). (Pubitemid 28465296)
29. Cherian, P. P., A. J. Siller-Jackson, S. Gu., X. Wang, L. F. Bonewald, E. Sprague and J. X. Jiang: Mechanical strain opens connexin 43 hemichannels in osteocytes: a novel mechanism for the release of prostaglandin. Mol Biol Cell 16, 3100-3106 (2005). (Pubitemid 40962583)
30. Nelson, W. J. and R. Nusse: Convergence of Wnt, betacatenin, and cadherin pathways. Science 303, 1483-1487 (2004). (Pubitemid 38314410)
31. Li, Y.-L. and Z.-S. Xiao: Advances in Runx2 regulation and its isoforms. Med Hypotheses 68, 169-175 (2007).
32. Saez, J. C., M. A. Retamal, D. Basilio, F. F. Bukauskas and M. V. L. Bennett: Connexin-based gap junction hemichannels: Gating mechanisms. Biochim Biophys Acta 1711, 215-224 (2005). (Pubitemid 40799296)
33. Alford, A. I., C. R. Jacobs and H. J. Donahue: Oscillating fluid flow regulates gap junction communication in osteocytic MLO-Y4 cells by an ERK1/2 MAP kinase-dependent mechanism. Bone 33, 64-70 (2003). (Pubitemid 36952688)
34. Plotkin, L. I., S. C. Manolagas and T. Bellido: Transduction of cell survival signals by connexin-43 hemichannels. J Biol Chem 277, 8648-8657 (2002). (Pubitemid 34968331)
35. Dougall, W. C. and M. Chaisson: The RANK/RANKL/OPG triad in cancer-induced bone diseases. Cancer Metastasis Rev 25, 541-549 (2006). (Pubitemid 46071863)
36. Blair, H. C., L. J. Robinson and M. Zaidi: Osteoclast signalling pathways. Biochem Biophys Res Commun 328, 728-738 (2005). (Pubitemid 40208310)
37. Boyle, W. J., W. S. Simonet and D. L. Lacey: Osteoclast differentiation and activation. Nature 423, 337-342 (2003). (Pubitemid 40852708)
38. Zhou, Z., D. Immel, C.-X. Xi, A. Bierhaus, X. Feng, L. Mei, P. Nawroth, D. M. Stern and W.-C. Xiong: Regulation of osteoclast function and bone mass by RAGE. J Exp Med 203, 1067-1080 (2006).
39. Halleen, J. M., S. L. Tiitinen, H. Ylipahkala, K. M. Fagerlund and H. K. Vaananen: Tartrate-resistant acid phosphatase 5b (TRACP 5b) as a marker of bone resorption. Clin Lab 52, 499-509 (2006). (Pubitemid 44649680)
40. Vaananen, K.: Mechanism of osteoclast mediated bone resorption - rationale for the design of new therapeutics. Adv Drug Deliv Rev 57, 959-971 (2005). (Pubitemid 40692288)
41. Zeng, G.-Z., N.-H. Tan, X.-J. Hao, Q.-Z. Mu and R.-T. Lia: Natural inhibitors targeting osteoclast-mediated bone resorption. Bioorg Med Chem Lett 16, 6178-6180 (2006). (Pubitemid 44709921)
42. Olney, R. C.: Regulation of bone mass by growth hormone. Med Pediatr Oncol 41, 228-234 (2003). (Pubitemid 36910133)
43. Boivin, G. and P. J. Meunier: Methodological considerations in measurement of bone mineral content. Osteoporos Int 14, S22-S27 (2003).
44. Jilka, R. L.: Biology of the basic multicellular unit and the pathophysiology of osteoporosis. Med Pediatr Oncol 41, 182-185 (2003). (Pubitemid 36910125)
45. Garnero, P., O. Borel, E. Gineyts, F. Duboeuf, H. Solberg, M. L. Bouxsein, C. Christiansen and P. D. Delmas: Extracellular post-translational modifications of collagen are major determinants of biomechanical properties of fetal bovine cortical bone. Bone 38, 300-309 (2006). (Pubitemid 43255423)
46. Gelse, K., E. Poschl and T. Aigner: Collagens - structure, function, and biosynthesis. Adv Drug Deliv Rev 55, 1531-1546. Copyright Elsevier (2003). (Pubitemid 37412592)
47. Myllyharju, J. and K. I. Kivirikko: Collagens, modifying enzymes and their mutations in humans, flies and worms. Trends Genet 20, 33-43 (2004). (Pubitemid 38032818)
48. Ottani, V., D. Martini, M. Franchi, A. Ruggeri and M. Raspanti: Hierarchical structures in fibrillar collagens. Micron 33, 587-596 (2002). (Pubitemid 35426583)
49. Ricard-Blum, S. and F. Ruggiero: The collagen superfamily: from the extracellular matrix to the cell membrane. Pathol Biol (Paris) 53, 430-442 (2005). (Pubitemid 41112079)
50. Grafenau, P., B. Carstanjen and O. M. Lepage: Osteocalcin: a biochemical marker of bone formation in equine medicine, Vet Med (Czech) 45, 209-216 (2000).
51. nd edition), Academic Press, London (United Kingdom), 320 pp. (1998).
52. Bouletreau, P. J., S. M. Warren and M. T. Longaker: The molecular biology of distraction osteogenesis. J Craniomaxillofac Surg 30, 1-11 (2002). (Pubitemid 34814706)
53. Sodek, J., B. Zhu, M.-H. Huynh, T. J. Brown and M. Ringuette: Novel functions of the matricellular proteins osteopontin and osteonectin/SPARC. Connect Tissue Res 43, 308-319 (2002). (Pubitemid 34777941)
54. Alford, A. I. and K. D. Hankenson: Matricellular proteins: Extracellular modulators of bone development, remodeling, and regeneration. Bone 38, 749-757 (2006). (Pubitemid 44498588)
55. Valverde, P., Q. Tu and J. Chen: BSP and RANKL induce osteoclastogenesis and bone resorption synergistically. J Bone Miner Res 20, 1669-1679 (2005). (Pubitemid 41243555)
56. Tu, Q., M. Yamauchi, S. C. Pageau and J. Chen: Autoregulation of bone sialoprotein gene in preosteoblastic and non-osteoblastic cells. Biochem Biophys Res Commun 316, 461-467 (2004). (Pubitemid 38338615)
57. Bi, Y., K. L. Nielsen, T. M. Kilts, A. Yoon, M. A. Karsdal, H. F. Wimer, E. M. Greenfield, A.-M. Heegaard and M. F. Young: Biglycan deficiency increases osteoclast differentiation and activity due to defective osteoblasts. Bone 38, 778-786 (2006). (Pubitemid 44500652)
58. Mochida, Y., D. Parisuthiman and M. Yamauchi: Biglycan is a positive modulator of BMP-2 induced osteoblast differentiation. Adv Exp Med Biol 585, 101-113 (2006).
59. Parisuthiman, D., Y. Mochida, W. R. Duarte and M. Yamauchi: Biglycan modulates osteoblast differentiation and matrix mineralization. J Bone Miner Res 20, 1878- 1886 (2005). (Pubitemid 41361890)
60. Waddington, R. J., H. C. Roberts, R. V. Sugars and E. Schonherr: Differential roles for small leucine-rich proteoglycans in bone formation. Eur Cell Mater 6, 12-21 (2003). (Pubitemid 38851418)
61. Mochida, Y., W. R. Duarte, H. Tanzawa, E. P. Paschalis and M. Yamauchi: Decorin modulates matrix mineralization in vitro. Biochem Biophys Res Commun 305, 6-9 (2003). (Pubitemid 36535401)
62. Globus, R. K., S. B. Doty, J. C. Lull, E. Holmuhamedov, M. J. Humphries and C. H. Damsky: Fibronectin is a survival factor for differentiated osteoblasts. J Cell Sci 111, 1385-1393 (1998). (Pubitemid 28274390)
63. Stein, G. S., J. B. Lian and T. A. Owen: Relationship of cell growth to the regulation of tissue-specific gene expression during osteoblast differentiation. FASEB J 4, 3111-3123 (1990).
64. Landis, W. J., K. J. Hodgens, J. Arena, M. J. Song and B. F. McEwen: Structural relations between collagen and mineral in bone as determined by high voltage electron microscopic tomography. Microsc Res Tech 33, 192-202. Reprinted with permission of Wiley-Liss, Inc., a subsidiary of John Wiley and Sons, Inc. (1996).
65. 2+ signaling pathway in osteoblasts. Am J Physiol Cell Physiol 247, C1686-C1698 (1998). (Pubitemid 28304207)
66. Urist, M. R.: Bone: formation by autoinduction. Science 150, 893-899 (1965).
67. Luginbuehl, V., L. Meinel, H. P. Merkle and B. Gander: Localized delivery of growth factors for bone repair. Eur J Pharm Biopharm 58, 197-208 (2004). (Pubitemid 39037229)
68. Brown, M. A., Q. Zhao, K. A. Baker, C. Naik, C. Chen, L. Pukac, M. Singh, T. Tsareva, Y. Parice, A. Mahoney, V. Roschke, I. Sanyal and S. Choe: Crystal structure of BMP-9 and functional interactions with pro-region and receptors. J Biol Chem 280, 25111-25118 (2005). (Pubitemid 40934603)
69. Ebendal, T., H. Bengtsson and S. Soderstrom: Bone morphogenetic proteins and their receptors: potential functions in the brain. J Neurosci Res 51, 139-146 (1998). (Pubitemid 28073021)
70. Kawabata, M., T. Imamura and K. Miyazono: Signal transduction by bone morphogenetic proteins. Cytokine Growth Factor Rev 9, 49-61 (1998). (Pubitemid 28280536)
71. Lou, E.: Bone morphogenetic proteins: an overview of therapeutic applications. Orthopedics 24, 504-509 (2001). (Pubitemid 32487438)
72. Reddi, A. H.: BMPs: From bone morphogenetic proteins to body morphogenetic proteins. Cytokine Growth Factor Rev 16, 249-250 (2005). (Pubitemid 40910314)
73. Wozney, J. M., V. Rosen, A. J. Celeste, L. M. Mitsock, M. J. Whitters, R. W. Kriz, R. M. Hewick and E. A. Wang: Novel regulators of bone formation: molecular clones and activities. Science 242, 1528-1534 (1988). (Pubitemid 19023695)
74. Nakase, T. and H. Yoshikawa: Potential roles of bone morphogenetic proteins (BMPs) in skeletal repair and regeneration. J Bone Miner Metab 24, 425-433 (2006). (Pubitemid 44663413)
75. Iwasaki, S., A. Hattori, M. Sato, M. Tsujimoto and M. Kohno: Characterization of the bone morphogenetic protein-2 as a neurotrophic factor - Induction of neuronal differentiation of PC12 cells in the absence of mitogen-activated protein kinase activation. J Biol Chem 271, 17360-17365 (1996). (Pubitemid 26244297)
76. Lecanda, F., L. V. Avioli and S. L. Cheng: Regulation of bone matrix protein expression and induction of differentiation of human osteoblasts and human bone marrow stromal cells by bone morphogenetic protein-2. J Cell Biochem 67, 386-398 (1997). (Pubitemid 27509474)
77. Ripamonti, U.: Soluble osteogenic molecular signals and the induction of bone formation. Biomaterials 27, 807- 822 (2006). (Pubitemid 41484113)
78. Scheufler, C., W. Sebald and M. Hulsmeyer: Crystal structure of human bone morphogenetic protein-2 at 2.7 angstroms resolution. J Mol Biol 287, 103-115 (1999). (Pubitemid 29134800)
79. Sykaras, N. and L. A. Opperman: Bone morphogenetic proteins (BMPs): how do they function and what can they offer the clinician? J Oral Science 45, 57-73 (2003).
