Mutation in Bmp7 exacerbates the phenotype of Bmp8a mutants in spermatogenesis and epididymis

Developmental Biology

Volumn 240, Issue 1, 2001, Pages 212-222

  Zhao, Guang Quan ^a,b   Chen, Ya Xiong ^b   Liu, Xiao Ming ^b   Xu, Zhisuo ^a,b   Qi, Xiaoxia ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

Author keywords

Bmp7; Epididymis; Male germ cells; Mouse; Spermatogenesis

Indexed keywords

BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 8; BONE MORPHOGENETIC PROTEIN RECEPTOR; OSTEOGENIC PROTEIN 1; UNCLASSIFIED DRUG;

ALLELE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DELETION MUTANT; EPIDIDYMIS; GENE EXPRESSION; GENE MUTATION; GERM CELL; IN SITU HYBRIDIZATION; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SEMINIFEROUS TUBULE; SPERMATOCYTE; SPERMATOGENESIS; SPERMATOGONIUM;

EID: 0035578386     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1006/dbio.2001.0448     Document Type: Article

References (40)

1. Differential roles for bone morphogenetic protein (BMP) receptor type IB and IA in differentiation and specification of mesenchymal precursor cells to osteoblast and adipocyte lineages
2. Expression of bone morphogenetic protein 7 in murine epididymis is developmentally regulated
3. Smadl recognition and activation by the ALK1 group of transforming growth factor-beta family receptors
4. Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis
5. A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye
6. Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4
7. The type I serine/threonine kinase receptor ActRIA (ALK2) is required for gastrulation of the mouse embryo
8. TGF-beta signalling from cell membrane to nucleus through SMAD proteins
9. Bone morphogenetic proteins: Multifunctional regulators of vertebrate development
10. MADR1, a MAD-related protein that functions in BMP2 signaling pathways
11. Skeletal abnormalities in doubly heterozygous Bmp4 and Bmp7 mice
12. Cloning of a novel type II serine/threonine kinase receptor through interaction with the type I transforming growth factor-beta receptor
13. Bmp4 is required for the generation of primordial germ cells in the mouse embryo
14. Human type II receptor for bone morphogenic proteins (BMPs), extension of the two-kinase receptor model to the BMPs
15. BMP 7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning
16. Controlling TGF-beta signaling
17. Multiple roles for activin-like kinase-2 signaling during mouse embryogenesis
18. Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis
19. TGF-beta signaling by Smad proteins
20. Receptor serine/threonine kinases implicated in the control of Drosophila body pattern by decapentaplegic
21. Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis
22. An absolute requirement for both the type II and type I receptors, punt and thick veins, for dpp signaling in vivo
23. Staging for the laboratory mouse
24. A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo
25. Signaling via hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors
26. Complementation between kinase-defective and activation-defective TGF-beta receptors reveals a novel form of receptor cooperativity essential for signaling
27. Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse
28. Signal transduction. Mad about SMADs
29. TGF beta signals through a heteromeric protein kinase receptor complex
30. Mechanism of activation of the TGF-beta receptor
31. Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects
32. Requirement of Bmp8b for the generation of primordial germ ceils in the mouse
33. Cooperation of endoderm-derived BMP2 and extraembryonic ectoderm-derived BMP4 in primordial germ cell generation in the mouse
34. Induction of primordial germ ceils from murine epiblasts by synergistic action of BMP4 and BMP8B signaling pathways
35. Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development
36. Cartilage homeoprotein 1, a homeoprotein selectively expressed in chondrocytes
37. The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse
38. Evidence that mouse Bmp8a (Op2) and Bmp8b are duplicated genes that play a role in spermatogenesis and placental development
39. Evidence that Mothers-against-dpp-related 1 (Madr1) plays a role in the initiation and maintenance of spermatogenesis in the mouse
40. Bone morphogenetic protein 8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis