Endothelial cellular response to altered shear stress

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 281, Issue 3 25-3, 2001, Pages

  Fisher, Aron B ^a   Chien, Shu ^b   Barakat, Abdul I ^c   Nerem, Robert M ^d  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c University of California Davis   (United States)

^d GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Cell signaling; Hypertension; Ischemia; Mechanosensors

Indexed keywords

CYTOSKELETON PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; INTEGRIN; MEMBRANE LIPID; MEMBRANE PROTEIN; MEMBRANE RECEPTOR; PROTEIN KINASE; TRANSCRIPTION FACTOR;

BASEMENT MEMBRANE; CELL GROWTH; CELL JUNCTION; CONFERENCE PAPER; CYTOSKELETON; ENDOTHELIUM CELL; HUMAN; HYPERTENSION; MECHANORECEPTOR; NONHUMAN; OSCILLATION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SHEAR STRESS; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; THROMBOSIS;

EID: 0034834895     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.2001.281.3.l529     Document Type: Conference Paper

References (32)

1. 2+- and phosphatidylinositol 3-kinase-dependent nitric oxide generation in lung endothelial cells in situ with ischemia
2. +
3. ATP-independent membrane depolarization with ischemia in the oxygen-ventilated isolated rat lung
4. A flow-activated chloride-selective membrane current in vascular endothelial cells
5. Shear stress induces a time- and position-dependent increase in endothelial cell membrane fluidity
6. Oscillatory shear stress stimulates adhesion molecule expression in cultured human endothelium
7. Mechanotransduction in response to shear stress: Roles of receptor tyrosine kinases, integrins, and Shc
8. Effects of mechanical forces on signal transduction and gene expression in endothelial cells
9. Effects of disturbed flows on endothelial cells
10. Flow-mediated endothelial mechanotransduction
11. Oscillatory and steady laminar shear stress differentially affect human endothelial redox state: Role of a superoxide-producing NADH oxidase
12. Endothelial dysfunction, hemodynamic forces, and atherogenesis
13. Modular microinstrumentation for endothelial cell research
14. Increase of reactive oxygen species (ROS) in endothelial cells by shear flow and involvement of ROS in shear-induced c-fos expression
15. Integrin-mediated mechano-transduction requires its dynamic interaction with specific ECM ligands
16. Characterization of phenotypically distinct endothelial cell populations from rat lungs
17. The Ras/JNK pathway is involved in shear-induced gene expression
18. G proteins mediate shear stress-sensitive ion channels in vascular endothelial cells
19. Molecular mechanism of endothelial growth arrest by laminar shear stress
20. Oxidative burst and NO generation as the initial response to "ischemia" in flow-adapted endothelial cells
21. The study of the influence of flow on vascular endothelial biology
22. Fluid shear stress induces endothelial TGF-β1 transcription and production: Modulation by potassium channel blockade
23. + current in vascular endothelial cells
24. Dynamic mechanical conditioning of collagen-gel blood vessel constructs induces remodeling in vitro
25. Fluid shear stress induces a biphasic response of human monocyte chemotactic protein 1 gene expression in vascular endothelium
26. Immediate endothelial cell signaling response to lung ischemia
27. - channels
28. Changes in organization and composition of the extracellular matrix underlying cultured endothelial cells exposed to laminar steady shear stress
29. In situ imaging of intracellular calcium with ischemia in lung subpleural microvascular endothelial cells
30. Laminar shear stress: Mechanisms by which endothelial cells transduce an atheroprotective force
31. Simulated ischemia in flow-adapted endothelial cells leads to generation of reactive oxygen species and cell signaling
32. An endothelial cell-smooth muscle cell co-culture model for use in the investigation of flow effects on vascular biology