80. Cheng, H., W. Jiang, F. M. Phillips, R. C. Haydon, Y. Peng, L. Zhou, H. H. Luu, N. An, B. Breyer, P. Vanichakarn, J. P. Szatkowski, J. Y. Park and T.-C. He: Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs). J Bone Joint Surg (Am) 85-A, 1544-1552 (2003). (Pubitemid 36951140)
81. Kang, Q., M. H. Sun, H. Cheng, Y. Peng, A. G. Montag, A. T. Deyrup, W. Jiang, H. H. Luu, J. Luo, J. P. Szatkowski, P. Vanichakarn, J. Y. Park, Y. Li, R. C. Haydon and T.-C. He: Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery. Gene Ther 11, 1312-1320 (2004). (Pubitemid 39213996)
82. Varga, A. C. and J. L. Wrana: The disparate role of BMP in stem cell biology. Oncogene 24, 5713-5721 (2005). (Pubitemid 43086131)
83. Mazerbourg, S. and A. J. W. Hsueh: Genomic analyses facilitate identification of receptors and signalling pathways for growth differentiation factor 9 and related orphan bone morphogenetic protein/growth differentiation factor ligands. Hum Reprod Update 12, 373-383 (2006). (Pubitemid 43923412)
84. Ro, T. B., R. U. Holt, A.-T. Brenne, H. Hjorth-Hansen, A. Waage, O. Hjertner, A. Sundan and M. Borset: Bone morphogenetic protein-5, -6 and -7 inhibit growth and induce apoptosis in human myeloma cells. Oncogene 23, 3024-3032 (2004). (Pubitemid 38648193)
85. Zhao, G.-Q. and B. L. M. Hogan: Evidence that mouse Bmp8a (Op2) and Bmp8b are duplicated genes that play a role in spermatogenesis and placental development. Mech Dev 57, 159-168 (1996). (Pubitemid 26252550)
86. Zhao, G.-Q., Y.-X. Chen, X.-M. Liu, Z. Xu and X. Qi: Mutation in BMP7 exacerbates the phenotype of BMP8a mutants in spermatogenesis and epididymis. Dev Biol 240, 212-222 (2001). (Pubitemid 33141118)
87. David, L., C. Mallet, S. Mazerbourg, J.-J. Feige and S. Bailly: Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells. Blood 109, 1953- 1961 (2007). (Pubitemid 46348192)
88. Miyazono, K.: Signal transduction by bone morphogenetic protein receptors: functional roles of Smad proteins. Bone 25, 91-93 (1999). (Pubitemid 29322068)
89. Zhang, J. and L. Li: BMP signaling and stem cell regulation. Dev Biol 284, 1-11 (2005). (Pubitemid 41096719)
90. Kugimiya, F., S. Ohba, K. Nakamura, H. Kawaguchi and U.-I. Chung: Physiological role of bone morphogenetic proteins in osteogenesis. J Bone Miner Metab 24, 95-99 (2006).
91. Heldin, C.-H., K. Miyazono and P. ten Dijke: TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature 390, 465-471 (1997). (Pubitemid 28013118)
92. Walker, D. H. and N. M. Wright: Bone morphogenetic proteins and spinal fusion. Neurosurg Focus 13, article 3, 1-13 (2002).
93. Neale, S. D., R. Smith, J. A. H. Wass and N. A. Athanasou: Osteoclast differentiation from circulating mononuclear precursors in Paget's disease is hypersensitive to 1, 25-dihydroxyvitamin D3 and RANKL. Bone 27, 409-416 (2000). (Pubitemid 30658125)
94. Suzuki, K., S. Takeyama, T. Kikuchi, S. Yamada, J. Sodek and H. Shinoda: Osteoclast responses to lipopolysaccharide, parathyroid hormone and bisphosphonates in neonatal murine calvaria analyzed by laser scanning confocal microscopy. J Histochem Cytochem 53, 1525-1537 (2005). (Pubitemid 41720692)
95. Hynes, R. O.: Integrins: bidirectional, allosteric signaling machines. Cell 110, 673-687 (2002). (Pubitemid 35283958)
96. Garcia, A. J.: Get a grip: integrins in cell-biomaterial interactions. Biomaterials 26, 7525-7529 (2005). (Pubitemid 41187551)
97. Hersel, U., C. Dahmen and H. Kessler: RGD modified polymers: biomaterials for stimulated cell adhesion and beyond. Biomaterials 24, 4385-4415 (2003). (Pubitemid 36960136)
98. Yamada, K. M., R. Pankov and E. Cukierman: Dimensions and dynamics in integrin function. Braz J Med Biol Res 36, 959-966 (2003). (Pubitemid 37080906)
99. Humphries, M. J., E. J. H. Symonds and A. P. Mould: Mapping functional residues onto integrin crystal structures. Curr Opin Struct Biol 13, 236-243 Copyright Elsevier (2003). (Pubitemid 36515153)
100. Humphries, M. J., P. A. McEwan, S. J. Barton, P. A. Buckley, J. Bella and A. P. Mould: Integrin structure: heady advances in ligand binding, but activation still makes the knees wobble. Trends Biochem Sci 28, 313-320 (2003). (Pubitemid 36776294)
101. Mould, P. A. and M. J. Humphries: Regulation of integrin function through conformational complexity: not simply a knee-jerk reaction? Curr Opin Cell Biol 16, 544- 551 (2004). (Pubitemid 39201239)
102. Bershadsky, A. D., N. Q. Balaban and B. Geiger: Adhesion-dependent cell mechanosensitivity. Annu Rev Cell Dev Biol 19, 677-695 (2003). (Pubitemid 37487365)
103. Garcia-Alvarez, B., J. M. de Pereda, D. A. Calderwood, T. S. Ulmer, D. Critchley, I. D. Campbell, M. H. Ginsberg and R. C. Liddington: Structural determinants of integrin recognition by talin. Mol Cell 11, 49-58 (2003). (Pubitemid 36131107)
104. Wary, K. K., F. Mainiero, S. J. Isakoff, E. E. Marcantonio and F. G. Giancotti: The adaptor protein Shc couples a class of integrins to the control of cell cycle progression. Cell 87, 733-743 (1996). (Pubitemid 26386946)
105. Cowles, E. A., L. L. Brailey and G. A. Gronowicz: Integrin-mediated signaling regulates AP-1 transcription factors and proliferation in osteoblasts. J Biomed Mater Res 52, 725-737 (2000).
106. Rodan, S. B. and G. A. Rodan: Integrin function in osteoclasts. J Endocrinol 154, S47-S56 (1997).
107. Sinha, R. K. and R. S. Tuan: Regulation of human osteoblast integrin expression by orthopedic implant materials. Bone 18, 451-457 (1996). (Pubitemid 26152308)
108. Anselme, K.: Osteoblast adhesion on biomaterials. Biomaterials 21, 667-681 (2000). (Pubitemid 30109157)
109. Bennett, J. H., D. H. Carter, A. L. Alavi, J. N. Beresford and S. Walsh: Patterns of integrin expression in a human mandibular explant model of osteoblast differentiation. Arch Oral Biol 46, 229-238 (2001). (Pubitemid 32156125)
110. Carvalho, R. S., P. J. Kostenuik, E. Salih, A. Bumann and L. C. Gerstenfeld: Selective adhesion of osteoblastic cells to different integrin ligands induces osteopontin gene expression. Matrix Biol 22, 241-249 (2003). (Pubitemid 36802366)
111. Jikko, A., S. E. Harris, D. Chen, D. L. Mendrick and C. H. Damsky: Collagen integrin receptors regulate early osteoblast differentiation induced by BMP-2. J Bone Miner Res 14, 1075-1083 (1999). (Pubitemid 29314050)
112. Pankov, R., E. Cukierman, B.-Z. Katz, K. Matsumoto, D. C. Lin, S. Lin, C. Hahn and K. M. Yamada: Integrin dynamics and matrix assembly: Tensin-dependent translocation of alpha 5 beta 1 integrins promotes early fibronectin fibrillogenesis. J Cell Biol 148, 1075-1090 (2000).
113. Zamir, E., B.-Z. Katz, S.-I. Aota, K. M. Yamada, B. Geiger and Z. Kam: Molecular diversity of cell-matrix adhesions. J Cell Sci 112, 1655-1669 (1999). (Pubitemid 29295043)
114. Zamir, E., M. Katz, Y. Posen, N. Erez, K. M. Yamada, B.-Z. Katz, S. Lin, D. C. Lin, A. Bershadsky, Z. Kam and B. Geiger: Dynamics and segregation of cell-matrix adhesions in cultured fibroblasts. Nat Cell Biol 2, 191-196 (2000).
115. Zamir, E. and B. Geiger: Molecular complexity and dynamics of cell-matrix adhesions. J Cell Sci 114, 3583-3590 (2001). (Pubitemid 33041040)
116. Duong, L. T., P. Lakkakorpi, I. Nakamura and G. A. Rodan: Integrins and signaling in osteoclast function. Matrix Biol 19, 97-105 (2000). (Pubitemid 30332433)
117. Luxenburg, C., L. Addadi and B. Geiger: The molecular dynamics of osteoclast adhesions. Eur J Cell Biol 85, 203-211 (2006).
118. Zaidel-Bar, R., M. Cohen, L. Addadi and B. Geiger: Hierarchical assembly of cell-matrix adhesion complexes. Biochem Soc Trans 32, 416-420 (2004). (Pubitemid 38813527)
119. Katsumi, A., W. Orr, E. Tzima and M. A. Schwartz: Integrins in mechanotransduction. J Biol Chem 279, 12001- 12004 (2004). (Pubitemid 38445760)
120. Tomasek, J. J. and C. J. Haaksma: Fibronectin filaments and actin microfilaments are organized into a fibronexus in Dupuytren's diseased tissue. Anat Rec 230, 175-182 (1991).
121. Sastry, S. K. and K. Burridge: Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics. Exp Cell Res 261, 25-36 (2000).
122. c-src and related tyrosine kinases: a role in the assembly and reorganization of matrix adhesions. J Cell Sci 114, 2279-2289 (2001). (Pubitemid 32633699)
123. Geiger, B., A. Bershadsky, R. Pankov and K. M. Yamada: Transmembrane crosstalk between the extracellular matrix and the cytoskeleton. Nat Rev Mol Cell Biol 2, 793-805 (2001). (Pubitemid 33674080)
124. Hanks, S. K., L. Ryzhova, N.-Y. Shin and J. Brabek: Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility. Front Biosci 8, d982-d996 (2003). (Pubitemid 38943176)
125. Okuda, M., M. Takahashi, J. Suero, C. E. Murry, O. Traub, H. Kawakatsu and B. C. Berk: Shear stress stimulation of p130cas tyrosine phosphorylation requires calcium-dependent c-Src activation. J Biol Chem 274, 26803-26809 (1999).
126. Brown, M. C. and C. E. Turner: Paxillin: adapting to change. Physiol Rev 84, 1315-1339 (2004). (Pubitemid 39287952)
127. Panetti, T. S.: Tyrosine phosphorylation of paxillin, FAK, and p130Cas: effects on cell spreading and migration. Front Biosci 7, d143-d150 (2002).
128. Sommerfeldt, D. W., K. J. McLeod, C. T. Rubin and M. Hadjiargyrou: Differential phosphorylation of paxillin in response to surface-bound serum proteins during early osteoblast adhesion. Biochem Biophys Res Commun 285, 355-363 (2001). (Pubitemid 32918078)
129. Boulter, E. and E. Van Obberghen-Schilling: Integrin-linked kinase and its partners: A modular platform regulating cell-matrix adhesion dynamics and cytoskeletal organization. Eur J Cell Biol 85, 255-263 (2006).
130. Luthen, F., R. Lange, P. Becker, J. Rychly, U. Beck and J. G. B. Nebe: The influence of surface roughness of titanium on beta1- and beta3-integrin adhesion and the organization of fibronectin in human osteoblastic cells. Biomaterials 26, 2423-2440 (2005). (Pubitemid 39600696)
131. Katz, B.-Z., M. Zohar, H. Teramoto, K. Matsumoto, J. S. Gutkind, D. C. Lin, S. Lin and K. M. Yamada: Tensin can induce JNK and p38 activation. Biochem Biophys Res Commun 272, 717-720 (2000). (Pubitemid 30420705)
132. Webb, D. J., J. T. Parsons and A. F. Horwitz: Adhesion assembly, disassembly and turnover in migrating cells - over and over and over again. Nat Cell Biol 4, E97-E100 (2002). (Pubitemid 34308850)
133. Rubin, J., C. Rubin and C. R. Jacobs: Molecular pathways mediating mechanical signaling in bone. Gene 367, 1-16 (2006). (Pubitemid 43286736)
134. Wiesner, S., K. R. Legate and R. Fassler: Integrinactin interactions. Cell Mol Life Sci 62, 1081-1099 (2005).
135. Calderwood, D. A., R. Zent, R. Grant, D. J. G. Rees, R. O. Hynes and M. H. Ginsberg: The talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation. J Biol Chem 274, 28071-28074 (1999).
