Bone morphogenetic proteins: An overview of therapeutic applications

Orthopedics

Volumn 24, Issue 5, 2001, Pages 504-509

  Lou, Emil ^a  

^a State University of New York Upstate Medical University: College of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; COLLAGEN TYPE 1; DRUG CARRIER; OSTEOGENIC PROTEIN 1; POLYGLACTIN; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICULAR CARTILAGE; BONE GROWTH; BONE REGENERATION; CELL DIFFERENTIATION; CLASSIFICATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG RESPONSE; EMBRYO PATTERN FORMATION; FEMUR; FRACTURE; FRACTURE HEALING; GENE TARGETING; GENE THERAPY; HUMAN; IMPLANTATION; NONHUMAN; OSTEOBLAST; PSEUDARTHROSIS; REVIEW; SPINE FUSION;

BONE MORPHOGENETIC PROTEINS; BONE REGENERATION; HUMANS; SPINAL FUSION;

EID: 0035009473     PISSN: 01477447     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (63)

1. Musculoskeletal injuries. In: Praemer A, Furner S, Rice DP, eds. Musculoskeletal Conditions in the United States. Park Ridge, Ill: American Academy of Orthopaedic Surgeons; 1992:83-124.
2. Cotler JM, Star AM. Complications of spinal fusions. In: Cotler JM, Cotler HM, eds. Spinal Fusion: Science and Technique. New York, NY: Springer-Verlag; 1990:361-387.
3. Urist MR. Bone: formation by autoinduction. Science. 1965; 150:893-899.
4. Wozney JM. Bone morphogenetic proteins. Progress in Growth Factor Research. 1989; 1:267-280.
5. Zheng MH, Wood DJ, Wysocki S, Papadimitriou JM, Wang EA. Recombinant human bone morphogenetic protein-2 enhances expression of interleukin-6 and transforming growth factor-beta 1 genes in normal human osteoblast-like cells. J Cell Physiol. 1994; 159:76-82.
6. Knutsen R, Honda Y, Strong DD, Sampath TK, Baylink DS, Mohan S. Regulation of insulin-like growth factor system components by osteogenic protein-1 in human bone cells. Endocrinology. 1995; 136:857-865.
7. Barboza E, Caula A, Machado F. Potential of recombinant human bone morphogenetic protein-2 in bone regeneration. Implant Dentistry. 1999; 8:360-367.
8. Wozney JM, Rosen V, Celeste AJ, et al. Novel regulators of bone formation: molecular clones and activities. Science. 1988; 242:1528-1534.
9. Massague J. TGF-beta signaling: receptors, transducers, and Mad proteins. Cell. 1996; 85:947-950.
10. Ludwig SC, Boden SD. Osteoinductive bone graft substitutes for spinal fusion: a basic science summary. Orthop Clin North Am. 1999; 30:635-645.
11. Wang EA, Rosen V, Cordes P, et al. Purification and characterization of other distinct bone-inducing factors. Proc Natl Acad Sci USA. 1988; 85:9484-9488.
12. Sampath TK, Reddi AH. Homology of bone-inductive proteins from human, monkey, bovine, and rat extracellular matrix. Proc Natl Acad Sci USA. 1983; 80:6591-6595.
13. Reddi AH, Wientroub S, Muthukumaran N. Biologic principles of bone induction. Orthop Clin North Am. 1987; 18:207-212.
14. Groeneveld EH, Burger EH. Bone morphogenetic proteins in human bone regeneration. Eur J Endocrinol. 2000; 142:9-21.
15. Urist MR. Bone morphogenetic protein: the molecularization of skeletal system development. J Bone Miner Res. 1997; 12:343-346.
16. Elima K. Osteoinductive proteins. Ann Med. 1993; 25:395-402.
17. Lyons KM, Pelton RW, Hogan BL. Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor-beta-like genes coordinately regulate aspects of embryonic development. Genes Dev. 1989; 3:1657-1668.
18. Helder MN, Ozkaynak E, Sampath KT, et al. Expression pattern of osteogenic protein-1 (bone morphogenetic protein-7) in human and mouse development. J Histochem Cytochem. 1995; 43:1035-1044.
19. Zegzula HD, Buck DC, Brekke J, Wozney JM, Hollinger JO. Bone formation with use of rhBMP-2 (recombinant human bone morphogenetic protein-2). J Bone Joint Surg Am. 1997; 79:1778-1790.
