Three-dimensional, bioactive, biodegradable, polymer-bioactive glass composite scaffolds with improved mechanical properties support collagen synthesis and mineralization of human osteoblast-like cells in vitro

Journal of Biomedical Materials Research - Part A

Volumn 64, Issue 3, 2003, Pages 465-474

  Lu, Helen H ^a,c,d   El Amin, Saadiq F ^a   Scott, Kimberli D ^a   Laurencin, Cato T ^a,b,c  

^a Drexel University   (United States)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^c DREXEL UNIVERSITY   (United States)

^d NONE   (United States)

Author keywords

Bioactive glass; Bioactivity; Biodegradable; Bone; Composite; Osteointegration; Polymer; Tissue engineering

Indexed keywords

BIODEGRADATION; BONE; CELLS; COLLAGEN; ENZYMES; GLASS; GRAFTING (CHEMICAL); TISSUE CULTURE;

TISSUE ENGINEERING;

BIOMATERIALS;

ALKALINE PHOSPHATASE; BIOMATERIAL; CALCIUM PHOSPHATE; COLLAGEN; COLLAGEN TYPE 1; GLASS; GLYCOLIC ACID; PLASMA PROTEIN; POLYGLACTIN; POLYLACTIC ACID; POLYMER; POLYSTYRENE;

ARTICLE; BONE TRANSPLANTATION; CELL DIFFERENTIATION; CELL GROWTH; CERAMICS; COLLAGEN SYNTHESIS; CONTROLLED STUDY; HUMAN; HUMAN CELL; MORPHOLOGY; OSTEOBLAST; SCANNING ELECTRON MICROSCOPY; TISSUE ENGINEERING; X RAY ANALYSIS;

EID: 0347568470     PISSN: 00219304     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbm.a.10399     Document Type: Article

References (37)

