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Volumn 5, Issue 6, 1999, Pages 623-628

VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC PROTEIN; VASCULOTROPIN;

EID: 0033027858     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/9467     Document Type: Article
Times cited : (1779)

References (44)
  • 1
    • 0001786414 scopus 로고
    • eds. Hall, B.K. & Newman, S.A. CRC Press, Boca Raton, Florida
    • Poole, A.R. in Cartilage: Molecular Aspects (eds. Hall, B.K. & Newman, S.A.) 179-211 (CRC Press, Boca Raton, Florida, 1991).
    • (1991) Cartilage: Molecular Aspects , pp. 179-211
    • Poole, A.R.1
  • 2
    • 0003132436 scopus 로고
    • ed. Weiss, L. Urban & Schwarzemberg, New York
    • Jee, W.S.S. in Cell and Tissue Biology (ed. Weiss, L.) 213-253 (Urban & Schwarzemberg, New York, 1988).
    • (1988) Cell and Tissue Biology , pp. 213-253
    • Jee, W.S.S.1
  • 3
    • 0028073943 scopus 로고
    • Induction of growth plate cartilage ossification by basic fibroblast growth factor
    • Baron J. et al. Induction of growth plate cartilage ossification by basic fibroblast growth factor. Endocrinology 135, 2790-2793 (1994).
    • (1994) Endocrinology , vol.135 , pp. 2790-2793
    • Baron, J.1
  • 4
    • 0032568608 scopus 로고    scopus 로고
    • CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth
    • Babic A.M., Kireeva M.L., Kolesnikova T.V., & Lau L.F. CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth. Proc. Natl. Acad. Sci. USA 95, 6355-6360 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 6355-6360
    • Babic, A.M.1    Kireeva, M.L.2    Kolesnikova, T.V.3    Lau, L.F.4
  • 5
    • 0027512284 scopus 로고
    • Differential expression of insulin-like growth factor-I (IGF-I) and IGF-II messenger ribonucleic acid in growing rat bone
    • Shinar, D.M., Endo, N., Halperin, D., Rodan, G.A, & Weinreb, M. Differential expression of insulin-like growth factor-I (IGF-I) and IGF-II messenger ribonucleic acid in growing rat bone. Endocrinology 132, 1158-1167 (1993).
    • (1993) Endocrinology , vol.132 , pp. 1158-1167
    • Shinar, D.M.1    Endo, N.2    Halperin, D.3    Rodan, G.A.4    Weinreb, M.5
  • 6
    • 0029360399 scopus 로고
    • Transforming growth factor-beta 1 and fibroblast growth factors in rat growth plate
    • Jingushi, S, Scully, S.P., Joyce, M.E., Sugioka, Y., & Bolander, M.E. Transforming growth factor-beta 1 and fibroblast growth factors in rat growth plate. J. Orthop. Res. 13, 761-768 (1995).
    • (1995) J. Orthop. Res. , vol.13 , pp. 761-768
    • Jingushi, S.1    Scully, S.P.2    Joyce, M.E.3    Sugioka, Y.4    Bolander, M.E.5
  • 7
    • 0030864073 scopus 로고    scopus 로고
    • Transferrin promotes endothelial cell migration and invasion: Implication in cartilage neovascularization
    • Carlevaro, M.F. et al. Transferrin promotes endothelial cell migration and invasion: implication in cartilage neovascularization J. Cell Biol. 136, 1375-1384 (1997).
    • (1997) J. Cell Biol. , vol.136 , pp. 1375-1384
    • Carlevaro, M.F.1
  • 8
    • 0031039243 scopus 로고    scopus 로고
    • The biology of vascular endothelial growth factor
    • Ferrara, N. & Davis-Smyth, T. The biology of vascular endothelial growth factor. Endocr. Rev. 18, 4-25 (1997).
    • (1997) Endocr. Rev. , vol.18 , pp. 4-25
    • Ferrara, N.1    Davis-Smyth, T.2
  • 9
    • 0029021660 scopus 로고
    • Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
    • Fong, G. H., Rossant, J., Gertsenstein, M., & Breitman, M. L. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 376, 66-70 (1995).
    • (1995) Nature , vol.376 , pp. 66-70
    • Fong, G.H.1    Rossant, J.2    Gertsenstein, M.3    Breitman, M.L.4
  • 10
    • 0029006696 scopus 로고
    • Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
    • Shalaby, F. et al. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature 376, 62-66 (1995).