20. Kingsley DM. What do BMPs do in mammals? Clues from the mouse short-ear mutation. Trends Genet. 1994; 10:16-21.
21. Kingsley DM. The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. Genes Dev. 1994; 8:133-146.
22. Winnier G, Blessing M, Labosky PA, Hogan BL. Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev. 1995; 9:2105-2116.
23. Wozney JM. The bone morphogenetic protein family and osteogenesis. Mol Reprod Dev. 1992; 32:160-167.
24. Sandhu HS, Grewal HS, Parvataneni H. Bone grafting for spinal fusion. Orthop Clin North Am. 1999; 30:685-698.
25. Urist MR, Huo YK, Brownell AG, et al. Purification of bovine bone morphogenetic protein by hydroxyapatite chromatography. Proc Natl Acad Sci USA. 1984; 81:371-375,
26. Urist MR, Mikulski A, Lietze A. Solubilized and insolubilized bone morphogenetic protein. Proc Natl Acad Sci USA. 1979; 76:1828-1832.
27. Cook SD. Preclinical and clinical evaluation of osteogenic protein-1 (BMP-7) in bony sites. Orthopedics. 1999; 22:669-671.
28. Gerhart TN, Kirker-Head CA, Kriz MJ, et al. Healing segmental femoral defects in sheep using recombinant human bone morphogenetic protein. Clin Orthop. 1993; 293:317-326.
29. Itoh H, Ebara S, Kamimura M, et al. Experimental spinal fusion with use of recombinant human bone morphogenetic protein 2. Spine. 1999; 24:1402-1405.
30. Sheehan JP, Kallmes DF, Sheehan JM, et al. Molecular methods of enhancing lumbar spine fusion. Neurosurgery. 1996; 39:548-554.
31. Si X, Jin Y, Yang L. Induction of new bone by ceramic bovine bone with recombinant human bone morphogenetic protein 2 and transforming growth factor beta. Int J Oral Maxillofac Surg. 1998; 27:310-314.
32. Takuwa Y, Ohse C, Wang EA, Wozney JM, Yamashita K. Bone morphogenetic protein-2 stimulates alkaline phosphatase activity and collagen synthesis in cultured osteoblastic cells, MC3T3-E1. Biochem Biophys Res Commun. 4991; 174:96-101.
33. Vukicevic S, Kopp JB, Luyten FP, Sampath TK. Induction of nephrogenic mesenchyme by osteogenic protein 1 (bone morphogenetic protein 7). Proc Natl Acad Sci USA. 1996; 93:9021-9026.
34. Bone morphogenetic proteins and tissue engineering. Nat Biotechnol. 1996; 14:242.
35. Sandhu HS, Kanim LE, Kabo JM, et al. Effective doses of recombinant human bone morphogenetic protein-2 in experimental spinal fusion. Spine. 1996; 21:2115-2122.
36. Laursen M, Hoy K, Hansen ES, Gelineck J, Christensen FB, Bunger CE. Recombinant bone morphogenetic protein-7 as an intracorporal bone growth stimulator in unstable thoracolumbar burst fractures in humans: preliminary results. Eur Spine J. 1999; 8:485-490.
37. Johnson EE, Urist MR. Human bone morphogenetic protein allografting for reconstruction of femoral nonunion. Clin Orthop. 2000; 371:61-74.
38. Cook SD, Rueger DC. Osteogenic protein-1: biology and applications. Clin Orthop. 1996; 324:29-38.
39. Cook SD, Salkeld SL, Rueger DC. Evaluation of recombinant human osteogenic protein-1 (rhOP-1 ) placed with dental implants in fresh extraction sites. Journal of Oral Implantolgy. 1996; 21:1-6.
40. Bessho K, Carnes DL, Cavin R, Chen HY, Ong JL. BMP stimulation of bone response adjacent to titanium implants in vivo. Clinical Oral Implants Research. 1999; 10:212-218.
41. Cook SD, Baffes GC, Wolfe MW, Sampath TK, Rueger DC. Recombinant human bone morphogenetic protein-7 induces healing in a canine long-bone segmental defect model. Clin Orthop. 1994; 301:302-312.
42. Ripamonti U, Van Den Heever B, Sampath TK, Tucker MM, Rueger DC, Reddi AH. Complete regeneration of bone in the baboon by recombinant human osteogenic protein-1 (hOP-1, bone morphogenetic protein-7). Growth Factors. 1996; 123:273-289.
43. Linde A, Hedner E. Recombinant bone morphogenetic protein-2 enhances bone healing, guided by osteopromotive e-PTFE membranes: an experimental study in rats. Calcif Tissue Int. 1995; 56:549-553.