136. Izard, T., G. Evans, R. A. Borgon, C. L. Rush, G. Bricogne and P. R. J. Bois: Vinculin activation by talin through helical bundle conversion. Nature 427, 171-175 (2004). (Pubitemid 38094959)
137. Balaban, N. Q., U. S. Schwarz, D. Riveline, P. Goichberg, G. Tzur, I. Sabanay, D. Mahalu, S. Safran, A. Bershadsky, L. Addadi and B. Geiger: Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates. Nat Cell Biol 3, 466-472 (2001). (Pubitemid 32422082)
138. Ziegler, W. H., R. C. Liddington and D. R. Critchley: The structure and regulation of vinculin. Trends Cell Biol 16, 453-460 (2006). (Pubitemid 44293400)
139. Li, S., M. Kim, Y.-L. Hu, S. Jalali, D. D. Schlaepfer, T. Hunter, S. Chien and J. Y.-J. Shyy: Fluid shear stress activation of focal adhesion kinase. Linking to mitogen-activated protein kinases. J Biol Chem 272, 30455-30462 (1997). (Pubitemid 27512256)
140. Li, S., P. Butler, Y. Wang, Y. Hu, D. C. Han, S. Usami, J.-L. Guan and S. Chien: The role of the dynamics of focal adhesion kinase in the mechanotaxis of endothelial cells. Proc Natl Acad Sci USA 99, 3546-3551 (2002). (Pubitemid 34252144)
141. von Wichert, G., B. Haimovich, G.-S. Feng and M. P. Sheetz: Force-dependent integrin-cytoskeleton linkage formation requires down-regulation of focal complex dynamics by Shp2. EMBO J 22, 5023-5035 (2003). (Pubitemid 37222023)
142. Wang, H.-B., M. Dembo, S. K. Hanks and Y.-L. Wang: Focal adhesion kinase is involved in mechanosensing during fibroblast migration. Proc Natl Acad Sci USA 98, 11295-11300 (2001). (Pubitemid 32928722)
143. Zaidel-Bar, R., R. Milo, Z. Kam and B. Geiger: A paxillin tyrosine phosphorylation switch regulates the assembly and form of cell-matrix adhesions. J Cell Sci 120, 137-148 (2007). (Pubitemid 46206656)
144. Jurdic, P., F. Saltel, A. Chabadel and O. Destaing: Podosome and sealing zone: specificity of the osteoclast model. Eur J Cell Biol 85, 195-202 (2006).
145. Linder, S. and M. Aepfelbacher: Podosomes: adhesion hot-spots of invasive cells. Trends Cell Biol 13, 376-385 Copyright Elsevier (2003). (Pubitemid 36776715)
146. Nakamura, I., G. A. Rodan and L. T. Duong: Regulatory mechanism of osteoclast activation. J Electron Microsc (Tokyo) 52, 527-533 (2003). (Pubitemid 38092540)
147. Luxenburg, C., D. Geblinger, E. Klein, K. Anderson, D. Hanein, B. Geiger and L. Addadi: The architecture of the adhesive apparatus of cultured osteoclasts: from podosome formation to sealing zone assembly. PLoS ONE 2, e179 (8 pp.) (2007).
148. Okumura, S., T. Mizoguchi, N. Sato, M. Yamaki, Y. Kobayashi, H. Yamauchi, H. Ozawa, N. Udagawa and N. Takahashi: Coordination of microtubules and the actin cytoskeleton is important in osteoclast function, but calcitonin disrupts sealing zones without affecting microtubule networks. Bone 39, 684-693 (2006). (Pubitemid 44311721)
149. Duong, L. T. and G. A. Rodan: The role of integrins in osteoclast function. J Bone Miner Metab 17, 1-6 (1999). (Pubitemid 29117744)
150. Destaing, O., F. Saltel, B. Gilquin, A. Chabadel, S. Khochbin, S. Ory and P. Jurdic: A novel Rho-mDia2-HDAC6 pathway controls podosome patterning through microtubule acetylation in osteoclasts. J Cell Sci 118, 2901-2911 (2005). (Pubitemid 41136367)
151. Li, R., N. Mitra, H. Gratkowski, G. Vilaire, R. Litvinov, C. Nagasami, J. W. Weisel, J. D. Lear, W. F. DeGrado, J. S. Bennett: Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations. Science 300, 795-798 (2003). (Pubitemid 36532114)
152. Suzuki, K., S. Takeyama, Y. Sakai, S. Yamada and H. Shinoda: Current topics in pharmacological research on bone metabolism: inhibitory effects of bisphosphonates on the differentiation and activity of osteoclasts. J Pharmacol Sci 100, 189-194 (2006).
153. Miao, H., S. Li, Y.-L. Hu, S. Yuan, Y. Zhao, B. P. C. Chen, W. Puzon-McLaughlin, T. Tarui, H. Y.-J. Shyy, Y. Takada, S. Usami and S. Chien: Differential regulation of Rho GTPases by beta 1 and beta 3 integrins: the role of an extracellular domain of integrin in intracellular signalling. J Cell Sci 115, 2199-2206 (2002). (Pubitemid 34746385)
154. Huang, C., K. Jacobson and M. D. Schaller: MAP kinases and cell migration. J Cell Sci 117, 4619-4628 (2004). (Pubitemid 39433429)
155. Kapur, S., D. J. Baylink and K.-H. W. Lau: Fluid flow shear stress stimulates human osteoblast proliferation and differentiation through multiple interacting and competing signal transduction pathways. Bone 32, 241-251 (2003). (Pubitemid 36349527)
156. Weyts, F. A. A., Y.-S. Li, J. van Leeuwen, H. Weinans and S. Chien: ERK activation and alpha v beta 3 integrin signaling through Shc recruitment in response to mechanical stimulation in human osteoblasts. J Cell Biochem 87, 85-92 (2002). (Pubitemid 34969151)
157. Boutahar, N., A. Guignandon, L. Vico and M.-H. Lafage-Proust: Mechanical strain on osteoblasts activates autophosphorylation of focal adhesion kinase and proline-rich tyrosine kinase 2 tyrosine sites involved in ERK activation. J Biol Chem 279, 30588-30599 (2004). (Pubitemid 38937991)
158. Sai, X., K. Naruse and M. Sokabe: Activation of pp60src is critical for stretch-induced orienting response in fibroblasts. J Cell Sci 112, 1365-1373 (1999). (Pubitemid 29243459)
159. Urbich, C., E. Dernbach, A. Reissner, M. Vasa, A. M. Zeiher and S. Dimmeler: Shear stress-induced endothelial cell migration involves integrin signaling via the fibronectin receptor subunits alpha 5 and beta 1. Arterioscler Thromb Vasc Biol 22, 69-75 (2002). (Pubitemid 34076234)
160. Wang, J. G., M. Miyazu, P. Xiang, S. N. Li, M. Sokabe and K. Naruse: Stretch-induced cell proliferation is mediated by FAK-MAPK pathway. Life Sci 76, 2817-2825 (2005). (Pubitemid 40460327)
161. You, J., G. C. Reilly, X. Zhen, C. E. Yellowley, Q. Chen, H. J. Donahue and C. R. Jacobs: Osteopontin gene regulation by oscillatory fluid flow via intracellular calcium mobilization and activation of mitogen-activated protein kinase in MC3T3-E1 osteoblasts. J Biol Chem 276, 13365- 13371 (2001).
162. Fisher, A. B., S. Chien, A. I. Barakat and R. M. Nerem: Endothelial cellular response to altered shear stress. Am J Physiol Lung Cell Mol Physiol 281, L529-L533 (2001).
163. Choquet, D., D. P. Felsenfeld and M. P. Sheetz: Extracellular matrix rigidity causes strengthening of integrin-cytoskeleton linkages. Cell 88, 39-48 (1997). (Pubitemid 27180329)
164. Rubin, J., T. C. Murphy, X. Fan, M. Goldschmidt and W. R. Taylor: Activation of extracellular signal-regulated kinase is involved in mechanical strain inhibition of RANKL expression in bone stromal cells. J Bone Miner Res 17, 1452-1460 (2002). (Pubitemid 34803829)
165. Takeuchi, Y., M. Suzawa, T. Kikuchi, E. Nishida, T. Fujita and T. Matsumoto: Differentiation and transforming growth factor-beta receptor down-regulation by collagenalpha 2 beta 1 integrin interaction is mediated by focal adhesion kinase and its downstream signals in murine osteoblastic cells. J Biol Chem 272, 29309-29316 (1997). (Pubitemid 27498224)
166. Kretzschmar, M., J. Doody and J. Massague: Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1. Nature 389, 618-622 (1997). (Pubitemid 27446181)
167. Ridley, A. J.: Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking. Trends Cell Biol 16, 522-529 (2006). (Pubitemid 44444995)
168. Schiller, M. R.: Coupling receptor tyrosine kinases to Rho GTPases - GEFs what's the link. Cell Signal 18, 1834-1843 (2006). (Pubitemid 44485993)
169. Bershadsky, A. D., C. Ballestrem, L. Carramusa, Y. Zilberman, B. Gilquin, S. Khochbin, A. Y. Alexandrova, A. B. Verkhovsky, T. Shemesh and M. M. Kozlov: Assembly and mechanosensory function of focal adhesions: experiments and models. Eur J Cell Biol 85, 165-173 (2006).
170. Tzima, E., M. A. Del Pozo, W. B. Kiosses, S. A. Mohamed, S. Li, S. Chien and M. A. Schwartz: Activation of Rac1 by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression. EMBO J 21, 6791-6800 (2002). (Pubitemid 36014551)
171. Chellaiah, M. A., N. Soga, S. Swanson, S. McAllister, U. Alvarez, D. M. Wang, S. F. Dowdy and K. A. Hruska: Rho-A is critical for osteoclast podosome organization, motility, and bone resorption. J Biol Chem 275, 11993- 12002 (2000). (Pubitemid 30237772)
172. Chellaiah, M. A.: Regulation of podosomes by integrin alpha v beta 3 and Rho GTPase-facilitated phosphoinositide signalling. Eur J Cell Biol 85, 311-317 (2006).
173. Chellaiah, M. A.: Regulation of actin ring formation by Rho GTPases in osteoclasts. J Biol Chem 280, 32930- 32943 (2005). (Pubitemid 41368343)
174. Faccio, R., M. Grano, S. Colucci, A. Villa, G. Giannelli, V. Quaranta and A. Zallone: Localization and possible role of two different alpha v beta 3 integrin conformations in resting and resorbing osteoclasts. J Cell Sci 115, 2919-2929 (2002).
175. Reyes, C. D. and A. J. Garcia: alpha 2 beta 1 integrin-specific collagen-mimetic surfaces supporting osteoblastic differentiation. J Biomed Mater Res 69A, 591-600 (2004). (Pubitemid 38745705)
176. Damsky, C. H.: Extracellular matrix-integrin interactions in osteoblast function and tissue remodeling. Bone 25, 95-96 (1999). (Pubitemid 29322069)
177. Sato, M., M. K. Sardana, W. A. Grasser, V. M. Garsky, J. M. Murray and R. J. Gould: Echistatin is a potent inhibitor of bone resorption in culture. J Cell Biol 111, 1713-1723 (1990).
178. Chen, D., M. Zhao, S. E. Harris and Z. Mi: Signal transduction and biological functions of bone morphogenetic proteins. Front Biosci 9, 349-358 (2004). (Pubitemid 38925465)
179. Elsegood, C. L., Y. Zhuo, G. A. Wesolowski, J. A. Hamilton, G. A. Rodan and L. T. Duong: M-CSF induces the stable interaction of cFms with alpha v beta 3 integrin in osteoclasts. Int J Biochem Cell Biol 38, 1518-1529 (2006). (Pubitemid 44250951)
180. Schwartz, Z. and B. D. Boyan: Underlying mechanisms at the bone-biomaterial interface. J Cell Biochem 56, 340-347 (1994). (Pubitemid 24360052)
181. Ramaswamy, Y., D. R. Haynes, G. Berger, R. Gildenhaar, H. Lucas, C. Holding and H. Zreiqat: Bioceramics composition modulate resorption of human osteoclasts. J Mater Sci: Mater Med 16, 1199-1205 (2005). (Pubitemid 41805083)
182. Rezwan, K., Q. Z. Chen, J. J. Blaker and A. R. Boccaccini: Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. Biomaterials 27, 3413-3431 (2006).
