Development and characterization of a porous poly(methyl methacrylate) scaffold with controllable modulus and permeability

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Volumn 80, Issue 2, 2007, Pages 360-369

  Shimko, Daniel A ^a,b   Nauman, Eric A ^a,b  

^a Tulane University   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

Bone tissue engineering; Fatigue; Modulus; Permeability; Porous PMMA; Scaffold

Indexed keywords

BONE; ELASTIC MODULI; FATIGUE TESTING; GRAFTS; MECHANICAL PERMEABILITY; POROUS MATERIALS; TISSUE CULTURE;

BONE GRAFTING; PORE INTERCONNECTIVITY; SCAFFOLD PERMEABILITY; TISSUE ENGINEERING;

POLYMETHYL METHACRYLATES;

BIOMATERIAL; POLY(METHYL METHACRYLATE);

ARTICLE; BIOCOMPATIBILITY; BONE ALLOGRAFT; BONE GRAFT; BONE INJURY; BONE MARROW CELL; BONE REGENERATION; CANCELLOUS BONE; COMPRESSION; CYTOTOXICITY; EVALUATION; FOOD AND DRUG ADMINISTRATION; IN VITRO STUDY; LEACHING; PERMEABILITY; POROSITY; STRENGTH; STROMA CELL; TECHNIQUE; TISSUE ENGINEERING; YOUNG MODULUS;

ANIMALS; BONE MARROW CELLS; BONE SUBSTITUTES; CELLS, CULTURED; ELASTICITY; HUMANS; MATERIALS TESTING; MICROSCOPY, ELECTRON, SCANNING; PERMEABILITY; POLYMETHYL METHACRYLATE; RATS; STERILIZATION; STRESS, MECHANICAL; TISSUE ENGINEERING;

EID: 33846958752     PISSN: 15524973     EISSN: 15524981     Source Type: Journal    
DOI: 10.1002/jbm.b.30605     Document Type: Article

References (57)

