Focal adhesions: A nexus for intracellular signaling and cytoskeletal dynamics

Experimental Cell Research

Volumn 261, Issue 1, 2000, Pages 25-36

  Sastry, Sarita K ^a   Burridge, Keith ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GUANOSINE TRIPHOSPHATASE; INTEGRIN; LYSOPHOSPHATIDIC ACID; RAS PROTEIN; RHO FACTOR; TYROSINE KINASE RECEPTOR;

ACTIN FILAMENT; ANIMAL CELL; CELL ADHESION; CELL INTERACTION; CYTOSKELETON; EMBRYO; EXTRACELLULAR MATRIX; MICROTUBULE; NONHUMAN; PRIORITY JOURNAL; RAT; SHORT SURVEY; SIGNAL TRANSDUCTION;

ANIMALIA; NEXUS;

EID: 0034715923     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2000.5043     Document Type: Article

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48. RAFTK/PYK2 tyrosine kinase mediates the association of p190RhoGAP with RasGAP and is involved in breast cancer cell invasion
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59. Syndecan-4 deficiency impairs focal adhesion formation only under restricted conditions
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61. Monocyte adhesion and spreading on human endothelial cells is dependent on Rho-regulated receptor clustering
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63. Inhibition of RhoA by p120 catenin
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66. Cytoskeletal changes induced by GRAF, the GTPase regulator associated with focal adhesion kinase, are mediated by Rho
67. Morphological changes and detachment of adherent cells induced by p122, a GTPase-activating protein for Rho
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69. The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts
70. Rho-stimulated contractility contributes to the fibroblastic phenotype of Rastransformed epithelial cells
71. Oncogenic Ras downregulates Rac activity, which leads to increased Rho activity and epithelial-mesenchymal transition
72. Interplay between Rac and Rho in the control of substrate contact dynamics
73. Inhibition of myosin light chain kinase by p21-activated kinase (PAK)
74. A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion
75. RhoE regulates actin cytoskeleton organization and cell migration
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81. The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility
82. Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice
83. Stimulation of cell migration by overexpression of focal adhesion kinase and its association with src and fyn
84. Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesion
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86. Evidence for a calpeptin-sensitive protein-tyrosine phosphatase upstream of the small GTPase Rho
87. The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions
88. The carboxyl-terminal tyrosine residue of protein-tyrosine phosphatase a mediates association with focal adhesion plaques
89. Dissociation of FAK/p130cas/c-Src complex during mitosis: Role of mitosis-specific serine phosphorylation of FAK
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94. Integrin dynamics on the tail region of migrating fibroblasts
95. Focal adhesion motility revealed in stationary fibroblasts
96. Rho guanosine triphosphatase mediates the selective stabilization of microtubules induced by lysophosphatidic acid
97. Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts
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100. Contact formation during fibroblast locomotion: Involvement of membrane ruffles and microtubules
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103. ARF1 mediates paxillin recruitment to focal adhesions and potentiates Rho-stimulated stress fiber formation in intact and permeabilized Swiss 3T3 fibroblasts
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105. Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling
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112. Phosphoinositide 3-OH kinase activates the beta2 integrin adhesion pathway and induces membrane recruitment of cytohesin-1