Ectopic bone formation via rhBMP-2 delivery from porous bioabsorbable polymer scaffolds

Journal of Biomedical Materials Research

Volumn 42, Issue 4, 1998, Pages 491-499

  Whang, K ^a,b   Tsai, D C ^c   Nam, E K ^c   Aitken, M ^c   Sprague, S M ^c   Patel, P K ^d   Healy, K E ^a,b,e  

^a Division of Biological Materials   (United States)

^b Northwestern University   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d CHILDREN'S MEMORIAL HOSPITAL   (United States)

^e NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Biodegradable; Bone morphogenetic protein; Bone regeneration; Osteogenesis; Polymer

Indexed keywords

BIOASSAY; BONE; DRUG THERAPY; POLYMERS; POROUS MATERIALS; PROTEINS; RADIOGRAPHY; TISSUE CULTURE;

BONE MORPHOGENETIC PROTEIN; BONE REGENERATION; HISTOMORPHOMETRY; OSTEOGENESIS; RADIOMORPHOMETRY; TISSUE ENGINEERING;

IMPLANTS (SURGICAL);

BONE MORPHOGENETIC PROTEIN; POLYMER; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOAVAILABILITY; BONE PROSTHESIS; CELL PROLIFERATION; CONTROLLED STUDY; DEVICE; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; ECTOPIC TISSUE; HISTOPATHOLOGY; MORPHOMETRICS; NONHUMAN; PROTEIN EXPRESSION; RAT;

ABSORPTION; ANIMALS; BIOPOLYMERS; BONE AND BONES; BONE MORPHOGENETIC PROTEINS; CHORISTOMA; DRUG CARRIERS; HUMANS; OSTEOGENESIS; PROSTHESES AND IMPLANTS; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0032534524     PISSN: 00219304     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4636(19981215)42:4<491::AID-JBM3>3.0.CO;2-F     Document Type: Article

References (38)

