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Volumn 19, Issue 7, 2001, Pages 255-265

Delivering on the promise of bone morphogenetic proteins

Author keywords

[No Author keywords available]

Indexed keywords

BONE; GENETIC ENGINEERING; ORTHOPEDICS;

EID: 0035400037     PISSN: 01677799     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-7799(01)01665-1     Document Type: Review
Times cited : (273)

References (91)
  • 1
  • 2
    • 0024256133 scopus 로고
    • Novel regulators of bone formation: Molecular clones and activities
    • (1988) Science , vol.242 , pp. 1528-1534
    • Wozney, J.M.1
  • 3
    • 0025362715 scopus 로고
    • OP-1 cDNA encodes an osteogenic protein in the TGF-β family
    • (1990) EMBO J. , vol.9 , pp. 2085-2093
    • Ozkaynak, E.1
  • 7
    • 0029008655 scopus 로고
    • Immunolocalization of expression of bone morphogenetic proteins 2 and 4 in fracture healing
    • (1995) J. Orthop. Res. , vol.13 , pp. 357-367
    • Bostrom, M.1
  • 12
    • 0031759970 scopus 로고    scopus 로고
    • Carriers that concentrate native bone morphogenetic protein in vivo
    • (1998) Tissue Eng. , vol.4 , pp. 337-341
    • DeGroot, K.1
  • 13
  • 14
    • 0023755311 scopus 로고
    • Ectopic bone induction on and in porous hydroxyapatite combined with collagen and bone morphogenetic protein
    • (1988) Clin. Orthop. , vol.234 , pp. 250-254
    • Takaoka, K.1
  • 16
    • 0033564706 scopus 로고    scopus 로고
    • Posterolateral lumbar intertransverse process spine arthrodesis with recombinant human bone morphogenetic protein 2/hydroxyapatite-tricalcium phosphate after laminectomy in the non-human primate
    • (1999) Spine , vol.15 , pp. 1179-1185
    • Boden, S.D.1
  • 17
    • 0029912758 scopus 로고    scopus 로고
    • Composites of bone morphogenetic protein (BMP) and type IV collagen, coral-derived coral hydroxyapatite, and tricalcium phosphate ceramics
    • (1996) Int. Orthop. (SICOT) , vol.20 , pp. 321-325
    • Gao, T.1
  • 18
    • 0031219591 scopus 로고    scopus 로고
    • Repair of bone defect in primate mandible using a bone morphogenetic protein (BMP)-hydroxyapatite-collagen composite
    • (1997) J. Med. Dent. Sci. , vol.44 , pp. 63-70
    • Asahina, I.1
  • 23
    • 0027318019 scopus 로고
    • Healing segmental femoral defects in sheep using recombinant human bone morphogenetic protein
    • (1993) Clin. Orthop. , vol.293 , pp. 317-326
    • Gerhart, T.N.1
  • 24
    • 0029018646 scopus 로고
    • Effect of recombinant osteogenic protein-1 on healing of segmental defects in non-human primates
    • (1995) J. Bone Joint Surg. Am. , vol.77 A , pp. 734-750
    • Cook, S.D.1
  • 29
  • 30
    • 0032534524 scopus 로고    scopus 로고
    • Ectopic bone formation via rhBMP-2 delivery from porous bioabsorbable polymer scaffolds
    • (1998) J. Biomed. Mater. Res. , vol.42 , pp. 491-499
    • Whang, K.1
  • 31
  • 34
    • 0025457693 scopus 로고
    • Ectopic induction of cartilage and bone by water soluble proteins from bovine bone using a polyanhydride delivery vehicle
    • (1990) J. Biomed. Mater. Res. , vol.24 , pp. 901-911
    • Lucas, P.A.1
  • 37
    • 0027313504 scopus 로고
    • Polylactic acid-polyethylene glycol block copolymer. A new biodegradable synthetic carrier for bone morphogenetic protein
    • (1993) Clin. Orthop. , vol.109 , pp. 333-343