1. Citardi MJ, Friedman CD. Nonvascularized autogenous bone grafts for craniofacial skeletal augmentation and replacement. Otolaryngol Clin North Am 1994;27:891-910.
2. Lew DP, Waldvogel FA. Osteomyelitis. Lancet 2004;364:369-379.
3. Mastro AM, Gay CV, Welch DR. The skeleton as a unique environment for breast cancer cells. Clin Exp Metastasis 2003;20:275-284.
4. Bubendorf L, Schopfer A, Wagner U, Sauter G, Moch H, Willi N, Gasser TC, Mihatsch MJ. Metastatic patterns of prostate cancer: An autopsy study of 1,589 patients. Hum Pathol 2000;31:578-583.
5. Prolo DJ, Rodrigo JJ. Contemporary bone graft physiology and surgery. Clin Orthop Relat Res 1985;(200):322-342.
6. Lane JM, Sandhu HS. Current approaches to experimental bone grafting. Orthop Clin North Am 1987;18:213-225.
7. St John TA, Vaccaro AR, Sah AP, Schaefer M, Berta SC, Albert T, Hilibrand A. Physical and monetary costs associated with autogenous bone graft harvesting. Am J Orthop 2003;32:18-23.
8. Silber JS, Anderson DG, Daffner SD, Brislin BT, Leland JM, Hilibrand AS, Vaccaro AR, Albert TJ. Donor site morbidity after anterior iliac crest bone harvest for single-level anterior cervical discectomy and fusion. Spine 2003;28:134-139.
9. Tomford WW, Thongphasuk J, Mankin HJ, Ferraro MJ. Frozen musculoskeletal allografts. A study of the clinical incidence and causes of infection associated with their use. J Bone Joint Surg Am 1990;72:1137-1143.
10. Hardin CK. Banked bone. Otolaryngol Clin North Am 1994;27:911-925.
11. Ishaug SL, Crane GM, Miller MJ, Yasko AW, Yaszemski MJ, Mikos AG. Bone formation by three-dimensional stromal osteoblast culture in biodegradable polymer scaffolds. J Biomed Mater Res 1997;36:17-28.
12. Shimko DA, White KK, Nauman EA, Dee KC. A device for long term, in vitro loading of three-dimensional natural and engineered tissues. Ann Biomed Eng 2003;31:1347-1356.
13. Fricain JC, Bareille R, Ulysse F, Dupuy B, Amedee J. Evaluation of proliferation and protein expression of human bone marrow cells cultured on coral crystallized in the aragonite of calcite form. J Biomed Mater Res 1998;42:96-102.
14. Findlay DM, Welldon K, Atkins GJ, Howie DW, Zannettino AC, Bobyn D. The proliferation and phenotypic expression of human osteoblasts on tantalum metal. Biomaterials 2004;25:2215-2227.
15. Ishaug-Riley SL, Crane GM, Gurlek A, Miller MJ, Yasko AW, Yaszemski MJ, Mikos AG. Ectopic bone formation by marrow stromal osteoblast transplantation using poly(DL-lactic-co-glycolic acid) foams implanted into the rat mesentery. J Biomed Mater Res 1997;36:1-8.
16. Martin RB, Chapman MW, Holmes RE, Sartoris DJ, Shors EC, Gordon JE, Heitter DO, Sharkey NA, Zissimos AG. Effects of bone ingrowth on the strength and non-invasive assessment of a coralline hydroxyapatite material. Biomaterials 1989;10:481-488.
17. Holmes R, Mooney V, Bucholz R, Tencer A. A coralline hydroxyapatite bone graft substitute. Preliminary report. Clin Orthop Relat Res 1984;(188):252-262.
18. Wang JC, Yu WD, Sandhu HS, Tam V, Delamarter RB. A comparison of magnetic resonance and computed tomographic image quality after the implantation of tantalum and titanium spinal instrumentation. Spine 1998;23:1684-1688.
19. Bobyn JD, Stackpool GJ, Hacking SA, Tanzer M, Krygier JJ. Characteristics of bone ingrowth and interface mechanics of a new porous tantalum biomaterial. J Bone Joint Surg Br 1999;81:907-914.
20. Hutmacher DW. Scaffolds in tissue engineering bone and cartilage. Biomaterials 2000;21:2529-2543.
21. Hui PW, Leung PC, Sher A. Fluid conductance of cancellous bone graft as a predictor for graft-host interface healing. J Biomech 1996;29:123-132.
22. Yang S, Leong KF, Du Z, Chua CK. The design of scaffolds for use in tissue engineering. Part I. Traditional factors. Tissue Eng 2001;7:679-689.
23. Liu JK, Gottfried ON, Cole CD, Dougherty WR, Couldwell WT. Porous polyethylene implant for cranioplasty and skull base reconstruction. Neurosurg Focus 2004;16:ECP1.
24. Park HK, Dujovny M, Diaz FG, Guthikonda M. Biomechanical properties of high-density polyethylene for pterional prosthesis. Neurol Res 2002;24:671-676.
25. Zou X, Li H, Baatrup A, Lind M, Bunger C. Engineering of bone tissue with porcine bone marrow stem cells in three-dimensional trabecular metal: In vitro and in vivo studies. APMIS Suppl 2003;(109):127-132.
26. Zou X, Li H, Bunger M, Egund N, Lind M, Bunger C. Bone ingrowth characteristics of porous tantalum and carbon fiber interbody devices: An experimental study in pigs. Spine J 2004;4:99-105.
27. Bobyn JD, Toh KK, Hacking SA, Tanzer M, Krygier JJ. Tissue response to porous tantalum acetabular cups: A canine model. J Arthroplasty 1999;14:347-354.
28. Hacking SA, Bobyn JD, Toh K, Tanzer M, Krygier JJ. Fibrous tissue ingrowth and attachment to porous tantalum. J Biomed Mater Res 2000;52:631-638.
29. Shimko DA, Shimko VF, Sander EA, Dickson KF, Nauman EA. Effect of porosity on the fluid flow characteristics and mechanical properties of tantalum scaffolds. J Biomed Mater Res B Appl Biomater 2005;73:315-324.
30. Heiner AD, Poggie RA, Brown TD. Flexural rigidity of laboratory and surgical substitutes for human fibular bone grafts. J Muscoskel Res 1998;2:267-272.
31. Zardiackas LD, Parsell DE, Dillon LD, Mitchell DW, Nunnery LA, Poggie R. Structure, metallurgy, and mechanical properties of a porous tantalum foam. J Biomed Mater Res 2001;58:180-187.
32. Haddock SM, Debes JC, Nauman EA, Fong KE, Arramon YP, Keaveny TM. Structure-function relationships for coralline hydroxyapatite bone substitute. J Biomed Mater Res 1999;47:71-78.
33. Zhang Y, Ni M, Zhang M, Ratner B. Calcium phosphate-chitosan composite scaffolds for bone tissue engineering. Tissue Eng 2003;9:337-345.
34. Muller K. Use and properties of PMMA bone cement. In: Winter GD, Leray JL, Groot KD, editors. Evaluation of Biomaterials. New York: Wiley; 1980. pp 175-187.
35. Churchill RS, Boorman RS, Fehringer EV, Matsen FA III. Glenoid cementing may generate sufficient heat to endanger the surrounding bone. Clin Orthop Relat Res 2004;(419):76-79.
36. Saha S, Pal S. Mechanical properties of bone cement: A review. J Biomed Mater Res 1984;18:435-462.
37. Leeson MC, Lippitt SB. Thermal aspects of the use of polymethylmethacrylate in large metaphyseal defects in bone. A clinical review and laboratory study. Clin Orthop Relat Res 1993;(295):239-245.
38. Shastri VP, Martin I, Langer R. Macroporous polymer foams by hydrocarbon templating. Proc Natl Acad Sci USA 2000;97:1970-1975.
39. Ma PX, Choi JW, Biodegradable polymer scaffolds with well-defined interconnected spherical pore network. Tissue Eng 2001;7:23-33.
40. Mikos AG, Thorsen AJ, Czerwonka LA, Bao Y, Langer R, Winslow DN, Vacanti JP. Preparation and characterization of poly(L-lactic acid) foams. Polymer 1994;35:1068-1077.
41. Mikos AG, Lyman MD, Freed LE, Langer R. Wetting of poly(L-lactic acid) and poly(DL-lactic-co-glycolic acid) foams for tissue culture. Biomaterials 1994;15:55-58.
42. Mikos AG, Sarakinos G, Leite SM, Vacanti JP, Langer R. Laminated three-dimensional biodegradable foams for use in tissue engineering. Biomaterials 1993;14:323-330.
43. Sander EA, Alb AM, Nauman EA, Reed WF, Dee KC. Solvent effects on the microstructure and properties of 75/25 poly(D,L-lactide-co- glycolide) tissue scaffolds. J Biomed Mater Res A 2004;70:506-513.
44. Murphy WL, Dennis RG, Kileny JL, Mooney DJ. Salt fusion: An approach to improve pore interconnectivity within tissue engineering scaffolds. Tissue Eng 2002;8:43-52.
45. Nauman EA, Fong KE, Keaveny TM. Dependence of intertrabecular permeability on flow direction and anatomic site. Ann Biomed Eng 1999;27:517-524.
46. Grimm MJ, Williams JL. Measurements of permeability in human calcaneal trabecular bone. J Biomech 1997;30:743-745.
47. Kohles SS, Roberts JB, Upton ML, Wilson CG, Bonassar LJ, Schlichting AL. Direct perfusion measurements of cancellous bone anisotropic permeability. J Biomech 2001;34:1197-202.
48. Gibson LJ, Ashby MF. Cellular Solids: Structure and Properties. Cambridge: Cambridge University Press; 1997. p 510.
49. Carter DR, Hayes WC. The compressive behavior of bone as a two-phase porous structure. J Bone Joint Surg Am 1977;59: 954-962.
50. Keaveny TM, Morgan EF, Niebur GL, Yeh OC. Biomechanics of trabecular bone. Annu Rev Biomed Eng 2001;3:307-333.
51. Majumdar S, Kothari M, Augat P, Newitt DC, Link TM, Lin JC, Lang T, Lu Y, Genant HK. High-resolution magnetic resonance imaging: Three-dimensional trabecular bone architecture and biomechanical properties. Bone 1998;22:445-454.
52. Morgan EF, Bayraktar HH, Keaveny TM. Trabecular bone modulus-density relationships depend on anatomic site. J Biomech 2003;36:897-904.
53. Hodgskinson R, Currey JD. Young modulus, density and material properties in cancellous bone over a large density range. J Mater Sci Mater Med 1992;3:377-381.
54. Ashman RB, Rho JY, Turner CH. Anatomical variation of orthotropic elastic moduli of the proximal human tibia. J Biomech 1989;22:895-900.
55. Bensusan JS, Davy DT, Heiple KG, Verdin PJ. Tensile, compressive and torsional testing of cancellous bone. Trans Orthop Res Soc 1983;8:132.
56. Lotz JC, Gerhart TN, Hayes WC. Mechanical properties of trabecular bone from the proximal femur: A quantitative CT study. J Comput Assist Tomogr 1990;14:107-114.
57. Bruens ML, Pieterman H, de Wijn JR, Vaandrager JM. Porous polymethylmethacrylate as bone substitute in the craniofacial area. J Craniofac Surg 2003;14:63-68.