-
1
-
-
8744228282
-
Mechanisms of integration of cells and extracellular matrices by integrins
-
Humphries M.J., Travis M.A., Clark K., and Mould A.P. Mechanisms of integration of cells and extracellular matrices by integrins. Biochem Soc Trans 32 (2004) 822-825
-
(2004)
Biochem Soc Trans
, vol.32
, pp. 822-825
-
-
Humphries, M.J.1
Travis, M.A.2
Clark, K.3
Mould, A.P.4
-
4
-
-
0036636095
-
Building epithelial architecture: insights from three-dimensional culture models
-
O'Brien L.E., Zegers M.M., and Mostov K.E. Building epithelial architecture: insights from three-dimensional culture models. Nat Rev Mol Cell Biol 3 (2002) 531-537
-
(2002)
Nat Rev Mol Cell Biol
, vol.3
, pp. 531-537
-
-
O'Brien, L.E.1
Zegers, M.M.2
Mostov, K.E.3
-
5
-
-
0038738331
-
Fibroblast biology in three-dimensional collagen matrices
-
Grinnell F. Fibroblast biology in three-dimensional collagen matrices. Trends Cell Biol 13 (2003) 264-269
-
(2003)
Trends Cell Biol
, vol.13
, pp. 264-269
-
-
Grinnell, F.1
-
6
-
-
25444443688
-
Modelling glandular epithelial cancers in three-dimensional cultures
-
Debnath J., and Brugge J.S. Modelling glandular epithelial cancers in three-dimensional cultures. Nat Rev Cancer 5 (2005) 675-688
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 675-688
-
-
Debnath, J.1
Brugge, J.S.2
-
7
-
-
33644529130
-
Capturing complex 3D tissue physiology in vitro
-
Griffith L.G., and Swartz M.A. Capturing complex 3D tissue physiology in vitro. Nat Rev Mol Cell Biol 7 (2006) 211-224
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 211-224
-
-
Griffith, L.G.1
Swartz, M.A.2
-
8
-
-
11144224316
-
Responses of fibroblasts to anchorage of dorsal extracellular matrix receptors
-
The differences between cell morphologies on 2D and 3D substrates can be partially resolved when dorsal receptors on cells in 2D are engaged by anchored fibronectin or collagen, thereby mimicking a 3D environment. These responses are dependent on substrate rigidity and calcium.
-
Beningo K.A., Dembo M., and Wang Y.L. Responses of fibroblasts to anchorage of dorsal extracellular matrix receptors. Proc Natl Acad Sci U S A 101 (2004) 18024-18029. The differences between cell morphologies on 2D and 3D substrates can be partially resolved when dorsal receptors on cells in 2D are engaged by anchored fibronectin or collagen, thereby mimicking a 3D environment. These responses are dependent on substrate rigidity and calcium.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 18024-18029
-
-
Beningo, K.A.1
Dembo, M.2
Wang, Y.L.3
-
9
-
-
13944265302
-
Basic mechanism of three-dimensional collagen fibre transport by fibroblasts
-
Meshel A.S., Wei Q., Adelstein R.S., and Sheetz M.P. Basic mechanism of three-dimensional collagen fibre transport by fibroblasts. Nat Cell Biol 7 (2005) 157-164
-
(2005)
Nat Cell Biol
, vol.7
, pp. 157-164
-
-
Meshel, A.S.1
Wei, Q.2
Adelstein, R.S.3
Sheetz, M.P.4
-
10
-
-
0346850860
-
Different molecular motors mediate platelet-derived growth factor and lysophosphatidic acid-stimulated floating collagen matrix contraction
-
Abe M., Ho C.H., Kamm K.E., and Grinnell F. Different molecular motors mediate platelet-derived growth factor and lysophosphatidic acid-stimulated floating collagen matrix contraction. J Biol Chem 278 (2003) 47707-47712
-
(2003)
J Biol Chem
, vol.278
, pp. 47707-47712
-
-
Abe, M.1
Ho, C.H.2
Kamm, K.E.3
Grinnell, F.4
-
11
-
-
31944433804
-
P21-activated kinase 1: convergence point in PDGF- and LPA-stimulated collagen matrix contraction by human fibroblasts
-
Two important signaling pathways that are initiated by the serum components LPA and PDGF converge on PAK1 to regulate collagen matrix contraction through cofilin 1. PDGF and LPA can also stimulate matrix contraction in cooperation with PAK1, via Rho kinase and mDia1, respectively.