    • Miyamoto, S.1
  • 40
    • 0028518688 scopus 로고
    • Osseous regeneration in the rat calvarium using novel delivery systems for recombinant bone morphogenetic protein 2 (rhBMP-2)
    • (1994) J. Biomed. Mater. Res. , vol.28 , pp. 1139-1147
    • Kenley, R.1
  • 41
    • 0033194875 scopus 로고    scopus 로고
    • Bone regeneration by recombinant human bone morphogenetic protein-2 in rat mandibular defects. An experimental model of defect filling
    • (1999) J. Periodontol. , vol.70 , pp. 1026-1031
    • Higuchi, T.1
  • 43
    • 0032992531 scopus 로고    scopus 로고
    • Characterization of rhBMP-2 pharmacokinetics implanted with biomaterial carriers in the rat ectopic model
    • (1999) J. Biomed. Mat. Res. , vol.46 , pp. 193-202
    • Uludag, H.1
  • 49
    • 0343069792 scopus 로고    scopus 로고
    • Posterolateral intertransverse process spinal fusion arthrodesis with rhBMP-2 in a non-human primate - Important lessons learned regarding dose, carrier, and safety
    • (1999) J. Spinal Disord. , vol.12 , pp. 179-186
    • Martin, G.J.1
  • 50
    • 0034609627 scopus 로고    scopus 로고
    • Effects of geometry of hydroxyapatite as a cell substratum in BMP-induced ectopic bone formation
    • (2000) J. Biomed. Mater. Res. , vol.51 , pp. 491-499
    • Jin, Q.M.1
  • 51
    • 0033847185 scopus 로고    scopus 로고
    • Options for tissue engineering to address challenges of the aging skeleton
    • (2000) Tissue Eng. , vol.6 , pp. 341-350
    • Hollinger, J.1
  • 52
    • 0033564001 scopus 로고    scopus 로고
    • Tissue engineered bone biomimetic to regenerate calvarial critical-sized defects in athymic rats
    • (1999) J. Biomed. Mater. Res. , vol.45 , pp. 414-421
    • Winn, S.R.1
  • 53
    • 0032866489 scopus 로고    scopus 로고
    • The effect of regional gene therapy with bone morphogenetic protein-2-producing bone-marrow cells on the repair of segmental femoral defects in rats
    • (1999) J. Bone Joint Surg. , vol.81 A , pp. 905-917
    • Lieberman, J.R.1
  • 54
    • 0033021062 scopus 로고    scopus 로고
    • Localized, direct plasmid gene delivery in vivo: Prolonged therapy results in reproducible tissue regeneration
    • (1999) Nat. Med. , vol.5 , pp. 753-759
    • Bonadio, J.1
  • 56
    • 0031683897 scopus 로고    scopus 로고
    • Effect of recombinant human bone morphogenetic protein-2 on fracture healing in a goat tibial fracture model
    • (1998) J. Bone Miner. Res. , vol.13 , pp. 1483-1490
    • Welch, R.D.1
  • 57
    • 0032816770 scopus 로고    scopus 로고
    • Novel formulation of fibroblast growth factor-2 in a hyaluronan gel accelerates fracture healing in non-human primates
    • (1999) J. Orthop. Res. , vol.17 , pp. 607-614
    • Radomsky, M.L.1
  • 58
    • 0031781483 scopus 로고    scopus 로고
    • Recombinant human basic fibroblast growth factor accelerates fracture healing by enhancing callus remodeling in experimental dog tibial fracture
    • (1998) J. Bone Miner. Res. , vol.13 , pp. 942-949
    • Nakamura, T.1
  • 59
    • 0032134684 scopus 로고    scopus 로고
    • Use of an osteoinductive biomaterial (rhOP-1) in healing large segmental bone defects
    • (1998) J. Orthop. Trauma , vol.12 , pp. 407-412
    • Cook, S.D.1
  • 60
  • 61
  • 65
    • 0027987472 scopus 로고
    • Evaluation of human bone morphogenetic protein-2 in a canine fusion model