44. Rickard DJ, Sullivan TA, Shenker BJ, Leboy PS, Kazhdan I. Induction of rapid osteoblast differentiation in rat bone marrow stromal cell cultures by dexamethasone and BMP-2. Dev Biol. 1994; 161:218-228.
45. Amedee J, Bareille R, Rouais F, Cunningham N, Reddi H, Harmand MF. Osteogenin (bone morphogenetic protein 3) inhibits proliferation and stimulates differentiation of osteoprogenitors in human bone marrow. Differentiation. 1994; 58:157-164.
46. Boden SD, McCuaig K, Hair G, et al. Differential effects and glucocorticoid potentiation of bone morphogenetic protein action during rat osteoblast differentiation in vitro. Endocrinology. 1996; 137:3401-3407.
47. Sellers RS, Zhang R, Glasson SS, et al. Repair of articular cartilage defects one year after treatment with recombinant human bone morphogenetic protein-2 (rhBMP-2). J Bone Joint Surg Am. 2000; 82:151-160.
48. Urist MR, Lietze A, Dawson E. Beta-tricalcium phosphate delivery system for bone morphocgenetic protein. Clin Orthop. 1984; 187:277-280.
49. Lucas PA, Syftestad GT, Goldberg VM, Caplan AI. Ectopic induction of cartilage and bone by water-soluble proteins from bovine bone using a collagenous delivery vehicle. J Biomed Mater Res. 1989; 23:23-39.
50. Einhorn TA, Majeska RJ, Rush EB, Levine PM, Horowitz MC. The expression of cytokine activity by fracture callus. J Bone Miner Res. 1995; 10:1272-1281.
51. Santavirta S, Konttinen YT, Nordstrom D, et al. Immunologic studies of nonunited fractures. Acta Orthop Scand. 1992; 63:579-586.
52. Andrew JG, Andrew SM, Freemont AJ, Marsh DR. Inflammatory cells in normal human fracture healing. Acta Orthop Scand. 1994; 65:462-466.
53. Mahy PR, Urist MR. Experimental heterotopic bone formation induced by bone morphogenetic protein and recombinant human interleukin-1B. Clin Orthop. 1988; 237:236-244.
54. Todescan R, Sodek J, Davies JE. Reconstituted collagen produces different healing reactions in bony and soft tissue peri-implant compartments. Int J Oral Maxillofac Implants. 1994; 9:298-304.
55. Boyne PJ, Marx RE, Nevins M, et al. A feasibility study evaluating rhBMP-2/absorbable collagen sponge for maxillary sinus floor augmentation. International Journal of Periodontics and Restorative Dentistry. 1997; 17:11-25.
56. Nakagawa T, Tagawa T. Ultrastructural study of direct bone formation induced by BMPs-collagen complex implanted into an ectopic site. Oral Diseases. 2000; 6:172-179.
57. Heckman JD, Ehler W, Brooks BP, et al. Bone morphogenetic protein but not transforming growth factor-beta enhances bone formation in canine diaphyseal nonunions implanted with a biodegradable composite polymer. J Bone Joint Surg Am. 1999; 81:1717-1729.
58. Isobe M, Yamazaki Y, Oida S, Ishihara K, Nakabayashi N, Amagasa T. Bone morphogenetic protein encapsulated with a biodegradable and biocompatible polymer. J Biomed Mater Res. 1996; 32:433-438.
59. Boden SD, Titus SL, Hair G, et al. Lumbar spine fusion by local gene therapy with a cDNA encoding a novel osteoinductive protein (LMP-1). Spine. 1998; 23:2486-2492.
60. Baltzer AWA, Lattermann C, Whalen JD, et al. Genetic enhancement of fracture repair: healing of an experimental segmental defect by adenoviral transfer of the BMP-2 gene. Gene Therapy. 2000; 7:734-739.
61. Alden TD, Pittman DD, Hankins GR, et al. In vivo endochondral bone formation using a bone morphogenetic protein 2 adenoviral vector. Hum Gene Ther. 1999; 10:2245-2253.
62. Krebsbach PH. Gu K, Franceschi RT, Rutherford RB. Gene therapy-directed osteogenesis: BMP-7-transduced human fibroblasts form bone in vivo. Hum Gene Ther. 2000; 11:1201-1210.
63. Soda H, Raymond E, Sharma S, et al. Antiproliferative effects of recombinant human bone morphogenetic protein-2 on human tumor colony-forming units. Anticancer Drugs. 1998; 9:327-331.