-
Rhee S., and Grinnell F. P21-activated kinase 1: convergence point in PDGF- and LPA-stimulated collagen matrix contraction by human fibroblasts. J Cell Biol 172 (2006) 423-432. Two important signaling pathways that are initiated by the serum components LPA and PDGF converge on PAK1 to regulate collagen matrix contraction through cofilin 1. PDGF and LPA can also stimulate matrix contraction in cooperation with PAK1, via Rho kinase and mDia1, respectively.
-
(2006)
J Cell Biol
, vol.172
, pp. 423-432
-
-
Rhee, S.1
Grinnell, F.2
-
12
-
-
0034611008
-
1 integrins promotes early fibronectin fibrillogenesis
-
1 integrins promotes early fibronectin fibrillogenesis. J Cell Biol 148 (2000) 1075-1090
-
(2000)
J Cell Biol
, vol.148
, pp. 1075-1090
-
-
Pankov, R.1
Cukierman, E.2
Katz, B.Z.3
Matsumoto, K.4
Lin, D.C.5
Lin, S.6
Hahn, C.7
Yamada, K.M.8
-
13
-
-
14044270216
-
1 integrin conformation promotes directional integrin translocation and fibronectin matrix formation
-
5 integrin antibody (SNAKA51), capable of promoting fibronectin matrix formation, is used as a tool to identify a subset of adhesion contacts associated with integrin translocation from focal contacts into fibrillar adhesions, a mechanism of fibronectin fibrillogenesis.
-
5 integrin antibody (SNAKA51), capable of promoting fibronectin matrix formation, is used as a tool to identify a subset of adhesion contacts associated with integrin translocation from focal contacts into fibrillar adhesions, a mechanism of fibronectin fibrillogenesis.
-
(2005)
J Cell Sci
, vol.118
, pp. 291-300
-
-
Clark, K.1
Pankov, R.2
Travis, M.A.3
Askari, J.A.4
Mould, A.P.5
Craig, S.E.6
Newham, P.7
Yamada, K.M.8
Humphries, M.J.9
-
14
-
-
0347723887
-
The receptor for urokinase-type plasminogen activator regulates fibronectin matrix assembly in human skin fibroblasts
-
Monaghan E., Gueorguiev V., Wilkins-Port C., and McKeown-Longo P.J. The receptor for urokinase-type plasminogen activator regulates fibronectin matrix assembly in human skin fibroblasts. J Biol Chem 279 (2004) 1400-1407
-
(2004)
J Biol Chem
, vol.279
, pp. 1400-1407
-
-
Monaghan, E.1
Gueorguiev, V.2
Wilkins-Port, C.3
McKeown-Longo, P.J.4
-
15
-
-
33646920445
-
Urokinase-type plasminogen activator receptor regulates a novel pathway of fibronectin matrix assembly requiring Src-dependent transactivation of epidermal growth factor receptor
-
Monaghan-Benson E., and McKeown-Longo P.J. Urokinase-type plasminogen activator receptor regulates a novel pathway of fibronectin matrix assembly requiring Src-dependent transactivation of epidermal growth factor receptor. J Biol Chem 281 (2006) 9450-9459
-
(2006)
J Biol Chem
, vol.281
, pp. 9450-9459
-
-
Monaghan-Benson, E.1
McKeown-Longo, P.J.2
-
16
-
-
27644473227
-
Stimulatory effects of a three-dimensional microenvironment on cell-mediated fibronectin fibrillogenesis
-
This paper demonstrates that a 3D fibronectin matrix can stimulate cellular fibronectin fibril assembly to a greater extent than a 2D fibronectin matrix. In addition, cells normally requiring activation of integrins for matrix formation on 2D substrates can assemble fibronectin matrix on 3D substrates without exogenous activation.