1. F. G. Heineken and R. Skalak, "Tissue engineering: A brief overview," J. Biomech. Eng., 113, 111-112 (1991).
2. J. H. Brauker, V. E. Carr-Brendel, L. A. Martinson, J. Crudele, W. D. Johnston, and R. C. Johnson, "Neovascularization of synthetic membranes directed by membrane microarchitecture," J. Biomed. Mater. Res., 29, 1517-1524 (1995).
3. D. J. Mooney, L. Cima, R. Langer, L. Johnson, L. K. Hansen, D. E. Ingber, and J. P. Vacanti, "Principles of tissue engineering and reconstruction using polymer-cell constructs," Mater. Res. Soc. Symp. Proc., 252, 345-352 (1992).
4. J. Glowacki, E. Trepman, and J. Folkman, "Cell shape and phenotypic expression in chondrocytes," Proc. Soc. Exp. Biol. Med., 172, 93-98 (1983).
5. J. J. Klawitter and S. F. Hulbert, "Application of porous ceramics for the attachment of load-bearing internal orthopedic applications," J. Biomed. Mater. Res. Symp., 2, 161-229 (1971).
6. K. Whang, K. E. Healy, D. R. Elenz, E. K. Nam, D. C. Tsai, C. H. Thomas, G. W. Nuber, F. H. Glorieux, R. Travers, and S. M. Sprague, "Engineering bone regeneration with bioabsorbable scaffolds with novel microarchitecture," Tissue Eng., to appear.
7. A. Rezania, C. H. Thomas, A. B. Branger, C. M. Waters, and K. E. Healy, "Detachment strength and morphology of bone cells contacting materials modified with a peptide sequence found within bone sialoprotein," J. Biomed. Mater. Res., 37,9-19 (1997).
8. K. E. Healy, D. Tsai, and J. E. Kim, "Osteogenic cell attachment to degradable polymers," Mater. Res. Soc. Symp. Proc., 252,109-114 (1992).
9. L. E. Freed, J. C. Marquis, A. Nohria, J. Emmanual, A. G. Mikos, and R. Langer, "Neocartilage formation in vitro and in vivo using cells cultured on synthetic biodegradable polymers," J. Biomed. Mater. Res., 27, 11-23 (1993).
10. J. Beumer, C. A. van Blitterswijk, and M. Ponec, "Biocompatibility of a biodegradable matrix used as a skin substitute: An in vivo evaluation," J.Biomed. Mater. Res., 28, 545-552 (1994).
11. S. Gogolewski, M. Jovanovic, S. M. Perren, J. G. Dillon, and M. K. Hughes, "Tissue response and in vivo degradation of selected polyhydroxyacids: Polylactides (PLA), poly(3-hydroxybutyrate) (PHB), and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHB/VA)," J. Biomed. Mater. Res., 27, 1135-1148 (1993).
12. M. Centrella, M. C. Horowitz, J. M. Wozney, and T. L. McCarthy, "Transforming growth factor-beta gene family members and bone," Endocrin. Rev., 15, 27-39 (1994).
13. J. M. Wozney, "The bone morphogenetic protein family and osteogenesis," Mol. Reprod. Dev., 32, 160-167 (1992).
14. R. Langer, "New methods of drug delivery," Science, 249, 1527-1533 (1990).
15. T. K. Sampath, J. C. Maliakal, P. V. Hauschka, W. K. Jones, H. Sasak, R. F. Tucker, K. H. White, J. E. Coughlin, M. M. Tucker, R. H. L. Pang, C. Corbett, E. Özkaynak, H. Öppermann, and D. C. Rueger, "Recombinant human osteogenic protein (hOP)-1 induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro," J Biol. Chem., 267, 20352-20362 (1992).
16. L S. Beck, E. P. Amento, Y. Xu, L. Deguzman, W. P. Lee, T. Nguyen, and N. A. Gellet, "TGF-beta 1 induces bone closure of skull defects: Temporal dynamics of bone formation in defects exposed to rhTGF-beta 1," J. Bone Miner. Res., 8,753-761 (1993).
17. E. A. Wang, V. Rosen, J. S. D'Alessandro, M. Bauduy, P. Cordes, T. Harada, D. I. Israel, R. M. Hewick, K. M. Kerns, P. LaPan, D. P. Luxenberg, D. McQuaid, I. K. Moutsatsos, J. Nove, and J. M. Wozney, "Recombinant human bone morphogenetic protein induces bone formation," Proc. Natl. Acad. Sci. USA, 87, 2220-2224 (1990).
18. L. S. Beck, A. J. Ammann, T. B. Aufdemorte, L. Deguzman, Y. Xu, W. P. Lee, L. A. McFatridge, and T. L. Chen, "In vivo induction of bone by recombinant human transforming growth factor beta 1," J. Bone Miner. Res., 6, 961-968 (1991).
19. T. K. Sampath, K. E. Rashka, J. S. Doctor, R. F. Tucker, and F. M. Hoffmann, "Drosophila transforming growth factor beta superfamily proteins induce endochondral bone formation in mammals," Proc. Natl. Acad. Sci. USA, 90, 6004-6008 (1993).