183. Jin, Q.-M., H. Takita, T. Kohgo, K. Atsumi, H. Itoh and Y. Kuboki: Effects of geometry of hydroxyapatite as a cell substratum in BMP-induced ectopic bone formation. J Biomed Mater Res 51, 491-499 (2000). (Pubitemid 30452154)
184. Koempel, J. A., B. S. Patt, K. O'Grady, J. Wozney and D. M. Toriumi: The effect of recombinant human bone morphogenetic protein-2 on the integration of porous hydroxyapatite implants with bone. J Biomed Mater Res 41, 359-363 (1998). (Pubitemid 28300098)
185. Gao, T., T. S. Lindholm, A. Marttinen and M. R. Urist: Composites of bone morphogenetic protein (BMP) and type IV collagen, coral-derived coral hydroxyapatite, and tricalcium phosphate ceramics. Int Orthop 20, 321-325 (1996). (Pubitemid 26377293)
186. Edwards, R. B., H. J. Seeherman, J. J. Bogdanske, J. Devitt, P. Vanderby and M. D. Markel: Percutaneous injection of recombinant human bone morphogenetic protein-2 in a calcium phosphate paste accelerates healing of a canine tibial osteotomy. J Bone Joint Surg (Am) 86-A, 1425-1438 (2004). (Pubitemid 38898645)
187. Seeherman, H. J., M. Bouxsein, H. Kim, R. Li, X. J. Li, M. Aiolova and J. M. Wozney: Recombinant human bone morphogenetic protein-2 delivered in an injectable calcium phosphate paste accelerates osteotomy-site healing in a non-human primate model. J Bone Joint Surg (Am) 86-A, 1961-1972 (2004). (Pubitemid 39232119)
188. Kamakura, S., S. Nakajo, O. Suzuki and Y. Sasano: New scaffold for recombinant human bone morphogenetic protein-2. J Biomed Mater Res 71A, 299-307 (2004). (Pubitemid 39362911)
189. Ijiri, S., T. Nakamura, Y. Fujisawa, M. Hazama and S. Komatsudani: Ectopic bone induction in porous apatitewollastonite-containing glass ceramic combined with bone morphogenetic protein. J Biomed Mater Res 35, 421-432 (1997). (Pubitemid 27250906)
190. Simmons, C. A., E. Alsberg, S. Hsiong, W. J. Kim and D. J. Mooney: Dual growth factor delivery and controlled scaffold degradation enhance in vivo bone formation by transplanted bone marrow stromal cells. Bone 35, 562-569 (2004). (Pubitemid 38953205)
191. Spiro, R. C., A. Y. Thompson and J. W. Poser: Spinal fusion with recombinant human growth and differentiation factor-5 combined with a mineralized collagen matrix. Anat Rec 263, 388-395 (2001). (Pubitemid 32730267)
192. Marques, A. P., R. L. Reis and J. A. Hunt: The biocompatibility of novel starch-based polymers and composites: in vitro studies. Biomaterials 23, 1471-1478 (2002). (Pubitemid 34037084)
193. Lee, J.-Y., S.-H. Nam, S.-Y. Im, Y.-J. Park, Y.-M. Lee, Y.-J. Seol, C.-P. Chung and S.-J. Lee: Enhanced bone formation by controlled growth factor delivery from chitosanbased biomaterials. J Control Release 78, 187-197 (2002). (Pubitemid 34081864)
194. Holland, T. A., J. K. V. Tessmar, Y. Tabata and A. G. Mikos: Transforming growth factor-beta1 release from oligo(poly(ethylene glycol) fumarate) hydrogels in conditions that model the cartilage wound healing environment. J Control Release 94, 101-114 (2004). (Pubitemid 37542381)
195. Clokie, C. M. L. and M. R. Urist: Bone morphogenetic protein excipients: Comparative observations on poloxamer. Plast Reconstr Surg 105, 628-637 (2000). (Pubitemid 30111000)
196. Hollinger, J. O. and K. Leong: Poly(alpha-hydroxy acids): Carriers for bone morphogenetic proteins. Biomaterials 17, 187-194 (1996). (Pubitemid 26031374)
197. Zegzula, H. D., D. C. Buck, J. Brekke, J. M. Wozney and J. O. Hollinger: Bone formation with use of rhBMP-2 (Recombinant human bone morphogenetic protein-2). J Bone Joint Surg (Am) 79-A, 1778-1790 (1997). (Pubitemid 28016582)
198. Whang, K., D. C. Tsai, E. K. Nam, M. Aitken, S. M. Sprague, P. K. Patel and K. E. Healy: Ectopic bone formation via rhBMP-2 delivery from porous bioabsorbable polymer scaffolds. J Biomed Mater Res 42, 491-499 (1998). (Pubitemid 28503752)
199. Daniels, A. U., K. P. Andriano, W. P. Smutz, M. K. O. Chang and J. Heller: Evaluation of absorbable poly(ortho esters) for use in surgical implants. J Appl Biomater 5, 51- 64 (1994).
200. Lucas, P. A., C. Laurencin, G. T. Syftestad, A. Domb, V. M. Goldberg, A. I. Caplan and R. Langer: Ectopic induction of cartilage and bone by water-soluble proteins from bovine bone using a polyanhydride delivery vehicle. J Biomed Mater Res 24, 901-911 (1990). (Pubitemid 20319153)
201. Laurencin, C. T., M. E. Norman, H. M. Elgendy, S. F. El-Amin, H. R. Allcock, S. R. Pucher and A. A. Ambrosio: Use of polyphosphazenes for skeletal tissue regeneration. J Biomed Mater Res 27, 963-973 (1993). (Pubitemid 23178673)
202. Richards, M., B. I. Dahiyat, D. M. Arm, P. R. Brown and K. W. Leong: Evaluation of polyphosphates and polyphosphonates as degradable biomaterials. J Biomed Mater Res 25, 1151-1167 (1991).
203. Bergeron, E., M. E. Marquis, I. Chretien and N. Faucheux: Differentiation of preosteoblasts using a delivery system with BMPs and bioactive glass microspheres. J Mater Sci: Mater Med 18, 255-263 (2007). (Pubitemid 46332846)
204. Eglin, D., S. Maalheem, J. Livage and T. Coradin: In vitro apatite forming ability of type I collagen hydrogels containing bioactive glass and silica sol-gel particles. J Mater Sci: Mater Med 17, 161-167 (2006).
205. Sotome, S., T. Uemura, M. Kikuchi, J. Chen, S. Itoh, J. Tanaka, T. Tateishi and K. Shinomiya: Synthesis and in vivo evaluation of a novel hydroxyapatite/collagen-alginate as a bone filler and a drug delivery carrier of bone morphogenetic protein. Mater Sci Eng C 24, 341-347 (2004). (Pubitemid 38464311)
206. Silva, G. A., A. Pedro, F. J. Costa, N. M. Neves, O. P. Coutinho and R. L. Reis: Soluble starch and composite starch bioactive glass 45S5 particles: Synthesis, bioactivity, and interaction with rat bone marrow cells. Mater Sci Eng C 25, 237-246 (2005). (Pubitemid 40584245)
207. Tamai, N., A. Myoui, M. Hirao, T. Kaito, T. Ochi, J. Tanaka, K. Takaoka and H. Yoshikawa: A new biotechnology for articular cartilage repair: subchondral implantation of a composite of interconnected porous hydroxyapatite, synthetic polymer (PLA-PEG), and bone morphogenetic protein-2 (rhBMP-2). Osteoarthr Cartil 13, 405-417 (2005). (Pubitemid 40631286)
208. Kato, M., H. Toyoda, T. Namikawa, M. Hoshino, H. Terai, S. Miyamoto and K. Takaoka: Optimized use of a biodegradable polymer as a carrier material for the local delivery of recombinant human bone morphogenetic protein-2 (rhBMP-2). Biomaterials 27, 2035-2041 (2006). (Pubitemid 41759497)
209. Higuchi, T., A. Kinoshita, K. Takahashi, S. Oda and I. Ishikawa: Bone regeneration by recombinant human bone morphogenetic protein-2 in rat mandibular defects. An experimental model of defect filling. J Periodontol 70, 1026-1031 (1999).
210. Saito, N., T. Okada, H. Horiuchi, H. Ota, J. Takahashi, N. Murakami, M. Nawata, S. Kojima, K. Nozaki and K. Takaoka: Local bone formation by injection of recombinant human bone morphogenetic protein-2 contained in polymer carriers. Bone 32, 381-386 (2003). (Pubitemid 36407538)
211. Shimko, D. A. and E. A. Nauman: Development and characterization of a porous poly(methyl methacrylate) scaffold with controllable modulus and permeability. J Biomed Mater Res Part B: Appl Biomater 80B, 360-369 (2007).
212. Tanaka, E. and T. van Eijden: Biomechanical behavior of the temporomandibular joint disc. Crit Rev Oral Biol Med 14, 138-150 (2003).
213. Kim, H.-W., J. C. Knowles and H.-E. Kim: Hydroxyapatite porous scaffold engineered with biological polymer hybrid coating for antibiotic Vancomycin release. J Mater Sci: Mater Med 16, 189-195 (2005). (Pubitemid 40386272)
214. Ryan, G., A. Pandit and D. P. Apatsidis: Fabrication methods of porous metals for use in orthopaedic applications. Biomaterials 27, 2651-2670 (2006). (Pubitemid 43122070)
215. Julien, M., I. Khairoun, R. Z. LeGeros, S. Delplace, P. Pilet, P. Weiss, G. Daculsi, J. M. Bouler and J. Guicheux: Physico-chemical-mechanical and in vitro biological properties of calcium phosphate cements with doped amorphous calcium phosphates. Biomaterials 28, 956-965 (2007). (Pubitemid 44816377)
216. Wilson, C. E., J. D. de Bruijn, C. A. van Blitterswijk, A. J. Verbout and W. J. A. Dhert: Design and fabrication of standardized hydroxyapatite scaffolds with a defined macro-architecture by rapid prototyping for bone- tissueengineering research. J Biomed Mater Res 68A, 123-132 (2004). (Pubitemid 38030192)
217. Barrack, R. L.: Bone graft extenders, substitutes, and osteogenic proteins. J Arthroplasty 20, 94-97 (2005). (Pubitemid 41327571)
218. Oliveira, A. L., P. B. Malafaya and R. L. Reis: Sodium silicate gel as a precursor for the in vitro nucleation and growth of a bone-like apatite coating in compact and porous polymeric structures. Biomaterials 24, 2575-2584 (2003). (Pubitemid 36506480)
219. Riminucci, M. and P. Bianco: Building bone tissue: matrices and scaffolds in physiology and biotechnology. Braz J Med Biol Res 36, 1027-1036 (2003). (Pubitemid 37080913)
220. Hattar, S., A. Asselin, D. Greenspan, M. Oboeuf, A. Berdal and J.-M. Sautier: Potential of biomimetic surfaces to promote in vitro osteoblast-like cell differentiation. Biomaterials 26, 839-848 (2005). (Pubitemid 39194955)
221. Bosetti, M., L. Zanardi, L. Hench and M. Cannas: Type I collagen production by osteoblast-like cells cultured in contact with different bioactive glasses. J Biomed Mater Res 64A, 189-195 (2003). (Pubitemid 37521483)
222. Effah Kaufmann, A. B. E., P. Ducheyne and I. M. Shapiro: Evaluation of osteoblast response to porous bioactive glass (45S5) substrates by RT-PCR analysis. Tissue Eng 6, 19-28 (2000). (Pubitemid 30123979)
223. Hattar, S., A. Asselin, D. Greenspan, M. Oboeuf, A. Berdal and J.-M. Sautier: Effect of enamel matrix protein-coated bioactive glasses on the proliferation and differentiation of the osteogenic MC3T3.E1 cell line. Key Eng Mater 254-256, 749-752 (2004).
224. Ning, C. Q., J. Mehta and A. El-Ghannam: Effects of silica on the bioactivity of calcium phosphate composites in vitro. J Mater Sci: Mater Med 16, 355-360 (2005). (Pubitemid 40575658)
225. Silver, I. A., J. Deas and M. Erecinska: Interactions of bioactive glasses with osteoblasts in vitro: effects of 45S5 Bioglass, and 58S and 77S bioactive glasses on metabolism, intracellular ion concentrations and cell viability. Biomaterials 22, 175-185 (2001).
226. Xynos, I. D., M. V. J. Hukkanen, J. J. Batten, L. D. Buttery, L. L. Hench and J. M. Polak: Bioglass 45S5 stimulates osteoblast turnover and enhances bone formation in vitro: implications and applications for bone tissue engineering. Calcif Tissue Int 67, 321-329 (2000).