1. Langer R, Vacanti JP. Tissue engineering. Science 1993;260:920-926.
2. Cook SD, Baffes GC, Wolfe MW, Sampath TK, Rueger DC, Whitecloud TS3. The effect of recombinant human osteogenic protein-1 on healing of large segmental bone defects. J Bone Joint Surg Am 1994;76:827-838.
3. Laurencin C.T., Ambrosio AMA, Borden MD, Cooper JA. Tissue engineering: orthopedic applications. Ann Rev Biomed Eng 1999;1:19-46.
4. Laurencin CT, ElAmin SF, Ibim SE, Willoughby DA, Attawia M, Allcock HR, Ambrosio AA. A highly porous 3-dimensional polyphosphazene polymer matrix for skeletal tissue regeneration. J Biomed Mater Res 1996;30:133-138.
5. El-Ghannam A, Ducheyne P, Shapiro IM. Bioactive material template for in vitro synthesis of bone. J Biomed Mater Res 1995;29:359-370.
6. Zhang R, Ma PX. Poly(alpha-hydroxyl acids)/hydroxyapatite porous composites for bone-tissue engineering. I. Preparation and morphology. J Biomed Mater Res 1999;44:446-455.
7. Mikos AG, Sarakinos G, Leite SM, Vacanti JP, Langer R. Laminated three-dimensional biodegradable foams for use in tissue engineering. Biomaterials 1993;14:323-330.
8. Marra KG, Szem JW, Kumta PN, DiMilla PA, Weiss LE. In vitro analysis of biodegradable polymer blend/hydroxyapatite composites for bone tissue engineering. J Biomed Mater Res 1999;47:324-335.
9. Shikinami Y, Okuno M. Bioresorbable devices made of forged composites of hydroxyapatite (HA) particles and poly-L-lactide (PLLA): Part I. Basic characteristics. Biomaterials 1999;20:859-877.
10. Leenslag JW, Pennings AJ, Bos RR, Rozema FR, Boering G. Resorbable materials of poly(L-lactide). VII. In vivo and in vitro degradation. Biomaterials 1987;8:311-314.
11. Leenslag JW, Pennings AJ, Bos RR, Rozema FR, Boering G. Resorbable materials of poly(L-lactide). VI. Plates and screws for internal fracture fixation. Biomaterials 1987;8:70-73.
12. Matsusue Y, Yamamuro T, Oka M, Shikinami Y, Hyon SH, Ikada Y. In vitro and in vivo studies on bioabsorbable ultra-high-strength poly(L-lactide) rods. J Biomed Mater Res 1992;26:1553-1567.
13. Fini M, Giannini S, Giardino R, Giavaresi G, Grimaldi M, Aldini NN, Orienti L, Rocca M. Resorbable device for fracture fixation: in vivo degradation and mechanical behaviour. Int J Artif Organs 1995;18:772-776.
14. Ignjatovic N, Tomic S, Dakic M, Miljkovic M, Plavsic M, Uskokovic D. Synthesis and properties of hydroxyapatite/poly-L-lactide composite biomaterials. Biomaterials 1999;20:809-816.
15. Lin FH, Chen TM, Lin CP, Lee CJ. The merit of sintered PDLLA/TCP composites in management of bone fracture internal fixation. Artif Organs 1999;23:186-194.
16. Slivka MA, Chu CC. Fiber-matrix interface studies on bioabsorbable composite materials for internal fixation of bone fractures. II. A new method using laser scanning confocal microscopy. J Biomed Mater Res 1997;37:353-362.
17. Slivka MA, Chu CC, Adisaputro IA. Fiber-matrix interface studies on bioabsorbable composite materials for internal fixation of bone fractures. I. Raw material evaluation and measurement of fiber-matrix interfacial adhesion. J Biomed Mater Res 1997;36:469-477.
18. Ducheyne P. Bioceramics: material characteristics versus in vivo behavior. J Biomed Mater Res 1987;21:219-236.
19. Hench LL. Bioceramics: from concept to clinic. J Am Ceram Soc 1991;74:1487-1510.
20. Kokubo T. Bioactivity of glasses and glass ceramics. In: Ducheyne P, Kokubo T, van Blitterswijk, editors. Bone-bonding. Amsterdam: Reed Healthcare Communications; 1992. p 31-46.
21. Oonishi H. Orthopaedic applications of hydroxyapatite. Biomaterials 1991;12:171-178.
22. Oonishi H, Kushitani S, Yasukawa E, Iwaki H, Hench LL, Wilson J, et al. Particulate bioglass compared with hydroxyapatite as a bone graft substitute. Clin Orthop 1997;316-325.
23. Davies JE, Baldan N. Scanning electron microscopy of the bone-bioactive implant interface. J Biomed Mater Res 1997;36:429-440.
24. Hench LL, Wilson J. Surface-active biomaterials. Science 1984;226:630-636.
25. Gatti AM, Valdre G, Andersson OH. Analysis of the in vivo reactions of a bioactive glass in soft and hard tissue. Biomaterials 1994;15:208-212.
26. Schepers E, de Clercq M, Ducheyne P, Kempeneers R. Bioactive glass particulate material as a filler for bone lesions. J Oral Rehabil 1991;18:439-452.
27. Yaszemski MJ, Payne RG, Hayes WC, Langer R, Mikos AG. Evolution of bone transplantation: molecular, cellular and tissue strategies to engineer human bone. [Review] Biomaterials 1996;17:175-185.
28. Habal MB, Reddi AH. Bone grafts and bone induction substitutes. [Review] Clin Plastic Surg 1994;21:525-542.
29. El-Amin SF, Attawia M, Lu HH, Shah AK, Chang R, Hickok NJ, Tuan RS, Laurencin CT. Integrin expression by human osteoblasts cultured on degradable polymeric materials applicable for tissue engineered bone. J Orthop Res 2002;20:20-28.
30. Borden MD, El-Amin M, Attawia M, Laurencin C.T. Structural and human cellular assessment of novel microsphere-based tissue engineered scaffold for bone repair. Biomaterials. In press.
31. Lu HH, El-Amin S, Laurencin CT. 3-D Porous polymer-bioactive glass composite promotes collagen synthesis and mineralization of human osteoblast-like cells. Sixth World Biomaterials Congress Transactions 2000;II:972-972 (Abstract).
32. Niederauer GG, Cullen LC, Kieswetter K., Leatherbury N.C., Walter M.A., Greenspan DC, et al. Development of polylactide-co-glycolide/bioglass composites. [Abstract] Soc Biomater Proc 1997;23:162-162.
33. Qiu QQ, Ducheyne P, Ayyaswamy PS. New bioactive, degradable composite microspheres as tissue engineering substrates. J.Biomed.Mater.Res. 2000;52:66-76.
34. Marcolongo M, Ducheyne P, Garino J, Schepers E. Bioactive glass fiber/polymeric composites bond to bone tissue. J Biomed Mater Res 1998;39:161-170.
35. Qiu Q, Ducheyne P, Ayyaswamy P. 3-D bone tissue engineering with bioactive and resorbable microcarriers. [Abstract] Sixth World Biomaterials Congress Transactions 2000;II:938-938.
36. Lu HH, Pollack SR, Ducheyne P. Temporal zeta potential variations of 45S5 bioactive glass immersed in an electrolyte solution. J Biomed Mater Res 2000;51:80-87.
37. El-Ghannam A, Ducheyne P, Shapiro IM. Bioactive material template for in vitro synthesis of bone. J. Biomed Mater Res 1998;40:48-56.