20. M. Liebergall, R. G. Young, N. Ozawa, J. H. Reese, D. T. Davy, V. M. Goldberg, and A. I. Caplan, "The effects of cellular manipulation and TGF-β in a composite bone graft," in Bone Formation and Repair, C. T. Brighton, G. E. Friedlaender, and J. M. Lane (eds.), Academic Academy of Orthopaedic Surgeons, Rosemont, Illinois, 1994, pp. 367-378.
21. S. Miyamoto, K. Takaoka, and K. Ono, "Bone induction in monkeys by bone morphogenetic protein. A trans-filter technique," J. Bone Joint Surg., 75-B, 107-110 (1993).
22. A. Yamaguchi, T. Katagiri, T. Ikeda, J. M. Wozney, V. Rosen, E. A. Wang, A. J. Kahn, T. Suda, and S. Yoshiki, "Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro," J. Cell Biol., 113, 681-687 (1991).
23. R. A. Kenley, K. Yim, J. Abrams, E. Ron, T. Turek, L. J. Marden, and J. O. Hollinger, "Biotechnology and bone graft substitutes," Pharm. Res., 10, 1393-1401 (1993).
24. E. E. Johnson, M. R. Urist, and G. A. M. Finerman, "Bone morphogenetic protein augmentation grafting of resistant femoral nonunions. A preliminary report," Clin. Orthop., 230, 257-(1988).
25. Y. Takuwa, C. Ohse, E. A. Wang, J. M. Wozney, and K. Yamashita, "Bone morphogenetic protein-2 stimulates alkaline phosphatase activity and collagen synthesis in cultured osteoblastic cells, MC3T3-E1," Biochem. Biophys. Res. Commun., 174, 96-101 (1991).
26. K. Bessho, "Ectopic osteoinductive difference between purified bovine and recombinant human bone morphogenetic protein," in Bone Morphogenetic Proteins: Biology, Biochemistry and Reconstructive Surgery, T. S. Lindholm (ed.), R. G. Landes Co., Georgetown, Texas, 1996, pp. 105-111.
27. K. Whang, C. K. Thomas, G. Nuber, and K. E. Healy, "A novel method to fabricate bioabsorbable scaffolds," Polymer, 36, 837-842 (1995).
28. K. Whang, T. K. Goldstick, and K. E. Healy, "Controlled release of macromolecules from bioabsorbable emulsion freeze-dried scaffolds: In vitro protein release," J. Contr. Rel., submiited.
29. J. P. Bearinger, D. G. Castner, S. L. Golledge, S. Hubchak, and K. E. Healy, "P(AAM-co-EG) interpenetrating polymer networks grafted to oxide surfaces: Surface characterization, protein adsorption, and cell detachment studies," Langmuir, 13, 5175-5183 (1997).
30. S. Miyamoto and K. Takaoka, "Bone induction and bone repair by composites of bone morphogenetic protein and biodegradable synthetic polymers," Ann. Chir. Gynaecol., 82, 69-75 (1993).
31. C. J. Damien, P. S. Christel, J. J. Benedict, J.-L. Patat, and G. Guillemin, "A composite of natural coral, collagen, bone protein and basic fibroblast growth factor tested in a rat subcutaneous model," Ann. Chir. Gynaecol., 82, 117-128 (1993).
32. O. M. Bostman, "Absorbable implants for the fixation of fractures," J. Bone Joint Surg., 73-A, 148-153 (1991).
33. J. Suganuma and H. Alexander, "Biological response of intra-medullary bone to poly-L-lactic acid," J. Appl. Biomater., 4,13-27 (1993).
34. M. Therin, P. Christel, S. Li, H. Carreau, and M. Vert, "In vivo degradation of massive poly(alpha-hydroxy acids): Validation of in vitro findings," Biomaterials, 13, 594-600 (1992).
35. K. Whang, T. K. Goldstick, and K. E. Healy, "Controlled release of protein from emulsion freeze-dried PLGA scaffold," Proc. Int. Symp. Control. Rel. Bioact. Mater., 22, 536 (1995).
36. T. Verrecchia, P. Huve, D. Bazile, M. Veillard, G. Spenlehauer, and P. Couvreur, "Adsorption/desorption of human serum albumin at the surface of poly(lactic acid) nanoparticles prepared by a solvent evaporation process," J. Biomed. Mater. Res., 27, 1019-1028 (1993).
37. F. MacRitchie, "Consequences of protein adsorption at fluid interfaces," in Proteins at Interfaces: Physicochemical and Biochemical Studies, J. L. Brash and T. A. Horbett (eds.), American Chemical Society, Washington, DC, 1987, pp. 176-178.
38. W. Norde and J. Lyklema, "Why proteins prefer interfaces?," J. Biomater. Sci., Polym. Edn., 2, 183-202 (1991).