227. Bosetti, M. and M. Cannas: The effect of bioactive glasses on bone marrow stromal cells differentiation. Biomaterials 26, 3873-3879 (2005). (Pubitemid 40038778)
228. van den Dolder, J., P. H. M. Spauwen and J. A. Jansen: Evaluation of various seeding techniques for culturing osteogenic cells on titanium fiber mesh. Tissue Eng 9, 315-325 (2003). (Pubitemid 36944181)
229. van den Dolder, J., G. N. Bancroft, V. I. Sikavitsas, P. H. Spauwen, A. G. Mikos and J. A. Jansen: Effect of fibronectin-and collagen I-coated titanium fiber mesh on proliferation and differentiation of osteogenic cells. Tissue Eng 9, 505-515 (2003). (Pubitemid 36736133)
230. Di Toro, R., V. Betti and S. Spampinato: Biocompatibility and integrin-mediated adhesion of human osteoblasts to poly(DL-lactide-co-glycolide) copolymers. Eur J Pharm Sci 21, 161-169 (2004). (Pubitemid 38156153)
231. Borden M., S. F. El-Amin, M. Attawia and C. T. Laurencin: Structural and human cellular assessment of a novel microsphere-based tissue engineered scaffold for bone repair. Biomaterials 24, 597-609 (2003). (Pubitemid 35346389)
232. Lin, A. S. P., T. H. Barrows, S. H. Cartmell and R. E. Guldberg: Microarchitectural and mechanical characterization of oriented porous polymer scaffolds. Biomaterials 24, 481-489 (2003). (Pubitemid 35287519)
233. Ginebra, M.-P., T. Traykova and J. A. Planell: Calcium phosphate cements: Competitive drug carriers for the musculoskeletal system? Biomaterials 27, 2171-2177 (2006). (Pubitemid 41782020)
234. Lind, M. and C. Bunger: Orthopaedic applications of gene therapy. Int Orthop 29, 205-209 (2005). (Pubitemid 41125316)
235. Takita, H., J. W. M. Vehof, J. A. Jansen, M. Yamamoto, Y. Tabata, M. Tamura and Y. Kuboki: Carrier dependent cell differentiation of bone morphogenetic protein-2 induced osteogenesis and chondrogenesis during the early implantation stage in rats. J Biomed Mater Res 71A, 181-189 (2004). (Pubitemid 39244409)
236. Winn, S. R., H. Uludag and J. O. Hollinger: Sustained release emphasizing recombinant human bone morphogenetic protein-2. Adv Drug Deliv Rev 31, 303-318 (1998). (Pubitemid 28191871)
237. Garcia, A. J., M. D. Vega and D. Boettiger: Modulation of cell proliferation and differentiation through substrate-dependent changes in fibronectin conformation. Mol Biol Cell 10, 785-798 (1999). (Pubitemid 29144638)
238. Siebers, M. C., P. J. ter Brugge, X. F. Walboomers and J. A. Jansen: Integrins as linker proteins between osteoblasts and bone replacing materials. A critical review. Biomaterials 26, 137-146 (2005). (Pubitemid 38789096)
239. Lim, J. Y., A. F. Taylor, Z. Li, E. A. Vogler and H. J. Donahue: Integrin expression and osteopontin regulation in human fetal osteoblastic cells mediated by substratum surface characteristics. Tissue Eng 11, 19-29 (2005). (Pubitemid 40515172)
240. Hamilton, D. W., K. S. Wong and D. M. Brunette: Microfabricated discontinuous-edge surface topographies influence osteoblast adhesion, migration, cytoskeletal organization, and proliferation and enhance matrix and mineral deposition in vitro. Calcif Tissue Int 78, 314-325 (2006). (Pubitemid 43725191)
241. Deligianni, D. D., N. Katsala, S. Ladas, D. Sotiropoulou, J. Amedee and Y. F. Missirlis: Effect of surface roughness of the titanium alloy Ti-6Al-4V on human bone marrow cell response and on protein adsorption. Biomaterials 22, 1241-1251 (2001). (Pubitemid 32409945)
242. Lee, T. M., R. S. Tsai, E. Chang, C. Y. Yang and M. R. Yang: The cell attachment and morphology of neonatal rat calvarial osteoblasts on the surface of Ti-6Al-4V and plasma-sprayed HA coating: effect of surface roughness and serum contents. J Mater Sci: Mater Med 13, 341-350 (2002). (Pubitemid 34280715)
243. Brett, P. M., J. Harle, V. Salih, R. Mihoc, I. Olsen, F. H. Jones and M. Tonetti: Roughness response genes in osteoblasts. Bone 35, 124-133 (2004). (Pubitemid 38789155)
244. Wennerberg, A., T. Albrektsson, C. Johansson and B. Andersson: Experimental study of turned and grit-blasted screw-shaped implants with special emphasis on effects of blasting material and surface topography. Biomaterials 17, 15-22 (1996). (Pubitemid 126755187)
245. Lim, J. Y., A. D. Dreiss, Z. Zhou, J. C. Hansen, C. A. Siedlecki, R. W. Hengstebeck, J. Cheng, N. Winograd and H. J. Donahue: The regulation of integrin-mediated osteoblast focal adhesion and focal adhesion kinase expression by nanoscale topography. Biomaterials 28, 1787-1797 (2007). (Pubitemid 46137997)
246. Diener, A., B. Nebe, F. Luthen, P. Becker, U. Beck, H. G. Neumann and J. Rychly: Control of focal adhesion dynamics by material surface characteristics. Biomaterials 26, 383-392 (2005). (Pubitemid 38951105)
247. Kunzler, T. P., T. Drobek, M. Schuler and N. D. Spencer: Systematic study of osteoblast and fibroblast response to roughness by means of surface-morphology gradients. Biomaterials 28, 2175-2182 (2007). (Pubitemid 46216454)
248. Di Palma, F., A. Guignandon, A. Chamson, M.-H. Lafage-Proust, N. Laroche, S. Peyroche, L. Vico and A. Rattner: Modulation of the responses of human osteoblast-like cells to physiologic mechanical strains by biomaterial surfaces. Biomaterials 26, 4249-4257 (2005). (Pubitemid 40430852)
249. Liao, H., A.-S. Andersson, D. Sutherland, S. Petronis, B. Kasemo and P. Thomsen: Response of rat osteoblast-like cells to microstructured model surfaces in vitro. Biomaterials 24, 649-654 (2003). (Pubitemid 35346394)
250. Faucheux, N., R. Schweiss, K. Lutzow, C. Werner and T. Groth: Self-assembled monolayers with different terminating groups as model substrates for cell adhesion studies. Biomaterials 25, 2721-2730 (2004). (Pubitemid 38202319)
251. Groth, T., B. Seifert, G. Malsch, W. Albrecht, D. Paul, A. Kostadinova, N. Krasteva and G. Altankov: Interaction of human skin fibroblasts with moderate wettable polyacrylonitrile-copolymer membranes. J Biomed Mater Res 61, 290-300 (2002). (Pubitemid 34602377)
252. Keselowsky, B. G., D. M. Collard and A. J. Garcia: Surface chemistry modulates focal adhesion composition and signaling through changes in integrin binding. Biomaterials 25, 5947-5954 (2004). (Pubitemid 38747017)
253. Tamada, Y. and Y. Ikada: Fibroblast growth on polymer surfaces and biosynthesis of collagen. J Biomed Mater Res 28, 783-789 (1994). (Pubitemid 24184819)
254. Michael, K. E., V. N. Vernekar, B. G. Keselowsky, J. C. Meredith, R. A. Latour and A. J. Garcia: Adsorption-induced conformational changes in fibronectin due to interactions with well-defined surface chemistries. Langmuir 19, 8033-8040 (2003).
255. Mrksich, M. and G. M. Whitesides: Using selfassembled monolayers to understand the interactions of man-made surfaces with proteins and cells. Annu Rev Biophys Biomol Struct 25, 55-78 (1996).
256. Andrade, J. D. and V. Hlady: Protein adsorption and materials biocompatibility: a tutorial review and suggested hypotheses. Adv Polym Sci 79, 1-63 (1986).
257. Lee, M. H., P. Ducheyne, L. Lynch, D. Boettiger and R. J. Composto: Effect of biomaterial surface properties on fibronectin-alpha 5 beta 1 integrin interaction and cellular attachment. Biomaterials 27, 1907-1916 (2006). (Pubitemid 41759485)
258. Conti, M., G. Donati, G. Cianciolo, S. Stefoni and B. Samori: Force spectroscopy study of the adhesion of plasma proteins to the surface of a dialysis membrane: role of the nanoscale surface hydrophobicity and topography. J Biomed Mater Res 61, 370-379 (2002). (Pubitemid 34666050)
259. Meadows, P. Y. and G. C. Walker: Force microscopy studies of fibronectin adsorption and subsequent cellular adhesion to substrates with well-defined surface chemistries. Langmuir 21, 4096-4107 (2005). (Pubitemid 40654618)
260. Pettit, D. K., T. A. Horbett and A. S. Hoffman: Influence of the substrate binding characteristics of fibronectin on corneal epithelial cell outgrowth. J Biomed Mater Res 26, 1259-1275 (1992).
261. Culp, L. A. and C. N. Sukenik: Cell type-specific modulation of fibronectin adhesion functions on chemically-derivatized self-assembled monolayers. J Biomater Sci Polym Ed 9, 1161-1176 (1998). (Pubitemid 28524165)
262. Scotchford, C. A., C. P. Gilmore, E. Cooper, G. J. Leggett and S. Downes: Protein adsorption and human osteoblast-like cell attachment and growth on alkylthiol on gold self-assembled monolayers. J Biomed Mater Res 59, 84-99 (2002).
263. Keselowsky, B. G., D. M. Collard and A. J. Garcia: Surface chemistry modulates fibronectin conformation and directs integrin binding and specificity to control cell adhesion. J Biomed Mater Res 66A, 247-259 (2003). (Pubitemid 37517224)
264. Pellenc, D., H. Berry and O. Gallet: Adsorption-induced fibronectin aggregation and fibrillogenesis. J Colloid Interface Sci 298, 132-144 (2006).
265. Healy, K. E., C. H. Thomas, A. Rezania, J. E. Kim, P. J. McKeown, B. Lom and P. E. Hockberger: Kinetics of bone cell organization and mineralization on materials with patterned surface chemistry. Biomaterials 17, 195-208 (1996). (Pubitemid 26032285)
266. Schneider, G. B., A. English, M. Abraham, R. Zaharias, C. Stanford and J. Keller: The effect of hydrogel charge density on cell attachment. Biomaterials 25, 3023-3028 (2004). (Pubitemid 38210194)
267. Kilpadi, K. L., A. A. Sawyer, C. W. Prince, P.-L. Chang and S. L. Bellis: Primary human marrow stromal cells and Saos-2 osteosarcoma cells use different mechanisms to adhere to hydroxylapatite. J Biomed Mater Res 68A, 273-285 (2004). (Pubitemid 38524721)
268. Klee, D., Z. Ademovic, A. Bosserhoff, H. Hoecker, G. Maziolis and H.-J. Erli: Surface modification of poly(vinylidenefluoride) to improve the osteoblast adhesion. Biomaterials 24, 3663-3670 (2003). (Pubitemid 36773602)
269. Rapuano, B. E., C. Wu and D. E. MacDonald: Osteoblast-like cell adhesion to bone sialoprotein peptides. J Orthop Res 22, 353-361 (2004). (Pubitemid 38155292)
270. Shin, H., K. Zygouraskis, M. C. Farach-Carson, M. J. Yaszemski and A. G. Mikos: Attachment, proliferation and migration of marrow stromal osteoblasts cultured on biomimetic hydrogels modified with an osteopontin-derived peptide. Biomaterials 25, 895-906 (2004). (Pubitemid 37371997)
271. de Taillac, L. B., M. C. Porte-Durrieu, C. Labrugere, R. Bareille, J. Amedee and C. Baquey: Grafting of RGD peptides to cellulose to enhance human osteoprogenitor cells adhesion and proliferation. Compos Sci Technol 64, 827-837 (2004). (Pubitemid 38398551)
272. Rowley, J. A., G. Madlambayan and D. J. Mooney: Alginate hydrogels as synthetic extracellular matrix materials. Biomaterials 20, 45-53 (1999). (Pubitemid 29002544)
273. Burdick, J. A. and K. S. Anseth: Photoencapsulation of osteoblasts in injectable RGD-modified PEG hydrogels for bone tissue engineering. Biomaterials 23, 4315-4323 (2002).
274. Nguyen, H., J. J. Qian, R. S. Bhatnagar and S. Li: Enhanced cell attachment and osteoblastic activity by P-15 peptide-coated matrix in hydrogels. Biochem Biophys Res Commun 311, 179-186 (2003). (Pubitemid 37297904)
275. Behravesh, E., K. Zygourakis and A. G. Mikos: Adhesion and migration of marrow-derived osteoblasts on injectable in situ crosslinkable poly(propylene fumarate-co-ethylene glycol)-based hydrogels with a covalently linked RGDS peptide. J Biomed Mater Res 65A, 260-270 (2003). (Pubitemid 37521433)
276. Hu, Y., S. R. Winn, I. Krajbich and J. O. Hollinger: Porous polymer scaffolds surface-modified with arginineglycine-aspartic acid enhance bone cell attachment and differentiation in vitro. J Biomed Mater Res 64A, 583-590 (2003). (Pubitemid 37522499)
277. Wiemann, M., H. P. Jennissen, H. Rumpf, L. Winkler, M. Chatzinikolaidou, I. Schmitz and D. Bingmann: A reporter-cell assay for the detection of BMP-2 immobilized on porous and nonporous materials. J Biomed Mater Res 62, 119-127 (2002). (Pubitemid 34831400)
278. Hasenbein, M. E., T. T. Andersen and R. Bizios: Micropatterned surfaces modified with select peptides promote exclusive interactions with osteoblasts. Biomaterials 23, 3937-3942 (2002). (Pubitemid 34756747)
279. Pallu, S., R. Bareille, M. Dard, H. Kessler, A. Jonczyk, M. Vernizeau and J. Amedee-Vilamitjana: A cyclo peptide activates signalling events and promotes growth and the production of the bone matrix. Peptides 24, 1349-1357 (2003). (Pubitemid 38045542)
280. El-Ghannam, A. R., P. Ducheyne, M. Risbud, C. S. Adams, I. M. Shapiro, D. Castner, S. Golledge and R. J. Composto: Model surfaces engineered with nanoscale roughness and RGD tripeptides promote osteoblast activity. J Biomed Mater Res 68A, 615-627 (2004). (Pubitemid 38263928)
281. Harbers, G. M. and K. E. Healy: The effect of ligand type and density on osteoblast adhesion, proliferation, and matrix mineralization. J Biomed Mater Res 75A, 855-869 (2005). (Pubitemid 41772703)
282. Rezania, A. and K. E. Healy: Biomimetic peptide surfaces that regulate adhesion, spreading, cytoskeletal organization and mineralization of the matrix deposited by osteoblast-like cells. Biotechnol Prog 15, 19-32 (1999). (Pubitemid 29087584)
283. Benoit, D. S. W. and K. S. Anseth: Heparin functionalized PEG gels that modulate protein adsorption for hMSC adhesion and differentiation. Acta Biomater 1, 461-470 (2005). (Pubitemid 43348782)
284. Shin, M., H. Yoshimoto and J. P. Vacanti: In vivo bone tissue engineering using mesenchymal stem cells on a novel electrospun nanofibrous scaffold. Tissue Eng 10, 33- 41 (2004). (Pubitemid 38199358)
285. Stile, R. A. and K. E. Healy: Thermo-responsive peptide-modified hydrogels for tissue regeneration. Biomacromolecules 2, 185-194 (2001). (Pubitemid 32707490)
286. Porte-Durrieu, M. C., F. Guillemot, S. Pallu, C. Labrugere, B. Brouillaud, R. Bareille, J. Amedee, N. Barthe, M. Dard and C. Baquey: Cyclo-(DfKRG) peptide grafting onto Ti-6Al-4V: physical characterization and interest towards human osteoprogenitor cells adhesion. Biomaterials 25, 4837-4846 (2004). (Pubitemid 38561172)
287. Barber, T. A., G. M. Harbers, S. Park, M. Gilbert and K. E. Healy: Ligand density characterization of peptide-modified biomaterials. Biomaterials 26, 6897-6905 (2005). (Pubitemid 41095513)
288. Schaffner, P. and M. M. Dard: Structure and function of RGD peptides involved in bone biology. Cell Mol Life Sci 60, 119-132 (2003). (Pubitemid 36223121)
289. Cutler, S. M. and A. J. Garcia: Engineering cell adhesive surfaces that direct integrin alpha 5 beta 1 binding using a recombinant fragment of fibronectin. Biomaterials 24, 1759-1770 (2003). (Pubitemid 36184731)
290. Kantlehner, M., P. Schaffner, D. Finsinger, J. Meyer, A. Jonczyk, B. Diefenbach, B. Nies, G. Holzemann, S. L. Goodman and H. Kessler: Surface coating with cyclic RGD peptides stimulates osteoblast adhesion and proliferation as well as bone formation. Chembiochem 1, 107-114 (2000).
291. Smith, E., J. Yang, L. McGann, W. Sebald and H. Uludag: RGD-grafted thermoreversible polymers to facilitate attachment of BMP-2 responsive C2C12 cells. Biomaterials 26, 7329-7338 (2005). (Pubitemid 41133584)
292. Massia, S. P. and J. A. Hubbell: An RGD spacing of 440 nm is sufficient for integrin alpha v beta 3- mediated fibroblast spreading and 140 nm for focal contact and stress fiber formation. J Cell Biol 114, 1089-1100 (1991). (Pubitemid 21909870)
293. Rezania, A. and K. E. Healy: The effect of peptide surface density on mineralization of a matrix deposited by osteogenic cells. J Biomed Mater Res 52, 595-600 (2000).
294. McCarthy, A. D., T. Uemura, S. B. Etcheverry and A. M. Cortizo: Advanced glycation endproducts interfere with integrin-mediated osteoblastic attachment to a type-I collagen matrix. Int J Biochem Cell Biol 36, 840-848 (2004). (Pubitemid 38299399)
295. McCann, T. J., W. T. Mason, M. C. Meikle and F. McDonald: A collagen peptide motif activates tyrosine kinase-dependent calcium signalling pathways in human osteoblast-like cells. Matrix Biol 16, 273-283 (1997). (Pubitemid 27503813)
296. Mineur, P., A. Guignandon, C. A. Lambert, M. Amblard, C. M. Lapiere and B. V. Nusgens: RGDS and DGEA-induced [Ca2+]i signalling in human dermal fibroblasts. Biochim Biophys Acta 1746, 28-37 (2005). (Pubitemid 41484083)
297. Mizuno, M., R. Fujisawa and Y. Kuboki: Type I collagen-induced osteoblastic differentiation of bonemarrow cells mediated by collagen-alpha 2 beta 1 integrin interaction. J Cell Physiol 184, 207-213 (2000). (Pubitemid 30432312)
298. Yang, X. B., R. S. Bhatnagar, S. Li and R. O. C. Oreffo: Biomimetic collagen scaffolds for human bone cell growth and differentiation. Tissue Eng 10, 1148-1159 (2004). (Pubitemid 39223793)
299. Reyes, C. D. and A. J. Garcia: Engineering integrin-specific surfaces with a triple-helical collagenmimetic peptide. J Biomed Mater Res 65A, 511-523 (2003). (Pubitemid 38075882)
300. Reyes, C. D., T. A. Petrie, K. L. Burns, Z. Schwartz and A. J. Garcia: Biomolecular surface coating to enhance orthopaedic tissue healing and integration. Biomaterials 28, 3228-3235 (2007). (Pubitemid 46654219)
301. Healy, K. E., A. Rezania and R. A. Stile: Designing biomaterials to direct biological responses. Ann NY Acad Sci 875, 24-35 (1999). (Pubitemid 29349059)
302. Kao, W. J., D. Lee, J. C. Schense and T. A. Hubbell: Fibronectin modulates macrophage adhesion and FBGC formation: the role of RGD, PHSRN, and PRRARV domains. J Biomed Mater Res 55, 79-88 (2001). (Pubitemid 32157789)
303. Dettin, M., M. T. Conconi, R. Gambaretto, A. Bagno, C. Di Bello, A. M. Menti, C. Grandi and P. P. Parnigotto: Effect of synthetic peptides on osteoblast adhesion. Biomaterials 26, 4507-4515 (2005). (Pubitemid 40269266)
304. Bagno, A., A. Piovan, M. Dettin, A. Chiarion, P. Brun, R. Gambaretto, G. Fontana, C. Di Bello, G. Palu and I. Castagliuolo: Human osteoblast-like cell adhesion on titanium substrates covalently functionalized with synthetic peptides. Bone 40, 693-699 (2007). (Pubitemid 46187232)
305. Dettin, M., M. T. Conconi, R. Gambaretto, A. Pasquato, M. Folin, C. Di Bello and P. P. Parnigotto: Novel osteoblast-adhesive peptides for dental/orthopedic biomaterials. J Biomed Mater Res 60, 466-471 (2002).
306. Balasundaram, G. and T. J. Webster: Increased osteoblast adhesion on nanograined Ti modified with KRSR. J Biomed Mater Res 80A, 602-611 (2007). (Pubitemid 46239072)
307. Sawyer, A. A., K. M. Hennessy and S. L. Bellis: The effect of adsorbed serum proteins, RGD and proteoglycanbinding peptides on the adhesion of mesenchymal stem cells to hydroxyapatite. Biomaterials 28, 383-392 (2007). (Pubitemid 44602226)
308. Huebsch, N., M. Gilbert and K. E. Healy: Analysis of sterilization protocols for peptide-modified hydrogels. J Biomed Mater Res Part B: Appl Biomater 74B, 440-447 (2005). (Pubitemid 40917714)
309. Abbott, A.: Cell culture: biology's new dimension. Nature 424, 870-872 (2003). (Pubitemid 37051657)
310. Kataoka, K., Y. Nagao, T. Nukui, I. Akiyama, K. Tsuru, S. Hayakawa, A. Osaka and N.-H. Huh: An organic-inorganic hybrid scaffold for the culture of HepG2 cells in a bioreactor. Biomaterials 26, 2509-2516 (2005). (Pubitemid 39600703)
311. Beningo, K. A., M. Dembo and Y.-L. Wang: Responses of fibroblasts to anchorage of dorsal extracellular matrix receptors. Proc Natl Acad Sci USA 101, 18024-18029 (2004). (Pubitemid 40054068)
312. Larsen, M., V. V. Artym, J. A. Green and K. M. Yamada: The matrix reorganized: extracellular matrix remodeling and integrin signalling. Curr Opin Cell Biol 18, 463-471 (2006). (Pubitemid 44332914)
313. Karageorgiou, V. and D. Kaplan: Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials 26, 5474-5491 (2005). (Pubitemid 40592136)
314. Sikavitsas, V. I., G. N. Bancroft and A. G. Mikos: Formation of three-dimensional cell/polymer constructs for bone tissue engineering in a spinner flask and a rotating wall vessel bioreactor. J Biomed Mater Res 62, 136-148 (2002). (Pubitemid 34831402)
315. Ellis, M. J. and J. B. Chaudhuri: Poly(lactic-co-glycolic acid) hollow fibre membranes for use as a tissue engineering scaffold. Biotechnol Bioeng 96, 177-187 (2007). (Pubitemid 46036170)
316. Holtorf, H. L., N. Datta, J. A. Jansen and A. G. Mikos: Scaffold mesh size affects the osteoblastic differentiation of seeded marrow stromal cells cultured in a flow perfusion bioreactor. J Biomed Mater Res 74A, 171-180 (2005). (Pubitemid 40995531)
317. Liu, X. and P. X. Ma: Polymeric scaffolds for bone tissue engineering. Ann Biomed Eng 32, 477-486 (2004).
318. Sharma, B. and J. H. Elisseeff: Engineering structurally organized cartilage and bone tissues. Ann Biomed Eng 32, 148-159 (2004).
319. Okii, N., S. Nishimura, K. Kurisu, Y. Takeshima and T. Uozumi: In vivo histological changes occurring in hydroxyapatite cranial reconstruction - case report. Neurol Med Chir (Tokyo) 41, 100-104 (2001). (Pubitemid 32232971)
320. Hutmacher, D. W. and A. J. Garcia: Scaffold-based bone engineering by using genetically modified cells. Gene 347, 1-10 (2005). (Pubitemid 40348695)
321. Kim, S.-H., Y. R. Choi, M. S. Park, J. W. Shin, K. D. Park, S.-J. Kim and J. W. Lee: ERK 1/2 activation in enhanced osteogenesis of human mesenchymal stem cells in poly(lactic-glycolic acid) by cyclic hydrostatic pressure. J Biomed Mater Res 80A, 826-836 (2007).
322. McBeath, R., D. M. Pirone, C. M. Nelson, K. Bhadriraju and C. S. Chen: Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev Cell 6, 483-495 (2004). (Pubitemid 38456178)
323. Cukierman, E., R. Pankov, D. R. Stevens and K. M. Yamada: Taking cell-matrix adhesions to the third dimension. Science 294, 1708-1712 (2001). (Pubitemid 33104840)
324. Tamariz, E. and F. Grinnell: Modulation of fibroblast morphology and adhesion during collagen matrix remodelling. Mol Biol Cell 13, 3915-3929 (2002). (Pubitemid 35398559)
325. Wozniak, M. A., R. Desai, P. A. Solski, C. J. Der and P. J. Keely: ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix. J Cell Biol 163, 583-595 (2003). (Pubitemid 37429871)
326. Grayson, W. L., T. Ma and B. Bunnell: Human mesenchymal stem cells tissue development in 3D PET matrices. Biotechnol Prog 20, 905-912 (2004). (Pubitemid 38784031)
327. Mao, Y. and J. E. Schwarzbauer: Stimulatory effects of a three-dimensional microenvironment on cell-mediated fibronectin fibrillogenesis. J Cell Sci 118, 4427-4436 (2005). (Pubitemid 41556341)
328. Reich, K. M. and J. A. Frangos: Effect of flow on prostaglandin E2 and inositol trisphosphate levels in osteoblasts. Am J Physiol Cell Physiol 261, C428-C432 (1991).