    • (1994) Clin. Orthop. , vol.308 , pp. 229-240
    • Muschler, G.F.1
  • 66
    • 0029073098 scopus 로고
    • Experimental spinal fusion with recombinant human bone morphogenetic protein-2
    • (1995) Spine , vol.20 , pp. 1326-1337
    • Schimandle, J.H.1
  • 67
    • 0029569034 scopus 로고
    • Evaluation of rhBMP-2 with an OPLA carrier in a canine posterolateral (transverse process) spinal fusion model
    • (1995) Spine , vol.20 , pp. 2669-2682
    • Sandhu, H.S.1
  • 68
    • 0028043934 scopus 로고
    • In vivo evaluation of recombinant human osteogenic protein (rhOP-1) implants as a bone graft substitute for spinal fusions
    • (1994) Spine , vol.19 , pp. 1655-1663
    • Cook, S.D.1
  • 70
    • 0031923287 scopus 로고    scopus 로고
    • Laparoscopic anterior spinal arthrodesis with rhBMP-2 in a titanium interbody threaded cage
    • (1998) J. Spinal Disord. , vol.11 , pp. 95-101
    • Boden, S.D.1
  • 71
    • 0033559935 scopus 로고    scopus 로고
    • Osteogenic protein versus autologous interbody arthrodesis in the sheep thoracic spine: A comparative endoscopic study using the Bagby and Kuslich interbody fusion device
    • (1999) Spine , vol.24 , pp. 509-518
    • Cunningham, B.W.1
  • 75
    • 0029249926 scopus 로고
    • Periodontal repair in dogs: Recombinant human bone morphogenetic protein-2 significantly enhances periodontal regeneration
    • (1995) J. Periodontol. , vol.66 , pp. 131-138
    • Sigurdsson, T.J.1
  • 78
    • 0029891982 scopus 로고    scopus 로고
    • Maxillary alveolar cleft repair in dogs using recombinant human bone morphogenetic protein-2 in a polymer carrier
    • (1996) Plast. Reconstr. Surg. , vol.98 , pp. 247-259
    • Mayer, M.1
  • 80
    • 0030720510 scopus 로고    scopus 로고
    • The effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on the healing of full-thickness defects of articular cartilage
    • (1997) J. Bone Joint Surg. Am. , vol.79 , pp. 1452-1463
    • Sellers, R.S.1
  • 81
    • 0033954799 scopus 로고    scopus 로고
    • Repair of articular cartilage defects one year after treatment with recombinant human bone morphogenetic protein-2 (rhBMP-2)
    • (2000) J. Bone Joint Surg. Am. , vol.82 , pp. 151-160
    • Sellers, R.S.1
  • 85
    • 0033159598 scopus 로고    scopus 로고
    • Preclinical and clinical evaluaton of osteogenic protein-1 (BMP-7) in bony sites
    • (1999) Orthopaedics J. , vol.22 , pp. 669-671
    • Cook, S.D.1
  • 89
    • 0004818361 scopus 로고    scopus 로고
    • Bone defect repair using subcutaneously induced bone by a bioresorbable calcium phosphate cement combined with rhBMP-2
    • (Ohgushi, H., Hastings, G.W. and Yoshikawa, T., eds). World Scientific Publishing Co. PTE. Ltd
    • (1999) Bioceramics
    • Ohura, K.1
  • 90
    • 8244262450 scopus 로고    scopus 로고
    • Ectopic bone induction in porous apatite-wollastonite-containing glass ceramic combined with bone morphogenetic protein
    • (1997) J. Biomed. Mat. Res. , vol.35 , pp. 421-432
    • Ijiri, S.1
  • 91
    • 0032764225 scopus 로고    scopus 로고
    • New synthetic absorbable polymers as BMP carriers: Plastic properties of poly-D,L-lactic acid-polyethylene glycol block copolymers
    • (1999) J. Biomed. Mater. Res. , vol.47 , pp. 104-110
    • Saito, N.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.