-
Mao Y., and Schwarzbauer J.E. Stimulatory effects of a three-dimensional microenvironment on cell-mediated fibronectin fibrillogenesis. J Cell Sci 118 (2005) 4427-4436. This paper demonstrates that a 3D fibronectin matrix can stimulate cellular fibronectin fibril assembly to a greater extent than a 2D fibronectin matrix. In addition, cells normally requiring activation of integrins for matrix formation on 2D substrates can assemble fibronectin matrix on 3D substrates without exogenous activation.
-
(2005)
J Cell Sci
, vol.118
, pp. 4427-4436
-
-
Mao, Y.1
Schwarzbauer, J.E.2
-
18
-
-
0041924762
-
1 integrin, RhoA, and fibronectin polymerization
-
1 integrin, RhoA, and fibronectin polymerization. Am J Pathol 163 (2003) 1045-1056
-
(2003)
Am J Pathol
, vol.163
, pp. 1045-1056
-
-
Li, S.1
Van Den Diepstraten, C.2
D'Souza, S.J.3
Chan, B.M.4
Pickering, J.G.5
-
20
-
-
0036796746
-
Fibronectin polymerization regulates the composition and stability of extracellular matrix fibrils and cell-matrix adhesions
-
Sottile J., and Hocking D.C. Fibronectin polymerization regulates the composition and stability of extracellular matrix fibrils and cell-matrix adhesions. Mol Biol Cell 13 (2002) 3546-3559
-
(2002)
Mol Biol Cell
, vol.13
, pp. 3546-3559
-
-
Sottile, J.1
Hocking, D.C.2
-
21
-
-
0038141338
-
Fibronectin requirement in branching morphogenesis
-
Sakai T., Larsen M., and Yamada K.M. Fibronectin requirement in branching morphogenesis. Nature 423 (2003) 876-881
-
(2003)
Nature
, vol.423
, pp. 876-881
-
-
Sakai, T.1
Larsen, M.2
Yamada, K.M.3
-
22
-
-
12344296398
-
Control of basement membrane remodeling and epithelial branching morphogenesis in embryonic lung by Rho and cytoskeletal tension
-
Moore K.A., Polte T., Huang S., Shi B., Alsberg E., Sunday M.E., and Ingber D.E. Control of basement membrane remodeling and epithelial branching morphogenesis in embryonic lung by Rho and cytoskeletal tension. Dev Dyn 232 (2005) 268-281
-
(2005)
Dev Dyn
, vol.232
, pp. 268-281
-
-
Moore, K.A.1
Polte, T.2
Huang, S.3
Shi, B.4
Alsberg, E.5
Sunday, M.E.6
Ingber, D.E.7
-
23
-
-
20144388729
-
Integrin α5 and delta/notch signaling have complementary spatiotemporal requirements during zebrafish somitogenesis
-
5 and Notch signaling are interdependent during the cell polarization and fibronectin matrix assembly that occur in somite formation.
-
5 and Notch signaling are interdependent during the cell polarization and fibronectin matrix assembly that occur in somite formation.
-
(2005)
Dev Cell
, vol.8
, pp. 575-586
-
-
Julich, D.1
Geisler, R.2
Holley, S.A.3
-
24
-
-
16244394860
-
Integrin α5-dependent fibronectin accumulation for maintenance of somite boundaries in zebrafish embryos
-
5 and fibronectin. The maintenance step involves somite epithelialization, which also involves Eph-Ephrin signaling that may function redundantly with the fibronectin pathway.
-
5 and fibronectin. The maintenance step involves somite epithelialization, which also involves Eph-Ephrin signaling that may function redundantly with the fibronectin pathway.
-
(2005)
Dev Cell
, vol.8
, pp. 587-598
-
-
Koshida, S.1
Kishimoto, Y.2
Ustumi, H.3
Shimizu, T.4
Furutani-Seiki, M.5
Kondoh, H.6
Takada, S.7
-
25
-
-
33645086641
-
Regulation of somitogenesis by Ena/VASP proteins and FAK during Xenopus development
-
In this paper, details of the molecular mechanisms for morphogenesis of somite formation are identified. FAK and Ena/VASP proteins are shown to be required for somite formation and fibronectin matrix formation, perhaps by regulating integrin activity.