329. Tanaka, S. M., H. B. Sun, R. K. Roeder, D. B. Burr, C. H. Turner and H. Yokota: Osteoblast responses one hour after load-induced fluid flow in a three-dimensional porous matrix. Calcif Tissue Int 76, 261-271 (2005). (Pubitemid 40991397)
330. Klein-Nulend, J., M. H. Helfrich, J. G. H. Sterck, H. MacPherson, M. Joldersma, S. H. Ralston, C. M. Semeins and E. H. Burger: Nitric oxide response to shear stress by human bone cell cultures is endothelial nitric oxide synthase dependent. Biochem Biophys Res Commun 250, 108-114 (1998). (Pubitemid 28448632)
331. Sikavitsas, V. I., G. N. Bancroft, H. L. Holtorf, J. A. Jansen and A. G. Mikos: Mineralized matrix deposition by marrow stromal osteoblasts in 3D perfusion culture increases with increasing fluid shear forces. Proc Natl Acad Sci USA 100, 14683-14688 (2003). (Pubitemid 37517951)
332. Pavalko, F. M., N. X. Chen, C. H. Turner, D. B. Burr, S. Atkinson, Y.-F. Hsieh, J. Qiu and R. L. Duncan: Fluid shear-induced mechanical signaling in MC3T3-E1 osteoblasts requires cytoskeleton-integrin interactions. Am J Physiol Cell Physiol 275, C1591-C1601 (1998).
333. Thi, M. M., T. Kojima, S. C. Cowin, S. Weinbaum and D. C. Spray: Fluid shear stress remodels expression and function of junctional proteins in cultured bone cells. Am J Physiol Cell Physiol 284, C389-C403 (2003). (Pubitemid 36120077)
334. Wadhwa, S., S. L. Godwin, D. R. Peterson, M. A. Epstein, L. G. Raisz and C. C. Pilbeam: Fluid flow induction of cyclo-oxygenase 2 gene expression in osteoblasts is dependent on an extracellular signal-regulated kinase signaling pathway. J Bone Miner Res 17, 266-274 (2002). (Pubitemid 34087659)
335. Ogasawara, A., T. Arakawa, T. Kaneda, T. Takuma, T. Sato, H. Kaneko, M. Kumegawa and Y. Hakeda: Fluid shear stress-induced cyclooxygenase-2 expression is mediated by C/EBP beta, cAMP-response element-binding protein, and AP-1 in osteoblastic MC3T3-E1 cells. J Biol Chem 276, 7048- 7054 (2001).
336. Ponik, S. M., J. W. Triplett and F. M. Pavalko: Osteoblasts and osteocytes respond differently to oscillatory and unidirectional fluid flow profiles. J Cell Biochem 100, 794-807 (2007). (Pubitemid 46180540)
337. McGarry, J. G., J. Klein-Nulend and P. J. Prendergast: The effect of cytoskeletal disruption on pulsatile fluid flow-induced nitric oxide and prostaglandin E2 release in osteocytes and osteoblasts. Biochem Biophys Res Commun 330, 341-348 (2005). (Pubitemid 40394972)
338. Mehrotra, M., M. Saegusa, S. Wadhwa, O. Voznesensky, D. Peterson and C. Pilbeam: Fluid flow induces Rankl expression in primary murine calvarial osteoblasts. J Cell Biochem 98, 1271-1283 (2006). (Pubitemid 44128365)
339. Bancroft, G. N., V. I. Sikavitsas, J. van den Dolder, T. L. Sheffield, C. G. Ambrose, J. A. Jansen and A. G. Mikos: Fluid flow increases mineralized matrix deposition in 3D perfusion culture of marrow stromal osteoblasts in a dose-dependent manner. Proc Natl Acad Sci USA 99, 12600- 12605 (2002).
340. Johnson, D. L., T. N. McAllister and J. A. Frangos: Fluid flow stimulates rapid and continuous release of nitric oxide in osteoblasts. Am J Physiol Endocrinol Metab 271, E205-E208 (1996).
341. Bakker, A. D., J. Klein-Nulend, E. Tanck, G. H. Albers, P. Lips and E. H. Burger: Additive effects of estrogen and mechanical stress on nitric oxide and prostaglandin E2 production by bone cells from osteoporotic donors. Osteoporos Int 16, 983-989 (2005). (Pubitemid 41127109)
342. Cheng, B., S. Zhao, J. Luo, E. Sprague, L. F. Bonewald and J. X. Jiang: Expression of functional gap junctions and regulation by fluid flow in osteocyte-like MLO-Y4 cells. J Bone Miner Res 16, 249-259 (2001). (Pubitemid 32105406)
343. Klein-Nulend, J., C. M. Semeins, N. E. Ajubi, P. J. Nijweide and E. H. Burger: Pulsating fluid flow increases nitric oxide (NO) synthesis by osteocytes but not periosteal fibroblasts - correlation with prostaglandin up-regulation. Biochem Biophys Res Commun 217, 640-648 (1995). (Pubitemid 26011757)
344. McAllister, T. N., T. Du and J. A. Frangos: Fluid shear stress stimulates prostaglandin and nitric oxide release in bone marrow-derived preosteoclast-like cells. Biochem Biophys Res Commun 270, 643-648 (2000). (Pubitemid 30446888)
345. Zhang, Q., X. Liang, B. Zhu, Q. Dong, L. Xu, L. Xia, J. Hu, J. Fu and M. Liu: Effects of fluid shear stress on mRNA expression of carbonic anhydrase II in polarized rat osteoclasts. Cell Biol Int 30, 714-720 (2006). (Pubitemid 44339605)
346. Kim, C. H., L. You, C. E. Yellowley and C. R. Jacobs: Oscillatory fluid flow-induced shear stress decreases osteoclastogenesis through RANKL and OPG signalling. Bone 39, 1043-1047 (2006). (Pubitemid 44528376)
347. Jiang, G.-L., C. R. White, H. Y. Stevens and J. A. Frangos: Temporal gradients in shear stimulate osteoblastic proliferation via ERK1/2 and retinoblastoma protein. Am J Physiol Endocrinol Metab 283, E383-E389 (2002). (Pubitemid 34827456)
348. Porter, B., R. Zauel, H. Stockman, R. Guldberg and D. Fyhrie: 3-D computational modeling of media flow through scaffolds in a perfusion bioreactor. J Biomech 38, 543-549 (2005). (Pubitemid 40126466)
349. Simmons, C. A., S. Matlis, A. J. Thornton, S. Chen, C.-Y. Wang and D. J. Mooney: Cyclic strain enhances matrix mineralization by adult human mesenchymal stem cells via the extracellular signal-regulated kinase (ERK1/2) signaling pathway. J Biomech 36, 1087-1096 (2003). (Pubitemid 36794104)
350. Pavalko, F. M., R. L. Gerard, S. M. Ponik, P. J. Gallagher, Y. Jin and S. M. Norvell: Fluid shear stress inhibits TNF-alpha-induced apoptosis in osteoblasts: a role for fluid shear stress-induced activation of PI3-kinase and inhibition of caspase-3. J Cell Physiol 194, 194-205 (2003). (Pubitemid 36043634)
351. Tan, S. D., A. M. Kuijpers-Jagtman, C. M. Semeins, A. L. J. J. Bronckers, J. C. Maltha, J. W. von den Hoff, V. Everts and J. Klein-Nulend: Fluid shear stress inhibits TNFalpha-induced osteocyte apoptosis. J Dent Res 85, 905-909 (2006). (Pubitemid 44578600)
352. Bakker, A., J. Klein-Nulend and E. Burger: Shear stress inhibits while disuse promotes osteocyte apoptosis. Biochem Biophys Res Commun 320, 1163-1168 (2004). (Pubitemid 38916665)
353. MacQuarrie, R. A., Y. Fang Chen, C. Coles and G. I. Anderson: Wear-particle-induced osteoclast osteolysis: the role of particulates and mechanical strain. J Biomed Mater Res Part B: Appl Biomater 69B, 104-112 (2004). (Pubitemid 38392005)
354. Muller, U., T. Imwinkelried, M. Horst, M. Sievers and U. Graf-Hausner: Do human osteoblasts grow into open-porous titanium? Eur Cell Mater 11, 8-15 (2006). (Pubitemid 43824726)
355. Riihonen, R., C. T. Supuran, S. Parkkila, S. Pastorekova, H. K. Vaananen and T. Laitala-Leinonen: Membrane-bound carbonic anhydrases in osteoclasts. Bone 40, 1021-1031 (2007). (Pubitemid 46386547)
356. Tuzlakoglu, K., N. Bolgen, A. J. Salgado, M. E. Gomes, E. Piskin and R. L. Reis: Nano- and micro-fiber combined scaffolds: a new architecture for bone tissue engineering. J Mater Sci: Mater Med 16, 1099-1104 (2005). (Pubitemid 41803733)
357. Pazzano, D., K. A. Mercier, J. M. Moran, S. S. Fong, D. D. DiBiasio, J. X. Rulfs, S. S. Kohles and L. J. Bonassar: Comparison of chondrogensis in static and perfused bioreactor culture. Biotechnol Prog 16, 893-896 (2000).
358. Manjubala, I., A. Woesz, C. Pilz, M. Rumpler, N. Fratzl-Zelman, P. Roschger, J. Stampfl and P. Fratzl: Biomimetic mineral-organic composite scaffolds with controlled internal architecture. J Mater Sci: Mater Med 16, 1111-1119 (2005). (Pubitemid 41803735)
359. Lee, K. W., S. Wang, L. Lu, E. Jabbari, B. L. Currier, M. J. Yaszemski: Fabrication and characterization of poly(propylene fumarate) scaffolds with controlled pore structures using 3-dimensional printing and injection molding. Tissue Eng 12, 2801-2811 (2006). (Pubitemid 46141248)
360. Ma, P. X. and R. Zhang: Synthetic nano-scale fibrous extracellular matrix. J Biomed Mater Res 46, 60-72 (1999). (Pubitemid 29233181)
361. Nam, Y. S. and T. G. Park: Biodegradable polymeric microcellular foams by modified thermally induced phase separation method. Biomaterials 20, 1783-1790 (1999). (Pubitemid 29421727)
362. Huang, Z.-M., Y.-Z. Zhang, M. Kotaki and S. Ramakrishna: A review on polymer nanofibers by electrospinning and their applications in nanocomposites. Compos Sci Technol 63, 2223-2253 (2003). (Pubitemid 37124181)
363. Ma, Z., M. Kotaki, R. Inai and S. Ramakrishna: Potential of nanofiber matrix as tissue-engineering scaffolds. Tissue Eng 11, 101-109 (2005). (Pubitemid 40515178)
364. Matthews, J. A., G. E. Wnek, D. G. Simpson and G. L. Bowlin: Electrospinning of collagen nanofibers. Biomacromolecules 3, 232-238 (2002). (Pubitemid 34257140)
365. Pham, Q. P., U. Sharma and A. G. Mikos: Electrospinning of polymeric nanofibers for tissue engineering applications: a review. Tissue Eng 12, 1197-1211 (2006). (Pubitemid 44024491)
366. Subbiah, T., G. S. Bhat, R. W. Tock, S. Parameswaran and S. S. Ramkumar: Electrospinning of nanofibers. J Appl Polym Sci 96, 557-569 (2005). (Pubitemid 40430269)
367. Hartgerink, J. D., E. Beniash and S. I. Stupp: Selfassembly and mineralization of peptide-amphiphile nanofibers. Science 294, 1684-1688 (2001).
368. Zhang, S., T. Holmes, C. Lockshin and A. Rich: Spontaneous assembly of a self-complementary oligopeptide to form a stable macroscopic membrane. Proc Natl Acad Sci USA 90, 3334-3338 (1993). (Pubitemid 23111360)
369. Zhang, S., T. C. Holmes, C. M. DiPersio, R. O. Hynes, X. Su and A. Rich: Self-complementary oligopeptide matrices support mammalian cell attachment. Biomaterials 16, 1385-1393 (1995).
370. Thomson, R. C., M. J. Yaszemski, J. M. Powers and A. G. Mikos: Fabrication of biodegradable polymer scaffolds to engineer trabecular bone. J Biomater Sci Polym Ed 7, 23-38 (1995).
371. Ma, P. X. and J.-W. Choi: Biodegradable polymer scaffolds with well-defined interconnected spherical pore network. Tissue Eng 7, 23-33 (2001). (Pubitemid 32175959)
372. Liao, C.-J., C.-F. Chen, J.-H. Chen, S.-F. Chiang, Y.-J. Lin and K.-Y. Chang: Fabrication of porous biodegradable polymer scaffolds using a solvent merging/particulate leaching method. J Biomed Mater Res 59, 676-681 (2002). (Pubitemid 34044470)
373. Whang, K., C. H. Thomas, K. E. Healy and G. Nuber: A novel method to fabricate bioabsorbable scaffolds. Polymer 36, 837-842 (1995).
374. Harris, L. D., B.-S. Kim and D. J. Mooney: Open pore biodegradable matrices formed with gas foaming. J Biomed Mater Res 42, 396-402 (1998). (Pubitemid 28452514)
375. Sachs, E., M. Cima, P. Williams, D. Brancazio and J. Cornie: Three-dimensional printing: rapid tooling and prototypes directly from a CAD model. J Eng Ind 114, 481-488 (1992). (Pubitemid 23581969)
376. Yoshimoto, H., Y. M. Shin, H. Terai and J. P. Vacanti: A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering. Biomaterials 24, 2077-2082 (2003). (Pubitemid 36298779)
377. Frenot, A. and I. S. Chronakis: Polymer nanofibers assembled by electrospinning. Curr Opin Colloid Interface Sci 8, 64-75 (2003). (Pubitemid 36740825)
378. Gelain, F., D. Bottai, A. Vescovi and S. Zhang: Designer self-assembling peptide nanofiber scaffolds for adult mouse neural stem cell 3-dimensional cultures. PLoS ONE 1, e119 (11 pp.) (2006).
