Mechanical strain opens connexin 43 hemichannels in osteocytes: A novel mechanism for the release of prostaglandin

Molecular Biology of the Cell

Volumn 16, Issue 7, 2005, Pages 3100-3106

  Cherian, Priscilla P ^a   Siller Jackson, Arlene J ^a   Gu, Sumin ^a   Wang, Xin ^a   Bonewald, Lynda F ^b   Sprague, Eugene ^a   Jiang, Jean X ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBENOXOLONE; CARRIER PROTEIN; CONNEXIN 43; GLYCYRRHETINIC ACID; PROSTAGLANDIN; PROSTAGLANDIN E2; PURINE P2X7 RECEPTOR;

ANIMAL CELL; ARTICLE; BIOTINYLATION; CELL DENSITY; CELL SURFACE; CONTROLLED STUDY; FLUID FLOW; GAP JUNCTION; MECHANICAL STRESS; MECHANOTRANSDUCTION; NONHUMAN; OSTEOCYTE; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SHEAR STRESS;

ANIMALS; BIOTINYLATION; BLOTTING, WESTERN; BONE AND BONES; CARBENOXOLONE; CELL LINE; CELL MEMBRANE; CELLS, CULTURED; CHICKENS; CONNEXIN 43; DENDRITES; GAP JUNCTIONS; GLYCYRRHETINIC ACID; MICE; MICROSCOPY, FLUORESCENCE; OLIGONUCLEOTIDES, ANTISENSE; OSTEOCYTES; PROSTAGLANDINS; RATS; RECEPTORS, PURINERGIC P2; STRESS, MECHANICAL;

EID: 21844442343     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E04-10-0912     Document Type: Article

References (39)