-
Kragtorp K.A., and Miller J.R. Regulation of somitogenesis by Ena/VASP proteins and FAK during Xenopus development. Development 133 (2006) 685-695. In this paper, details of the molecular mechanisms for morphogenesis of somite formation are identified. FAK and Ena/VASP proteins are shown to be required for somite formation and fibronectin matrix formation, perhaps by regulating integrin activity.
-
(2006)
Development
, vol.133
, pp. 685-695
-
-
Kragtorp, K.A.1
Miller, J.R.2
-
28
-
-
24944547482
-
Tensional homeostasis and the malignant phenotype
-
This paper examines the relationship between tissue rigidity and tumor behavior. It demonstrates that ECM stiffness perturbs epithelial morphogenesis by clustering integrins and inducing focal adhesion assembly to enhance ERK activation and increase ROCK-mediated contractility.
-
Paszek M.J., Zahir N., Johnson K.R., Lakins J.N., Rozenberg G.I., Gefen A., Reinhart-King C.A., Margulies S.S., Dembo M., Boettiger D., et al. Tensional homeostasis and the malignant phenotype. Cancer Cell 8 (2005) 241-254. This paper examines the relationship between tissue rigidity and tumor behavior. It demonstrates that ECM stiffness perturbs epithelial morphogenesis by clustering integrins and inducing focal adhesion assembly to enhance ERK activation and increase ROCK-mediated contractility.
-
(2005)
Cancer Cell
, vol.8
, pp. 241-254
-
-
Paszek, M.J.1
Zahir, N.2
Johnson, K.R.3
Lakins, J.N.4
Rozenberg, G.I.5
Gefen, A.6
Reinhart-King, C.A.7
Margulies, S.S.8
Dembo, M.9
Boettiger, D.10
-
29
-
-
19944428596
-
Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion
-
Yeung T., Georges P.C., Flanagan L.A., Marg B., Ortiz M., Funaki M., Zahir N., Ming W., Weaver V., and Janmey P.A. Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion. Cell Motil Cytoskeleton 60 (2005) 24-34
-
(2005)
Cell Motil Cytoskeleton
, vol.60
, pp. 24-34
-
-
Yeung, T.1
Georges, P.C.2
Flanagan, L.A.3
Marg, B.4
Ortiz, M.5
Funaki, M.6
Zahir, N.7
Ming, W.8
Weaver, V.9
Janmey, P.A.10
-
31
-
-
0032217084
-
Reciprocal interactions between β1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology
-
Wang F., Weaver V.M., Petersen O.W., Larabell C.A., Dedhar S., Briand P., Lupu R., and Bissell M.J. Reciprocal interactions between β1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology. Proc Natl Acad Sci U S A 95 (1998) 14821-14826
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 14821-14826
-
-
Wang, F.1
Weaver, V.M.2
Petersen, O.W.3
Larabell, C.A.4
Dedhar, S.5
Briand, P.6
Lupu, R.7
Bissell, M.J.8
-
32
-
-
0242509224
-
ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix
-
Wozniak M.A., Desai R., Solski P.A., Der C.J., and Keely P.J. ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix. J Cell Biol 163 (2003) 583-595
-
(2003)
J Cell Biol
, vol.163
, pp. 583-595
-
-
Wozniak, M.A.1
Desai, R.2
Solski, P.A.3
Der, C.J.4
Keely, P.J.5
-
34
-
-
0842281652
-
Rho and Rac take center stage
-
Burridge K., and Wennerberg K. Rho and Rac take center stage. Cell 116 (2004) 167-179
-
(2004)
Cell
, vol.116
, pp. 167-179
-
-
Burridge, K.1
Wennerberg, K.2
-
35
-
-
27644562231
-
Proteases and metastasis: clinical relevance nowadays?