    • (1995) Nature , vol.376 , pp. 62-66
    • Shalaby, F.1
  • 11
    • 0027997863 scopus 로고
    • Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor
    • Waltenberger, J., Claesson-Welsh, L., Siegbahn, A., Shibuya, M. & Heldin, C.-H. Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor J. Biol. Chem. 268, 26988-26995 (1994).
    • (1994) J. Biol. Chem. , vol.268 , pp. 26988-26995
    • Waltenberger, J.1    Claesson-Welsh, L.2    Siegbahn, A.3    Shibuya, M.4    Heldin, C.-H.5
  • 12
    • 0029920944 scopus 로고    scopus 로고
    • Identification of VEGF determinants for binding Flt-1 and KDR receptors. Generation of receptor-selective VEGF variants by site-directed mutagenesis
    • Keyt, B.A. et al. Identification of VEGF determinants for binding Flt-1 and KDR receptors. Generation of receptor-selective VEGF variants by site-directed mutagenesis. J. Biol. Chem. 271, 5638-5646 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 5638-5646
    • Keyt, B.A.1
  • 13
    • 0032515047 scopus 로고    scopus 로고
    • VEGF regulates endothelial cell survival by the PI3-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation
    • Gerber, H.P. et al. VEGF regulates endothelial cell survival by the PI3-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation. J. Biol. Chem. 273, 30336-30345 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 30336-30345
    • Gerber, H.P.1
  • 14
    • 0032482978 scopus 로고    scopus 로고
    • Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice
    • Hiratsuka, S., Minowa, O., Kuno, J., Noda, T., and Shibuya, M. Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice. Proc. Natl. Acad. Sci. USA 95, 9349-9354 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 9349-9354
    • Hiratsuka, S.1    Minowa, O.2    Kuno, J.3    Noda, T.4    Shibuya, M.5
  • 15
    • 0029867554 scopus 로고    scopus 로고
    • Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1
    • Barleon, B. et al. Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1. Blood 87 3336-3343 (1996).
    • (1996) Blood , vol.87 , pp. 3336-3343
    • Barleon, B.1
  • 16
    • 0032549799 scopus 로고    scopus 로고
    • Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor
    • Soker, S., Takashima, S., Miao, H. Q., Neufeld, G., & Klagsbrun, M. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 92 735-745 (1998).
    • (1998) Cell , vol.92 , pp. 735-745
    • Soker, S.1    Takashima, S.2    Miao, H.Q.3    Neufeld, G.4    Klagsbrun, M.5
  • 17
    • 0030004485 scopus 로고    scopus 로고
    • Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
    • Ferrara, N. et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380, 439-442 (1996).
    • (1996) Nature , vol.380 , pp. 439-442
    • Ferrara, N.1
  • 18
    • 0343920277 scopus 로고    scopus 로고
    • Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
    • Carmeliet, P. et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380, 435-439 (1996).
    • (1996) Nature , vol.380 , pp. 435-439
    • Carmeliet, P.1
  • 19
    • 0032931234 scopus 로고    scopus 로고
    • VEGF is required for growth and survival in neonatal mice
    • Gerber, H. P. et al. VEGF is required for growth and survival in neonatal mice. Development. 126, 1149-1159 (1999).
    • (1999) Development , vol.126 , pp. 1149-1159
    • Gerber, H.P.1
  • 20
    • 0031940839 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is essential for corpus luteum angiogenesis
    • Ferrara, N. et al. Vascular endothelial growth factor is essential for corpus luteum angiogenesis. Nature Med. 4, 336-340 (1998).
    • (1998) Nature Med. , vol.4 , pp. 336-340
    • Ferrara, N.1
  • 21
    • 0029790466 scopus 로고    scopus 로고
    • The second immunoglobulin-like domain of the VEGF tyrosine kinase receptot Flt-1 determines ligand binding and may initiate a signal transduction cascade
    • Davis-Smyth, T., Chen, H., Park, J., Presta, L.G., & Ferrara, N. The second immunoglobulin-like domain of the VEGF tyrosine kinase receptot Flt-1 determines ligand binding and may initiate a signal transduction cascade. EMBO J. 15, 4919-4927 (1996).
    • (1996) EMBO J. , vol.15 , pp. 4919-4927
    • Davis-Smyth, T.1    Chen, H.2    Park, J.3    Presta, L.G.4    Ferrara, N.5
  • 22
    • 0025251582 scopus 로고
    • Completion of the intron-exon structure of the gene for human type II procollagen (COL2A1): Variations in the nucleotide sequences of the alleles from three chromosomes
    • Ala-Kokko, L., & Prockop, D. J. Completion of the intron-exon structure of the gene for human type II procollagen (COL2A1): variations in the nucleotide sequences of the alleles from three chromosomes. Genomics 8, 454-460 (1990).
    • (1990) Genomics , vol.8 , pp. 454-460
    • Ala-Kokko, L.1    Prockop, D.J.2
  • 23
    • 0027459150 scopus 로고
    • The mouse collagen X gene: Complete nucleotide sequence, exon structure and expression pattern
    • Elima, K. et al. The mouse collagen X gene: complete nucleotide sequence, exon structure and expression pattern. Biochem. J. 289, 247-253 (1993).
    • (1993) Biochem. J. , vol.289 , pp. 247-253
    • Elima, K.1
  • 24
    • 0024457668 scopus 로고
    • Condensation of hypertrophic chondrocytes at the chondro-osseous junction of growth plate cartilage in Yucatan swine: Relationship to long bone growth
    • Farnum, C.E. & Wilsman, N.J. Condensation of hypertrophic chondrocytes at the chondro-osseous junction of growth plate cartilage in Yucatan swine: relationship to long bone growth. Am. J. Anot. 186, 346-358 (1989).
    • (1989) Am. J. Anot. , vol.186 , pp. 346-358
    • Farnum, C.E.1    Wilsman, N.J.2
  • 25
    • 0026748311 scopus 로고
    • Chondroclasts and endothelial cells collaborate in the process of cartilage resorption
    • Lewinson, D., & Silberman, M. Chondroclasts and endothelial cells collaborate in the process of cartilage resorption. Anat. Rec. 233, 504-514 (1992).
    • (1992) Anat. Rec. , vol.233 , pp. 504-514
    • Lewinson, D.1    Silberman, M.2
  • 26
    • 0346963598 scopus 로고    scopus 로고
    • MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes
    • Vu, T.H. et al. MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell 93, 411-422 (1998).
    • (1998) Cell , vol.93 , pp. 411-422
    • Vu, T.H.1
  • 27
    • 0032491429 scopus 로고    scopus 로고
    • Homologous up-regulation of KDR/Flk-1 receptor expression by vascular endothelial growth factor in vitro
    • Shen, B.Q. et al. Homologous up-regulation of KDR/Flk-1 receptor expression by vascular endothelial growth factor in vitro. J. Biol. Chem. 273, 29979-29985 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 29979-29985
    • Shen, B.Q.1
  • 28
    • 0030609013 scopus 로고    scopus 로고
    • Vascular endothelial growth factor up-regulates its receptor fms- Like tyrosine kinase 1 (FLT-1) and a soluble variant of FLT-1 in human vascular endothelial cells
    • Barleon, B. et al. Vascular endothelial growth factor up-regulates its receptor fms- like tyrosine kinase 1 (FLT-1) and a soluble variant of FLT-1 in human vascular endothelial cells. Cancer Res. 57, 5421-5425 (1997).
    • (1997) Cancer Res. , vol.57 , pp. 5421-5425
    • Barleon, B.1
  • 29
    • 0028803509 scopus 로고
    • Vascular endothelial growth factor acts a s survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity
    • Alon, T. et al. Vascular endothelial growth factor acts a s survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nature Med. 1, 1024-1028 (1995).
    • (1995) Nature Med. , vol.1 , pp. 1024-1028
    • Alon, T.1
  • 30
    • 0029949160 scopus 로고    scopus 로고
    • Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by anti-VEGF/VPF antibody
    • Yuan, F. et al. Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by anti-VEGF/VPF antibody Proc. Nat. Acad. Sci. USA 93, 14765-14770 (1996).
    • (1996) Proc. Nat. Acad. Sci. USA , vol.93 , pp. 14765-14770
    • Yuan, F.1
  • 32
    • 0028237788 scopus 로고
    • Vasculotropin/vascular endothelial growth factor induces differentiation in cultured osteoblasts
    • Midy, V. & Plouet, J. Vasculotropin/vascular endothelial growth factor induces differentiation in cultured osteoblasts. Biochem. Biophys. Res. Commun. 199 380-386 (1994).
    • (1994) Biochem. Biophys. Res. Commun. , vol.199 , pp. 380-386
    • Midy, V.1    Plouet, J.2
  • 33
    • 0031780324 scopus 로고    scopus 로고
    • Vascular development and disorders: Molecular analysis and pathogenic insights
    • Carmeliet, P., & Collen, D. Vascular development and disorders: molecular analysis and pathogenic insights. Kidney Internat. 53, 1519-1549 (1998).