1. Aarden, E. M., Burger, E.H., and Nijweide, P. J. (1994). Function of osteocytes in bone. J. Cell. Biochem. 55, 287-299.
2. Ajubi, N. E., Klein-Nulend, J., Nijweide, P. J., Vrijheid-lammers, T., Alblas, M. J., and Burger, E. H. (1996). Pulsating fluid flow increases prostaglandin production by cultured chicken osteocytes-a cytoskeleton-dependent process. Biochem. Biophys. Res. Commun. 225, 62-68.
3. Banu, S. K., Arosh, J. A., Chapdelaine, P., and Fortier, M. A. (2003). Molecular cloning and spatial-temporal expression of the prostaglandin transporter: a basis for the action of prostaglandins in the bovine reproductive system. Proc. Nat. Acad. Sci. USA 100, 11747-11752.
4. Baylink, T. M., Mohan, S., Fitzsimmons, R. J., and Baylink, D. J. (1995). Evidence that the mitogenic effect of prostaglandin E2 on human bone cells involves protein kinase C and calcium pathways. J. Bone Miner. Res. 9 (suppl 31), B23.
5. Baylink, T. M., Mohan, S., Fitzsimmons, R. J., and Baylink, D. J. (1996). Evaluation of signal transduction mechanisms for the mitogenic effects of prostaglandin E2 in normal human bone cells in vitro. J. Bone Miner. Res. 11, 1413-1418.
6. Becker, D. L., McGonnell, I., Makarenkova, H. P., Patel, K., Tickle, C., Lorimer, J., and Green, C. R. (1999). Roles for a1 connexin in morphogenesis of chick embryos revealed using a novel antisense approach. Dev. Gene. 24, 33-42.
7. Breyer, R. M., Bagdassarian, C. K., Myers, S. A., and Breyer, M. D. (2001). Prostanoid receptors: subtypes and signaling. Annu. Rev. Pharmacol. Toxicol. 41, 661-690.
8. Chan, B. S., Satriano, J. A., Pucci, M., and Schuster, V. L. (1998). Mechanism of prostaglandin E2 transport across the plasma membrane of HeLa cells and Xenopus oocytes expressing the prostaglandin transporter "PGT". J. Biol. Chem. 273, 6689-6697.
9. 2 is essential for gap junction-mediated intercellular communication between osteocyte-like MLO-Y4 cells in response to mechanical strain. Endocrinology 142, 3464-3473.
10. Cheng, B., Zhao, S., Luo, J., Sprague, E., Bonewald, L. F., and Jiang, J. X. (2001b). Expression of functional gap junctions and regulation by fluid flow shear stress in osteocyte-like MLO-Y4 cells. J. Bone Miner. Res. 16, 249-259.
11. Collins, D. A., and Chambers, T. J. (1991). Effect of prostaglandins E1, E2, and F2a on osteoclast formation in mouse bone marrow cultures. J. Bone Miner. Res. 6, 157-164.
12. Collins, D. A., and Chambers, T. J. (1992). Prostaglandin E2 promotes osteoclast formation in murine hematopoietic cultures through an action on hematopoietic cells. J. Bone Miner. Res. 7, 555-561.
13. Daniels, G. M., and Amara, S. G. (1998). Selective labeling of neurotransmitter transporters at the cell surface. Methods Enzymol. 296, 307-318.
14. Dinchuk, J. E., et al. (1995). Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase 11. Nature 378, 406-409.
15. Forwood, M. R. (1996). Inducible cyclo-oxygenase (COX-2) mediates the induction of bone formation by mechanical loading in vivo. J. Bone Miner. Res. 11, 1688-1693.
16. Gomez-Hernandez, J. M., de Miguel, M., Larrosa, B., Gonzalez, D., and Barrio, L. C. (2003). Molecular basis of calcium regulation in connexin-32 hemichannels. Proc. Nat. Acad. Sci. USA 100, 16030-16035.
17. Goodenough, D. A., and Paul, D. L. (2003). Beyond the gap: functions of unpaired connexon channels. Nature Rev. 4, 1-10.
18. Harada, S. I., Balena, R., Rodan, G. A., and Rodan, S. B. (1995). The role of prostaglandins in bone formation. Connect. Tissue Res. 31, 279-282.
19. 2-mediated inflammatory pain sensitization. Science 304, 884-887.
20. Jee, W.S.S., Ueno, K., Deng, Y. P., and Woodbury, D. M. (1985). The effects of prostaglandin E2 in growing rats: increased metaphyseal hard tissue and corticoendosteal bone formation. Calcif. Tissue Int. 37, 148-156.
21. 2by osteocytes in response to mechanical strain. Cell Commun. Adhes. 10, 259-264.
22. Kaji, H., Sugimoto, T., Kanatani, M., Fukase, M., Kumegawa, M., and Chichara, K. (1996). Prostaglandin E2 stimulates osteoclast-like cell formation and bone-resorbing activity via osteoclasts: role of cAMP-dependent protein kinase. J. Bone Miner. Res. 11, 62-71.
23. Kanai, N., Lu, R., Satriano, J. A., Bao, Y., Wolkoff, A. W., and Schuster, V. L. (1995). Identification and characterization of a prostaglandin transporter. Science 268, 866-869.
24. 2on fracture callus in rabbit. Acta Orthop. Scand. 64, 59-63.
25. Klein-Nulend, J., Van Der Plas, A., Semeins, C. M., Ajubi, N. E., Frangos, J. A., Nijweide, P. J., and Burger, E. H. (1995). Sensitivity of osteocytes to biomechanical stress in vitro. FASEB J. 9, 441-445.
26. Lampe, P. D. (1994). Analyzing phorbol ester effects on gap junctional communication: a dramatic inhibition of assembly. J. Cell Biol. 127, 1895-1905.
27. Langenbach, R., et al. (1995). Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. Cell 83, 483-492.
28. North, R. A. (2002). Molecular physiology of P2X receptors. Physiol. Rev. 82, 1013-1067.
29. Plotkin, L. I., Manolagas, S. C., and Bellido, T. (2002). Transduction of cell survival signals by connexin-43 hemichannels. J. Biol. Chem. 277, 8648-8657.
30. Quist, A. P., Rhee, S. K., Lin, H., and Lal, R. (2000). Physiological role of gap-junctional hemichannels: extracellular calcium-dependent isosmotic volume regulation. J. Cell Biol. 148, 1063-1074.
31. 2and inositol trisphosphate levels in osteoblasts. Am. J. Physiol. 261, C428-C432.
32. Reich, K. M., Gay, C. V., and Frangos, J. A. (1990). Fluid shear stress as a mediator of osteoblast cyclic adenosine monophosphate production. J. Cell. Physiol. 143, 100-104.
33. Romanello, M., Veronesi, V., and D'Andrea, P. (2003). Mechanosensitivity and intercellular communication in HOBIT osteoblastic cells: a possible role for gap junction hemichannels. Biorheology 40, 119-121.
34. Schuster, V. L. (1998). Molecular mechanisms of prostaglandin transport. Annu. Rev. Physiol. 60, 221-242.
35. Schuster, V. L. (2002). Prostaglandin transport. Prostaglandins Other Lipid Mediat. 68-69, 633-647.
36. Sterck, J.G.H., Klein-Nulend, J., Lips, P., and Burger, E. H. (1998). Response of normal and osteoporotic human bone cells to mechanical stress in vitro. Am. J. Physiol. 274, E1113-E1120.
37. Stout, C. E., Costantin, J. L., Naus, C.C.G., and Charles, A. C. (2002). Intercellular calcium signaling in astrocytes via ATP release through connexin hemichannels. J. Biol. Chem. 277, 10482-10488.
38. Tanaka, K., Yamaguchi, Y., and Hakeda, Y. (1995). Isolated chick osteocytes stimulate formation and bone-resorbing activity of osteoclast-like cells. J. Bone Miner. Res. 13, 61-70.
39. Topper, J. N., Cai, J., Tavrakis, G., Anderson, K. R., Woolf, E. A., Sampson, B. A., Schoen, F. J., Falb, D., and Bimbrone, Jr., M. A. (1998). Human prostaglandin transporter gene (hPGT) is regulated by fluid mechanical stimuli in cultured endothelial cells and expressed in vascular endothelium in vivo. Circulation 98, 2396-2403.