-
Decock J., Paridaens R., and Cufer T. Proteases and metastasis: clinical relevance nowadays?. Curr Opin Oncol 17 (2005) 545-550
-
(2005)
Curr Opin Oncol
, vol.17
, pp. 545-550
-
-
Decock, J.1
Paridaens, R.2
Cufer, T.3
-
36
-
-
0038784546
-
Membrane type I matrix metalloproteinase usurps tumor growth control imposed by the three-dimensional extracellular matrix
-
Hotary K.B., Allen E.D., Brooks P.C., Datta N.S., Long M.W., and Weiss S.J. Membrane type I matrix metalloproteinase usurps tumor growth control imposed by the three-dimensional extracellular matrix. Cell 114 (2003) 33-45
-
(2003)
Cell
, vol.114
, pp. 33-45
-
-
Hotary, K.B.1
Allen, E.D.2
Brooks, P.C.3
Datta, N.S.4
Long, M.W.5
Weiss, S.J.6
-
37
-
-
33646571255
-
Type I collagen abrogates the clathrin-mediated internalization of membrane type 1 matrix metalloproteinase (MT1-MMP) via the MT1-MMP hemopexin domain
-
A new regulatory mechanism for cell surface MT1-MMP presentation is described in this report. Upon type I collagen binding to its cell surface receptor, MT1-MMP internalization via clathrin-coated-pit-mediated endocytosis is inhibited through interactions with the hemopexin domain.
-
Lafleur M.A., Mercuri F.A., Ruangpanit N., Seiki M., Sato H., and Thompson E.W. Type I collagen abrogates the clathrin-mediated internalization of membrane type 1 matrix metalloproteinase (MT1-MMP) via the MT1-MMP hemopexin domain. J Biol Chem 281 (2006) 6826-6840. A new regulatory mechanism for cell surface MT1-MMP presentation is described in this report. Upon type I collagen binding to its cell surface receptor, MT1-MMP internalization via clathrin-coated-pit-mediated endocytosis is inhibited through interactions with the hemopexin domain.
-
(2006)
J Biol Chem
, vol.281
, pp. 6826-6840
-
-
Lafleur, M.A.1
Mercuri, F.A.2
Ruangpanit, N.3
Seiki, M.4
Sato, H.5
Thompson, E.W.6
-
38
-
-
9444290419
-
Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase MT1-MMP
-
This paper reports that fibroblasts and tumor cells are able to traverse through dense cross-linked type I collagen barriers in vitro and in vivo via a proteolytic process that is uniquely mediated by MT1-MMP. Data presented in the paper identify MT1-MMP as a required pericellular collagenolysin that confers tissue-invasive capability on normal and neoplastic cells.
-
Sabeh F., Ota I., Holmbeck K., Birkedal-Hansen H., Soloway P., Balbin M., Lopez-Otin C., Shapiro S., Inada M., Krane S., et al. Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase MT1-MMP. J Cell Biol 167 (2004) 769-781. This paper reports that fibroblasts and tumor cells are able to traverse through dense cross-linked type I collagen barriers in vitro and in vivo via a proteolytic process that is uniquely mediated by MT1-MMP. Data presented in the paper identify MT1-MMP as a required pericellular collagenolysin that confers tissue-invasive capability on normal and neoplastic cells.
-
(2004)
J Cell Biol
, vol.167
, pp. 769-781
-
-
Sabeh, F.1
Ota, I.2
Holmbeck, K.3
Birkedal-Hansen, H.4
Soloway, P.5
Balbin, M.6
Lopez-Otin, C.7
Shapiro, S.8
Inada, M.9
Krane, S.10
-
41
-
-
1642282882
-
Prespecification and plasticity: shifting mechanisms of cell migration
-
Friedl P. Prespecification and plasticity: shifting mechanisms of cell migration. Curr Opin Cell Biol 16 (2004) 14-23
-
(2004)
Curr Opin Cell Biol
, vol.16
, pp. 14-23
-
-
Friedl, P.1
-
43
-
-
33645507413
-
Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: defining the stages of invadopodia formation and function
-
This paper uses three-color live-cell imaging and multispectral confocal microscopy to reveal the dynamics of the stepwise formation of invadopodia. Cortactin accumulates first and is followed by MT1-MMP, leading to matrix degradation.