379. Horii, A., X. Wang, F. Gelain and S. Zhang: Biological designer self-assembling peptide nanofiber scaffolds significantly enhance osteoblast proliferation, differentiation and 3-D migration. PLoS ONE 2, e190 (9 pp.) (2007).
380. Hing, K. A., S. M. Best, K. E. Tanner, W. Bonfield and P. A. Revell: Quantification of bone ingrowth within bone-derived porous hydroxyapatite implants of varying density. J Mater Sci: Mater Med 10, 663-670 (1999).
381. Boland, E. D., T. A. Telemeco, D. G. Simpson, G. E. Wnek and G. L. Bowlin: Utilizing acid pretreatment and electrospinning to improve biocompatibility of poly(glycolic acid) for tissue engineering. J Biomed Mater Res Part B: Appl Biomater 71B, 144-152 (2004). (Pubitemid 39299414)
382. Oh, S. H., I. K. Park, J. M. Kim and J. H. Lee: In vitro and in vivo characteristics of PCL scaffolds with pore size gradient fabricated by a centrifugation method. Biomaterials 28, 1664-1671 (2007). (Pubitemid 46098965)
383. Lemaire, T., S. Naili and A. Remond: Multiscale analysis of the coupled effects governing the movement of interstitial fluid in cortical bone. Biomech Model Mechanobiol 5, 39-52 (2006). (Pubitemid 43261229)
384. Bobyn, J. D., R. M. Pilliar, H. U. Cameron and G. C. Weatherly: The optimum pore size for the fixation of porous-surfaced metal implants by the ingrowth of bone. Clin Orthop Relat Res 150, 263-270 (1980). (Pubitemid 10039063)
385. Itala, A. I., H. O. Ylanen, C. Ekholm, K. H. Karlsson and H. T. Aro: Pore diameter of more than 100 microns is not requisite for bone ingrowth in rabbits. J Biomed Mater Res (Appl Biomater) 58, 679-683 (2001). (Pubitemid 33096568)
386. Robinson, B. P., J. O. Hollinger, E. H. Szachowicz and J. Brekke: Calvarial bone repair with porous D, L-polylactide. Otolaryngol Head Neck Surg 112, 707-713 (1995).
387. Goldstein, A. S., T. M. Juarez, C. D. Helmke, M. C. Gustin and A. G. Mikos: Effect of convection on osteoblastic cell growth and function in biodegradable polymer foam scaffolds. Biomaterials 22, 1279-1288 (2001). (Pubitemid 32409949)
388. Ishaug-Riley, S. L., G. M. Crane-Kruger, M. J. Yaszemski and A. G. Mikos: Three-dimensional culture of rat calvarial osteoblasts in porous biodegradable polymers. Biomaterials 19, 1405-1412 (1998). (Pubitemid 28425460)
389. Zou, X., H. Li, A. Baatrup, M. Lind and C. Bunger: Engineering of bone tissue with porcine bone marrow stem cells in three-dimensional trabecular metal: in vitro and in vivo studies. APMIS 111 Suppl 109, 127-132 (2003). (Pubitemid 36723745)
390. Mygind, T., M. Stiehler, A. Baatrup, H. Li, X. Zou, A. Flyvbjerg, M. Kassem and C. Bunger: Mesenchymal stem cell ingrowth and differentiation on coralline hydroxyapatite scaffolds. Biomaterials 28, 1036-1047 (2007). (Pubitemid 44809415)
391. Lu, J. X., B. Flautre, K. Anselme, P. Hardouin, A. Gallur, M. Descamps and B. Thierry: Role of interconnections in porous bioceramics on bone recolonization in vitro and in vivo. J Mater Sci: Mater Med 10, 111-120 (1999). (Pubitemid 29097627)
392. Olivier, V., N. Faucheux and P. Hardouin: Biomaterial challenges and approaches to stem cell use in bone reconstructive surgery. Drug Discov Today 9, 803-811 (2004). (Pubitemid 39201327)
393. Hui, P. W., P. C. Leung and A. Sher: Fluid conductance of cancellous bone graft as a predictor for graft-host interface healing. J Biomech 29, 123-132 (1996). (Pubitemid 26009412)
394. Ma, P. X., R. Zhang, G. Xiao and R. Franceschi: Engineering new bone tissue in vitro on highly porous poly(alpha-hydroxyl acids)/hydroxyapatite composite scaffolds. J Biomed Mater Res 54, 284-293 (2001).
395. Hutmacher, D. W.: Scaffold design and fabrication technologies for engineering tissues - state of the art and future perspectives. J Biomater Sci Polym Ed 12, 107-124 (2001). (Pubitemid 32335467)
396. Christenson, E. M., K. S. Anseth, J. J. J. P. van den Beucken, C. K. Chan, B. Ercan, J. A. Jansen, C. T. Laurencin, W.-J. Li, R. Murugan, L. S. Nair, S. Ramakrishna, R. S. Tuan, T. J. Webster and A. G. Mikos: Nanobiomaterial applications in orthopedics. J Orthop Res 25, 11-22 (2007). (Pubitemid 46070727)
397. Woo, K. M., V. J. Chen and P. X. Ma: Nano-fibrous scaffolding architecture selectively enhances protein adsorption contributing to cell attachment. J Biomed Mater Res 67A, 531-537 (2003). (Pubitemid 37522460)
398. Elias, K. L., R. L. Price and T. J. Webster: Enhanced functions of osteoblasts on nanometer diameter carbon fibers. Biomaterials 23, 3279-3287 (2002). (Pubitemid 34522140)
399. Awwad, H. K., M. el Naggar, N. Mocktar and M. Barsoum: Intercapillary distance measurement as an indicator of hypoxia in carcinoma of the cervix uteri. Int J Radiat Oncol Biol Phys 12, 1329-1333 (1986). (Pubitemid 16030610)
400. Ishaug-Riley, S. L., G. M. Crane, A. Gurlek, M. J. Miller, A. W. Yasko, M. J. Yaszemski and A. G. Mikos: Ectopic bone formation by marrow stromal osteoblast transplantation using poly(DL-lactic-co-glycolic acid) foams implanted into the rat mesentery. J Biomed Mater Res 36, 1-8 (1997). (Pubitemid 27270992)
401. Muschler, G. F., C. Nakamoto and L. G. Griffith: Engineering principles of clinical cell-based tissue engineering. J Bone Joint Surg (Am) 86-A, 1541-1558 (2004). (Pubitemid 38886548)
402. Gerber, H.-P., T. H. Vu, A. M. Ryan, J. Kowalski, Z. Werb and N. Ferrara: VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat Med 5, 623-628 (1999). (Pubitemid 29289424)
403. Shepherd, B. R., H. Y. Chen, C. M. Smith, G. Gruionu, S. K. Williams and J. B. Hoying: Rapid perfusion and network remodeling in a microvascular construct after implantation. Arterioscler Thromb Vasc Biol 24, 898-904 (2004). (Pubitemid 38620869)
404. Matsumoto, T., Y. C. Yung, C. Fischbach, H. J. Kong, R. Nakaoka and D. J. Mooney: Mechanical strain regulates endothelial cell patterning in vitro. Tissue Eng 13, 207-217 (2007). (Pubitemid 46175542)
405. Black, A. F., F. Berthod, N. L'Heureux, L. Germain and F. A. Auger: In vitro reconstruction of a human capillary-like network in a tissue-engineered skin equivalent. FASEB J 12, 1331-1340 (1998). (Pubitemid 28475574)
406. Schechner, J. S., A. K. Nath, L. Zheng, M. S. Kluger, C. C. W. Hughes, M. R. Sierra-Honigmann, M. I. Lorber, G. Tellides, M. Kashgarian, A. L. M. Bothwell and J. S. Pober: In vivo formation of complex microvessels lined by human endothelial cells in an immunodeficient mouse. Proc Natl Acad Sci USA 97, 9191-9196 (2000). (Pubitemid 30626696)
407. Wu, X., E. Rabkin-Aikawa, K. J. Guleserian, T. E. Perry, Y. Masuda, F. W. Sutherland, F. J. Schoen, J. E. Mayer Jr and J. Bischoff: Tissue-engineered microvessels on threedimensional biodegradable scaffolds using human endothelial progenitor cells. Am J Physiol Heart Circ Physiol 287, H480- H487 (2004). (Pubitemid 38955275)
408. Upchurch, G. R. Jr, J. A. Leopold, G. N. Welch and J. Loscalzo: Nitric oxide alters human microvascular endothelial cell response to cyclic strain. J Cardiovasc Pharmacol Ther 3, 135-141 (1998).
409. Liu, X.-M., D. Ensenat, H. Wang, A. I. Schafer and W. Durante: Physiologic cyclic stretch inhibits apoptosis in vascular endothelium. FEBS Lett 541, 52-56 (2003). (Pubitemid 36428916)
410. Jain, R. K.: Molecular regulation of vessel maturation. Nat Med 9, 685-693 (2003). (Pubitemid 36749217)
411. Zachary, I. and G. Gliki: Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family. Cardiovasc Res 49, 568-581 (2001). (Pubitemid 32146420)
412. Hirschi, K. K., S. A. Rohovsky, L. H. Beck, S. R. Smith and P. A. D'Amore: Endothelial cells modulate the proliferation of mural cell precursors via platelet-derived growth factor-BB and heterotypic cell contact. Circ Res 84, 298-305 (1999). (Pubitemid 29095570)
413. Kofron, M. D. and C. T. Laurencin: Bone tissue engineering by gene delivery. Adv Drug Deliv Rev 58, 555- 576 (2006). (Pubitemid 43928172)
414. Pepper, M. S., J.-D. Vassalli, L. Orci and R. Montesano: Biphasic effect of transforming growth factorbeta- 1 on in vitro angiogenesis. Exp Cell Res 204, 356-363 (1993). (Pubitemid 23200200)
415. Rouwkema, J., J. de Boer and C. A. Van Blitterswijk: Endothelial cells assemble into a 3-dimensional prevascular network in a bone tissue engineering construct. Tissue Eng 12, 2685-2693 (2006). (Pubitemid 46141291)
416. Wenger, A., A. Stahl, H. Weber, G. Finkenzeller, H. G. Augustin, G. B. Stark and U. Kneser: Modulation of in vitro angiogenesis in a three-dimensional spheroidal coculture model for bone tissue engineering. Tissue Eng 10, 1536-1547 (2004). (Pubitemid 39557857)
417. Hoying, J. B., C. A. Boswell and S. K. Williams: Angiogenic potential of microvessel fragments established in three-dimensional collagen gels. In Vitro Cell Dev Biol Anim 32, 409-419 (1996). (Pubitemid 26269495)
418. Carter, W. B., K. Uy, M. D. Ward and J. B. Hoying: Parathyroid-induced angiogenesis is VEGF-dependent. Surgery 128, 458-464 (2000).
419. Holder, W. D. Jr, H. E. Gruber, A. L. Moore, C. R. Culberson, W. Anderson, K. J. Burg and D. J. Mooney: Cellular ingrowth and thickness changes in poly-L-lactide and polyglycolide matrices implanted subcutaneously in the rat. J Biomed Mater Res 41, 412-421 (1998). (Pubitemid 28300106)
420. Wake, M. C., C. W. Patrick Jr and A. G. Mikos: Pore morphology effects on the fibrovascular tissue growth in porous polymer substrates. Cell Transplant 3, 339-343 (1994). (Pubitemid 24216213)
421. Martin, Y. and P. Vermette: Bioreactors for tissue mass culture: design, characterization, and recent advances. Biomaterials 26, 7481-7503 (2005). (Pubitemid 41133599)
422. Granet, C., N. Laroche, L. Vico, C. Alexandre and M. H. Lafage-Proust: Rotating-wall vessels, promising bioreactors for osteoblastic cell culture: comparison with others 3D conditions. Med Biol Eng Comput 36, 513-519 (1998). (Pubitemid 28353675)
423. Ontiveros, C. and L. R. McCabe: Simulated microgravity suppresses osteoblast phenotype, Runx2 levels and AP-1 transactivation. J Cell Biochem 88, 427- 437 (2003). (Pubitemid 36158264)
424. Rucci, N., S. Migliaccio, B. M. Zani, A. Taranta and A. Teti: Characterization of the osteoblast-like cell phenotype under microgravity conditions in the NASA-approved Rotating Wall Vessel bioreactor (RWV). J Cell Biochem 85, 167-179 (2002). (Pubitemid 34204079)