    • (1998) Kidney Internat. , vol.53 , pp. 1519-1549
    • Carmeliet, P.1    Collen, D.2
  • 34
    • 0032192493 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-C: A growth factor for lymphatic and blood vessel endothelial cells
    • Enholm, B., Jussila, L., Karkkainen, M., & Alitalo, K. Vascular endothelial growth factor-C: A growth factor for lymphatic and blood vessel endothelial cells. Trends Cardiovasc. Med. 8, 292-296 (1998).
    • (1998) Trends Cardiovasc. Med. , vol.8 , pp. 292-296
    • Enholm, B.1    Jussila, L.2    Karkkainen, M.3    Alitalo, K.4
  • 35
    • 0032979775 scopus 로고    scopus 로고
    • Preclinical safety evaluation of rhuMAbVEGF, an antiangiogenic humanized monoclonal antibody
    • Ryan, A.M. et al. Preclinical safety evaluation of rhuMAbVEGF, an antiangiogenic humanized monoclonal antibody. Toxicol. Pathol. 27, 78-86 (1999).
    • (1999) Toxicol. Pathol. , vol.27 , pp. 78-86
    • Ryan, A.M.1
  • 37
    • 0030987617 scopus 로고    scopus 로고
    • 1,25-Dihydroxyvitamin D3 induces the expression of vascular endothelial growth factor in osteoblastic cells
    • Schlaeppi, J.M., Gutzwiller, S., Finkenzeller, G., & Fournier, B. 1,25-Dihydroxyvitamin D3 induces the expression of vascular endothelial growth factor in osteoblastic cells. Endocr. Res. 23, 213-229 (1997).
    • (1997) Endocr. Res. , vol.23 , pp. 213-229
    • Schlaeppi, J.M.1    Gutzwiller, S.2    Finkenzeller, G.3    Fournier, B.4
  • 38
    • 0021222872 scopus 로고
    • Opsismodysplasia: A new type of chondrodysplasia with predominant involvement of the bones of the hand and the vertebrae
    • Maroteaux, P. et al. Opsismodysplasia: a new type of chondrodysplasia with predominant involvement of the bones of the hand and the vertebrae. Am. J. Med. Genet. 19, 171-182 (1984).
    • (1984) Am. J. Med. Genet. , vol.19 , pp. 171-182
    • Maroteaux, P.1
  • 41
    • 0025863378 scopus 로고
    • Specific hybridization probes for mouse type I, II, III and IX collagen mRNAs
    • Metsaranta, M., Toman, D., De Crombrugghe, B., & Vuorio, E. Specific hybridization probes for mouse type I, II, III and IX collagen mRNAs. Biochim. Biophys. Acta 1089, 241-243 (1991).
    • (1991) Biochim. Biophys. Acta , vol.1089 , pp. 241-243
    • Metsaranta, M.1    Toman, D.2    De Crombrugghe, B.3    Vuorio, E.4
  • 42
    • 0028223234 scopus 로고
    • High expression of 92-kD type IV collagenase (gelatinase B) in the osteoclast lineage during mouse development
    • Reponen, P., Sahlberg, C., Munaut, C., Thesleff, I., & Tryggvason, K. High expression of 92-kD type IV collagenase (gelatinase B) in the osteoclast lineage during mouse development. J. Cell Biol. 124, 1091-1102 (1994).
    • (1994) J. Cell Biol. , vol.124 , pp. 1091-1102
    • Reponen, P.1    Sahlberg, C.2    Munaut, C.3    Thesleff, I.4    Tryggvason, K.5
  • 43
    • 0027184550 scopus 로고
    • Molecular cloning of murine FLT and FLT4
    • Finnerty, H. et al. Molecular cloning of murine FLT and FLT4. Oncogens 8, 2293-2298 (1993).
    • (1993) Oncogens , vol.8 , pp. 2293-2298
    • Finnerty, H.1
  • 44
    • 0027249239 scopus 로고
    • Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium
    • Quinn, T.P., Peters, K.G., deVries, C., Ferrara, N. & Williams, L.T. Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium. Proc. Natl. Acad. Sci. USA 90, 7533-7537 (1993).
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 7533-7537
    • Quinn, T.P.1    Peters, K.G.2    DeVries, C.3    Ferrara, N.4    Williams, L.T.5


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