-
Artym V.V., Zhang Y., Seillier-Moiseiwitsch F., Yamada K.M., and Mueller S.C. Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: defining the stages of invadopodia formation and function. Cancer Res 66 (2006) 3034-3043. This paper uses three-color live-cell imaging and multispectral confocal microscopy to reveal the dynamics of the stepwise formation of invadopodia. Cortactin accumulates first and is followed by MT1-MMP, leading to matrix degradation.
-
(2006)
Cancer Res
, vol.66
, pp. 3034-3043
-
-
Artym, V.V.1
Zhang, Y.2
Seillier-Moiseiwitsch, F.3
Yamada, K.M.4
Mueller, S.C.5
-
45
-
-
21844432918
-
Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability
-
This work identifies a novel molecular pathway by which MMP-3 induces the expression of Rac1b, leading to increased ROS and subsequent oxidative damage to DNA, genomic instability and malignant transformation.
-
Radisky D.C., Levy D.D., Littlepage L.E., Liu H., Nelson C.M., Fata J.E., Leake D., Godden E.L., Albertson D.G., Nieto M.A., et al. Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature 436 (2005) 123-127. This work identifies a novel molecular pathway by which MMP-3 induces the expression of Rac1b, leading to increased ROS and subsequent oxidative damage to DNA, genomic instability and malignant transformation.
-
(2005)
Nature
, vol.436
, pp. 123-127
-
-
Radisky, D.C.1
Levy, D.D.2
Littlepage, L.E.3
Liu, H.4
Nelson, C.M.5
Fata, J.E.6
Leake, D.7
Godden, E.L.8
Albertson, D.G.9
Nieto, M.A.10
-
46
-
-
33646365644
-
Lysyl oxidase is essential for hypoxia-induced metastasis
-
Erler J.T., Bennewith K.L., Nicolau M., Dornhofer N., Kong C., Le Q.T., Chi J.T., Jeffrey S.S., and Giaccia A.J. Lysyl oxidase is essential for hypoxia-induced metastasis. Nature 440 (2006) 1222-1226
-
(2006)
Nature
, vol.440
, pp. 1222-1226
-
-
Erler, J.T.1
Bennewith, K.L.2
Nicolau, M.3
Dornhofer, N.4
Kong, C.5
Le, Q.T.6
Chi, J.T.7
Jeffrey, S.S.8
Giaccia, A.J.9
-
47
-
-
33644893402
-
Elastic fiber formation: a dynamic view of extracellular matrix assembly using timer reporters
-
Kozel B.A., Rongish B.J., Czirok A., Zach J., Little C.D., Davis E.C., Knutsen R.H., Wagenseil J.E., Levy M.A., and Mecham R.P. Elastic fiber formation: a dynamic view of extracellular matrix assembly using timer reporters. J Cell Physiol 207 (2006) 87-96
-
(2006)
J Cell Physiol
, vol.207
, pp. 87-96
-
-
Kozel, B.A.1
Rongish, B.J.2
Czirok, A.3
Zach, J.4
Little, C.D.5
Davis, E.C.6
Knutsen, R.H.7
Wagenseil, J.E.8
Levy, M.A.9
Mecham, R.P.10
-
48
-
-
24644466511
-
Stroma-derived three-dimensional matrices are necessary and sufficient to promote desmoplastic differentiation of normal fibroblasts
-
Amatangelo M.D., Bassi D.E., Klein-Szanto A.J., and Cukierman E. Stroma-derived three-dimensional matrices are necessary and sufficient to promote desmoplastic differentiation of normal fibroblasts. Am J Pathol 167 (2005) 475-488
-
(2005)
Am J Pathol
, vol.167
, pp. 475-488
-
-
Amatangelo, M.D.1
Bassi, D.E.2
Klein-Szanto, A.J.3
Cukierman, E.4
-
49
-
-
33748797944
-
-
Larsen M, Wei C, Yamada KM: Cell and fibroenctin dynamics during branching morphogenesis. J Cell Sci 2006, in press. Two-color confocal time-lapse imaging is used to examine both cell and matrix dynamics in salivary glands in organ culture. These studies reveal that both embryonic epithelial cells and local sites of 3D fibronectin matrix are unexpectedly highly dynamic during development.
-
-
-
|